Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis by Lu Gan, Jianli Zhao, Peng Yao, Theodore A. Christopher, Bernard Lopez, Wayne B. Lau, Walter Koch, Erhe Gao, Xinliang Ma, Yajing Wang

“…Intramyocardial injection of an equal number of diabetic plasma sEV in nondiabetic hearts significantly increased cardiac apoptosis and exacerbated MI/R-induced cardiac dysfunction. …”
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The Chinese State, Incomplete Proletarianization and Structures of Inequality in Two Epochs by Wu Jieh-min, Mark Selden

“…., distinguishing those “sojourning” in the cities from those with full urban citizen rights on the basis of hukou.6Less studied, but equally important, in our view, is the interrelationship between inequality, on the one hand, and savings and underconsumption, on the other. …”
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Development of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation by More SM, Rashid MA, Kharwade RS, Taha M, Alhamhoom Y, Elhassan GO, Gangane P, Asar TO, Pise A, Kaleem M, Mujtaba MA

“…Sachin Madhusudan More1 *, Md Abdur Rashid,2 Rohini S Kharwade3 *, Murtada Taha,4 Yahya Alhamhoom,2 Gamal Osman Elhassan,5 Purushottam Gangane,3 Turky Omar Asar,6 Ajay Pise,7 Mohammed Kaleem,1 Md Ali Mujtaba8,9 1Department of Pharmacology, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, MH, 440037, India; 2Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Saudi Arabia; 3Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, MH, 440037, India; 4Department of Clinical Laboratory Science, Prince Sultan Military College of Health Sciences, Dhahran, Saudi Arabia; 5Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraidah, Saudi Arabia; 6Department of Biology, College of Science and Arts at Alkamil, University of Jeddah, Jeddah, Saudi Arabia; 7Department of Regulatory Affairs Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, MH, 440037, India; 8Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Arar, Saudi Arabia; 9Center for Health Research, Northern Border University, Arar, Saudi Arabia* These authors contributed equally to this workCorrespondence: Md Ali Mujtaba; Mohammed Kaleem, Email m.mujtaba@nbu.edu.sa; kaleemmubin88@gmail.comIntroduction: Rhein, a natural bioactive lipophilic compound with numerous pharmacological activities, faces limitations in clinical application due to poor aqueous solubility and low bioavailability. …”
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Development of a Russian version of the Minnesota low vision reading chart by I.R. Stepanets, A.N. Kulikov, S.A. Koskin, D.I. Zhilchuk

“…Binocular MRS for test chart 1 was 198±4.51 words/min, for test chart 2 — 200±4.76 words/min; CPS in binocular conditions was the same for both charts and equaled to 0.08±0.02 logMAR; binocular RA for test chart 1 was (-)0.04±0.01 logMAR and test chart 2 — (-)0,06±0,01 logMAR; binocular ACC was 1.00±0.02 and 1.03±0.02, respectively. …”
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Five-Year Prospective Follow-Up of Patients with Hepatitis C Virus Infection Treated with Direct-Acting Antiviral Agents by Zhang Y, Xia H, Fan L, Jiang L, Yang B, Wang F

“…Yaping Zhang,1,2,* Huan Xia,3,* Luchang Fan,1 Lu Jiang,4 Bin Yang,2 Fengmei Wang4,5 1The Third Central Clinical College of Tianjin Medical University, Tianjin Medical University, Tianjin, 300170, People’s Republic of China; 2Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Nankai University Affiliated Third Central Hospital, Tianjin, 300072, People’s Republic of China; 3Department of Infectious Diseases, Tianjin Second People’s Hospital, Tianjin, 300192, People’s Republic of China; 4Department of Hepatology and Gastroenterology, Tianjin First Central Hospital, Tianjin, 300192, People’s Republic of China; 5Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer, Tianjin First Central Hospitial, Tianjin, 300192, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fengmei Wang; Bin Yang, Email wangfengmeitj@126.com; bioyang@126.comPurpose: The research intended to present prospective data on the long-term prognosis of individuals with hepatitis C virus (HCV) infection who received direct-acting antiviral agent (DAA) treatment.Patients and Methods: Patients who received DAA treatment at Tianjin Third Central Hospital and Tianjin Second People’s Hospital were prospectively enrolled and subsequently underwent a longitudinal follow-up. …”
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Comparison of Lesser galangal, Alpinia officinarum extract and Letrozole in masculinization of Nile tilapia, Oreochromis niloticus by Seyed Mohammad Reza Taheri, Sakineh Yeganeh, Homayon Hoseinzadeh Sahafi

