Irisin Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis in Bile Duct Ligation Mice Model and Improves Mitochondrial Dysfunction by Thuy Linh Lai, So Young Park, Giang Nguyen, Phuc Thi Minh Pham, Seon Mee Kang, Jeana Hong, Jae-Ho Lee, Seung-Soon Im, Dae-Hee Choi, Eun-Hee Cho

“…In vivo, liver fibrosis was induced in mice via BDL, followed by daily intraperitoneal injections of irisin (100 μg/kg/day) for 10 days. …”
Get full text

Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics by Jibon Kumar Paul, Mahir Azmal, Md Naimul Haque Shohan, Mohua Mrinmoy, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh

“…Molecular docking results revealed that millettone (CID 442810) exhibited the highest binding affinity to AKT2, with a docking score of −9.5 kcal/mol, followed by uzarigenin (CID 92760), dihydrobiochanin A (CID 439784), and abyssinone I (CID 442152) with docking scores of −9.0 kcal/mol, −8.9 kcal/mol, and −8.7 kcal/mol respectively, outperforming the control inhibitor, ipatasertib (CID 24788740) docking score of −7.56 kcal/mol. …”
Get full text

Effectiveness of screening for colorectal cancer with a faecal occult-blood test, in Finland by J Pitkäniemi, K Seppä, M Hakama, O Malminiemi, T Palva, M-S Vuoristo, H Järvinen, H Paimela, P Pikkarainen, A Anttila, L Elovainio, T Hakulinen, S Karjalainen, L Pylkkänen, M Rautalahti, T Sarkeala, H Vertio, N Malila

“…In 2012, the programme covered 43% of the target age population in Finland.Results The median follow-up time was 4.5 years (maximum 8.3 years), with a total of 1.6 million person-years. …”
Get full text

The efficacy analysis of laparoscopic-assisted Soave procedure for Hirschsprung’s disease in neonates and infants within 3 months of age by Renpeng Xia, Tidong Ma, Fan Zhao, Yong Xiao, Yong Feng, Ming Li, Chanjuan Zou, Guang Xu, Chonggao Zhou

“…Of the 267 cases, 214 cases were followed up (80.1%), 60 cases with fecal contamination, the incidence rate was 28.0%, and 5 cases were tertiary fecal contamination. …”
Get full text

The scoping, design, and plasma physics optimization of the Eos neutron source stellarator by C.P.S. Swanson, D.A. Gates, S.T.A. Kumar, M.F. Martin, T.G. Kruger, D.W. Dudt, P.J. Bonofiglo, the Thea Energy team

“…Higher-fidelity analyses will follow. Models of 1D profile-dependent neutral beam stopping, ion beam slowing down, beam-target fusion, electron-ion classical heat transfer, energy confinement (ISS04), beam pressure, beam heating of ions and electrons, beam-beam fusion fraction, and neutral beam injection and gyrotron heating electrical efficiencies are included. …”
Get full text

PFAS residue analysis in fish and fish feed by applying a modified QuEChERS method in combination with LC-HRMS detection by Ourania Koloka, Vasiliki Boti, Dimitra Hela, Triantafyllos Albanis, Ioannis Konstantinou

“…This method combines a modified QuEChERS extraction methodology that includes sonication followed by Liquid Chromatography- Linear Ion Trap/Orbitrap High Resolution Mass Spectrometry (LC- LTQ/Orbitrap HRMS) analysis. …”
Get full text

Breast cancers with neuroendocrine differentiation: Retrospective case studies series from a single institution based on the 2019 WHO classification by Youngkyung Jeon, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Kyuehee Choi, Sun Young Jeong, Yeji Jung, Jaeyeon Jang, Dae-Ho Choi, Joohyun Hong, Hyo Jung Kim, Soo Youn Cho, Yeon Hee Park

“…All patients were treated with curative intent surgery; five patients received neoadjuvant chemotherapy, twelve patients received radiotherapy, six patients received adjuvant chemotherapy, and eight patients received hormone therapy. The median follow-up period for the eight patients with breast NEC was 20.4 months. …”
Get full text

Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia by Dong-Qing Yuan, Wei-Wei Zhang, Liu-Wei Gu, Qing-Huai Liu

“…Integrating mfERG into initial assessments or treatment follow-ups can aid in identifying potential hidden retinal defects and predicting the prognosis of the amblyopic eye.…”
Get full text

Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease by Carolinne Thaísa de Oliveira Fernandes Miranda, Victor Hugo Rezende Duarte, Marina Sampaio de Menezes Cruz, Mychelle Kytchia Rodrigues Nunes Duarte, Jéssica Nayara Góes de Araújo, Ayda Maria Quirino Silva dos Santos, Juliana Marinho de Oliveira, Maria Sanali Moura Oliveira Paiva, Adriana Augusto Rezende, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata, Karla Danielly da Silva Ribeiro, André Ducati Luchessi, Vivian Nogueira Silbiger

“…Accordingly, patients were grouped as follows: FI = 0–4 (n=90), FI = 5–9 (n=50), and FI = 10–15 (n=37). …”
Get full text

Phenotypic Presentation of Children with Joint Hypermobility: Preclinical Signs by Mateus Marino Lamari, Neuseli Marino Lamari, Michael Peres de Medeiros, Gerardo Maria de Araújo Filho, Adriana Barbosa Santos, Matheus Gomes Giacomini, Vitor Roberto Pugliesi Marques, Eny Maria Goloni-Bertollo, Érika Cristina Pavarino

“…Results: The concave sitting position was the most common, followed by W, F, and S in decreasing order. A total of 52.4% of the children had BS > 6, with a higher prevalence among girls (60.8%) compared to boys (40.0%); a difference statistically significant (<i>p</i> = 0.024, Fisher’s exact test). …”
Get full text

Painless Silent Chronic Fibrosing Pancreatitis Caused Complete Biliary Obstruction in a Toddler: A Case Report by Magd Ahmed Kotb, Mohamed Elbarbary, Sherif Kaddah, Martina Magdy, Rania Hamdy, Reham Osama Mahmoud, Nevian Nabil, Noha Adel Yassin, Ahmed Nabil, Ahmed El Hatw, Sayed Khedr

“…He underwent percutaneous trans hepatic drainage (PTD) with T tube insertion for drainage of the biliary obstruction followed by Frey procedure with coring of pancreatic head to allow biliary drainage. …”
Get full text

Floristic Diversity and Potential of Site of Biological and Ecological Interest Brikcha, Prérif (North-West Morocco) by Ahmed Chriqui, Ouafae Benkhnigue, Issam El Khadir, Yassine Mouniane, Sidi Mohamed Hachimi Alaoui, Lahcen Zidane, Driss Hmouni

“…Life forms are mainly represented by therophytes (46.01%), followed by geophytes (17.49%) and phanerophytes (14.11%). …”
Get full text

Helicobacter pylori antibacterial resistance patterns in Latvia: results from the Gistar pilot study by D. Rudzīte, R. Vangravs, I. Daugule, Ģ. Šķenders, I. Poļaka, A. Vanags, J. Atstupens, I. Tolmanis, P. Pūpola, Y. Tarasenko, J. Park

“…Resistance to metronidazole was detected in 31 cases (34.8%; 95% CI: 25.2-45.7), followed by rifampicin in nine cases (10.1%; 95% CI: 5.0-18.8%), clarithromycin in five (5.6%; 95% CI: 2.1-13.2) and to levofloxacin in four cases (4.5%; 95% CI: 1.5-11.8). …”
Get full text

Neglecting the neglected: Tobacco cessation support is 'essential' for the management of asthma and COPD by Dilek Karadogan, İlknur Kaya, Merve Yumrukuz Şenel, Esin Bilgin Konyalıhatipoğlu, Tahsin Gökhan Telatar, Metin Akgün

“…Routine cessation interventions were implemented for current smokers, and they were followed via phone calls after one month regarding their quit status and access to cessation clinics. …”
Get full text

Machine Learning Diagnostic Model for Hepatocellular Carcinoma Based on Liquid–Liquid Phase Separation and Ferroptosis-Related Genes by Wenchao Chen, Ting Zhu, Xiaofan Pu, Linlin Zhao, Senhao Zhou, Xin Zhong, Suihan Wang, Tianyu Lin

“…Materials and Methods: The differentially expressed genes (DEGs) were identified based on 3 GEO datasets, followed by overlapping with LLPS-related and ferroptosis-related genes. …”
Get full text

