Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study by Li X, Liu S, Yu M, Xi W, Wu X, Liu D, Liu A, Wang H

“…Xiuqi Li,1,* Shupeng Liu,1,* Mengyang Yu,1 Wanlin Xi,1 Xiaofei Wu,1 Dan Liu,2 Aijing Liu,1 Hongyun Wang1 1Clinical Pharmacology Research Center, Peking Union Medical College Hospital, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China; 2School of Life Science and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongyun Wang, Email wanghy@pumch.cnBackground: Proton pump inhibitors (PPIs) and potassium competitive acid blockers (P-CABs) are widely used to treat acid-related diseases (ARDs). …”
Get full text

Personality's Time Perspective as a Resource for Overcoming the Identity Crisis at Different Stages of Life Realization by E.M. Meshcheryakova, A.V. Seryy, M.S. Yanitskiy

“…The total sample was divided into groups according to age periods: older adolescence (15-17 years, 38 people), adolescence (18-22 years, 47 people), early adulthood (23-29 years, 26 people), maturity/late adulthood (30-55 years, 28 people). All groups were equalized by gender. <br><strong>Measurements. </strong>Zimbardo's ZTPI time perspective methodology (modified by A. …”
Get full text

Functional and Cognitive Impairment in Patients with Relapsing–Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels by Elina Polunosika, Joel Simren, Arta Akmene, Nikita Klimovskis, Kaj Blennow, Daina Pastare, Henrik Zetterberg, Renars Erts, Guntis Karelis

“…For the BVMT-R, we found no difference between the two groups; both groups were able to learn the task equally well, but we found a weak correlation between age and learning in both groups, which could be related to the normal aging process. …”
Get full text

Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation by Xiao F, Yan B, Yuan T, He Y, Zhang X, He X, Peng W, Xu Y, Cao J

“…Feng Xiao,1,&ast; Bisong Yan,2,&ast; Tianwen Yuan,2 Yang He,2 Xiaojun Zhang,3 Xiaoyun He,1 Wei Peng,1 Ying Xu,3 Jun Cao1,4 1Shanghai Eighth People’s Hospital, Xuhui District, Shanghai, 200030, People’s Republic of China; 2Department of Interventional Oncology, Dahua Hospital, Xuhui District, Shanghai, 200237, People’s Republic of China; 3College of Pharmacy, Jiangsu University, Zhenjiang, 212013, People’s Republic of China; 4Shanghai University of Medicine and Health Science, Pudong New Area, Shanghai, 201318, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jun Cao, Shanghai Eighth People’s Hospital, Xuhui District, Shanghai, 200030, People’s Republic of China, Email juncao11@sina.com Ying Xu, College of Pharmacy, Jiangsu University, Zhenjiang, 212013, People’s Republic of China, Email ingyx@sina.com.cnPurpose: Gastrostomy is the commonly used enteral feeding technology. …”
Get full text

Association of Serum Irisin With Severity and Prognosis in Patients With Coronavirus Disease 2019: A Prospective Cohort Study by Zhang X, Wang W, Li Y, Liu X, Zhang L, Cheng Z, Liu M, Wang Y, Fu L, Yang J

“…Xinli Zhang,1,2,&ast; Wennan Wang,1,3,&ast; Ye Li,2 Xiaoning Liu,2 Liangzhu Zhang,2 Zhenyu Cheng,1,4 Mingyan Liu,1,4 Yu Wang,1,4 Lin Fu,1,4 Jin Yang1,4,5 1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China; 2The First Department of Tuberculosis, Anhui Chest Hospital, Hefei, Anhui Province, People’s Republic of China; 3The Fifth Department of Tuberculosis, Anhui Chest Hospital, Hefei, Anhui Province, People’s Republic of China; 4Institute of Respiratory Diseases, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China; 5Information Management Center, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lin Fu; Jin Yang, Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China, Email fulindev@126.com; yangqj1015@foxmail.comBackground: Irisin is the cleaved form of fibronectin type III domain-containing protein 5 (FNDC5), which can confer antioxidant and anti-inflammatory effects. …”
Get full text

Like mother like daughter, the role of low human capital in intergenerational cycles of disadvantage: the Pune Maternal Nutrition Study by Akanksha A. Marphatia, Akanksha A. Marphatia, Jonathan C. K. Wells, Alice M. Reid, Aboli Bhalerao, Chittaranjan S. Yajnik

“…Increasing education and delaying girls' marriage may lead to sustained intergenerational improvements across Sustainable Development Goals 1 to 5, relating to poverty, hunger, health, education and gender equality.…”
Get full text

