A multi-stakeholder collaborative approach to awareness, education and support needed in the haemophilia gene therapy patient journey – a report on insights from a European patient... by O’Mahony Brian, Fletcher Simon, Baarslag Manuel, Khair Kate, Breederveld Daan, Jansen Nathalie, Pembroke Luke, Pinachyan Karen, Sivasubramaniyam Sujan

“…Other key educational needs included follow-up commitments, the role and potential side effects of corticosteroids or other immunosuppressants, impact on sense of identity, mental health, family planning, and managing bleeds after gene therapy. …”
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Development and Evaluation of a Mental Health Chatbot Using ChatGPT 4.0: Mixed Methods User Experience Study With Korean Users by Boyoung Kang, Munpyo Hong

“…ResultsUsers generally expressed positive views towards the chatbot, with positivity and support receiving the highest score on a 10-point scale (mean 9.0, SD 1.2), followed by empathy (mean 8.7, SD 1.6) and active listening (mean 8.0, SD 1.8). …”
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The LIFTMOR-M (Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men) trial: protocol for a semirandomised controlled trial of supervised targeted exerci... by Benjamin K Weeks, Belinda R Beck, Amy T Harding, Steven L Watson

“…Intervention group responses will be compared with those of a self-selected, non-randomised control sample of sex-matched and age-matched men who will follow their usual lifestyle activities for 8 months.Methods and analysis Apparently healthy men over 50 years with low bone mass, screened for medical conditions and medications known to adversely affect bone health, will be recruited. …”
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Histological chorioamnionitis and its predictors among mothers with premature rupture of membranes delivering at tertiary hospitals in Uganda: a multicenter cross-sectional study by Ibrahim Abdi Abdinasir, Marie Pascaline Sabine Ishimwe, Maxwell Okello, Paul Byaruhanga, Ralph Samson Enyamitoit, Theoneste Hakizimana

“…The most common histological finding was neutrophil infiltration in 22 cases (50.0%), followed by funisitis in 13 cases (29.6%). Referral status (aOR = 4.5, 95% CI: 1.511–13.315, p = 0.007) and lack of prenatal care (PNC) attendance (aOR = 9.8, 95% CI: 2.802–14.504, p = 0.000) were independently associated with histological chorioamnionitis. …”
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Clinical Features and Prognosis of Double-Positive Anti-MDA5 and Anti-CCP Antibodies in Dermatomyositis: A Retrospective Study by Xu X, Zhu L, Li S, Wang G, Ge Y

“…The clinical manifestations of MDA5+/CCP+ DM with or without anti-Ro-52 antibody were not significantly different from those of the ILD type. During the follow-up period, there was no significant difference in survival between the two groups.Conclusion: More than half of the patients with MDA5+/CCP+ DM may present with arthritis as one of the initial symptoms. …”
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Domestic sewage irrigation on dynamics of nutrients and heavy metals in soil and wheat (Triticum aestivum L.) production by S. R. Salakinkop, C. S. Hunshal

“…In general, concentration of heavy metals was higher in root followed by stem and lower in grain. The Pb concentration in plant parts (root, stem and grain) was not influenced by land type and sources of irrigation. …”
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Outcomes of Worsened Left Ventricular Ejection Fraction After Transcatheter Aortic Valve Replacement by Hu Z, Wang C, Luo S, Yang B, Zheng S, Hu X, Sun Y, Chen J, Fu M, Fan R, Luo J, Li J

“…Patients were divided into worsened LVEF and non-worsened LVEF according to whether or not they had an LVEF decline of ≥ 5% at discharge. Survival at follow-up was compared between two groups. Logistic regression analysis was used to determine independent predictors of worsening LVEF.Results: A total of 439 patients were included in the analysis, and 112 (25.5%) patients had worsened LVEF. …”
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Le site antique de la clinique des Dames Blanches à Tours (Indre-et-Loire) : aménagements d’un embarcadère romain sur la Loire et évolution du trait de rive by Nicolas Fouillet, Philippe Gardère

“…Stratigraphic and dendrochronological analyses show that four different phases of the landing stage followed one another in the same place between the mid-1st and the 2nd c. …”
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Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis by Xiang F, Zhang Z, Nie Y, Cao X, Li Y, Chen X, Gong S, Zou J, Teng J, Ding X, Shen B

“…Diminished CD73-adenosine signaling contributes to severe infections.Methods: In this prospective cohort study, 393 patients who underwent HD for over six months were evaluated for CD73+Tcell ratios and were followed up for three years to track infection events. …”
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Evaluation of the Competitiveness Model in the Steel Industry with a Technology Transfer Approach by Ali Amraei, Safieh Mehrinejad, Amir Bayattork

“…Methods This research is applied considering its objective and follows a descriptive survey methodology for data collection. …”
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Liquid crystal template-assisted electrodeposition of nanoporous nickel microspheres: A sensitive electrochemical sensing platform for electrocatalytic oxidation and quantitative d... by R. Dehdari Vais, M. Negahdary, S.R. Rasouli Nasrabadi, A. Rahi, S.A. Dastgheib, H. Heli

