Clinical and radiological outcomes of lumbar endoscopic decompression for treating lumbar spinal stenosis and degenerative lumbar scoliosis: a retrospective study at mean 4.4 years follow-up by Ning Fan, Aobo Wang, Shuo Yuan, Peng Du, Tianyi Wang, Lei Zang

“…However, patients in the DLS group reported more severe back pain at the final follow-up than those in the LSS group (p = 0.039). …”
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A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in Healthy Adult Subjects by Lee HW, Kang WY, Park JS, Lee JH, Park JJ, Gwon MR, Yoon YR, Seong SJ

“…YYD601 20 mg was safe and well tolerated following single and multiple oral administrations, supporting its use as an effective alternative to conventional esomeprazole therapy.Clinical Trial Registry: http://clinicaltrials.gov, NCT03985319 (Date of registration: May 29, 2019; Study period: between July 2019 and March 2020).Keywords: esomeprazole, dual delayed-release formulation, pharmacokinetics, pharmacodynamics…”
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Increased Co-Expression of PD-L1 and CTLA-4 Predicts Poor Overall Survival in Patients with Acute Myeloid Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation by Chen C, Qiu K, Chen J, Wang S, Zhang Y, Wang C, Li Y

“…Importantly, PD-L1/CTLA-4 was the best combination model for predicting poor OS in AML patients following allo-HSCT, especially combined with minimal residual disease (MRD).Conclusion: High expression of ICs in BM of AML patients following allo-HSCT was related to poor outcomes, and increasing co-expression of PD-L1 and CTLA-4 might be one of the best immune biomarkers to predict outcomes in patients with AML.Keywords: acute myeloid leukemia, allo-HSCT, immune checkpoint, biomarker, prognosis…”
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Influence of Anti-TNF and Disease Modifying Antirheumatic Drugs Therapy on Pulmonary Forced Vital Capacity Associated to Ankylosing Spondylitis: A 2-Year Follow-Up Observational Study by Alberto Daniel Rocha-Muñoz, Aniel Jessica Leticia Brambila-Tapia, María Guadalupe Zavala-Cerna, José Clemente Vásquez-Jiménez, Liliana Faviola De la Cerda-Trujillo, Mónica Vázquez-Del Mercado, Norma Alejandra Rodriguez-Jimenez, Valeria Díaz-Rizo, Viviana Díaz-González, Ernesto German Cardona-Muñoz, Ingrid Patricia Dávalos-Rodríguez, Mario Salazar-Paramo, Jorge Ivan Gamez-Nava, Arnulfo Hernan Nava-Zavala, Laura Gonzalez-Lopez

“…Similarly, patients in anti-TNF + DMARDs group had greater improvement in BASDAI, BASFI, Borg scale, and 6MWT when compared to DMARDs alone. After 2 years of follow-up, 14/16 (87.5%) in the anti-TNF + DMARDs group achieved the primary outcome: FVC% ≥80%, compared with 11/20 (55%) in the DMARDs group (P=0.04). …”
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Relationship Between Physical Activity Level and Primary Care Costs in Older Diabetic Patients From a Middle-Size Brazilian City: An Eight-Year Follow-Up Study by Kelly Akemi Kikuti Koyama, Monique Yndawe Castanho Araujo, Luana Carolina de Morais, Italo Ribeiro Lemes, Rômulo Araújo Fernandes, Bruna Camilo Turi-Lynch, Flávia Mori Sarti, Thais Cristina Delacosta, Henrique Luiz Monteiro, Jamile Sanches Codogno

“…This study aims to investigate the relationship between changes in physical activity level and changes in healthcare costs among older diabetic adults in an 8-year follow-up study.MethodsThe study followed 151 diabetic adults ≥50 years of age, for a period of 8 years, who were patients of Basic Health Care Units in the city of Bauru (Brazil). …”
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Biodentine™ Partial Pulpotomy of a Young Permanent Molar with Signs and Symptoms Indicative of Irreversible Pulpitis and Periapical Lesion: A Case Report of a Five-Year Follow-Up by W. Chinadet, T. Sutharaphan, P. Chompu-inwai

“…Follow-up radiographs showed a dentine bridge and periapical healing.…”
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Locking compression plate as a sequential external fixator following the distraction phase for the treatment of tibial bone defects caused by fracture-related infection: experiences from 22 cases by Xiriaili Kadier, Kai Liu, Aierbanjiang Shali, Yimurang Hamiti, Sulong Wang, Xin Yang, Alimu Keremu, Aihemaitijiang Yusufu

“…The mean postoperative follow-up time was 29 ± 2.65 months. The mean number of previous surgical interventions per patient was 5.22 ± 1.26. …”
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Endovascular Management of a Refractory Pseudoaneurysm of the Sternocleidomastoid Artery Caused by Attempted Internal Jugular Central Line Placement with Long-Term Follow-Up: A Case Report and Review by Yassmeen Abdel-Aty, Michael P. Bellew

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Bernese Periacetabular Osteotomy in a Hip Extra-Articular Resection Followed by Reconstruction Using an Extracorporeal Irradiated Acetabulum Autograft with Megaprosthesis, for Proximal Femur Osteosarcoma in a Pediatric Patient by Victor Barro, Roberto Velez, Daniel Pacha, Jordi Giralt, Isabel Roca, Marius Aguirre

