Efficacy and Safety of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting Transforming Growth Factor-β and Programmed Death-Ligand 1, Plus Chemotherapy in Patients With Stage... by Christian Rolfo, MD, PhD, Laurent Greillier, MD, PhD, Remi Veillon, MD, PhD, Firas Badin, MD, MBA, Francois Ghiringhelli, MD, PhD, Nicolas Isambert, MD, PhD, Astrid Paulus, MD, PhD, Surendra Pal Chaudhary, MD, Yulia Vugmeyster, PhD, Masashi Sato, MSc, Sandrine Hiret, MD, PhD

“…In cohorts A+B+C, the overall response rate was 48.3%, and in patients with PD-L1 tumor proportion score of more than or equal to 50.0%, it was 71.4%. On the basis of an interim analysis, the data were considered mature, and no further analysis has been planned. …”
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Efficacy and Tolerance of Vascular Electrical Stimulation Therapy in the Management of Vaso-Occlusive Crises in Patients with Sickle Cell Disease: A Phase II Single-Centre Randomiz... by Renée-Paule Botti, Sie Saïda Bokoum, Etienne L’Hermite, Dohoma Alexis Silue, Boidy Kouakou, Sarah Anastasie Bognini, Serge Arnaud Agoua, Edgar Mandeng Ma Linwa, Roméo Ayemou, Kouassi Gustave Koffi

“…The study arms were divided as follows: our control group (group 0) constituted of 10 patients followed with conventional therapy (Analgesics + Hydration + NSAIDs), while 20 patients were divided equally into two interventional arms—10 patients followed with VEST + Analgesics + Hydration (group 1) and the other 10 patients followed with VEST + Analgesics + Hydration + NSAIDs (group 2). …”
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Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…On 14 and 16 d, birds in Sal and PA were orally challenged with 109 CFU S. typhimurium, while birds in Ctr received an equal amount of PBS. The results showed that protocatechuic acid improved growth performance and jejunal structure in Salmonella-infected chickens (P < 0.05). …”
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Optimising Access Surgery in Senior Haemodialysis Patients (OASIS): study protocol for a multicentre randomised controlled trial by Patrick WHE Vriens, Edith M Willigendael, Maarten A Lijkwan, Friedo W Dekker, Chava L Ramspek, Michiel W de Haan, Çaĝdaş Ünlü, Boudewijn DC Heggen, Koen E A van der Bogt, Marc H Hemmelder, Mickaël J C Hiligsmann, Magda M van Loon, Joris I Rotmans, Jan H M Tordoir, Geert Willem H Schurink, Maarten G J Snoeijs, Marijke J Molegraaf, Philippe WM Cuypers, Denise Nio, Cora H Arts, Jacobien C Verhave, Goos D Laverman, Aron S Bode, Marcel C Weijmer, Bas Govaert, Aaltje Y Adema, Gijs MJM Welten, Michel MPJ Reijnen, Marc JH Groeneveld, Hans S Brink, Jeroen B van der Net, Arno Kuijper, Hilde PE Peters, Roos C van Nieuwenhuizen, Rombout R Kruse, Yvonne C Schrama, Karina A de Groot, Karima Farhat

“…Therefore, we designed the Optimising Access Surgery in Senior Haemodialysis Patients (OASIS) trial to determine the best strategy for vascular access creation in elderly haemodialysis patients.Methods and analysis OASIS is a multicentre randomised controlled trial with an equal participant allocation in three treatment arms. …”
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dyphAI dynamic pharmacophore modeling with AI: a tool for efficient screening of new acetylcholinesterase inhibitors by Yasser Hayek-Orduz, Dorian Armando Acevedo-Castro, Dorian Armando Acevedo-Castro, Juan Sebastián Saldarriaga Escobar, Brandon Eli Ortiz-Domínguez, María Francisca Villegas-Torres, Paola A. Caicedo, Álvaro Barrera-Ocampo, Natalie Cortes, Edison H. Osorio, Andrés Fernando González Barrios

“…Experimental results revealed that molecules, 4 (P-1894047), with its complex multi-ring structure and numerous hydrogen bond acceptors, and 7 (P-2652815), characterized by a flexible, polar framework with ten hydrogen bond donors and acceptors, exhibited IC₅₀ values lower than or equal to that of the control (galantamine), indicating potent inhibitory activity. …”
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Synthetic Data Generation and Evaluation Techniques for Classifiers in Data Starved Medical Applications by Wan D. Bae, Shayma Alkobaisi, Matthew Horak, Siddheshwari Bankar, Sartaj Bhuvaji, Sungroul Kim, Choon-Sik Park

