UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research by Zhan R, Liu Y, Wu J, Shen Y, Xu X, Lin G, Chen X

“…The multiple reaction monitoring (MRM) in positive ion mode was used to detect the mass transition pairs for givinostat and IS as follows: m/z 422.01→ 186.11 for givinostat, and m/z 405.40→ 84.10 for IS, respectively.Results: In the bioanalytical method, good linearity was observed between 2 and 4000 ng/mL (r2=0.998). …”
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Nutritional Quality of Three Iron-Rich Porridges Blended with Moringa oleifera, Hibiscus sabdariffa, and Solanum aethiopicum to Combat Iron Deficiency Anemia among Children by Brice Ulrich Foudjo Saha, Aphrodite Tchewonpi Choumessi, Alvain Meshi Ayamo, Ronald Blaise Mouafo Kuagny, Ismael Teta, Edouard Akono Nantia, Richard Aba Ejoh

“…The sensory analysis showed that the moringa leaf-based porridge (82%) was the most appreciated followed by eggplant leaf-based porridge (80%) and folere leaf-based porridge (70%). …”
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System of Administrative and Legal Regulation of the Status of the Cabinet of Ministers of Ukraine in the Field of Scientific, Research and Technical Activity in Ukraine by V. S. Tarasenko

“…Thus, the mechanism of administrative and legal regulation of the status of the Cabinet of Ministers of Ukraine in the field of scientific, research and technical activities in Ukraine can be presented as follows: – administrative and legal norms that determine the administrative and legal status of the Cabinet of Ministers of Ukraine in the field of scientific, research and technical activities in Ukraine, their sources; – principles of the activity of the Cabinet of Ministers of Ukraine in the sphere of administrative relations in the field of science and technology in Ukraine; – interpretation of administrative and legal norms regulating the administrative and legal status of the Cabinet of Ministers of Ukraine in the field of scientific and scientific and technical activities in Ukraine; – the nature of administrative and legal relations in the field of scientific, research and technical activities, the participant of which is the Cabinet of Ministers of Ukraine; – individual acts of the Cabinet of Ministers of Ukraine in the field of scientific, research and technical activity; – forms of activity of the Cabinet of Ministers of Ukraine in the field of scientific, research and technical activity as the participant of administrative and legal relations; – methods of administrative and legal regulation of the status of the Cabinet of Ministers of Ukraine in the field of scientific, research and technical activities in Ukraine; – administrative and legal regimes regulating the status of the Cabinet of Ministers of Ukraine in the field of scientific, research and technical activities in Ukraine; – administrative procedures of the Cabinet of Ministers of Ukraine in the field of scientific, research and technical activities; – efficiency of administrative and legal regulation of the status of the Cabinet of Ministers of Ukraine in the field of scientific, research and technical activity.…”
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CMR assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new-onset atrial arrhythmias after STEMI by Yanfei Ren, Xinjia Du, Maochen Li, Lei Chen, Jiahua Liu, Yixuan Wu, Yuan Lu

“…We consecutively selected patients who completed CMR during their hospitalisation for PCI after STEMI from May 2019-January 2023, and then underwent regular follow-up, grouped by the presence or absence of new atrial arrhythmias, and enrolled patients were divided into atrial arrhythmia and non-atrial arrhythmia groups. …”
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Predictors and long-term patterns of medication adherence to glaucoma treatment in Denmark—an observational registry study of 30 100 Danish patients with glaucoma by Miriam Kolko, Rikke Faergemann Hansen, Louise G Dal, Emma Sabelström, Magnus Brandel, Andreas Hoiberg Bentsen, Anne Cathrine Falch-Joergensen

“…Poor adherence results in worse outcomes in terms of visual field loss.Objective To investigate patterns in medication adherence among Danish patients with glaucoma in relation to selected predictors of adherence, long-term adherence patterns, and long-term societal economic consequences of poor adherence.Methods and analysis This register-based study included 30 100 glaucoma patients followed for 10 years between 2000 and 2018. Glaucoma was identified from the Danish national registers by diagnosis of Open Angle Glaucoma and/or by redeemed prescriptions of glaucoma medication. …”
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Hypoglychemic activity of Moringa oleifera extract in streptozotocin-induced diabetic rats by Rabiatul Adawiyah, Tri Setyawati, Rahma Badaruddin, Listawati

