Prevalence of diabetes-related sarcopenia and its defining components within primary care: A cross-sectional study by Rubén Silva-Tinoco, Lilia Castillo-Martínez, Berenice Cabrera-Victoria, Eileen Guzmán-Olvera, Christian Hinojosa-Segura, Alejandro Avalos-Bracho, Cira Santillán-Díaz

“…This study aimed to assess the prevalence of sarcopenia and at-risk morphofunctional (MF) phenotypes and to identify the factors associated in patients with type 2 diabetes (T2D), including non-elderly adults, in primary care settings Methods: This cross-sectional study included 261 individuals managed in primary care units in Mexico City, between July 2022 and May 2024. Assessments followed the guidelines of the European Working Group on Sarcopenia in Older Adults (EWGSOP2) to identify isolated low muscle mass, low muscle strength, and sarcopenia or severe sarcopenia Results: The mean age of the participants (57.1 % female) was 51.1 ± 12.1 years, with a median diabetes duration of 7 (1–15) years. …”
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Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypan... by Peylhard, Moana, Berthier, David, Dayo, Guiguigbaza-Kossigan, Chantal, Isabelle, Sylla, Souleymane, Nidelet, Sabine, Dubois, Emeric, Martin, Guillaume, Sempéré, Guilhem, Flori, Laurence, Thévenon, Sophie

“…The functional analysis of differentially expressed genes over time in each breed confirmed an early activation of the innate immune response, followed by an activation of the humoral response and an inhibition of T cell functions at the chronic stage of infection. …”
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Effect of total intravenous-based immediate extubation on patient outcomes in adult liver transplantation: A retrospective cohort study by Yan-Jun Chu, Hui Zhang, Bing-Xin Jin, Yu-Fan Liu, Yong-Xing Yao

“…Patients in Group F received propofol- and remifentanil-based total intravenous anesthesia, followed by immediate tracheal extubation. Patients in Group C received sevoflurane-based balanced anesthesia and were step-down extubated in the intensive care unit. …”
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Transfer from long-term care to acute care and risk of new permanent cognitive or physical disability among long-term care residents in Canada: protocol for a retrospective cohort... by Sharon Kaasalainen, Daniel I McIsaac, Steven Hawken, Daniel Kobewka, Peter Tanuseputro, Amy Hsu, Robert Talarico, Colleen Webber, Ramtin Hakimjavadi, Celeste Fung, Mary M Scott, Doug Manuel, Christina Y Yin, Jackie Kierulf, Frank Molnar, Sandy Shamon, Aliza Moledina

“…All participants will be followed until 31 March 2023. The exposure is any transfer from LTC to an emergency department or acute care hospital. …”
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Сandidate SNP-markers of rheumatoid arthritis that can significantly alter the affinity of the TATA-binding protein for human gene promoters by I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, I. A. Drachkova, E. A. Oshchepkova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, V. A. Kozlov

“…Rheumatoid polyarthritis (RA) is an autoimmune disease with autoantibodies, including antibodies to citrullant antigens and proinflammatory cytokines, such as TNF-α and IL-6, which are involved in the induction of chronic synovitis, bone erosion, followed by deformity. Immunopathogenesis is based on the mechanisms of the breakdown of immune tolerance to its own antigens, which is characterized by an increase in the activity of T-effector cells, causing RA symptomatology. …”
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The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors by Mingchuan Huang, Shenghui Wu, Pengfei Gao, Li Zhou, Qian Fu, Chenglin Wu, Huanxi Zhang, Yitao Zheng, Xiaojun Su, Wenrui Wu, Jinghong Tan, Qiang Zhang, Pei Xia, Zhe Xu, Longshan Liu, Jun Li, Changxi Wang

“…Outcome encompassed recipient and graft survival, renal function, and adverse events.Result Forty recipients were included. The average follow-up period was 54.6 months. The 1, 3, and 5-year patient survival were 97.4%, with no significant differences between en-bloc and split dual kidney transplantation or between BWLM and BWHM groups. …”
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Case report: A severe myositis mimicking bulbar palsy after administration of immune checkpoint inhibitors by Philippe Rochigneux, Philippe Rochigneux, Alexandre Bertucci, Elika Loir, Alexia Mattei, Danielle Robert, Michael Dassa, Brice Chanez, Mikael Ebbo, Lea Gaigne, Anne Sophie Chretien, Giovanni Corazza, Giovanni Corazza, Nicolas Schleinitz

