UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research by Zhan R, Liu Y, Wu J, Shen Y, Xu X, Lin G, Chen X

“…Ruanjuan Zhan,1,* Yanan Liu,1,2,* Jun Wu,1,2 Yuxin Shen,1,2 Xinhao Xu,1,2 Guanyang Lin,1,2 Xiaocheng Chen1 1The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China; 2School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanyang Lin; Xiaocheng Chen, Email 13867702133@163.com; cxcwzcn@139.comBackground: Givinostat, a potent histone deacetylase (HDAC) inhibitor, is promising for the treatment of relapsed leukemia and myeloma.Purpose: This study aimed to develop and verify a quick assay for the measurement of givinostat concentration using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) with eliglustat as the internal standard (IS), establishing a basic pharmacokinetic profile for its pre-clinical application and metabolic stability in vitro.Methods: Sample preparation was performed via protein precipitation using acetonitrile. …”
Get full text

Retrospective analysis of scientific and psychological concepts of domestic violence by N. E. Miloradova, V. V. Dotsenko, P. D. Chervonyi

“…The approach sees the main cause of domestic violence and violence against women as the so-called male dominance in social relations, the lack of gender equality, and the existence of established patriarchal norms that contribute to violence. …”
Get full text

Gender Disparities in Medical and Dental Admissions: Students' Perspectives on Barriers by Nabiha Farasat Khan, Muhammad Ilyas, Usama Saeed Usama, Muhammad Saeed, Muhammad Saim, Raz Muhammad

“…In MBBS, female admissions ranged from 39.2% (n=89/227) in 2019-2020 to 30.62% (n=105/343) in 2023-2024, while female enrollment in BDS remained relatively equal, at 61.36% (n=27/44) in 2019-2020 and 52.27% (n=23/47) in 2023-2024. …”
Get full text

Enhancing Periodontal Ligament Regeneration via PDLSC Delivery Using Electrospun PCL/Collagen/Cellulose Acetate Scaffolds and Collagen Hydrogel Incorporated with Curcumin-Loaded ZI... by Lan X, Wang Y, Yin M

“…Xiaomin Lan,1,* Yi Wang,2,* Ming Yin3,4 1Department of Stomatology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, China; 2Department of Stomatology, The Second People’s Hospital of Taiyuan, Taiyuan, 030002, China; 3Department of Stomatology, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China; 4Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China*These authors contributed equally to this workCorrespondence: Ming Yin, Email yinm0616@163.comBackground: Regenerating periodontal ligament (PDL) tissue is a vital challenge in dentistry that aims to restore periodontal function and aesthetics. …”
Get full text

Supporting implementation of universal prevention initiatives in K-12 schools: impacts on fidelity through organizational readiness and team functioning in a cluster-randomized tri... by Christopher M. Fleming, Hannah G. Calvert, Lindsey Turner

“…Forty public K-12 schools in Idaho, located in rural areas or townships, were recruited for the trial and were equally randomized to either the basic supports condition, including standard trainings, or to the RS3 condition. …”
Get full text

Permeability-Enhancing and Protective Effect on Small Intestine of Punicic Acid in Different Forms and Their Nanoemulsions With Low Toxicity by Duan D, Xie H, Jiang J, Yang P, Guo Z, Guo X, Chen X, Yao Q

“…Dongyan Duan,1,* Hua Xie,2,* Jiayi Jiang,1 Ping Yang,1 Zhiyuan Guo,2 Xiaoqiang Guo,1 Xingyu Chen,1 Qian Yao1 1Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, People’s Republic of China; 2Sichuan Provincial Institute for Drug Control and Research, Chengdu, 610000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian Yao, School of Pharmacy, Chengdu University, Shiling Town, Longquan District, Chengdu, Sichuan Province, 610106, People’s Republic of China, Email yaoqian@cdu.edu.cnPurpose: Most absorption enhancers boost the oral absorption of drugs via increasing intestinal permeability. …”
Get full text

MATHEMATICAL RATIONALE FOR CREATING AN APPLICATION FOR CONDUCTING RANDOM MEETINGS «COFFEE BREAK» by Vadym Ziuziun, Daniil Osoka

“…The model ensures that users are matched in a way that promotes engagement, as each participant can be assured that their matched partner is equally motivated for the encounter. As the application continues to evolve, it can incorporate additional scheduling criteria to enhance the quality of matches and distribution. …”
Get full text

Integrated Analysis and Validation of Ferroptosis-Related Genes Associated with Ischemia/Reperfusion Injury in Lung Transplantation by Li Q, Yin J, Lin Q, He J, Shi X, Nie H

“…Qingqing Li,* Jing Yin,* Qibin Lin, Jilong He, Xiu Shi, Hanxiang Nie Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hanxiang Nie, Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuchang District, Wuhan, 430060, People’s Republic of China, Email nhxiang@whu.edu.cnBackground: Lung transplantation is the only effective therapeutic option for patients with end-stage lung disease. …”
Get full text

Role and mechanism of dexmedetomidine in regulating bone metabolism in tail-suspended osteoporotic rats by GUO Yunliang, WANG Can, ZHANG Xinyu

“…Dex at a dose of 10 μg/kg was given intraperitoneally, once every other day from the day of tail suspension. And equal amount of normal saline was given to the control and model group. …”
Get full text

Comparative effects of gong’s mobilization and mobilization with movement in patients with adhesive capsulitis: a randomized clinical trial by Fareeha Amjad, Hasha Asghar