“…Ideally, the dataset should have an equal number of samples for each label to encourage the model to make predictions based on the input data rather than the distribution of the training data. …”
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Genetic and biochemical characterization of staphylococci occurring in Novosibirsk, Russia by Y. N. Kozlova, N. V. Fomenko, V. V. Morozova, I. V. Saranina, A. Yu. Tikunov, D. A. Ganichev, A. G. Samokhin, V. V. Pavlov, O. M. Rozhnova, I. A. Bondar’, E. V. Zenkova, V. V. Nimaev, V. V.  Klimontov, N. V. Tikunova

“…However, S. aureus and S. epi dermidis strains were isolated in an approximately equal proportion from community­associated samples. …”
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Attitudes toward artificial intelligence and robots in healthcare in the general population: a qualitative study by Paulina Smoła, Iwona Młoźniak, Monika Wojcieszko, Urszula Zwierczyk, Mateusz Kobryn, Elżbieta Rzepecka, Mariusz Duplaga

“…Negative attitudes originated from convictions regarding unreliability and the lack of proper technological and political control over AI; an equally important topic was the inability of artificial entities to feel and express emotions. …”
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E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age by E. Meldolesi, A. Nicolì, N. Dinapoli, G. Chiloiro, A. Romano, R. Menghi, R. Persiani, F. Pacelli, C. Coco, C. Ratto, S. Manfrida, L. Boldrini, B. Corvari, M.A. Gambacorta

“…Results: All patients were classified in different risk groups, according to the ESMO 2017 rectal cancer clinical practice guidelines. 88 % of patients under 55 years old at the diagnosis belonged to the bad or advanced risk groups with an equal division. In patients over 55 years old, there was a clear dominance of the advanced risk class (62 % of the total). …”
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Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naïve Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring S... by Rengna Yan, Yun Hu, Fengfei Li, Lanlan Jiang, Xiaohua Xu, Jie Wang, Ying Zhang, Lei Ye, Kok Onn Lee, Xiaofei Su, Jianhua Ma

“…Regression analyses indicate that the contributions of FG and PG were equal (both 50%) when the level of HbA1c was 8.5%. …”
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Radiological and Clinical Features and Outcomes of Patients with Primary Pulmonary Salivary Gland-Type Tumors by Xiaoyu Han, Jianchu Zhang, Jun Fan, Yukun Cao, Jin Gu, Heshui Shi

“…Mucoepidermoid carcinoma (MEC) was more likely to occur in younger patients than was adenoid cystic carcinoma (ACC) (35 ± 15 years vs 48 ± 16 years, p=0.038). MEC was equally distributed between both sexes, whereas ACC was more frequent in females (66.7%). …”
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Hidden Urban Biodiversity: A New Species of the Genus <i>Scincella</i> Mittleman, 1950 (Squamata: Scincidae) from Chengdu, Sichuan Province, Southwest China by Ru-Wan Jia, Zong-Yuan Gao, Di-Hao Wu, Guan-Qi Wang, Gang Liu, Min Liu, Ke Jiang, De-Chun Jiang, Jin-Long Ren, Jia-Tang Li