“…In a multidisciplinary setting, she was treated with IV corticosteroids (methylprednisolone 1 mg/kg started at day 10, with a progressive decrease until 1 mg of prednisone in March 2024), IV immunoglobulins started at day 18 (1.5 g/kg in 2 days, administered monthly, with a progressive decrease and a cessation in June 2022), enteral nutrition, speech therapy and physical therapy, with noticeable improvement. After 4 years of follow-up, and only one infusion of Ipi/Nivo, the melanoma is still in complete response.ConclusionWe report an ICI-induced severe myositis mimicking bulbar palsy after the administration of Ipi/Nivo. …”
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Insulin-Attenuated Inflammatory Response of Dendritic Cells in Diabetes by Regulating RAGE-PKCβ1-IRS1-NF-κB Signal Pathway: A Study on the Anti-Inflammatory Mechanism of Insulin in... by Liding Zhao, Ya Li, Qingbo Lv, Min Wang, Yi Luan, Jiale Song, Guosheng Fu, Junbo Ge, Yunzeng Zou, Wenbin Zhang

“…Insulin has the capability of attenuating the inflammatory response of DCs in diabetes, partly through the downregulation of RAGE expression followed by the inhibition of PKCβ1 phosphorylation and IRS1 serine phosphorylation, resulting in the inactivation of IR binding-independent NF-κB. …”
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Efficacy and Safety of an Aflibercept Treat-and-Extend Regimen in Treatment-Naïve Patients with Macular Oedema Secondary to Central Retinal Vein Occlusion (CRVO): A Prospective 12-... by Jose Garcia-Arumi, Francisco Gómez-Ulla, Navea Amparo, Enrique Cervera, Alex Fonollosa, Luis Arias, Javier Araiz, Juan Donate, Marta Suárez de Figueroa, Lucia Manzanas, Jaume Crespí, Roberto Gallego

“…Intravitreal aflibercept 2 mg monthly (3 months) followed by proactive individualized dosing. Main Outcomes. …”
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Sustainable foam glass property prediction using machine learning: A comprehensive comparison of predictive methods and techniques by Mohamed Abdellatief, Leong Sing Wong, Norashidah Md Din, Ali Najah Ahmed, Abba Musa Hassan, Zainah Ibrahim, G. Murali, Kim Hung Mo, Ahmed El-Shafie

“…Model performance was evaluated through R-values, mean absolute error, and root mean square error metrics, demonstrating that the GPR model achieved superior prediction accuracy with R-values of 0.91 and 0.82 for porosity and CS, respectively. The GB model followed closely, while the RF and LR models showed lower accuracy. …”
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Prednisolone versus antihistamine for allergic rhinitis: No significant difference found in randomized trial by Carl Skröder, Laila Hellkvist, Ulla Westin, Pernilla Sahlstrand‐Johnsson, Kerstin Hansson, Agneta Karlsson, Åslög Dahl, Leif Bjermer, Lars Olaf Cardell

“…The Swedish tree pollen season starts in February with alder and hazel pollination, followed by birch and ends with oak in May. Systemic corticosteroids are often prescribed when topical treatments fail, despite limited evidence supporting their efficacy. …”
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Associations between interpersonal violence and cigarette smoking, e-cigarette use, and dual use among Mexican adolescent students by Rosibel Rodríguez-Bolaños, Evangelina Díaz-Andrade, Evangelina Díaz-Andrade, Paula Ramírez-Palacios, Anabel Rojas-Carmona, Anabel Rojas-Carmona, Katia Gallegos-Carrillo, Inti Barrientos-Gutiérrez, Lizeth Cruz-Jiménez, Dèsirée Vidaña-Pérez, Edna Arillo-Santillán, James F. Thrasher, James F. Thrasher

“…Almost half (46.9%) of adolescents reported having been the target of physical violence, followed by psychological violence (42.6%), neglect (34.9%), digital violence (12.3%), and sexual violence (5.2%). …”
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Biofilmed-PGPR: Next-Generation Bioinoculant for Plant Growth Promotion in Rice under Changing Climate by Jeberlin Prabina Bright, Hemant S. Maheshwari, Sugitha Thangappan, Kahkashan Perveen, Najat A. Bukhari, Debasis Mitra, Riyaz Sayyed, Andrea Mastinu

