Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study by Helen Blackshaw, Anne GM Schilder, Rishi Mandavia, Gerjon Hannink, Muhammad Nayeem Ahmed, Yaami Premakumar, Timothy Shun Man Chu, Tanjinah Ferdous, Nishchay Mehta, Joseph Manjaly, Maha Khan

“…Mean change in QoL scores will be calculated from initial presentation to follow-up.Ethics and dissemination Health Research Authority and NHS Research Ethics Committee approved the study. …”
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A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children by Joana Llauradó-Pont, Nikos Stratakis, Giovanni Fiorito, Evangelos Handakas, Alexander Neumann, Henrique Barros, Anne Lise Brantsæter, Kiara Chang, Leda Chatzi, Janine F. Felix, Regina Grazuleviciene, Vincent W. V. Jaddoe, Marianna Karachaliou, Marion Lecorguillé, Carla Lopes, Christopher Millett, Rosemary R. C. McEachan, Eleni Papadopoulou, Remy Slama, Eszter P. Vamos, Paolo Vineis, Martine Vrijheid, John Wright, Trudy Voortman, Mariona Bustamante, Oliver Robinson, Camille Lassale

“…Associations were estimated within each cohort using robust linear regression models, adjusting for relevant covariates, followed by a meta-analysis of the resulting EWAS estimates. …”
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Multimorbidity is associated with risk of incident venous thromboembolism – A nationwide proof-of-concept study by Jonatan Ahrén, MirNabi Pirouzifard, Björn Holmquist, Jan Sundquist, Kristina Sundquist, Bengt Zöller

“…Swedish national registers were linked and three landmarks (L1, L2, L3), i.e. baselines, were created with 14-, nine- and four-year follow-up times, respectively. Two or more NCDs defined multimorbidity and ≥5 marked multimorbidity severity. …”
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Phantom motor execution as a treatment for phantom limb pain: protocol of an international, double-blind, randomised controlled clinical trial by Brian E McGuire, Lina Bunketorp-Käll, Eva Lendaro, Liselotte Hermansson, Helena Burger, Corry K Van der Sluis, Monika Pilch, Katarzyna Kulbacka-Ortiz, Ingrid Rignér, Anita Stockselius, Lena Gudmundson, Cathrine Widehammar, Wendy Hill, Sybille Geers, Max Ortiz-Catalan

“…Secondary outcomes include: frequency, duration, quality of pain, intrusion of pain in activities of daily living and sleep, disability associated to pain, pain self-efficacy, frequency of depressed mood, presence of catastrophising thinking, health-related quality of life and clinically significant change as patient’s own impression. Follow-up interviews are conducted up to 6 months after the treatment.Ethics and dissemination The study is performed in agreement with the Declaration of Helsinki and under approval by the governing ethical committees of each participating clinic. …”
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Mechanical properties and crack propagation law of coal under different CO2 adsorption time by WANG Lei, WU Yuxuan, CHEN Lipeng, WANG Yong, LIAO Zhipeng, YANG Zhenyu

“…Between 5 and 7 days, the change in the deterioration effect is only about 0.5%, indicating a stabilization trend over time. ② The CT scan results show that the cracks in coal propagate from the outside to the inside, and this trend is influenced by the CO2 adsorption time, exhibiting a pattern of initially rapid change followed by slower change. At 7 days, the cracking rate and coalescence rate of coal reach 14.03% and 1.59, respectively, indicating that CO2 has a certain damaging effect on the coal structure. ③ The authors carried out migration modeling for CO2 on the representative volume element (REV) of coal. …”
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Yorkshire Enhanced Stop Smoking (YESS) study: a protocol for a randomised controlled trial to evaluate the effect of adding a personalised smoking cessation intervention to a lung... by Richard D Neal, David Baldwin, Sarah Lewis, John Britton, Rachael L Murray, Qi Wu, Kate Brain, Samantha L Quaife, Matthew EJ Callister, Philip A J Crosbie, Harriet D Quinn-Scoggins, Grace M McCutchan, Alex Ashurst, Suzanne Rogerson, Rebecca Thorley

“…Secondary outcomes include CO validated cessation at 4 weeks and 12 months, self-reported continuous cessation at 4 weeks, 3 months and 12 months, attempts to quit smoking and changes in psychological variables, including perceived risk of lung cancer, motivation to quit smoking tobacco, confidence and efficacy beliefs (self and response) at all follow-up points. A process evaluation will explore under which circumstances and on which groups the intervention works best, test intervention fidelity and theory test the mechanisms of intervention impact.Ethics and dissemination This study has been approved by the East Midlands-Derby Research Ethics Committee (18/EM/0199) and the Health Research Authority/Health and Care Research Wales. …”
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First demonstration of a TES based cryogenic Li $$_2$$ 2 MoO $$_4$$ 4 detector for neutrinoless double beta decay search by G. Bratrud, C. L. Chang, R. Chen, E. Cudmore, E. Figueroa-Feliciano, Z. Hong, K. T. Kennard, S. Lewis, M. Lisovenko, L. O. Mateo, V. Novati, V. Novosad, E. Oliveri, R. Ren, J. A. Scarpaci, B. Schmidt, G. Wang, L. Winslow, V. G. Yefremenko, J. Zhang, D. Baxter, M. Hollister, C. James, P. Lukens, D. J. Temples

