Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa by Frank Phoya, Claire Butters, Timothy F. Spracklen, Timothy F. Spracklen, Hanna L. Kassa, Hamza van der Ross, Chris Scott, Kate Webb, Kate Webb

“…This highlights the need to continue to follow up these patients and offer more comprehensive long-term care.…”
Get full text

Acute kidney injury is associated with liver-related outcomes in patients with hepatitis B virus infection: a retrospective cohort study by Jiao Liu, Ruixuan Chen, Shiyu Zhou, Zhixin Guo, Licong Su, Lisha Cao, Yanqin Li, Xiaodong Zhang, Fan Luo, Ruqi Xu, Qi Gao, Yuxin Lin, Xin Xu, Sheng Nie, the CRDS study Investigators

“…Results Of the 86,204 inpatients with HBV infection and without liver cancer or cirrhosis at baseline, 4407(5.1%) patients experienced AKI. During a mean follow-up of 4.6 ± 2.4 years, 334 (0.4%) patients died of liver-related events. …”
Get full text

Biomarkers troponin and procalcitonin in addition to CRB-65 enhance risk stratification in patients with community-acquired pneumonia by Imrana Farhat, Maciej Rosolowski, Katharina Ahrens, Jasmin Lienau, Peter Ahnert, Mathias Pletz, Gernot Rohde, Jan Rupp, Markus Scholz, Martin Witzenrath, the CAPNETZ Study Group

“…TnT-hs exhibited the highest predictive performance among individual features (area under the receiver operating characteristic curve, AUC=0.74), followed closely by PCT (AUC=0.73). Combining biomarkers with the CRB-65 score significantly improved prediction accuracy. …”
Get full text

Targeting KRAS G12C and G12S mutations in lung cancer: In silico drug repurposing and antiproliferative assessment on A549 cells by Mansour S. Alturki, Nada Tawfeeq, Amal Alissa, Zahra Ahbail, Mohamed S. Gomaa, Abdulaziz H. Al Khzem, Thankhoe A. Rants'o, Mohammad J. Akbar, Waleed S. Alharbi, Bayan Y. Alshehri, Amjad N. Alotaibi, Fahad A. Almughem, Abdullah A. Alshehri

“…The antiproliferative efficacy of these drugs was evaluated by MTS tests, and their IC50 values were determined in which natamycin, although non-selective, and cortisone showed the highest activity with IC50 of 53.42 and 53.51 μg/mL, respectively, followed by cefadroxil (84.63 μg/mL). This study promisingly repurposed five drugs for KRAS mutant lung cancer, of which cefadroxil, and cortisone are particularly warranting further assessment either as a standalone or combination therapy while capreomycin is still an effective inhibitor for KRAS G12C mutant as evident from in silico and in vitro studies.…”
Get full text

Assessing anxiety symptoms and Traumatic Event Scale scores among medical staff during the COVID-19 pandemic in Colombia: a descriptive cohort study in Bogotá by Pablo Vásquez-Hoyos, Jhon Camacho-Cruz, Sara Marcela Torres Ayala, Susan Tatiana Cárdenas Rojas, Carolina Alexandra Zambrano Pérez, Juanita Yolanda Atuesta-Fajardo, Licet Villamizar-Gómez

“…Objective This study aims to assess anxiety and suffering symptoms amid the pandemic, determine factors linked to physicians’ anxiety with COVID-19 patients and describe symptom progression in the initial year of follow-up.Methods Descriptive cohort study involving general practitioners, specialists and interns in the city of Bogotá. …”
Get full text

Diagnostic Management and Surgical Treatment of Isolated Tricuspid Regurgitation by Arthur Cicupira Rodrigues de Assis, Gustavo Andre Boeing Boros, Lea Maria Macruz Ferreira Demarchi, Thiago Luis Scudeler, Paulo Cury Rezende