“…Materials and Methods: The number of 2760 pieces of Nile tilapia larvae seven days after fertilization with an average weight of 0.026 ± 0.002 g distributed in 24 aquaria (200-L in volume) equipped with aeration and filtration systems in equal and completely random released. Larvae were tested for 30 days. …”
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Coupling Bio-Resonance Neurotechnology (BRNT) and Dual Hemispheric Repetitive Transcranial Magnetic Stimulation (rTMS) Reduces Comorbid Major Depressive Disorder (MDD) and Generali... by Sunder K, Makale MT, Makale M, Bodhanapati J, Murphy KT, Dennen CA, Baron D, Thanos PK, Hanna C, Ashford Jnr JW, Lewandrowski KU, Blum K

“…., Colombia*These authors contributed equally to this workCorrespondence: Kenneth Blum, Email drd2gene@gmail.comAbstract: Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) are prevalent comorbidities related to a greater likelihood of poor treatment outcomes and prolonged treatment for Reward Deficiency Syndrome (RDS) behaviors. …”
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Air pollution and health in Eastern India: Findings from a primary survey conducted in West Bengal and Jharkhand by Arup Halder, Aditi Kundu, Arunava Ghoshal

“…Although air pollution is considered a global problem affecting rural and urban equally, it is still observed that the people of developing countries are disproportionately affected by it. …”
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Spatial and temporal heterogeneity of soil respiration in a bare-soil Mediterranean olive grove by S. Aranda-Barranco, S. Aranda-Barranco, P. Serrano-Ortiz, P. Serrano-Ortiz, A. S. Kowalski, A. S. Kowalski, E. P. Sánchez-Cañete, E. P. Sánchez-Cañete

“…To study spatial variability, the automatic chambers were distributed equally under the canopy (<span class="inline-formula"><i>R</i>_{s  Under-Tree}</span>) and in the center of the alley (<span class="inline-formula"><i>R</i>_s Alley</span>), and the gradient of <span class="inline-formula"><i>R</i>_s</span> between both locations was measured in several manual campaigns in addition to angular changes about the olive trees. …”
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Synthesis, Characterization, and Cytotoxic Activity of New Lanthanum(III) Complexes of Bis-Coumarins

“…<p>Complexes of lanthanum(III) with bis-coumarins: 3,<mml:math alttext="$3'$"> <mml:msup> <mml:mn>3</mml:mn> <mml:mo>&#x2032;</mml:mo> </mml:msup> </mml:math>-benzylidene-bis(4-hydroxy-2H-1-benzopyran-2-one) (<mml:math alttext="$chem{H_{2}}$"> <mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> </mml:math>L1) and bis(4-hydroxy-2-oxo-2H-chromen-3-yl)-(1H-pyrazol-3-yl)-methane (<mml:math alttext="$chem{H_{2}}$"> <mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> </mml:math>L2) were synthesized by reaction of lanthanum(III) salt and the ligands, in amounts equal to metal : ligand molar ratio of <mml:math alttext="$1 : 2$"> <mml:mn>1</mml:mn><mml:mo>:</mml:mo><mml:mn>2</mml:mn> </mml:math>. …”
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Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer by Guo Z, Li G, Shen L, Pan J, Dou D, Gong Y, Shi W, Sun Y, Zhang Y, Ma K, Cui C, Li W, Liu Q, Zhu X

“…Zhaoming Guo,1,2,&ast; Guqing Li,2,&ast; Lanjun Shen,2 Jiawei Pan,2 Danni Dou,2 Yuwei Gong,2 Wanwan Shi,2 Yuhua Sun,2 Yi Zhang,2 Kun Ma,2 Changhao Cui,2 Wenxin Li,3,4 Qiang Liu,5 Xudong Zhu1,4,6 1Department of General Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People’s Republic of China; 2School of Chemical Engineering, Marine and Life Sciences, Dalian University of Technology, Panjin, Liaoning, 124221, People’s Republic of China; 3The second Department of Hepatopancreatobiliary Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People’s Republic of China; 4Liaoning Provincial Key Laboratory of Precision Medicine for Malignant Tumors, Shenyang, Liaoning, 110042, People’s Republic of China; 5Faculty of Medicine, Dalian University of Technology, Dalian, Liaoning, 116024, People’s Republic of China; 6Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xudong Zhu, Department of General Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People’s Republic of China, Tel +86 13354204706, Email xdzhu@cmu.edu.cn; XudongZhu@uky.edu Qiang Liu, Faculty of Medicine, Dalian University of Technology, Dalian, Liaoning, 116024, People’s Republic of China, Email andyliu_1844@dlut.edu.cnPurpose: Phototherapy has remarkable advantages in cancer treatment, owing to its high efficiency and minimal invasiveness. …”
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Fu Tu Sheng Jin Rehabilitation Formula Mitigate Airway Inflammation, Mucus Secretion and Immune Dysfunction Induced by SARS-CoV-2 Spike Protein by Wang BH, Yu KY, Zhang XN, Sun XH, Tang LL, Shi XL

