Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a C... by Raphael Cinotti, Yvan Derouin, Amandine Chenet, Lydia Oujamaa, Bertrand Glize, Yoann Launey, Claire Dahyot-Fizelier, Emmanuelle Cartron, Melodie Renvoise, Benedicte Sautenet, Veronique Sebille

“…MethodsThis study will follow five distinct steps: (1) systematic review to identify outcomes that have been reported in trials; (2) semistructured interviews with patients and their families to identify their priorities after TBI and explore potential patient-centered outcomes; (3) health care stakeholder focus groups with clinicians, researchers, and policy makers to describe potential outcomes; (4) an eDelphi survey with stakeholder groups to make a list of previously identified core outcomes; and (5) a consensus workshop to establish a COS for moderate-to-severe TBI clinical trials. …”
Get full text

Quantification of antimicrobial use on Irish dairy farms: A comparison of three recording methods by Hannah Martin, Edgar Garcia Manzanilla, Simon J. More, Robert Hyde, Conor McAloon

“…A sample of 33 Irish dairy herds were randomly selected from 6 private veterinary practices across Ireland. The herds were followed for a 12-mo period, and their AMU was monitored using 3 recording methods: (1) veterinary prescription data (VET), (2) the inventory of medicine bins on the farms (MB), and (3) farmer treatment records from herd recording software (APP). …”
Get full text

Une double discordance cardiaque complexe décompensée, à propos d’un cas et revue de la littérature by Nabila Soufi Taleb Bendiab, Rachid Djaziri, Fouad Sekkal, Nesrine Khedim, Abderrahim Meziane-Tani

“… Abstract Double discordance is an extremely rare complex congenital heart disease; It is characterized by atrioventricular discordance followed by another ventriculo-arterial discordance. …”
Get full text

HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation by Juliet A. Emamaullee, Mariusz Bral, Glenda Meeberg, Aldo J. Montano-Loza, Vincent G. Bain, Kelly Warren Burak, David Bigam, A. M. James Shapiro, Norman Kneteman

“…Data was collected through December 2017 to have a minimum of two years of follow-up. Results. In the study period, 128 adult LT were performed. 44 patients were HCV+, and 68.2% (N=30) also had HCC. 38.6% (N=17) of HCV+ patients received DAA pre-LT, and 94.1% (N=16/17) achieved sustained virologic response (SVR) pre-LT. …”
Get full text

Clinical and cost-effectiveness of a guided internet-based Acceptance and Commitment Therapy to improve chronic pain–related disability in green professions (PACT-A): study protoco... by Claudia Buntrock, Harald Baumeister, Yannik Terhorst, Lina Braun, Ingrid Titzler, Johanna Freund, Janika Thielecke, David Ebert

“…Outcomes will be measured using online self-report questionnaires at baseline, 9-week, 6-month, 12-month, 24-month and 36-month follow-ups.Ethics and dissemination This study was approved by the Ethics Committee of the University of Ulm, Germany (file no. 453/17—FSt/Sta; 22 February 2018). …”
Get full text

evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomat... by Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

“…Randomized participants follow an 8-week dose escalation regimen (3 mg [weeks 0–4], 7 mg [weeks 4–8], and 14 mg [weeks 8–156]). …”
Get full text

Do Nonsuicidal Severely Depressed Individuals with Diabetes Profit from Internet-Based Guided Self-Help? Secondary Analyses of a Pragmatic Randomized Trial by Sandra Schlicker, Kiona K. Weisel, Claudia Buntrock, Matthias Berking, Stephanie Nobis, Dirk Lehr, Harald Baumeister, Frank J. Snoek, Heleen Riper, David D. Ebert

“…Treatment response was seen in significantly more participants in the intervention (4/20; 20%) compared to the control group (0/20, 0%; χ2 2N=40=4.44; p<0.02). At the 6-month follow-up, effects were maintained for depressive symptom reduction (dpr6f=0.71; 95% CI: 0.19-1.61) but not treatment response. …”
Get full text

The Evaluation of Serum KIM-1 in a Pediatric Cohort of Renal Transplantation—A Pilot Study by Paul Luchian Aldea, Roxana Andreea Turbuleasa-Jurje, Bogdan Bulata, Dan Delean, Florin Ioan Elec, Lorena Ciumarnean, Andreea Liana Bot (Rachisan)

“…Patients and Methods: We included 21 patients who had their first kidney transplantation (8 females, 13 males), with a follow-up period from transplantation of 3.14 years, without prior immunization, having complete HLA typing and a negative cross-match test before transplantation. …”
Get full text

Characteristics and Influencing Factors of Soil CH4 and N2O Fluxes in Typical Broad-leaved Forests in the Yangtze River Delta Region, China by JIA Qinqi, XU Fei, CHEN Bingjiang, LU Yanran, CHEN Lihan, HU Jiahao, GUO Na, FANG Shuangxi

“…The N2O emission fluxes of the two treatments also showed similar seasonal variations, with the highest in summer, followed by spring, and lower in autumn and winter. …”
Get full text

Preserving postharvest storage quality of fresh-cut cactus pears by using different bio-materials by İbrahim Kahramanoğlu, Serhat Usanmaz, Volkan Okatan, Chunpeng Wan