“…Results of independent t test used to calculate across the group differences indicated that Gong’s Mobilization was more effective in reducing disability (SPADI)(p < 0.001) and improving ROM(p < 0.001), meanwhile both groups were equally effective in reducing NPRS scores(p = 0.78). …”
Get full text

Comparison of Medical Students&rsquo; Peer Evaluation and Teaching Staff Evaluation of Community Health Projects: Perceptions and Experiences by Mahmoud MA, Almutairi ZS, Mahmoud AM, Alanazi HB, Abdulrahman SM, Bin Abdulrahman KA

“…The analysis of the Full Project Level indicated no substantial disparity between medical students and Staff, as evidenced by the p-value of 0.920.Conclusion: This study validates that peer evaluation of student projects is equally practical as evaluation conducted by faculty members. …”
Get full text

Cytopathological characteristics for provoked lesions of squamous epithelia of digestive system in animal models by V. G. Shestakova, L. I. Nigmatullina, I. B. Atadzhanov, S. A. Donskov, Yu. V. Kozlovskaya, I. S. Dolgopolov, M. Yu. Rykov

“…The method of chronic experiment on animals is applied: 40 female non-linear white rats, which are divided into 4 equal groups (n = 10). The first (I) and second (II) control groups of animals were exposed to mechanical trauma of the oral mucosa with additional application of 0.9 % NaCl solution and 1 % aqueous dimethyl sulfoxide (DMSO) solution with a frequency of 2 times a week. …”
Get full text

Prominence of Microbiota to Predict Fibrous Stenosis in Crohn&rsquo;s Disease by Yang X, Pan Y, Gao CP, Li H, Zhang YH, Huang CL, Cao L, Xiao SY, Zhou Z

“…Xue Yang,&ast; Yan Pan,&ast; Cai-Ping Gao, Hang Li, Ying-Hui Zhang, Chun-Li Huang, Lu Cao, Shi-Yu Xiao, Zhou Zhou Department of Gastroenterology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhou Zhou; Shi-Yu Xiao, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China, Email doublezhouu2006@163.com; xiaoshiyu57@163.comPurpose: Intestinal fibrous stenosis due to Crohn’s disease (CD) is highly prevalent. …”
Get full text

Erbin Regulates Tissue Factors Through Ras/Raf Pathway in Coagulation Disorders in Sepsis by Yang C, Lei C, Jing G, Xia Y, Zhou H, Wu D, Zuo J, Gong H, Wang X, Dong Y, Aidebaike D, Wu X, Song X

“…Cheng Yang,1,&ast; Chuntian Lei,1,&ast; Guoqing Jing,1 Yun Xia,1 Huimin Zhou,1 Die Wu,1 Jing Zuo,1 Hailong Gong,1 Xing Wang,1 Yingyue Dong,1 Delida Aidebaike,1 Xiaojing Wu,2 Xuemin Song1 1Research Centre of Anesthesiology and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, 430062, People’s Republic of China; 2Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaojing Wu; Xuemin Song, Email RM000851@whu.edu.cn; xueminsong@whu.edu.cnBackground: Sepsis, as a clinically critical disease, usually induces coagulation disorders. …”
Get full text

Immoral misdemeanor incompatible with the continuation of work as a ground for termination of the employment contract at the initiative of the owner or authorized body by V. V. Sychova

“…However, the legislator, enshrining this additional basis for equalization of the employment contract, does not specify the legal content of immoral misconduct, incompatible with the continuation of work, which creates difficulties in its substantive understanding and therefore significantly weakens the protection of labor rights of workers. …”
Get full text

The Effects of Active Teaching and Learning Methods on The Pupils' Academic Performance in Four Selected Primary Schools in Bugamba Sub-County in Rwampara District. by Ampurire, Motion

“…The research used a sample size of 80 respondents using sample random sampling techniques in collecting and analyzing data and was used to provide equal chances to the sample size. Purposive sampling was also used to collect data from respondents that participated in the study. …”
Get full text

The Impact of Family Conflicts on Socio-Economic Prosperity: A Case Study of Muko Sub-County Rubanda District. by Akankwasa, Winfred

“…The researcher used simple random sampling techniques in collecting and analyzing data and was used to provide equal chances to the sample size. Purposive sampling was also used to collect data from respondents who participated in the study. …”
Get full text

The Contribution Of Universal Education Towards Girl Child Education: A Case Study Of Nyarubuye Sub-County Kisoro District. by Nizeyimana, Bakunzi Moses

“…The study collected and analyzed data using simple random sampling techniques and was designed to give each of the 55 respondents an equal chance. Purposive sampling was also used to collect data from respondents who participated in the study. …”
Get full text

Teacher Professional Development on Students Learning and Academic Performance: A Case Study of Selected Schools in Rubanda Town Council. by Owomugisha, Edith

“…The findings of the study conclude that there were several important observations that are essential to ensure that teachers and students are equally productive. The data produced by this study shows that schools are not working to keep their faculty fit for the challenges of generations to come. …”
Get full text

Effectiveness of Non-Governmental Organizations on Social Service Delivery: A Case Study of Uganda Red Cross Society Kabale District. by Aharizira, Zackaria

“…On challenges faced by NGOs in the study area the study mentioned a barrage of laws, poor governance, unsuccessful projects, cultural dorms, and beliefs, lack of enough finance, and staffing the study also Suggested possible strategies for challenges faced by the nongovernmental organizations on service delivery as provisional of equal relationships between donors NGO, funding of the NGO, employment of trained and strong staff and provision of good governance. …”
Get full text