“…Data were analyzed using ANOVA followed by post-hoc analysis. Results: The fasting blood glucose levels significantly differed among the groups (ANOVA, p = 0.0426). …”
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Attitudes of German General Practitioners Toward eHealth Apps for Dementia Risk Reduction: Qualitative Interview Study by Adrian Schultz, Melanie Luppa, Markus Bleckwenn, Steffi G Riedel-Heller, Andrea Zuelke

“…Eight themes were identified and elaborated on in the data as follows: “addressing dementia,” “knowledge about dementia,” “need for information,” “potential for prevention,” “chances for apps for prevention,” “development of apps for prevention,” and “barriers of apps for prevention.” …”
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The effect of Camellia sinensis ointment on perineal pain and episiotomy wound healing in primiparous women: A triple-blind randomized clinical trial. by Masoumeh Sayahi, Azam Jahangirimehr, Zahra Hatami Manesh, Faraz Mojab, Maryam Nikbina

“…Participants were randomly assigned into two groups of intervention (Camellia sinensis extract ointment) and control (placebo) with a follow-up of 14 days. REEDA scale (redness, edema, ecchymosis, discharge, and approximation) was used to measure wound healing and the Visual Analog Scale (VAS) was used to measure the pain intensity.…”
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Forensic-medical determination of the severity of closed injuries of the hyoid-laryngeal complex according to the data of a specialized clinic by M.V. Gubin, V.O. Olkhovskyi, G.I. Garyuk, V.M. Gubin

“…The mechanism of occurrence of injuries of the hyoid-laryngeal complex was as follows: in 51 (82.3% of cases there were blows to the neck with blunt hard objects (blows with fists and other objects), in 11 (17.7%) cases – squeezing of the neck with hands or blunt hard objects. …”
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Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial by Judith Bellapart, Vinesh Appadurai, Melissa Lassig-Smith, Janine Stuart, Christopher Zappala, Rob Boots

“…Randomized allocation to placebo or enteral melatonin, using a previously described regimen (loading dose of 3 mg at 21 h, followed by 0.5 mg hourly maintenance dose until 03am through a nasogastric tube). …”
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Effects of Dietary Protein-to-Energy Ratios on Growth, Immune Response, Antioxidative Capacity, Liver and Intestinal Histology, and Growth-Related Gene Expression in Hybrid Yellow... by Sehrish Taj, Quan Han, Xiaoyi Wu, Haoran Yin, Lixia Tian, Huijun Yang, Yongjian Liu, Junwa Huang

“…A significant (P<0.05) increase in percent weight gain (WG%) and specific growth rate (SGR) was seen as the dietary P/E ratio ameliorated from P/E84 to P/E95, followed by a decreased pattern in these parameters. …”
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Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial by Hui Chen, Shuai Liu, Lu Ji, Tianfeng Wu, Yong Ji, Yuying Zhou, Miaoyan Zheng, Meilin Zhang, Weili Xu, Guowei Huang

“…The Mini-Mental State Examination (MMSE) was administered to all patients at baseline and follow-up, and blood samples were taken before and after treatment. …”
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Efficacy of Ivermectin, Liquid Paraffin, and Carbaryl against Mange of Farmed Rabbits in Central Kenya by Kennedy O. Ogolla, Joyce Chebet, Robert M. Waruiru, Peter K. Gathumbi, Paul O. Okumu, Gabriel O. Aboge

“…Treatments were administered as follows: group 1 (G1) received two ivermectin injections at an interval of 14 days, group 2 (G2) was treated with a combination of carbaryl and liquid paraffin applied every other day up to the end of the experiment, group 3 (G3) was treated with liquid paraffin droplets applied daily until the lesion cleared, while group 4 (G4, infected-untreated) received distilled water applied topically on their ears and group 5 (G5, uninfected-untreated negative control) was not treated with any preparation. …”
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Liraglutide Regulates the Kidney and Liver in Diabetic Nephropathy Rats through the miR-34a/SIRT1 Pathway by Shan Xiao, Ye Yang, Yue-Tong Liu, Jun Zhu