PD(L)1 Inhibitors Plus Lenvatinib Vs Atezolizumab Plus Bevacizumab Combined With HAIC for Unresectable HCC: A Propensity Score Matching Study by He Z, Chen H, Liang C, Tang X, Jiang L, Xie F, Liu Q, Zheng Y

“…Zhaoqian He,1– 3,&ast; Hua Chen,1– 3,&ast; Chen Liang,1– 3,&ast; Xiang Tang,1– 3 Lingmin Jiang,1– 3 Feihu Xie,1– 3 Qi Liu,1– 3 Yun Zheng1– 3 1Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China; 2Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China; 3Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yun Zheng; Qi Liu, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, People’s Republic of China, Email zhengyun@sysucc.org.cn; liuqi9@sysucc.org.cnPurpose: To compare the clinical outcomes of different systemic therapies, specifically PD(L)1 inhibitors plus Lenvatinib versus Atezolizumab plus Bevacizumab, when combined with hepatic arterial infusion chemotherapy (HAIC) based on the FOLFOX regimen (oxaliplatin, fluorouracil, and leucovorin) as first line treatment for unresectable hepatocellular carcinoma.Patients and Methods: This real-world retrospective study enrolled 294 patients with unresectable HCC. …”
Get full text

Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System by Li L, He Z, Yu C, Zhang C, Yu Y, Li Y, Xu X

“…Li Li,1– 3,&ast; Zeyu He,3– 5,&ast; Chengqian Yu,3– 5 Chao Zhang,3– 5 Yanqiu Yu,6 Yuanhong Li,3– 5 Xuegang Xu3– 5 1ShanXi Medical University, Taiyuan, People’s Republic of China; 2Department of Dermatology, The First Hospital of ShanXi Medical University, Taiyuan, 030001, People’s Republic of China; 3Department of Dermatology, The First Hospital of China Medical University, Shenyang, 030001, People’s Republic of China; 4Key Laboratory of Immunodermatology (China Medical University), Ministry of Education, Shenyang, 110001, People’s Republic of China; 5NHC Key Laboratory of Immunodermatology (China Medical University), Shenyang, 110001, People’s Republic of China; 6Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, 110122, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xuegang Xu, Department of Dermatology, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, 110001, People’s Republic of China, Email xuxuegang2749290@163.com Li Li, Department of Dermatology, The First Hospital of ShanXi Medical University, No. 85 South Jiefang Road, Yingze District, Taiyuan, Shanxi Province, 030001, People’s Republic of China, Email lilizaimu0807@163.comBackground: Fractional carbon dioxide lasers and bone marrow mesenchymal stem cells (BMSCs) are commonly employed in the treatment of skin photoaging.Objective: This study was developed to explore the effects of combination carbon dioxide laser treatment and BMSC injection on skin photoaging and the underlying molecular mechanisms.Methods & Materials: In total, 24 mice with experimentally photoaged skin were separated into control, carbon dioxide fractional laser treatment, combination therapy, and BMSC injection groups. …”
Get full text

Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and Depression by Zeng G, Liang R, Xiao L, Cao W, Zhou W, Wang W, Liu C, Zhou H, Shi X, Chen B, Chen W

“…Gang Zeng,1,2,&ast; Rongyu Liang,2,3,&ast; Lingxian Xiao,2,4,&ast; Weiye Cao,5 Wenqing Zhou,2,6 Wen Wang,5 Cuixia Liu,2,7 Huarong Zhou,1,2 Xiaolei Shi,1,2 Ben Chen,1,2 Wanhua Chen2,4 1Geriatric Neuroscience Center, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, People’s Republic of China; 3Department of Geriatric Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 4Department of Nursing, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 5School of Nursing, Guangzhou Medical University, Guangzhou, People’s Republic of China; 6Adult Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 7Chronic Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wenqing Zhou, Adult Psychiatry Department, Affiliated Brain Hospital of Guangzhou Medical University, 36 mingXin Road, Liwan District, Guangzhou, People’s Republic of China, Tel +86 15918636953, Email 996459134@qq.com Weiye Cao, School of Nursing, Guangzhou Medical University, 195 Dongfeng West Road, Yuexiu District, Guangzhou, People’s Republic of China, Tel +86 13149399874, Email 1271932456@qq.comObjective: Negative symptoms significantly impair daily functioning and worsen clinical outcomes. …”
Get full text

Association Between Weight-Adjusted Waist Index and Cognitive Function in Older Adults Without Diabetes: A Cross-Sectional Study by Wang Q, Yin Y, Liu W, Li L, Wang Z, Tian Y, Fan J