“…Primary tricuspid regurgitation in the absence of pulmonary hypertension and of unknown etiology is a very rare condition with scarce data about its diagnosis, treatment, and follow-up. The particularities of surgery indication and outcomes are still not clearly known. …”
Get full text

Development of indicators and analysis of barriers for assessment and prevention of cutaneous graft-versus-host disease after haematopoietic stem cell transplantation in children by YANG Liling, ZHAN Sha, XUE Xiaoyan, CHEN Kai, LIU Qing, WANG Li, WANG Yiyi, WU Meng, LU Qunfeng

“…Using the Ottawa Model of Research Use, the three dimensions of evidence change, potential adopters, and practice environment were analyzed for barriers and facilitators, and corresponding strategies were developed.Results·A total of 24 pieces of best evidence were included in the study, comprising five dimensions: skin assessment, assessment of protection, management of adverse skin reactions, medication guidance and follow-up and screening. Twenty-two review indicators were constructed on this basis, of which 14 had an implementation rate of <60% and 10 had an implementation rate of 0%; 8 had an implementation rate of >60% and 6 had an implementation rate of 100.00%. …”
Get full text

The effects of Tripterygium wilfordii Hook F on renal outcomes in type 2 diabetic kidney disease patients with severe proteinuria: a single-center cohort study by Yaqi Cheng, Yuhao Liu, Liling Lin, Danni Li, Liying Peng, Ke Zheng, Jianling Tao, Mingxi Li

“…Kaplan-Meier curves and Cox regression analyses were performed to analyze prognostic factors for renal outcomes.Results By the end of the follow-up, renal outcomes were observed in 23 and 11 patients in the non-TwHF and TwHF groups, respectively (p = 0.006). …”
Get full text

Global human exposure of atmospheric polybrominated diphenyl ethers: Variation patterns of exposure pathways and phase contributions by Pengtuan Hu, Shimin Zhong, Jin Guo, Mengyao Wang, Shiyu Shi, Donghai Liu, Hao Yu, Fujie Zhu, Yi-Fan Li, Zhiguo Cao

“…The highest daily intake was found in Africa (75.4 pg/(kg·day)), followed by Asia (21.8 pg/(kg·day)), North America (5.38 pg/(kg·day)) and Europe (1.92 pg/(kg·day)). …”
Get full text

Prevalence and genotype distribution of cervical human papilomavirus infection in the pre-vaccination era: a population-based study in the Canary Islands by Silvia De Sanjosé, Vanesa Garcia, Octavio Arencibia, Virginia Benito, Amina Lubrano, Miguel Andujar, Esther Roura, Alejandra Torres, Begoña Vega, Marta Pavcovich, Miguel Angel Sanchez, Jose Luis Trujillo, Lucia Almeida, Milagros Santana, Rosaura Hurtado, Norberto Medina, Sonia Carballo, Maria del Carmen Camacho, Arancha Ruiz del Pozo, Alfoso Quesada, Eduardo Salido, Laia Bruni, Diana Alemán, Mónica Almeida, Ana María Arencibia, María Isabel Armas, Guillermina Batista, Victoria Bernal, Francisca Bernaldo de Quirós, Sili Bolaños, Dolores Casaña, Luisa Celedón, Isabel Cruz, Elisa Díaz, Inocencia Duarte, Felisa Expósito, Carmelo Felipe, Carlos Galván, María José García, María Isabel García, Virginia García, Elena Giménez, Teresa Godoy, Catalina Gómez, Lucia González, Luisa Gutiérrez, Mónica Hernández, Delia Herrera, Laura Herrera, Rosario Laseca, Carmen Marrero, Ofelia Marrero, Noa Mateos, Olivia Medina, Josefa Mendoza, Lucia Montesdeoca, Rosa Monzón, Cristina Morales, Mercedes Morales, M Dolores Navarro, María Ángeles Nieto, Noelia Pérez, Yurena Pérez, Antonio Ramos, Antonio Rico, Margarita Roldán, Esther Salamanca, Rosario Sánchez, Raquel Santana, Elvira Santos, Antonia Solanes, Elisabeth Soutto, Dulce Suarez, María Jesús Suárez, María Ángeles Tadeo, Virgen Valdés, Gabriela Valido, Iralla Vega, Maria del Pino Vega, María Angeles Afonso, Elisa Baena, María Pilar Baz, José de Armas, Alicia de la Puerta, Josefina García, María Asuncion González, Célida González, María Teresa Hernández, Josefa Limiñana, Carmen Rosa León, Fernando Marín, Emma Manrique, José Roberto Negrín, Rosa Olavarrieta, Verónica Perera, Concepción Sabater, Candelaria Sosvilla