“…Endoprosthetic reconstruction following proximal femur resection is a good treatment alternative achieving good postoperative function. …”
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Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2 by Chandrama Shrestha, Honghui He, Yiqun Liu, Shaihong Zhu, Jing Xiong, Zhaohui Mo

“…Although altered endocrine changes following bariatric surgery in morbidly obese patients with diabetes have been demonstrated by previous studies, little is known about their effects on low BMI patients of T2DM. …”
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Inferior outcome of stand-alone short versus long tibial stem in revision total knee arthroplasty. A retrospective comparative study with minimum 2 year follow-up by Abdelatif Elsayed Ahmed, Abu Mukh Assala, Elsaid Ahmed Nady Saleh, Youssef Ahmed Omar, Foissey Constant, Servien Elvire, Lustig Sebastien

“…The main hypothesis is that the two types of tibial stems would exhibit similar complication and revision rates in mid-term follow-up. Methods: Patients who underwent RTKA for all causes in a specialized arthroplasty center from 2010 to 2022 with minimum 2-year follow-up were included in this study. …”
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Regulation of MAP2, GFAP, and calcium in the CA3 Region Following Kainic Acid Exposure to  organotypic hippocampal slice culture [version 3; peer review: 2 approved] by Aulanni'am Aulanni'am, Kusworini Handono, Ettie Rukmigarsari, Hidayat Sujuti, Machlusil Husna

“…Bath application of kainic acid for 48 hours in DIV 10 followed by observation of its initial effects on neurons, astrocytes, and calcium via the expression of MAP2, GFAP, and intracellular calcium imaging, subsequently. …”
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Aesthetic Rehabilitation of a Patient with Bruxism Using Ceramic Veneers and Overlays Combined with Four-Point Monolithic Zirconia Crowns for Occlusal Stabilization: A 4-Year Follow-Up by André Moreira, Filipe Freitas, Duarte Marques, João Caramês

“…This case describes the 4-year follow-up clinical evaluation of a full mouth tooth-supported rehabilitation made on a 66-year-old man with bruxism and tooth wear, with aesthetic complaints and compromised masticatory function. …”
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Long non-coding RNA Malat1 modulates CXCR4 expression to regulate the interaction between induced neural stem cells and microglia following closed head injury by Qin Dong, Pengyu Chen, Wenqiao Qiu, Zhijun Yang, Yanteng Li, Yuhui Zhou, Lili Guo, Dan Zou, Ruxiang Xu, Mou Gao

“…Microglia plays pivotal and complex roles in neuroinflammation-mediated neuronal insult and repair following CHI. We previously reported that induced neural stem cells (iNSCs) can block the effects of CXCL12/CXCR4 signaling on NF-κB activation in activated microglia by CXCR4 overexpression. …”
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Is a Single Low Dose of Intrathecal Morphine a Useful Adjunct to Patient-Controlled Analgesia for Postoperative Pain Control Following Lumbar Spine Surgery? A Preliminary Report by David Yen, Kim Turner, David Mark

“…BACKGROUND: Several studies addressing intrathecal morphine (ITM) use following spine surgery have been published either involving the pediatric population, using mid- to high-dose ITM, or not in conjunction with morphine patient-controlled analgesia (PCA).…”
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Palovarotene Can Attenuate Heterotopic Ossification Induced by Tendon Stem Cells by Downregulating the Synergistic Effects of Smad and NF-κB Signaling Pathway following Stimulation of the Inflammatory Microenvironment by Junchao Huang, Jialiang Lin, Congbin Li, Bo Tang, Haijun Xiao

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Retrospective Analysis of the Efficacy and Safety of Ultrasound-Guided Radiofrequency Ablation in the Treatment of Papillary Thyroid Microcarcinoma: A Follow-Up Study of Continuous Postoperative Surveillance and Large-Sample Data by Gongli Zhou, Xuefeng Zhang, Ke Xu, Beibei Zhang, Ruiqing Su, Tingting Cai, Wei Zhao, Feng Li

“…To retrospectively evaluate the efficacy and safety of ultrasound-guided radiofrequency ablation (RFA) in the treatment of papillary thyroid microcarcinoma (PTMC) through a follow-up study of continuous postoperative surveillance and large-sample data. …”
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The efficacy and safety of induction chemotherapy combined with sintilimab followed by concurrent chemoradiotherapy plus sintilimab sequencing maintaining with sintilimab for patients with unresectable locally advanced esophageal squamous cell carcinoma by Ruifeng Wang, Tianhui Guo, Qi Wang, Wen Gao, Yimiao Yu, Jun Zhang, Wenqian Fu, Haiji Wang, Biyuan Zhang

“…Treatment effects were evaluated after 2 cycles of induction therapy and after CCRT by contrast-enhanced CT scans and esophagograms, followed by subsequent evaluations every 3 months post-treatment. …”
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Cone-Beam Computed Tomography Evaluation of the Mandibular Condyle and Articular Spaces Following Orthognathic Surgery Using Freehand Articulation Method in Patients With Class II and III Skeletal Deformity by Amir Jalal Abbasi, Mojtaba Azadbakht, Farzaneh Mosavat, Mahsa Bayati

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Health-related quality of life in patients with liver cirrhosis following adjunctive nurse-based care versus standard medical care: a pragmatic, multicentre, randomised controlled study by Anncarin Svanberg, Maria Hjorth, Daniel Sjöberg, Elenor Kaminsky, Fredrik Rorsman, Riccardo Lo Martire

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