“…Qing Wang,1,&ast; Yishan Yin,2,&ast; Wei Liu,3,&ast; Lingyu Li,1 Zhen Wang,1 Yue Tian,1 Jing Fan1 1Department of Laboratory Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China; 2Department of Orthopedics, The Armed Police Forces Hospital of Shandong, Jinan, Shandong, 250000, People’s Republic of China; 3Department of Emergency Critical Care Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jing Fan, Department of Laboratory Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China, Email sddzfanjing@163.comBackground: This study investigates the correlation between the weight-adjusted waist index (WWI) and cognitive performance in the senior American population, focusing on those without diabetes from 2011 to 2014.Methods: We analyzed data from the 2011– 2012 and 2013– 2014 National Health and Nutrition Examination Surveys (NHANES), focusing on non-diabetic participants aged 60 and older who completed cognitive tests: Establish a Registry for Alzheimer’s disease (CERAD), the Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST). …”
Get full text

Impact of Initial Heart Rate, Diastolic Pressure, and Pulse Pressure on Prognostic Outcomes in Heart Failure Patients with Mildly Reduced Ejection Fraction by Hu H, Liu Z, Zeng J, Jiang M

“…Hailong Hu,1,&ast; Zhican Liu,2,&ast; Jianping Zeng,1 Mingyan Jiang2 1Department of Cardiology, Xiangtan Central Hospital, The Affiliated Hospital of Hunan University, Xiangtan, 411100, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, Xiangtan Central Hospital, The Affiliated Hospital of Hunan University, Xiangtan, 411100, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Mingyan Jiang, Director of Department of Pulmonary and Critical Care Medicine, Xiangtan Central Hospital, The Affiliated Hospital of Hunan University, Xiangtan, 411100, People’s Republic of China, Email jiangmingyan1979@163.com Jianping Zeng, Director of Heart Center, Xiangtan Central Hospital, Xiangtan, 411100, People’s Republic of China, Email 571725929@qq.comBackground: Heart rate, diastolic pressure, and pulse pressure are key modifiable factors influencing heart failure prognosis. …”
Get full text

The effects of magnitude of calcium decline at the onset of lactation on serotonin dynamics and the serotonin-calcium axis by M.K. Connelly, R.M. Rodney, J. Kuehnl, J.P.N. Andrade, F. Sonnewend Andrade, S. Henschel, E. Block, I.J. Lean, L.L. Hernandez

“…Thirty-two multiparous Holstein cows were blocked by parity (2 vs. >2) to ensure equal parity number across the experiment, previous 305 d milk yield, and expected parturition date and randomly allocated to positive (+120 mEq/kg; +DCAD) or negative (−120 mEq/kg; −DCAD) DCAD diets from 251 d of gestation until parturition (n = 16/diet). …”
Get full text

Enhancing Learners’ Engagement and Performance in Learning through E-Resources and Services: National Open University of Nigeria Students as Beneficiaries by Patricia Ngozi Ofodu, Loveth Ogoegbunam Ekwueme

“…The study also revealed that the use of electronic resources influenced the users’ class tests, assignments, seminar presentations and more, while there was also evidence of non-assistance from the use of e-resources in some students’ learning pursuits. The study equally revealed some of the factors undermining the use of e-resources including inadequate power supply, poor internet connectivity, lack of technology competence and limited access to computer terminals, etc. …”
Get full text

Prospects for the use of a <i>Bacillus subtilis</i> metabolites-based feed additive in dairy farming by S. V. Malkov, A. S. Krasnoperov, A. P. Poryvaeva, O. Yu. Oparina, A. I. Belousov, A. N. Brilliant

“…The proportion of T-lymphocytes in blood of animals in test group 1 and test group 2 was 44.5 and 48.9%, respectively, proportion of T-lymphocytes in blood of control animals equaled to 37.5%. Trend for increase in total protein concentration in cow sera owing to increase in albumin fraction was observed in postpartum period: it was 72.91 ± 3.45 g/l in test group 1; 75.54 ± 4.12 g/l in test group 2; 70.95 ± 4.25 g/l in control group. …”
Get full text

Impact of Low Inclusion Rate of Olive Cake in Dairy Cow Rations on Uterine Health and Fertility Indices During Early Lactation by Ioannis Nanas, Themistoklis Giannoulis, Eleni Dovolou, Ilias Giannenas, Georgios S. Amiridis

“…The control ration (group C) was modified by replacing 1 kg of maize with an equal quantity of olive cake (group T). The experiment lasted from 60 days prepartum to 150 days postpartum. …”
Get full text

Relationship Between Obstructive Sleep Apnea and Enuresis in Children: Current Perspectives and Beyond by Wang Z, Zhang P, Shi R, Yang S, Liu K, Zhou Z, Li Q