“…The largest planned detector array, CUPID, is comprised of about 1500 individual Li $$_{2}$$ 2 $$^{100}$$ 100 MoO $$_4$$ 4 detector modules with a further scale up envisioned for a follow up experiment (CUPID-1T). In this article, we present a novel detector concept targeting this second stage with a low impedance TES based readout for the Li $$_2$$ 2 MoO $$_4$$ 4 absorber that is easily mass-produced and lends itself to a multiplexed readout. …”
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A comparative study between condensed polytetrafluoroethylene mesh versus other composite meshes in Endo-laparoscopic ventral herniorrhaphy by Meredeth Chin, James Lee Wai Kit, Sujith Wijerathne, Avelyn Aw, Daryl Chia Kai Ann, Sean Lee Kien Fatt, Tharun Ragupathi, Harry Ng Ho Man, Davide Lomanto

“…There were no differences in mean operating time, post-operative recovery and complications, as well as early (<30 days) and late (>30 days) complications during follow up. Conclusion: The use of cPTFE (Omyra™) mesh yielded comparable operative characteristic compared to other synthetic meshes for LVHR. …”
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Comparison of outcome and toxicity of postoperative intensity‐modulated radiation therapy with two‐dimensional radiotherapy in patients with soft tissue sarcoma of extremities and... by Jianyang Wang, Yongwen Song, Xinfan Liu, Jing Jin, Weihu Wang, Zihao Yu, Yueping Liu, Ning Li, Hui Fang, Hua Ren, Yuan Tang, Yu Tang, Bo Chen, Ningning Lu, Shunan Qi, Shulian Wang, Yexiong Li

“…Results With a median follow‐up time of 58.1 months, 30 local recurrences, 66 distant metastases, and 40 deaths occurred. …”
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Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease by Ana Vigil, Emilia Condés, Luis Vigil, Paloma Gallar, Aniana Oliet, Olimpia Ortega, Isabel Rodriguez, Milagros Ortiz, Juan Carlos Herrero, Carmen Mon, Gabriela Cobo, Juana Jimenez

“…Deaths related to the creatinine tertiles followed the same pattern, but differences were not as large. …”
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Deep immunophenotyping of circulating immune cells in major depressive disorder patients reveals immune correlates of clinical course and treatment response by Fabiola Stolfi, Claudio Brasso, Davide Raineri, Virginia Landra, Camilla Barbero Mazzucca, Ali Ghazanfar, Lorenza Scotti, Riccardo Sinella, Vincenzo Villari, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti

“…Traditional treatment strategies often follow a one-size-fits-all approach obtaining suboptimal outcomes for many patients who fail to experience response or recovery. …”
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Effects of Metformin Added to Insulin in Adolescents with Type 1 Diabetes: An Exploratory Crossover Randomized Trial by Daizhi Yang, Jinhua Yan, Hongrong Deng, Xubin Yang, Sihui Luo, Xueying Zheng, Jing Lv, Wen Liang, Mengjie Hong, Zekai Wu, Bin Yao, Jianping Weng, Wen Xu

“…Participants were randomly received metformin (≤1000 mg/d) added to insulin for 24 weeks followed by insulin monotherapy for a subsequent 24 weeks or vice versa. …”
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Genomic interrogation of invasive group A Streptococcus (iGAS) epidemiology and COVID-19 impacts in Victoria, Australia: a 6-year retrospective studyResearch in context by Jacqueline M. Morris, Jake A. Lacey, Kerrie Stevens, Lamali Sadeesh Kumar, Mathilda Wilmot, Janet Strachan, Marion Easton, Daneeta Hennessy, Tony M. Korman, Andrew J. Daley, Katherine B. Gibney, Adam W.J. Jenney, Steven Y.C. Tong, Benjamin P. Howden, Norelle L. Sherry

“…Fewer iGAS cases were noted between 2020 and 2021 in addition to genetic bottlenecks, likely reflecting the implementation of strict public health measures during the COVID pandemic, followed by a resurgence in cases post-COVID. Low levels of antimicrobial resistance were observed, primarily to macrolides and tetracyclines. …”
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Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status by Amanda Cristina Araújo Gomes, Amanda Machado Fiorotti, Amanda Motta de Bortoli, Beatriz Bobbio de Brito, João Arthur Souza Fiorido, Luciane Bresciani Salaroli, Andressa Bolsoni Lopes, Fabiano Kenji Haraguchi