“…Among them, the highest positive effect was received from A. vera gel treatment (0.98%), and is followed by cactus gel (1.15%), V. vinifera leaf (1.39%) and jelly (1.61%) at the end of the experiments (18 days). …”
Get full text

Association of Serum Irisin With Severity and Prognosis in Patients With Coronavirus Disease 2019: A Prospective Cohort Study by Zhang X, Wang W, Li Y, Liu X, Zhang L, Cheng Z, Liu M, Wang Y, Fu L, Yang J

“…Interestingly, chronic heart and kidney diseases significantly affected the associations between serum irisin and severity scores. The results of the follow-up study suggested that the level of serum irisin upon admission was reduced in patients who died within one month of hospitalization. …”
Get full text

Exploring the Use of Smartwatches and Activity Trackers for Health-Related Purposes for Children Aged 5 to 11 years: Systematic Review by Lauren Thompson, Sydney Charitos, Jon Bird, Paul Marshall, Amberly Brigden

“…The inclusion criteria for studies were as follows: (1) peer-reviewed, empirical studies; (2) published in English; (3) involved a child aged 5 to 11 years using a smartwatch for health-related purposes. …”
Get full text

N88S seipin-related seipinopathy is a lipidopathy associated with loss of iron homeostasis by Mariana O. Ribeiro, Mafalda Oliveira, Verónica Nogueira, Vítor Costa, Vitor Teixeira

“…Statistical comparisons were made using unpaired Student's t-tests or two-way ANOVA followed by Tukey´s / Šídák's multiple comparisons tests. …”
Get full text

Technique and long-term results of surgical resection of sclera in patients with primary glaucoma by E.A. Korchuganova, O.A. Rumyantseva, A.Yu. Kazantzeva

“…The operation is not followed by postoperative complications typical for glaucoma surgery, such as hyphema, hemophthalmia, ciliophorous detachment, uveitis.…”
Get full text

Microplastics contamination in two peripheral fish species harvested from a downstream river by M.R. Maulana, S. Saiful, Z.A. Muchlisin

“…Microplastics were analyzed in the digestive tract using a microscope, while waste in the carcass was detected using the fourier transform infrared analysis.FINDINGS:  In mullet, the highest number of microplastic particles were found in fish samples caught in river estuary (16 particles/fish on average), followed by the sample from residential areas (10 particles/fish on average). …”
Get full text

A comparison of drug‐eluting stent and coronary artery bypass grafting in mildly to moderately ischemic heart failure by Kun Wang, Le Wang, Hongliang Cong, Jingxia Zhang, Yuecheng Hu, Yingyi Zhang, Rui Zhang, Wenyu Li, Wei Qi

“…A total of 2050 patients (1330 PCIs and 720 CABGs) were included, and median follow‐up was 45 months (interquartile range 40 to 54). …”
Get full text

Predicting recurrence of non-muscle invasive bladder urothelial carcinoma: predictive value of the optimal cut-off value of Ki67 by Rende Peng, Yaoyu Zhang, Mingzhu Jia, Xinping Yi, Xiaoyao Yi, Shadan Li, Jiangchuan Pi, Wenjun Meng

“…This cut-off value can more accurately predict the risk of recurrence and has the potential clinical value for guiding the postoperative adjuvant treatment and follow-up strategy of NMIBUC.…”
Get full text

Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of <i>Centella asiatica</i> by Steven R. Chamberlin, Jonathan A. Zweig, Cody J. Neff, Luke Marney, Jaewoo Choi, Liping Yang, Claudia S. Maier, Amala Soumyanath, Shannon McWeeney, Nora E. Gray

“…Interestingly, in metabolomics analysis, the TTCQA treatment saw the highest number of changes in individual metabolites (20), followed by CQA (15), then TT (8), and finally CAW (3). …”
Get full text

Psychometric evaluation of the study interest questionnaire-short form among Chinese nursing students based on classical test theory and item response theory by Yue Yi Li, Lai Kun Tong, Mio Leng Au, Wai I. Ng, Si Chen Wang, Yongbing Liu, Liqiang Zhong, Yi Shen, Xichenhui Qiu

“…Methods The translation and cross-cultural adaptation rigorously followed the modified Brislin model. A cross-sectional survey was conducted using the Chinese version of the SIQ-SF and convenience sampling was employed to select nursing students. …”
Get full text

First report of Bemisia tabaci (Gennadius, 1889) (Hemiptera: Aleyrodidae), biotypes B and Q, in soybean Glycine max (L.) Merrill (Fabales: Fabaceae) in Paraguay by Nancy Noemí Espinoza-Morel, Marta Alicia Fernández-Gamarra, Liliana Noelia Talavera-Stefani, Cinthia Noemí Burgos-Cantoni, Felipe Giménez, Claudia Cabral, Andrés Sanabria-Velazquez

“…DNA was extracted using the Wizard genomic purification kit, followed by PCR amplification of the mitochondrial cytochrome oxidase I (mtCOI) region using specific primers for B. tabaci and T. vaporariorum. …”
Get full text