“…Principal component analysis showed that plant growth, yield, soil dehydrogenase activity, and soil chlorophyll content were positively correlated with rice plants amended with vermiculite-based CBB at 2 kg/hm2 followed by a spray with aqueous CBB formulation at 5 mL/L at 15 and 30 d after rice transplanting grown with a 25% reduced level of nitrogen/phosphorus/potassium chemical fertilizers than the recommended dose. …”
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Long time-series and high-frequency ecological evaluation of Henan section of the Yellow River by Jianzhong Guo, Daozhu Xu, Jian Xu, Ruoxin Zhu, Ning Li

“…Spring is the best, followed by autumn and summer, and winter is the worst. …”
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Game mechanics in eHealth interventions promoting self-management in young people with chronic diseases: a protocol for a systematic review and meta-analyses from the eHealth Junio... by Sanne L Nijhof, Elise van de Putte, Fernando Estévez-López, Wichor M Bramer, Lisa Levelt, Job van ’t Veer, Micah M Hrehovcsik, Valentijn Visch, Manon H. J. Hillegers, Remco C Veltkamp

“…This systematic review aims at identifying (1) the game mechanics that have been implemented in eHealth interventions to support young people’s self-management of their chronic (somatic or psychiatric) diseases, (2) the investigators’ rationale for implementing such game mechanics and, if possible, (3) the effects of these interventions.Methods and analysis The Preferred Reporting Items for Systematic reviews and Meta-Analysis statement guidelines will be followed. A systematic search of the literature will be conducted in Embase, Psycinfo and Web of Science from inception until 30 August 2022. …”
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Long‐term survival outcome with tyrosine kinase inhibitors and surgical intervention in patients with metastatic or recurrent gastrointestinal stromal tumors: A 14‐year, single‐cen... by Jwa Hoon Kim, Min‐Hee Ryu, Changhoon Yoo, Heejung Chae, Hana Na, Moyoul Beck, Beom Su Kim, Moon‐Won Yoo, Jeong Hwan Yook, Byung Sik Kim, Ki‐Hun Kim, Chan Wook Kim, Yoon‐Koo Kang

“…More patients in period 2 underwent surgical resection for TKI‐responsive diseases within the first 2 years (24.9%, P = 0.006). With a median follow‐up of 6.1 years (2.5‐16.0) in survivors, median progression‐free survival (PFS) was 5.4 years [95% confidence interval (CI), 4.0‐6.9]. …”
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MicroRNA-451a is a candidate biomarker and therapeutic target for major depressive disorder by Yan Chen, Yun Liu, Ming Xiao, Chun Wang, Panpan Hu, Qiuchen Cao, Hu Feng, Jingfan Xu, Weixi Feng, Huaiqing Sun, Huachen Ding, Junying Gao

“…Eight-week-old male C57BL/6 mice had miR-451a overexpression in the medial prefrontal cortex (mPFC) via adeno-associated virus serotype 9 vectors encoding a pri-mmu-miR-451a-GFP fusion protein followed by behavioural and pathological analyses. …”
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Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery by Michal Holub, Eva Bartáková, Alžběta Stráníková, Eva Koblihová, Simona Arientová, Marie Blahutová, Jan Máca, Miroslav Ryska

“…After surgery, the serum levels of calprotectin and calgranulin C were significantly (p<0.01) higher than their baseline values, and this elevation persisted throughout the seven days of the follow-up period. Interestingly, starting on day 1 of the postoperative period, the serum levels of both proteins were significantly (p<0.05) higher in the 37 patients who developed postoperative pancreatic fistulas (POPFs) than in the patients who had uneventful recoveries (n=61). …”
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Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis o... by Kei Sonehara, Kazunari Tateishi, Kiyotaka Yoh, Kazuhiro Usui, Yukio Hosomi, Kazuma Kishi, Go Naka, Kageaki Watanabe, Shu Tamano, Kohei Uemura, Hideo Kunitoh

“…The most common rechallenge EGFR‐TKI was afatinib (n = 24, 45.3%), followed by gefitinib (n = 16, 30.2%) and erlotinib (n = 8, 15.1%). …”
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The performance status gap in immunotherapy for frail patients with advanced non-small cell lung cancer by Julie Tsu-Yu Wu, June Corrigan, Chloe Su, Clark Dumontier, Jennifer La, Aparjita Khan, Shipra Arya, Alex H. S. Harris, Leah Backhus, Millie Das, Nhan V. Do, Mary T. Brophy, Summer S. Han, Michael Kelley, Nathanael R. Fillmore

“…Methods Patients in the veterans affairs national precision oncology program from 1/2019–12/2021 who received first-line ICI for advanced NSCLC were followed until death or study end 6/2022. Association of an electronic frailty index with treatment selection was examined using logistic regression stratified by PS. …”
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