Evaluating a targeted selective speech, language, and communication intervention at scale – Protocol for the Happy Talk cluster randomised controlled trial. [version 2; peer review... by Pauline Frizelle, Darren Dahly, Aoife O'Shea, Aileen Murphy, Cristina McKean

“…Blinded assessments pre- and immediately post-intervention and at 6 months follow up, will measure the primary outcomes of children’s receptive and expressive language and functional impact, and secondary outcomes of quality of life. …”
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Effect of dry needling, ischemic compression and cross-taping of the masseter in patients with orofacial myofascial pain: a randomized comparative study by B. Macedo de Sousa, N. López-Valverde, N. López-Valverde, A. López-Valverde, A. López-Valverde, D. Neves, M. Santos, J. A. Blanco Rueda, J. A. Blanco Rueda

“…Pain intensity was assessed, randomly, by a single blinded evaluator, according to the Numerical Pain Rating Scale in the pre-treatment period, immediately after, 1–2 weeks and one month later.ResultsImmediately after applying the therapies, there was a greater decrease in pain intensity in dry needling, followed by ischemic compression and a smaller decrease in the cross-taping technique (p < 0.0001; p = 0.0001; p = 0.0014, respectively). …”
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Prediction of CD4 T-Lymphocyte Count Using WHO Clinical Staging among ART-Naïve HIV-Infected Adolescents and Adults in Northern Ethiopia: A Retrospective Study by Abraham Desta Aregay, Kibriti Mehari Kidane, Asfawosen Berhe Aregay, Kiros Ajemu Fenta, Ataklti Gebretsadik Woldegebriel, Hagos Godefay, Tewolde Wubayehu Woldearegay

“…WHO clinical staging has long been used to assess the immunological status of HIV-infected patients at initiation of antiretroviral therapy and during treatment follow-up. In setups where CD4 count determination is not readily available, WHO clinical staging is a viable option. …”
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Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes by Yu-Yen Chen, Ying-Cheng Shen, Yun-Ju Lai, Chun-Yuan Wang, Keng-Hung Lin, Shih-Chao Feng, Chiao-Ying Liang, Li-Chen Wei, Pesus Chou

“…The metformin and nonmetformin groups were followed until the end of 2013. Cox regression analyses were used to estimate hazard ratios (HRs) for AMD development associated with metformin use. …”
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Identification of CD8+ T Cell-Related Genes: Correlations with Immune Phenotypes and Outcomes of Liver Cancer by Qi Pan, Ying Cheng, Donghua Cheng

“…We obtained the liver cancer gene matrix and clinical follow-up information data from TCGA liver hepatocellular carcinoma FPKM. …”
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The Needs for Visual Improvement of Patients Presented at Low-Vision Center in Wenzhou, China by Xiaoman Li, Guofu Chen, Ruzhi Deng, Na Lin, Lingzhi Ni, Longfei Jiang, Haishuang Lin, Frank Thorn, Jie Chen

“…The main need for visual improvement was engagement in hobbies (68.9%), followed by reading (20.9%), engaging in occupation (20.1%), and watching TV or movies (17.1%). …”
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Noninvasive diagnostic methods of liver fibrosis in patients with primary biliary cirrhosis and primary sclerosing cholangitis: role of indirect serological markers by A. F. Sheptulina, Ye. N. Shirokova, V. T. Ivashkin

“…Considering prognostic value and dynamic nature of liver fibrosis in chronic cholestatic diseases: primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), severity assessment by liver biopsy and/or noninvasive methods should be obligatory component of the investigation plan during patient follow-up to estimate treatment response. The aim of the present study was to evaluate diagnostic value of noninvasive tests based on indirect liver fibrosis serological markers for the estimation of fibrosis severity in PBC and PSC. …”
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Prevalence of mortality caused by injuries at Livingstone University Hospital, Zambia. A retrospective cross-sectional study. by Lukundo Siame, Malan Malumani, Chiyeñu O R Kaseya, Sergiy Ivashchenko, Leah Nombwende, Sepiso K Masenga, Benson M Hamooya, Michelo Haluuma Miyoba

“…Among those who died, the majority of the trauma occurred at home (90%, n = 9), followed by road (10%, n = 1) and were as a result of burns (60%, n = 6) and community violence (30%, n = 3). …”
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The UK Breast Cancer in Pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom:... by Marian Knight, Andrew Brand, Claudia Hardy, Philip Banfield, Julie Jones

“…With caveats, management followed that outside pregnancy, but there was considerable variation in practice. …”
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Associations of macrosomia with sociodemographic, anthropometric, lifestyle factors and perinatal outcomes in Southwest Nigeria by Ikeola A. Adeoye, Joshua I. Fakorede, Mobolaji M. Salawu, Kofoworola I. Adediran