“…Compared with the control group, the miR-34a levels were significantly decreased in kidney and liver tissues followed by liraglutide treatment (P<0.05). The levels of SIRT1 in the liraglutide group are significantly higher than those in the control group with the kidney and liver tissues (P<0.05). …”
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miR663 Prevents Epo Inhibition Caused by TNF-Alpha in Normoxia and Hypoxia by Mete Ozkurt, Thomas Hellwig-Bürgel, Reinhard Depping, Selda Kadabere, Rumeysa Ozyurt, Abdullah Karadag, Nilüfer Erkasap

“…We transfected the miR663 group with the mimic-miR663 (30 pmol) for 24 hrs; other groups were treated with a transfection reagent followed by treatment of TNF-α for 24 hrs; miR663 groups were treated with TNF-α for 24 hrs; and the control group was incubated with normal medium. …”
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Association of Plasma Levels of Nitric Oxide Oxidative Metabolites with Acute Stroke in Patients Presenting to the Emergency Department of a Low-Middle Income Country by Shahan Waheed, Ayaz Ghouse Kalsekar, Ayeesha Kamran Kamal, Nathan S. Bryan, Asad I. Mian

“…Clinical demographic information, ancillary blood, and diagnostic specimens were collected as per standard of care since the center follows stroke algorithmic guidelines. Plasma NOx analysis was performed using high performance liquid chromatography. …”
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Gender Disparities in Medical and Dental Admissions: Students' Perspectives on Barriers by Nabiha Farasat Khan, Muhammad Ilyas, Usama Saeed Usama, Muhammad Saeed, Muhammad Saim, Raz Muhammad

“…The primary obstacles identified were safety concerns and transportation issues at academic institutions (47.5%, n=19), followed by cultural norms and social pressures (20%, n=8), and a lack of female role models in college (12.5%, n=5). …”
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Study on Mechanical Performance of Prestressed UHPFRC U-Beam Bridges by Mengying Liu, Eugen Brühwiler, Fengkun Cui, Yue Xu

“…The finite element analysis results show that the maximum strain value appears at the central rib, followed by the transverse strain value of the bottom plate, while the minimum strain is the longitudinal strain value of the bottom plate. …”
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Exploring the immunohistochemical profile of basosquamous carcinoma and its clinicopathological associations by Cemile Tuğba Altunel, Gonca Özgün, Arzu Karataş, Özlem Özen, Deniz Seçkin, Tülin Güleç, Deren Özcan

“…High margin positivity favors wide-excision margins. Long-term follow-up studies will clarify the prognostic significance of immunohistochemical markers mentioned in the study.…”
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Prevalence and factors associated with modern contraceptive use among women of reproductive age in 20 African countries: a large population-based study by Robert Akparibo, Paschal Awingura Apanga, Maxwell Tii Kumbeni, Emmanuel Awine Ayamga, Mark B Ulanja

“…Overall, injectable (32%) was the most preferred method of CP, followed by oral pill (27%) and implants (16%). Women were more likely to use a modern CP if they: had a primary (adjusted prevalence odds ratios (aPORs): 1.68, 95% CI: 1.47 to 1.91)) or secondary/higher education (aPOR: 2.16, 95% CI: 1.80 to 2.59) compared with women with no formal education; had no delivery in the last 2 years (aPOR: 3.89, 95% CI: 2.76 to 5.47) compared with women who delivered in the last 2 years; were aged 25–34 years (aPOR: 1.33, 95% CI: 1.20 to 1.47) compared with women aged 15–24 years; were of middle-income status (aPOR: 1.25, 95% CI: 1.11 to 1.39) or rich (aPOR: 1.53, 95% CI: 1.27 to 1.84) compared with poor women and had two or more antenatal care visits compared with women without a visit. …”
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