“…The most frequent HPV type was 16 followed by types 51, 53, 31, 42 and 59. HPV types included in the nonavalent vaccine were detected in 54.1% of infected women. …”
Get full text

Analysis of Risk Factors of Gastric Low-Grade Intraepithelial Neoplasia in Asymptomatic Subjects Undergoing Physical Examination by Yingling Liu, Yuli Cai, Si Chen, Yawen Gou, Qiaomin Wang, Mingli Zhang, Yetao Wang, Haiou Hong, Kaiguang Zhang

“…The most common endoscopic classification of LGIN was erosive gastritis (50.78%), and the major endoscopic appearance was Paris IIa (flat with slight elevation located mostly in the antrum). During the mean follow-up period of 15.02 months, 49.4% of LGIN regressed, 0.61% of LGIN progressed, and 50% of LGIN remained unchanged. …”
Get full text

Effect of crystalline lens decentration and tilt on visual performance in eyes implanted with bifocal or extended depth of focus intraocular lenses by Yu Zhang, Jiaqing Zhang, Chen Liang, Yifan Xu, Jiaying Wu, Junming Wu, Yifan Zhang, Aixia Jin, Xuhua Tan, Lixia Luo

“…Postoperative visual acuity (VA), contrast sensitivity (CS), objective optical quality, and patient-reported outcomes were assessed at a 3-month follow-up. A LOWESS (LOcally WEighted Scatterplot Smoothing) curve was employed to analyze the changes in VA, CS, and objective optical quality relative to the decentration or tilt of crystalline lenses. …”
Get full text

FadA antigen of Fusobacterium nucleatum: implications for ceRNA network in colorectal cancer and adenomatous polyps progression by Sama Rezasoltani, Elahe Shams, Moein Piroozkhah, Yaser Aidi, Mehdi Azizmohammad Looha, Parmida Bagheri, Roudabeh Behzadi Andouhjerdi, Amir Sadeghi, Leili Rejali, Ehsan Nazemalhosseini-Mojarad

“…Results Elevated expression levels of FadA, ANXA2, hsa-let-7a-2, and LINC00460 were observed in CRC specimens, followed by AP cases, in comparison to samples from normal individuals. …”
Get full text

Iron Overload in Transfusion-Dependent Indonesian Thalassemic Patients by Pandji Irani Fianza, Anita Rahmawati, Sri Hudaya Widihastha, Shofura Afifah, Mohammad Ghozali, Andre Indrajaya, Dilli Marayuzan Akbar Pratama, Dimmy Prasetya, Teddy Arnold Sihite, Mas Rizky A. A. Syamsunarno, Djatnika Setiabudi, Suthat Fucharoen, Ramdan Panigoro

“…Transfusion-dependent thalassemic (TDT) outpatients (n = 66; mean age, 21.5 ± 7.2 years) were carried out for the complete assessment consisting of blood test including liver enzyme and serum ferritin, followed by electrocardiography (ECG) and echocardiography. …”
Get full text

Mental health phenotypes of well-controlled HIV in Uganda by Leah H. Rubin, Leah H. Rubin, Leah H. Rubin, Leah H. Rubin, Kyu Cho, Jacob Bolzenius, Julie Mannarino, Rebecca E. Easter, Raha M. Dastgheyb, Aggrey Anok, Stephen Tomusange, Deanna Saylor, Maria J. Wawer, Noeline Nakasujja, Gertrude Nakigozi, Robert Paul

