Efficacy and safety of glycyrrhizic acid combined to essential phospholipids (Phosphogliv) at non-alcoholic fatty liver disease: results of multicenter double blind randomized plac... by V. T. Ivashkin, I. G. Bakulin, P. O. Bogomolov, M. V. Matsiyevich, N. I. Geyvandova, P. V. Koroy, S. V. Nedogoda, O. A. Sablin, L. G. Lenskaya, Ye. V. Beloborodova, A. A. Bagretsova, R. A. Abdulkhakov, M. F. Osipenko, I. V. Osipova, D. A. Pocheptsov, Ye. V. Chumachek, O. M. Khromtsova, Ye. V. Kuzmicheva

“…The basic group patients received Phosphogliv 5 mg/day as intravenous bolus injection for 2 weeks, followed by oral intake of 2 capsules t.i.d. for 10 weeks (the total treatment duration was 12 weeks), control group patients received placebo in the same mode. …”
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Triglyceride-glucose-body mass index and the incidence of cardiovascular diseases: a meta-analysis of cohort studies by Xiyun Rao, Ziyi Xin, Qingwen Yu, Lanlan Feng, Yongmin Shi, Ting Tang, Xuhan Tong, Siqi Hu, Yao You, Shenghui Zhang, Jiake Tang, Xingwei Zhang, Mingwei Wang, Ling Liu

“…The results indicated that Compared with the lowest TyG-BMI index category, the highest TyG-BMI index was related to a higher incidence of cardiovascular diseases (CVD) (HR = 1.62; 95% confidence interval (CI): 1.35–1.95; I2 = 94%),coronary artery disease (CAD) (HR = 1.69; 95% (CI): 1.23–2.31; I2 = 94%). stroke(HR = 1.57; 95% (CI): 1.11–2.23; I2 = 94%).In the dose–response analysis, there was a linear association of the TyG-BMI index with the risk of CVD (Pnonlinear = 0.223), CAD (Pnonlinear = 0.693), and stroke (Pnonlinear = 0.122)No significant effects were observed regarding participants’ gender, length of follow-up, sample size or mean age(P > 0.05). Conclusion Higher TyG-BMI may be independently associated with an increased risk of CVD in individuals without CVD at baseline. …”
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Blood coagulation system in patients with chronic kidney disease: a prospective observational study by Xi Yang, Yang Wang, Ri-bao Wei, Ting-yu Su, Meng-jie Huang, Ping Li, Xiang-mei Chen, Ping Di, Qing-ping Li

“…During the 1-year of follow-up, one cardiovascular event occurred in patients with CKD 5 stage, whereas no thromboembolic event occurred in the CKD 3 and 4 and control groups.Conclusions Patients with CKD are characterised by endothelial dysfunction and increased coagulation, especially FVIII activity. …”
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Unveiling the nutraceutical potential of indigenous and exotic eggplant for bioactive compounds and antioxidant activity as well as its suitability to the nutraceutical industry by Yvonne Angel Lyngdoh, Yvonne Angel Lyngdoh, Partha Saha, Partha Saha, Bhoopal Singh Tomar, Rakesh Bhardwaj, Laxman L. Nandi, Mohita Srivastava, Bishal Gurung, Jeetendra Kumar Ranjan, Paresh Chaukhande

“…Cluster 1 had a maximum number of genotypes grouped together, i.e., 48, followed by cluster 2 with six genotypes, viz., Pusa Krishna (G-32), G-5, Mayurbhanj Local, HABI-2, Solanum gilo, and Solanum sisymbrifolium, and cluster 3 had only three genotypes, namely, Solanum insanum, Solanum khasianum, and Solanum xanthocarpum. …”
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Agronomic Performance of Irrigated and Rainfed Arabica Coffee Cultivars in the Cerrado Mineiro Region by Giovani Belutti Voltolini, Gladyston Rodrigues Carvalho, Vinícius Teixeira Andrade, André Dominghetti Ferreira, Francislei Vitti Raposo, João Paulo Felicori Carvalho, Diego Junior Martins Vilela, Cleidson Alves da Silva, Jéfferson de Oliveira Costa, Guilherme Barbosa Abreu, Juliana Costa de Rezende Abrahão, César Elias Botelho, Denis Henrique Silva Nadaleti, Marcelo Ribeiro Malta, Vânia Aparecida Silva, Sônia Maria de Lima Salgado, Reginério Soares de Faria, Antônio Carlos Baião de Oliveira, Antônio Alves Pereira