“…Bo-Han Wang,1,&ast; Ke-Yao Yu,2,&ast; Xiao-Na Zhang,3,&ast; Xian-Hong Sun,2 Ling-Ling Tang,4 Xiao-Lu Shi2 1NanJing JiangNing Hospital of Chinese Medicine/Affiliated jiangning Hospital of Chinese Medicine, China Pharmaceutical University, Nanjing, Jiangsu, 210029, People’s Republic of China; 2Affiliated Hospital of Nanjing University of Chinese Medicine/ Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, 210029, People’s Republic of China; 3Nanjing Hospital of Chinese Medicine, Nanjing, Jiangsu, 210029, People’s Republic of China; 4School of Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiao-Lu Shi; Ling-Ling Tang, Email fsyy00721@njucm.edu.cn; 290602@njucm.edu.cnObjective: To evaluate the effects of Fu Tu Sheng Jin Rehabilitation Formula (FTSJRF) on airway inflammation, mucus secretion, and immunoreaction in a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein-induced mouse model.Methods: Forty-two mice were randomly divided into seven groups: normal, D1, D3, D10, D10H, D10M and D10L, according to the days of modeling and different dosages of FTSJRF. …”
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Study of senile astheny markers against the background of acute inflammatory process in elderly and senile patients in emergency abdominal surgery by M. B. Danyliuk, S. M. Zavhorodnii, Ye. R. Fedotov, Ye. K. Mykhalchenko, I. V. Dobrodub

“…It was determined that the level of somatotropic hormone in the groups with asthenia (A and C) was equally low – p = 0.9646, U = 466.5, while when comparing the group with and without asthenia (A and B), a significant decrease in this hormone was found in group A – p = 0.0030, U = 248.5. …”
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Association of Estimated Glomerular Filtration Rate (eGFR) and High-Sensitivity C-Reactive Protein (Hs-CRP) with the Risk of New-Onset Atrial Fibrillation in Patients with Diabetes by Liu Y, Liu H, Sun D, Zheng Y, Tse G, Chen K, Qiu J, Wu S, Liu T

“…Ying Liu,1,&ast; Hongmin Liu,1,2,&ast; Dongkun Sun,1,&ast; Yi Zheng,1 Gary Tse,1,3,4 Kangyin Chen,1 Jiuchun Qiu,1 Shouling Wu,2 Tong Liu1 1Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, People’s Republic of China; 2Department of Cardiology, Kailuan General Hospital, Tangshan, 063001, People’s Republic of China; 3School of Nursing and Health Sciences, Hong Kong Metropolitan University, Hong Kong, People’s Republic of China; 4Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Research Institute, Hong Kong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Tong Liu, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin, 300211, People’s Republic of China, Email liutong@tmu.edu.cn; liutongdoc@126.com Shouling Wu, Department of Cardiology, Kailuan General Hospital, Tangshan, 063001, People’s Republic of China, Email drwusl@163.comBackground: Both renal function decline and systemic inflammation may synergistically increase the risk of atrial fibrillation (AF). …”
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Propolis mouthwashes efficacy in managing gingivitis and periodontitis: a systematic review of the latest findings by Muhammed Al-Huda Ballouk, Mohamed Altinawi, Abeer Al-Kafri, Talar S. Zeitounlouian, Piotr S. Fudalej

“…On the other hand, the aforementioned tested mouthwashes other than propolis were deemed equally effective or even superior to propolis in some studies. …”
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Pemodelan Simulasi Sistem Dinamik untuk Meningkatkan Jumlah Pendapatan Unit Rawat Inap Rumah Sakit Islam Surabaya A.Yani by Anwar Romadhon, Erma Suryani