“…Zhan Wang,1,&ast; Pengpeng Zhang,2,&ast; Run Shi,3,&ast; Shuai Yang,1 Kui Liu,4 Zhaokai Zhou,1 Qi Li5 1Pediatric Urodynamic Center, Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, 450052, People’s Republic of China; 2Department of Lung Cancer, Tianjin Lung Cancer Center, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China; 3Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 4Department of Pediatric Surgery, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, 471000, People’s Republic of China; 5Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhaokai Zhou, Pediatric Urodynamic Center, Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, 450052, People’s Republic of China, Email 13526278113@163.com Qi Li, Department of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of China, Email siloam1994@163.comBackground: Nocturnal enuresis (NE) and obstructive sleep apnea (OSA) are common diseases in children, which often cause various social and psychological problems. …”
Get full text

PCT/ALB Ratio in Initial Three days for the Prediction of Secondary Infection in Septic Patients by Zhang C, Huang G, Li H, Zhang T, Jian M, Huang C, Zhang Y, Wang Z, Hou X, Xia Y, Jiang W

“…Chunmei Zhang,1,&ast; Guoge Huang,2,&ast; Haizhong Li,1,3,&ast; Tiancao Zhang,1 Mengling Jian,1 Chunyang Huang,1 Yingqin Zhang,1,4 Zheng Wang,5 Xun Hou,1 Yuanyuan Xia,6 Wenqiang Jiang1,7 1Emergency Intensive Care Unit, Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Emergency Medicine, People’s Hospital of Longhua, Shenzhen, Guangdong, People’s Republic of China; 3Department of Emergency, Boai Hospital of Zhongshan, Zhongshan, Guangdong, People’s Republic of China; 4School of Medicine, South China University of Technology, Guangzhou University City, Guangzhou, Guangdong, People’s Republic of China; 5Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China; 6Medical Oncology Department, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 7Emergency Intensive Care Unit, Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wenqiang Jiang; Yuanyuan Xia, Email jiangwenqiang@gdph.org.cn; xiayuany1021@163.comBackground: Procalcitonin (PCT) to albumin (ALB) ratio (PAR) in initial three days is a rapidly available indicator to assess the prognosis of patients with sepsis. …”
Get full text

Intraoperative Intraluminal Endoscopy in the Surgical Treatment of Patients with Esophageal Diverticula of Various Localization by A. L. Shestakov, M. V. Khrustaleva, M. E. Shahbanov, N. A. Bulganina, T. T. Bitarov, I. A. Boeva, A. T. Tskhovrebov, I. A. Tarasova, O. V. Rykov, I. M. Selivanova, A. A. Bezaltynnykh

“…In patients with the diverticula of the middle and lower third of the esophagus, the average surgery duration was equal to 120.3 ± 11.2 min and 150.5 ± 17.3 (p &lt;0.05) min in the main and control groups, respectively. …”
Get full text

Impact of Timing the Combination of Radiotherapy and PD-1 Inhibitors on Outcomes in Patients with Hepatocellular Carcinoma by Zhong L, Peng W, Sun J, Luo Y, Sheng H, Wu Y, Zhou T, Zhou C, Cao C

“…Liting Zhong,1,2,&ast; Weiwei Peng,1,2,&ast; Jingyuan Sun,3 Yongyi Luo,3 Hailong Sheng,4 Yi Wu,5 Tonggang Zhou,5 Chaoming Zhou,1,2 Chuanhui Cao1,3 1Department of Oncology, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou, Jiangxi, People’s Republic of China; 2Department of Oncology, Ganzhou People’s Hospital, Ganzhou, Jiangxi, People’s Republic of China; 3Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 4Department of Radiation Oncology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China; 5Department of Interventional Radiology, Ganzhou People’s Hospital, Ganzhou, Jiangxi, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chuanhui Cao, Department of Oncology, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, No. 16 Meiguan Avenue, Ganzhou, Jiangxi, People’s Republic of China, Email huichuancao@163.comPurpose: The optimal timing for combining radiotherapy with immunotherapy in patients with hepatocellular carcinoma (HCC) remains uncertain and affects treatment efficacy and patient outcomes. …”
Get full text

Playing hide and seek with primates: A comparative study of Theory of Mind by Aurore San‑Galli, Marie Devaine, Cinzia Trapanese, Shelly Masi, Sébastien Bouret, Jean Daunizeau

“…Further analyses are in progress to identify predictive factors (e.g. familiarity with humans, age, motivation and frustration during the game) that could explain away inter-individual differences, thus eventually revealing (or not) inter‑species differences [Authors Aurore San‑Galli and Marie Devaine contributed equally to this work].…”
Get full text