“…Twelve cultivars were evaluated as follows: Catuaí Vermelho IAC 144, Bourbon Amarelo IAC J10, Topázio MG 1190, MGS Epamig 1194, Catiguá MG2, MGS Catiguá 3, MGS Ametista, Pau Brasil MG1, MGS Paraíso 2, MGS Aranãs, Sarchimor MG 8840, and IAC 125 RN. …”
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Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia by Betelhem Gezahegn, Ahmed Abdella, Fentahun Meseret, Ahmed Mohammed, Mulualem Keneni, Tesfaye Asfaw, Diribsa Tizazu, Assefa Desalew

“…In the multivariable logistic regression analysis, low white blood cell (WBC) count [adjusted odds ratio (AOR) = 4.24, 95% CI: 1.5–12.5], desaturation (aOR = 3.00, 95% CI: 1.6–5.5), pre-term birth (aOR = 2.14, 95% CI: 1.1–4.0), lack of maternal antenatal care (ANC) follow-up (aOR = 2.4, 95% CI: 1.2–4.7), and chorioamnionitis (aOR = 2.8, 95% CI: 1.2–6.5) were significantly associated with neonatal sepsis mortality.ConclusionApproximately one-quarter of patients with neonatal sepsis died. …”
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NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled... by Deborah D Stocken, Maureen Twiddy, Hisham Mehanna, Jonathan Wadsley, Neil Corrigan, Katie Gordon, Julie Croft, Neil Sharma, Anna Perry, Mark Strachan, Gemma Ainsworth, Elizabeth Glenister, Sabapathy Prakash P Balasubramanian

“…The trial incorporates a process evaluation (IDEAL (Idea, Development, Exploration, Assessment and Long-term follow-up framework) 2a) to inform the trial protocol, a phase II (IDEAL 2b) analysis using a surrogate primary outcome of 1 day transient hypocalcaemia to determine early futility and phase III (IDEAL 3) assessment of the primary outcome of PoSH at 6 months after surgery. 454 participants will be randomised on a 1:1 basis to evaluate thyroid surgery with NIRF and indocyanine green against standard thyroid surgery in reducing PoSH at 6 months after surgery, with the phase II analysis occurring once data are available for 200 participants. …”
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Percutaneous coronary intervention vs. medical therapy in patients on dialysis with coronary artery disease in China by Enmin Xie, Yaxin Wu, Zixiang Ye, Yong He, Hesong Zeng, Jianfang Luo, Mulei Chen, Wenyue Pang, Yanmin Xu, Chuanyu Gao, Xiaogang Guo, Lin Cai, Qingwei Ji, Yining Yang, Di Wu, Yiqiang Yuan, Jing Wan, Yuliang Ma, Jun Zhang, Zhimin Du, Qing Yang, Jinsong Cheng, Chunhua Ding, Xiang Ma, Chunlin Yin, Zeyuan Fan, Qiang Tang, Yue Li, Lihua Sun, Chengzhi Lu, Jufang Chi, Zhuhua Yao, Yanxiang Gao, Changan Yu, Jingyi Ren, Jingang Zheng, Rongman Jia

“…Of the 1146 patients on dialysis with significant CAD, 821 (71.6%) underwent PCI. After a median follow-up of 23.0 months, PCI was associated with a 43.0% significantly lower risk for MACE (33.9% [n = 278] vs. 43.7% [n = 142]; adjusted hazards ratio 0.57, 95% confidence interval 0.45–0.71), along with a slightly increased risk for bleeding outcomes that did not reach statistical significance (11.1% vs. 8.3%; adjusted hazards ratio 1.31, 95% confidence interval, 0.82–2.11). …”
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Protocol for Home-Based Solution for Remote Atrial Fibrillation Screening to Prevent Recurrence Stroke (HUA-TUO AF Trial): a randomised controlled trial by Jing Tan, Yan Liang, Yong Liu, Wei Jiang, Duo Huang, Ning Tan, Chung-Wah Siu, Jo Jo Hai, Xiaoyu Huang, Jianfeng Ye, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Li-Xue Yin, Ming-Liang Zuo, Kui Kai Lau, Zhen Lei, Yingqing Feng, Bryan P Yan, Wen-Sheng Yue, Wen-Jun Zhang, Yuk-Ming Lau, Hin-Wai LUI, Koon-Ho Chan, Toi Meng Mok, Weng-Chio Tam, Kun-Chong Tam, Xiuhua Feng, Xiaofei Jiang, Guanming Tan, Mario Alberto Evora