“…Data were analyzed using the one-way repeated measures ANOVA or Friedman's test, followed by Tukey's post hoc test. Relationship between PhA and biochemical and body parameters were assessed using the Spearman or Pearson correlation coefficient. …”
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Risk factors and prediction model of breast cancer-related lymphoedema in a Chinese cancer centre: a prospective cohort study protocol by Yue Wang, Xin Li, Ying Wang, Hongmei Zhao, Qian Lu, Yujie Zhou, Liyuan Zhang, Aomei Shen, Jingru Bian, Wanmin Qiang, Jingming Ye, Hongmeng Zhao, Yubei Huang, Zhongning Zhang, Peipei Wu

“…Bilateral limb circumferences will be measured by patients at home or by researchers at the outpatient clinics during follow-up visits. The diagnosis of lymphoedema is based on a relative limb volume increase of ≥10% from the preoperative assessment. …”
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Influence of Dentin Priming with Tannin-Rich Plant Extracts on the Longevity of Bonded Composite Restorations by Mackeler Ramos Polassi, Thales de Sá Oliveira, Ana Calheiros de Carvalho, Lívia Soman de Medeiros Medeiros, Thiago André Moura Veiga, Carlos Frederico de Oliveira Graeff, Alejandra Hortencia Miranda González, Maria Cristina Marcucci, Simone dos Santos Grecco, Paulo Henrique Perlatti D’Alpino

“…Tannin-containing plant extracts were applied to dentin before the application of the restorative system, as follows: control group (untreated, CTL), chlorhexidine 0.12% (CHX), mastruz (Dysphania ambrosioides, MTZ), cat’s claw (Uncaria tomentosa, CTC), guarana (Paullinia cupana, GUA), galla chinensis (Rhus chinensis, GCH), and tannic acid (extracted from Acacia decurrens, TNA). …”
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Prognostic Value of CXCL13, CCL11, and CCL20 Chemokines in Multiple Sclerosis by Işıl Peker, Hacer Eroğlu İçli, Belgin Mutluay, Burcu Yüksel, Zeynep Özdemir, Mesrure Köseoğlu, Aysu Şen, Dilek Ataklı, Aysun Soysal, Musa Öztürk

“…<b>Conclusions:</b> These findings suggest that CSF CXCL13 could serve as a useful biomarker for predicting active disease in RRMS, while follow-up serum CCL11 may assist in identifying progression. …”
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Vic9 mycobacteriophage: the first subcluster B2 phage isolated in Russia by Marina Zaychikova, Maja Malakhova, Dmitry Bespiatykh, Maria Kornienko, Ksenia Klimina, Aleksandra Strokach, Roman Gorodnichev, Arina German, Mikhail Fursov, Dmitry Bagrov, Dmitry Bagrov, Anna Vnukova, Alexandra Gracheva, Anastasia Kazyulina, Margarita Shleeva, Egor Shitikov

“…The phage adsorbs onto host strain cells within 30 min, and according to one-step growth experiments, its latent period lasts about 90 min, followed by a growth period of 150 min, with an average yield of approximately 68 phage particles per infected cell. …”
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Catheter ablation versus antiarrhythmic drugs with risk factor modification for treatment of atrial fibrillation: a protocol of a randomised controlled trial (PRAGUE-25 trial) by Stepan Havranek, Jiri Jarkovsky, Otakar Jiravský, Pavel Osmancik, Veronika Bulková, Jan Chovančík, Tomáš Roubíček, Dalibor Heřman, Zuzana Čarná, Vladimír Tuka, Martin Matoulek, Martin Fiala, Sylvie Stregl-Hruskova, Adam Latiňák, Jiřina Kotryová

“…Results of the study will be disseminated on scientific conferences and in peer-reviewed scientific journals. After the end of follow-up, data will be available upon request to principal investigator.Trial registration number ClinicalTrials.gov Registry (NCT04011800).…”
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Antimicrobial susceptibilities of oral Neisseria from men on HIV pre-exposure prophylaxis in Hanoi, Vietnam by Huan Vinh Dong, Paul Adamson, Dieu Hoa Pham, Quynh Hoa Pham, Hai Ha Long Le, Loc Quang Pham, Hao Thi Minh Bui, Giang Minh Le, Jeffrey D. Klausner

“…In total, 48 Neisseria isolates were recovered; N. sicca/subflava was the most common species (50%; n = 24), followed by N. mucosa (38%; n = 18). For azithromycin, 85% (n = 41) of isolates were resistant with MICs ≥ 1 ug/mL, including 25% (n = 12) with high-level resistance (MICs ≥ 256 ug/mL of which 67% (8/12) were N. mucosa. …”
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