“…This study examined the 1200 women who were not lost to follow-up, had health facility deliveries and the infants’ birthweight records. …”
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SuessR: Regional corrections for the effects of anthropogenic CO2 on δ13C data from marine organisms by Casey T. Clark, Mattias R. Cape, Mark D. Shapley, Franz J. Mueter, Bruce P. Finney, Nicole Misarti

“…In 2020, net corrections (Suess + Laws corrections) were as follows—Bering Sea: 1.29‰; Aleutian Islands: 1.30‰, Gulf of Alaska: 1.30‰; and Subpolar North Atlantic: 1.31‰ (compared to a global atmospheric CO2 change of ~2.43‰ across the same period). …”
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Digital health interventions for improving access to primary care in India: A scoping review. by Lenny Vasanthan, Sindhu Kulandaipalayam Natarajan, Andrew Babu, Mohan S Kamath, Sureshkumar Kamalakannan

“…A two-staged screening of titles and abstracts, followed by full-text was conducted independently by two reviewers, using the Rayyan software. …”
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A comprehensive investigation of Clerodendrum Infortunatum Linn. using LC-QTOF-MS/MS metabolomics as a promising anti-alzheimer candidate by Fatma Atef, Mostafa A. Abdelkawy, Basma M. Eltanany, Laura Pont, Ahmed M. Fayez, Mohamed F. Abdelhameed, Fernando Benavente, Inas Y. Younis, Asmaa M. Otify

“…Additionally, acetylcholinesterase enzyme activity, as well as the levels of acetylcholine, dopamine, noradrenaline, glutathione, malondialdehyde, tumor necrosis factor-α, interleukin-1β, and amyloid-β in the rat hippocampus, were measured using ELISA, followed by histopathological evaluation. A total of 79 metabolites, spanning various chemical classes, such as organic acids, phenolic acids, phenylpropanoids and phenylethanoids, flavonoids, coumarins, other phenolics, and fatty acids and their derivatives, were identified. …”
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Safety and efficacy of total colectomy with D3 lymph node dissection at colorectal cancer, developed at inflammatory bowel diseases (case control study) by P. V. Tsarkov, I. A. Tulina, S. K. Efetov, Yu. E. Kitsenko, D. N. Fedorov

“…The rate of metastatic LN was 33.3% in both groups. The mean follow-up time was 27.3±5.3 months. Distant metastases were detected in 33.3% and 16.7% of IBD-CRC and spCRC cases respectively (p=0.4), without local recurrence in both groups. …”
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Multilateral Use of Dandelion in Folk Medicine of Central-Eastern Europe by Robert Gruszecki, Magdalena Walasek-Janusz, Gianluca Caruso, Robert Pokluda, Alessio Vincenzo Tallarita, Nadezhda Golubkina, Agnieszka Sękara

“…During the period analysed, an increase in the types of raw materials was observed, and the order in which they appeared in the sources was as follows: latex > root = leaf = inflorescence > herb > herb with flowers. …”
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Genetic Associations Between Specific Sleep-Related Phenotypes and Idiopathic Sudden Sensorineural Hearing Loss: A Mendelian Randomization Analysis by Li M, He J, Liang Y, Zou F, Gou C, Lv J, Zhang X, Li D, Yu Z

“…The inverse variance weighted (IVW) method was utilized, followed by confirming the robustness and reliability using the MR Egger, weighted median, simple mode, and weighted mode. …”
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Predictive modeling to evaluate long-term treatment effectiveness of darvadstrocel in patients with complex perianal fistulas in Crohn’s disease by Chitra Karki, Gary Hantsbarger, Erika Turkstra, Elisabetta Fenu, Ken Genenz, Inmaculada Gilaberte, Julián Panés

“…Predictive statistical models extrapolated clinical outcomes beyond observed follow-up using parametric curves, which were implemented into a semi-Markov model to obtain the number of patients in remission. …”
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Prevalence and Associated Risk Factors of Soil-Transmitted Helminth Infections among Schoolchildren around Lake Tana, Northwest Ethiopia by Melsew Getaneh, Tamirat Hailegebriel, Abaineh Munshea, Endalkachew Nibret

“…Hookworm infection was the predominant STH infection, which was detected in 26.1% schoolchildren followed by A. lumbricoides (14.8%) and T. trichiura (1.5%). …”
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COMBINED TREATMENT OF LOCALLY-ADVANCED BLADDER CANCER by I. V. Chernyshev, Y. V. Samsonov, D. V. Perepechin, A. M. Ulbashev

“…The proportion of individuals who completed the treatment of the number of newly diagnosed patients with bladder cancer in 2013, was as follows: only surgical method — 65.4%, 33.5% combined. …”
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Integrating CT-based radiomics and clinical features to better predict the prognosis of acute pancreatitis by Hang Chen, Yao Wen, Xinya Li, Xia Li, Liping Su, Xinglan Wang, Fang Wang, Dan Liu

“…The patients were dichotomized into good and poor prognosis subgroups based on follow-up CT and clinical data. The radiomics features were extracted from contrast-enhanced CT. …”
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