“…The surface morphological characterization of the obtained nanoporous microspheres was followed by field emission scanning electron microscopy. …”
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Highly Stable Antitumor Silver-Lipid Nanoparticles Optimized for Targeted Therapy by Darwish A, Sándor N, Szenti I, Marosvölgyi T, Juhász K, Rónavári A, Kachal E, Kutus B, Kónya Z, Balogi Z

“…In this study we aimed to create highly stable and effective antitumor AgNP lipid formulations (LAgs).Methods: Uncapped and citrate-stabilized AgNPs were encapsulated by the lipid film hydration method using several phospholipid mixtures, followed by the essential removal of unencapsulated AgNPs by size exclusion chromatography (SEC). …”
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Study on Anaerobic Digestion and the Treatment of Livestock and Poultry Waste Liquid by Nanoparticles and Antibiotics in the Context of Carbon Neutrality and Microbial Ecosystems by Xiaofei Zhen, Han Zhan, Ke Li, Ruonan Jiao, Lei Feng, Tie Du

“…The results showed that (1) gas production reached its peak in the first 1–2 days of a single stress experiment, and the cumulative gas production in the first 10 days was as follows: R5 > R4 > R3 > R2 > CK > R1; (2) the concentrations of total volatile fatty acids (TVFAs) in the groups increased rapidly from day 1 to 10, and the concentrations of TVFAs in the nano-Fe₂O₃ and nano-C₆₀ groups were higher than those in the other four groups. …”
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Contribution of Short-Time Occlusion of the Amblyopic Eye to a Passive Dichoptic Video Treatment for Amblyopia beyond the Critical Period by Lauren Sauvan, Natacha Stolowy, Danièle Denis, Frédéric Matonti, Frédéric Chavane, Robert F. Hess, Alexandre Reynaud

“…Secondly, we tested if this effect could be enhanced by short-term monocular occlusion of the amblyopic eye. 17 subjects presenting stable functional amblyopia participated in this study. 10 subjects followed 6 sessions of 1.5 hour of dichoptic movie viewing (nonpatched group), and 7 subjects, prior to each of these sessions, had to wear an occluding patch over the amblyopic eye for two hours (patched group). …”
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The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis by Fei Huang, Yueqiang Li, Ranran Xu, Anying Cheng, Yongman Lv, Qingquan Liu

“…We evaluated 90 AAV patients with follow-up data and 35 normal controls; their plasma suPAR and C-reactive protein (CRP) levels were measured by ELISA. …”
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Effect of public relations activities conducted in professional football clubs on fan satisfaction by Hakan Salim Caglayan, Celalettin Bayar

“…In analyzing the data, necessary statistical analyses were carried out in accordance with the rules needed to be followed in the development process. Mann-Whitney U Test and Kruskal-Wallis One-Way Analysis of Variance have been used, respectively, for pairwise comparisons and multiple comparisons since all sub-dimensions were not shown normal distribution after test of normality performing for sub-dimensions of the scale that had provided its validity and reliability. …”
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Elevated Platelet‐to‐Lymphocyte Ratio as a Predictor of All‐Cause and Cardiovascular Mortality in Hypertensive Individuals by Rui Xu, Ling Chen, Changshun Yan, Hong Xu, Guiqiu Cao

“…Cox proportional hazards regression models assessed the independent association of PLR with mortality risk, with adjustments incrementally applied: Model 1 without adjustments; Model 2 adjusted for age and sex; Model 3 adjusted further for age, gender, race, marital status, diabetes, alcohol intake, smoking status, body mass index (BMI), history of cardiovascular disease (CVD), high‐density lipoprotein cholesterol (HDL), low‐density lipoprotein cholesterol (LDL), total cholesterol (TC), triglyceride (TG), and creatinine (CR). Over a median follow‐up of 79 months, there were 2820 all‐cause deaths and 758 cardiovascular deaths. …”
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Comparison of conventional versus robotic-assisted total hip arthroplasty using the Mako system: An Italian retrospective study by Roberta Banchetti, Silvia Dari, Maria Elisabetta Ricciarini, Domenico Lup, Francesco Carpinteri, Fabio Catani, Patrizio Caldora

“…Our evaluation was carried out before and after surgery at 24 months follow-up. Western Ontario and McMaster (WOMAC) Osteoarthritis Index, Harris Hip Modified Score (HHS), and Numeric Pain Rating Score (NPRS) scales were administered. …”
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Annexin V+ Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study by Vibeke Bratseth, Hanna D. Margeirsdottir, Gemma Chiva-Blanch, Martin Heier, Svein Solheim, Harald Arnesen, Knut Dahl-Jørgensen, Ingebjørg Seljeflot

“…Comparable levels of Annexin V (AV+) cMVs were observed at inclusion. At five-year follow-up, total AV+ cMVs were significantly lower in subjects with type 1 diabetes compared with controls; however, no significant differences were observed after adjusting for covariates. …”
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Impact of rock mineralogy on reactive transport of CO2 during carbon sequestration in a saline aquifer by Mohamed Gamal Rezk, Ahmed Farid Ibrahim

“…A compositional simulation model was created, wherein CO2 is injected for 25 years, followed by a 3000-year shut-in period. Various parameters, including CO2 plume migration, changes in pH, water density variations, mineral dissolution and precipitation, and porosity changes in the reservoir rock, are examined to understand the complex CO2–brine–rock interactions. …”
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