“…The primary endpoint is the time to first detection of AF at 24 months of follow-up. Secondary endpoints include recurrent stroke or transient ischaemic attack, initiation of long-term anticoagulation therapy, hospitalisation for heart failure, cardiovascular death and all-cause death.Ethics and dissemination The study protocol has been approved by the institutional review board of The University of Hong Kong, and Hong Kong West Cluster, Hospital Authority, Hong Kong SAR, China. …”
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T-cell receptor beta variable gene polymorphism predicts immune-related adverse events during checkpoint blockade immunotherapy by Linghua Wang, Siqing Fu, Aung Naing, Funda Meric-Bernstam, Carl Morrison, Joud Hajjar, Mingxuan Xu, Anas Alshawa, Bettzy Stephen, Ying Yuan, Jordi Rodon Ahnert, Abdulrazzak Zarifa, Shrutii Sarda, Timothy Looney, Sapna P Patel, Geoffrey M Lowman, Dzifa Yawa Duose, Jeffrey M Conroy, Evan Kwiatkowski

“…By using principal component analysis of the 81 TRBV allele profiles followed by k-means clustering, we identified six major TRBV haplotypes. …”
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Sorption and diffusion studies of radiocesium in soil samples from Ibu Kota Nusantara region of Indonesia by Hana Fikrinabilah Dely Supratman, Hendra Adhi Pratama, Budi Setiawan, Mochamad Adhiraga Pratama, Sucipta Sucipta, Sitti Hijraini Nur, Nurul Efri Ekaningrum, Gustri Nurliati, Moh. Cecep Cepi Hikmat, Andry Setiawan, Niken Siwi Pamungkas, Zico Pratama Putra, Muhammad Yusuf