Non-governmental organizations’ perceptions of challenges and opportunities for participating in the provision of government-purchased community-based psychiatric rehabilitation se... by Hao Yao, Siyuan He, Fei Yan, Wei Wang, Hanyi Lin, Yanli Liu, Lili Xue, Jun Cai, Weibo Zhang

“…External opportunities included China’s favorable policy environment, Shanghai’s developed economic environment, and increased public awareness of mental health, while internal opportunities included NGOs’ greater flexibility, high team cohesion, stronger focus on the holistic needs of clients, better resource integration capabilities, and ability to provide long-term follow-up and support for clients. Conclusions Based on the findings, recommendations for future actions are provided in the areas of research, public awareness, funding, training, referrals, collaboration, and service designing to improve the mechanism of government purchasing of CBPR services from NGOs in China.…”
Get full text

Retinal Nerve Fiber Layer Thickness Progression after Robotic-Assisted Laparoscopic Radical Prostatectomy in Glaucoma Patients by Kazuyuki Hirooka, Kaori Ukegawa, Eri Nitta, Nobufumi Ueda, Yushi Hayashida, Hiromi Hirama, Rikiya Taoka, Yuma Sakura, Mari Yamasaki, Hiroyuki Tsunemori, Mikio Sugimoto, Yoshiaki Kiuchi

“…Average IOP (mmHg) at each time point was as follows: T1 = 11.2 ± 3.8, T2 = 19.0 ± 4.4, T3 = 23.3 ± 6.3, T4 = 25.1 ± 4.3, T5 = 25.5 ± 5.1, T6 = 28.3 ± 4.8, and T7 = 22.6 ± 5.4. …”
Get full text

Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) trial: study protocol for a multicentre, double-blinded, placebo-controlled, phase IIa trial by Julian R Marchesi, Emma Nicholson, Benjamin H Mullish, Renuka Palanicawandar, Graham Wheeler, Francesca Kinsella, Andrew J Innes, Lauren A Roberts, Shian Anim-Burton, Lee Webber, Nicholas A Johnson, Rohma Ghani, Pakhshan Farshi, Anjum B Khan, Panagiotis Kottaridis, Pramila Krishnamurthy, Frances Davies, Jiří Pavlů

“…We hypothesised that IMT performed prior to initiation of HCT conditioning restores microbiome diversity during the early stages of HCT, leading to decreased frequency of complications and improved outcomes of HCT.Methods and analysis 50 adult patients receiving allogeneic HCT will be recruited into this phase IIa trial and randomised 1:1 to receive capsulised IMT or matched placebo shortly prior to initiation of HCT conditioning and followed for up to 12 months. The primary outcome will be to assess the increase in alpha diversity between pre-IMT and that measured at ~42 days after IMT administration (day +28 of HCT), comparing the difference between patients receiving IMT compared with placebo. …”
Get full text

Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients by Yongjie Xie, Xiaoran Feng, Youqun Gao, Xiaojiang Zhan, Fenfen Peng, Qian Zhou, Xianfeng Wu, Xiaoyang Wang, Na Tian, Qingdong Xu, Ning Su, Xingming Tang, Jianbo Liang, Jiao Li, Yueqiang Wen

“…Competitive risk analysis was used to examine the effects of other outcomes on all-cause mortality prognosis.Results In the 33-month follow-up period, there were 538 all-cause deaths. …”
Get full text

Novel combination therapy for platinum-eligible patients with locally advanced or metastatic urothelial carcinoma: a systematic review and network meta-analysis by Takafumi Yanagisawa, Keiichiro Mori, Akihiro Matsukawa, Tatsushi Kawada, Satoshi Katayama, Ekaterina Laukhtina, Pawel Rajwa, Fahad Quhal, Benjamin Pradere, Wataru Fukuokaya, Kosuke Iwatani, Renate Pichler, Jeremy Yuen-Chun Teoh, Marco Moschini, Wojciech Krajewski, Jun Miki, Shahrokh F. Shariat, Takahiro Kimura, European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)

“…Enfortumab vedotin (EV) + pembrolizumab ranked the highest for improving OS (100%), PFS (100%), ORR (96%), and CRR (96%), followed by nivolumab + chemotherapy. EV + pembrolizumab combination superiority held across PD-L1 status and cisplatin eligibility. …”
Get full text