“…Indonesian government policy that requires hospitals to work closely with the National Health Insurance (JKN) in order to equalize health services affects the amount of revenue. …”
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Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review by Bashir MBA, Milani GP, De Cosmi V, Mazzocchi A, Zhang G, Basna R, Hedman L, Lindberg A, Ekerljung L, Axelsson M, Vanfleteren LEGW, Rönmark E, Backman H, Kankaanranta H, Nwaru BI

“…Muwada Bashir Awad Bashir,1 Gregorio Paolo Milani,2,3,&ast; Valentina De Cosmi,4,5,&ast; Alessandra Mazzocchi,3,&ast; Guoqiang Zhang,1 Rani Basna,1 Linnea Hedman,6 Anne Lindberg,7 Linda Ekerljung,1 Malin Axelsson,8 Lowie EGW Vanfleteren,9 Eva Rönmark,6 Helena Backman,6 Hannu Kankaanranta,1,10,11 Bright I Nwaru1,12 1Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; 2Pediatric Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; 3Department of Clinical Science and Community Health, University of Milan, Milan, Italy; 4Department of Food Safety, Nutrition and Veterinary Public Health, Instituto Superiore Di Sanità - Italian National Institute of Health, Roma, Italy; 5Department of Clinical Sciences and Community Health, University of Milan, Milano, Italy; 6Department of Public Health and Clinical Medicine, Section of Sustainable Health/ the OLIN Unit, Umeå University, Umeå, Sweden; 7Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; 8Department of Care Science, Faculty of Health and Society, Malmö University, Malmö, Sweden; 9COPD Center, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden; 10Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland; 11Tampere University Respiratory Research Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; 12Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden&ast;These authors contributed equally to this workCorrespondence: Muwada Bashir Awad Bashir, Krefting Research Centre, Institute of Medicine, University of Gothenburg, P.O. …”
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Small Extracellular Vesicles from Young Healthy Human Plasma Inhibit Cardiac Fibrosis After Myocardial Infarction via miR-664a-3p Targeting SMAD4 by Wang W, Li Y, Zhang C, Zhou H, Li C, Cheng R, Chen X, Pu Y, Chen Y

“…Weiwei Wang,1,&ast; Ying Li,1,&ast; Cheng Zhang,2,&ast; Haoyang Zhou,1 Chunyu Li,3 Rong Cheng,1 Xufeng Chen,1 Yanan Pu,4 Yan Chen1,5,6 1Department of Emergency and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 2Long Jiang Central Laboratory, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China; 3Long Jiang Intensive Care Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 4Department of Clinical Laboratory, Nanjing Chest Hospital, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 5Department of Emergency and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215000, People’s Republic of China; 6Department of Emergency Management, School of Health Policy & Management, Nanjing Medical University, Nanjing, 211166, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yan Chen; Yanan Pu, Email chenyandoc@njmu.edu.cn; pyn342626@njmu.edu.cnPurpose: Cardiac fibrosis, a key contributor to ventricular pathologic remodeling and heart failure, currently lacks effective therapeutic approaches.Patients and Methods: Small extracellular vesicles from young healthy human plasma (Young-sEVs) were characterized via protein marker, transmission electron microscopy, and nanoparticle tracking analysis, then applied in cellular models and mouse models of cardiac fibrosis. …”
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Geopolitical (non) opportunities vs. "late" response of the foreign political service of North Macedonia in the process of European integration by Jelisavac-Trošić Sanja, Arnaudov Mitko

“…In this way, the principles of equality, sovereignty and political independence were placed in a subordinate position in relation to the factual political powers in interstate relations, directly harming the principle of self-determination, in the context of the identity attributes of North Macedonia and the Macedonian people.In the period when geopolitical circumstances were favourable to North Macedonia, the opportunity for this country to become a member of the European Union was missed, thus achieving a strategic foreign policy goal, which in the context of the EU did not cause any consequences when it comes to the EU itself. …”
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Projeto de extensão universitária ‘SaúHDe renal’: Efeitos na qualidade de vida e na aptidão física by Jordana Letícia Buratti, Thaís Severo Dutra, Moane Marchesan Krug, Clara Suemi da Costa Rosa, Paulo Ricardo Moreira, Robelius De-Bortoli, Rodrigo de Rosso Krug

“…For that, patients at the Renal Unit Therapy from the south of Brazil were divided into a control group (CG), composed of patients with a frequency lower or equal to 75% in TF, and an experimental group (EG), composed of patients with a frequency greater than 75% in TF. …”
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