“…Mineralogical revealed distinct characteristics among the samples, with the E sample having the highest clay content of 46.18 %, followed by HA (36.27 %) and M (23.69 %). The Da in groundwater (GW) solvent achieved at 12 × 10−12 m2/s for HA, 5.80 × 10−12 m2/s for M, and 9.91 × 10−12 m2/s for E sample. …”
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Clinical management of community-acquired meningitis in adults in the UK and Ireland in 2017: a retrospective cohort study on behalf of the National Infection Trainees Collaborativ... by Amy Robinson, Kamaljit Khalsa, Arjun Chandna, John Bowen, Viva Levee, Jan Coebergh, Tom Solomon, Clive Graham, David Turner, Robert Tilley, Tim Jones, Susan Hopkins, Matthew Stevens, Daniel White, Celestine Eshiwe, Anna Goodman, Ramandeep Singh, Robert S Heyderman, Nicholas Davies, Joseph Thompson, Ed Moran, Martin Williams, Rhea O’Regan, Simon Tiberi, Jonathan Lambourne, Naomi Bulteel, Susan Larkin, Ruth McEwen, Hassan Paraiso, Aarti Shah, Martin Wiselka, Sylviane Defres, Ernest Mutengesa, Maria Krutikov, Ruth Owen, David Griffith, David Harvey, Trupti Patel, Brendan Davies, Emma Mclean, Joanna Allen, Ali Khan, Alastair Miller, Ashutosh Deshpande, Christopher Green, Lewis Jones, Mark Melzer, Fiona McGill, Amanda Fife, Nimal Wickramasinghe, Stephanie Harris, Ewan Hunter, Jayne Ellis, Benedict Rogers, Imogen Fordham, Elen Vink, Victoria Ward, Anna Smith, Andrew Rosser, Alison Muir, Ken Woodhouse, John Shone, Iain Crossingham, Ryan Jayesinghe, Eavan Muldoon, Avneet Shahi, Terry John Evans, Jeremy Wong, Eloisa MacLachlan, Amy Chue, Karishma Gokani, Katherine Ajdukiewicz, Lucinda Barrett, Frances Edwards, Adam Usher, Mairi McLeod, Su su Htwe, Grace Duane, Nicholas Wong, Jennifer Poyner, Jenni Crane, Ollie Lloyd, Emma Chisholm, Ildiko Kustos, Sam Sutton, M. Estee Torok, Isobel Ramsay, Monica Ivan, Joshua York, Jennifer Ansett, Maithili Varadarajan, Priya Sekhon, James Cruise, Shivani Kanabar, Mirella Ling, Charlotte Milne, Jayanta Sarma, Aline Wilson, Lynn Urquhart, Sahar Eldirdiri, Leila White, Jody Aberdein, Phillip Simpson, Hnin Hay Mar, Keying Tan, Eint Shwe Zin thein, Mahmoud Aziz, Anthony Cadwgan, Natasha Weston, Salman Zeb, Angela Houston, Louise Wootton, Iona Willingham, Aimee Johnson, Ashley Horsley, Eamonn Trainor, Olivier Gaillemin, Nicholas J Norton, Katie Cheung, Megan Duxbury, Emilie Bellhouse, Helena Brezovjakova, Kanitkar Tanmay, Alexsander Dawidziuk, Razan Saman, Hugh Adler, Elshadai Ejere, Yiwen Soo, Wendy Beadles, Heather Sturgeon, Brodie Cameron, David Chadwick Ben Tomlinson, Claire McGoldrick, Katie McDowell, Mpho Molosiwa, Katherine FlackAdrian Kennedy, Phoebe Cross, Fay Perry, Vithusha Inpadhas, Sarathy Selvam, Vhairi Bateman, Henry Wu, Monika Pasztor, Ajanthiha Karunakaran, Basma Soliman, Andrew Blanshard, Harish Reddy, Helen Chesterfield, Ben Schroeder, Tee Keat Teoh, Sathyavani Subbarao, Caryn RosmarinLucy Bell, Emma McGuire, Robert Serafino, Ishaan Bhide, Karanjeet Sagoo, Indran Balakrishnan, Kajal Patel, Barzo Faris, Graeme Calver, Ricky Singh, Hazel Sanghvi, Mohamed Eltayeb, Rathur Haris

“…Work should be done to improve the impact of guidelines, understand why they are not followed and, once published, ensure they translate into changed practice.…”
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Adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a m... by Ernest Choy, Kerenza Hood, Emma Thomas-Jones, Eleanor Barnes, Keith Wilson, Christian H Ottensmeier, Debbie Harris, Adrian Hill, Mark Tuthill, Richard Adams, Catherine Porter, Katie Ewer, Sian Griffin, Rebecca Tangney, Joanne Euden, Shirley Pringle, Lawrence Raisanen, Ruby Ray, Lisette Sheena Nixon, Melanie Varley, Craig Bodman, Paola Cicconi, Vivien Dagley, Steven Knapper

“…Participants will be administered AZD7442 on day 0 followed by a SARS-CoV-2 vaccination 28 days later. …”
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Characterization of three novel Helicobacter species infecting stomachs of dogs and cats: Helicobacter gastrocanis sp. nov., Helicobacter gastrofelis sp. nov., and Helicobacter fel... by Emiko Rimbara, Sae Aoki, Masato Suzuki, Hirotaka Kobayashi, Taisuke Nakagawa, Yuko Goto-Koshino, Sachiyo Nomura, Sachiyo Nomura, Wan-Ying Du, Hidenori Matsui, Shigetarou Mori, Keigo Shibayama, Tsuyoshi Kenri, Koichi Ohno

“…We, thus, propose these novel Helicobacter species as follows: Helicobacter gastrocanis sp. nov. (type strain NHP19-003T [=JCM 39159T = DSM 111619T]), Helicobacter gastrofelis sp. nov. …”
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Parameter influences of FTO/ZnO/Cu₂O photodetectors fabricated by electrodeposition and spray pyrolysis techniques by Muthiah N. Najah, Frida A. Rahmania, Integralita Cahyanti, Maulida Hesnaty, Siti Hajar Alias, Djoko Hartanto, Wahyu Prasetyo Utomo, Retno Sari, Hadi Nur