“…A clustering pipeline consisting of dimension reduction with UMAP followed by HBDScan was used to identify MH subtypes using total symptom scores. …”
Get full text

Impact of Acute Myocardial Injury on Short‐ and Long‐Term Outcomes in Patients With Primary Intracerebral Hemorrhage by Shenghui Ma, Jiawen Li, Qi Kong, Zhiming Xu, Haojie Wu, Yujia Jin, Xianghua Ye, Dong Luo, Lusha Tong, Feng Gao

“…AMI was defined as an elevated cTn above the upper‐reference limit (14 ng/L) along with a rise/fall >20%. Patients were followed for up to 5 years. Outcomes included major adverse cardiac events (MACEs; a composite of vascular death, nonfatal coronary events, and nonfatal stroke) and 90‐day unfavorable outcomes (modified Rankin scale score ≥4). …”
Get full text

The Discovery and Characterization of Minimoon 2024 PT5 by Bryce T. Bolin, Larry Denneau, Laura-May Abron, Robert Jedicke, Kristin Chiboucas, Carl Ingebretsen, Brian C. Lemaux

“…The color indices are g − r = 0.58 ± 0.04, r − i = 0.29 ± 0.04, and i​​​​​​ ​ − Z = −0.27 ± 0.06, and the spectrum best matches lunar rock samples followed by S-complex asteroids. Assuming an albedo of 0.21 and using our measured absolute magnitude of 28.64 ± 0.04, 2024 PT _5 has a diameter of 5.4 ± 1.2 m. …”
Get full text

Accumulation conditions and target area evaluation of coalbed methane in eastern uplift of Junggar Basin by Qixiang YU, Mi TIAN, Yu LUO, Fan YANG, Yan'e CHEN, Feng WANG, Yuqiao GAO, Tao GUO

“…Coal seams of the Badaowan Formation are strongly segmented and mainly distributed in parts of the sags. ② This region contains self-sourced biogenic gas from coal seams, low-maturity thermogenic gas, and high-maturity deep-seated exogenous gas. ③ The organic components in coal rocks are mainly inertinite, followed by vitrinite with small amounts of exinite. …”
Get full text

Predictors and Outcomes of Hematoma Expansion and Neurological Decline in Intracerebral Hemorrhage: A Multisite Mobile Stroke Unit Study by Asish K. Gulati, Tianwen Ma, Isaiah Rolle, Ryan Peterson, Bianca Pirlog, Justine Chen, Megan Heckathorn, Jonathan Ratcliff, Nicolas Bianchi, Carol Fleming, Michael Frankel, James Grotta, Ritvij Bowry, Stephanie Parker, William Hicks, Digvijaya Navalkele

“…Data collection involved initial and follow‐up non‐contrast (computerized tomography) CT scans from MSUs and emergency departments, from which the rate of HE and ND were determined. …”
Get full text

Protocol of the Nurses’ Mental Health Study (NMHS): a nationwide hospital multicentre prospective cohort study by Jiaxin Yang, Chongmei Huang, Shuiyuan Xiao, Xuting Li, Meng Ning, Zengyu Chen, Yusheng Tian, Qiang Yu, Yamin Chen, Ya-Min Li

“…Variables including sociodemographic information, work-related factors, health status, lifestyle habits, objective experiences, family and social relations, current affairs opinions and overall evaluation will be collected. Annual follow-up will be conducted via a questionnaire link to monitor subsequent changes in nurses’ mental health and related factors.Patient and public involvement statement No patient and public involvement in the study design.Ethics and dissemination This study was approved by the Institute Review Board from the ethical committee of The Second Xiangya Hospital of Central South University (E20230048) and NMHS will be performed in line with Helsinki Declarations. …”
Get full text