“…To enhance conductivity, a ZnO layer was deposited on FTO, followed by a Cu2O layer via electrodeposition. The synthesis parameters are varied to determine their effect on the reaction and to identify the optimal conditions. …”
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Temporal trends of the utilization patterns of sedative-hypnotic medications in children, adolescents and young adults: a 21-year population-based study with joinpoint regression a... by Carltin Chun Ting Kwok, Heidi Ka Ying Lo, Ching Yui Chan, Joe Kwun Nam Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng, Chung Ho, Brian Man Ho Leung, Wilfred Shone Horn Wong, Zoe Hoi Shuen Yu, Edwin Ho Ming Lee, Wing Chung Chang

“…Young adults (18–24 years-old) displayed the highest prescription prevalence, followed by adolescents (12–17 years-old) and children (4–11 years-old). …”
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Comparable outcomes after busulfan- or treosulfan-based conditioning for allo-HSCT in children with ALL: results of FORUM by Krzysztof Kalwak, Laura M. Moser, Ulrike Pötschger, Peter Bader, Katharina Kleinschmidt, Roland Meisel, Jean-Hugues Dalle, Akif Yesilipek, Adriana Balduzzi, Gergely Krivan, Evgenios Goussetis, Raquel Staciuk, Petr Sedlacek, Herbert Pichler, Peter Svec, Melissa Gabriel, Tayfun Güngör, Ernest Bilic, Jochen Buechner, Marleen Renard, Kim Vettenranta, Marianne Ifversen, Cristina Diaz-de-Heredia, Jerry Stein, Jacek Toporski, Marc Bierings, Christina Peters, Marc Ansari, Franco Locatelli

“…Data were analyzed as of February 2023, with a median follow-up of 4.2 years (range, 0.3-9.1). 3-year overall survival was 0.71 (BU, 95% confidence interval [0.64-0.77]) and 0.72 (TREO, [0.63-0.79]) and 3-year event-free survival was 0.60 (BU, [0.53-0.67]) and 0.55 (TREO, [0.46-0.63]). …”
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The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023 by Miaomiao Zhao, Miaomiao Zhao, Haoxiang Chang, Haoxiang Chang, Yuxu Yue, Yuxu Yue, Xinyue Zeng, Xinyue Zeng, Shaobang Wu, Shaobang Wu, Xiuyun Ren, Xiuyun Ren

“…CiteSpace [6.3.R1 (64-bit) Advanced] was used to perform knowledge mapping and bibliometric studies.ResultsOver the past 23 years, 932 articles from 73 countries were collected, with the U.S. contributing over one-third (355), followed by Brazil (85) and India (59). The literature in this field has experienced multiple growth phases since 2000, with particularly rapid growth observed after 2019. …”
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Elevated Kappa Index in the Absence of Cerebrospinal Fluid IgG Oligoclonal Bands: Contribution of Intrathecal IgM and IgA Synthesis by Krzysztof Smolik, Roberta Bedin, Patrizia Natali, Martina Cardi, Diego Franciotta, Anna Maria Simone, Paolo Immovilli, Mario Santangelo, Matteo Gastaldi, Giulia De Napoli, Francesca Vitetta, Diana Ferraro

“…The most frequent diagnosis in the Kappa+OCB- group was MS (27/69), followed by INFECT (16/69). Additional evidence of IS was demonstrated through an elevated IgG/IgM/IgA index or by the presence of IgM OCBs in 59%, and through only IgM/IgA IS in 52% of cases. …”
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Development of a Predictive Model of Occult Cancer After a Venous Thromboembolism Event Using Machine Learning: The CLOVER Study by Anabel Franco-Moreno, Elena Madroñal-Cerezo, Cristina Lucía de Ancos-Aracil, Ana Isabel Farfán-Sedano, Nuria Muñoz-Rivas, José Bascuñana Morejón-Girón, José Manuel Ruiz-Giardín, Federico Álvarez-Rodríguez, Jesús Prada-Alonso, Yvonne Gala-García, Miguel Ángel Casado-Suela, Ana Bustamante-Fermosel, Nuria Alfaro-Fernández, Juan Torres-Macho

“…<i>Results</i>: A total of 815 patients with VTE were included (51.5% male and median age of 59). During follow-up, 56 patients (6.9%) were diagnosed with cancer. …”
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