“…The new species can be clearly distinguished by a combination of the following unique characters: (1) slender, medium-sized body, snout-vent length 28.4–43.2 mm; (2) infralabials seven, rarely six; (3) supraciliaries six or seven; (4) tympanum deeply recessed without lobules, tympanum diameters equal to or exceeding palpebral disc diameters; (5) midbody scale-row counts 23; (6) dorsal scales smooth, slightly enlarged, paravertebral scale-row counts 57–60, ventral scale-row counts 42–44, gulars 21–22; (7) upper edge of lateral longitudinal stripes relatively straight, four rows of dorsal scales in middle; (8) enlarged, undivided lamellae beneath finger IV 8–9, enlarged, undivided lamellae beneath toe IV 10–12; (9) ventral surface densely covered with dark spots; (10) grayish-brown, irregular dorsal stripes 2–3, black dorsolateral stripes from posterior corner of eye to lateral side of tail. …”
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The Lyman Continuum Escape Fraction of Star-forming Galaxies at 2.4 ≲ z ≲ 3.0 from UVCANDELS by Xin Wang, Harry I. Teplitz, Brent M. Smith, Rogier A. Windhorst, Marc Rafelski, Vihang Mehta, Anahita Alavi, Zhiyuan Ji, Gabriel Brammer, James Colbert, Norman Grogin, Nimish P. Hathi, Anton M. Koekemoer, Laura Prichard, Claudia Scarlata, Ben Sunnquist, Pablo Arrabal Haro, Christopher Conselice, Eric Gawiser, Yicheng Guo, Matthew Hayes, Rolf A. Jansen, Ray A. Lucas, Robert O’Connell, Brant Robertson, Michael Rutkowski, Brian Siana, Eros Vanzella, Teresa Ashcraft, Micaela Bagley, Ivano Baronchelli, Guillermo Barro, Alex Blanche, Adam Broussard, Timothy Carleton, Nima Chartab, Yingjie Cheng, Alex Codoreanu, Seth Cohen, Y. Sophia Dai, Behnam Darvish, Romeel Davé, Laura DeGroot, Duilia De Mello, Mark Dickinson, Najmeh Emami, Henry Ferguson, Leonardo Ferreira, Keely Finkelstein, Steven Finkelstein, Jonathan P. Gardner, Timothy Gburek, Mauro Giavalisco, Andrea Grazian, Caryl Gronwall, Shoubaneh Hemmati, Justin Howell, Kartheik Iyer, Sugata Kaviraj, Peter Kurczynski, Ilin Lazar, John MacKenty, Kameswara Bharadwaj Mantha, Alec Martin, Garreth Martin, Tyler McCabe, Bahram Mobasher, Kalina Nedkova, Charlotte Olsen, Lillian Otteson, Swara Ravindranath, Caleb Redshaw, Zahra Sattari, Emmaris Soto, L. Y. Aaron Yung, Bonnabelle Zabelle, the UVCANDELS team

“…The full stack at z  ≈ 2.44 from 28 galaxies places a stringent 1 σ upper limit of ${f}_{{\rm{esc}}}^{{\rm{abs}}}\lesssim 5 \% $ , whereas the full stack at z  ≈ 2.72 of an equal number of galaxies gives an upper limit of ${f}_{{\rm{esc}}}^{{\rm{abs}}}\lesssim 26 \% $ at 1 σ confidence level. …”
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Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for C... by Utae Katsushima, Takuya Fukushima, Jiro Nakano, Naoya Ogushi, Kazuki Fujii, Yutaro Nagata, Keisuke Kamisako, Yukiko Okuno, Yuta Okazaki, Kentaro Nakanishi, Kiyori Yoshida, Tatsuki Ikoma, Yuki Takeyasu, Yuta Yamanaka, Hiroshige Yoshioka, Kimitaka Hase, Takayasu Kurata

“…Both criteria had almost equal discriminative power for prognosis (EPCRC, C‐statistic = 0.658; AWGC, C‐statistic = 0.658). …”
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Shaping Ability of XP Endo Shaper File in Curved Root Canal Models by Abdulmohsen Alfadley, Abdalrhman Alrajhi, Hamad Alissa, Faisal Alzeghaibi, Lubna Hamadah, Khalid Alfouzan, Ahmed Jamleh

“…Ninety-six simulated root canals were equally distributed into XPS and WOG systems to be shaped by eight files each. …”
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Re-annotation of SARS-CoV-2 proteins using an HHpred-based approach opens new opportunities for a better understanding of this virus by Brézellec, Pierre

“…Interestingly, Prominin 1 showed similarities with 6 viral Spike glycoproteins, primarily from coronaviruses. Equally interestingly, Lutropin-choriogonadotropic hormone receptor showed similarities with 23 viral G-protein coupled receptors, particularly from Herpesvirales. …”
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The impact of fruit and vegetable waste on economic loss estimation by B. Parsafar, M. Ahmadi, Gh.R. Jahed Khaniki, N. Shariatifar, A. Rahimi Foroushani

“…Also, the amounts of vegetable waste in summer and spring were equal to 28 percent and 24 percent, respectively, indicating the higher economic loss due to vegetable in these seasons.CONCLUSION: The results showed that the economic loss due to vegetable waste was greater than the economic loss due to fruit waste. …”
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Prevalence and Economic Impact of Acute Respiratory Failure in the Prehospital Emergency Medical Service of the Madrid Community: Retrospective Cohort Study by Ana María Cintora-Sanz, Cristina Horrillo-García, Víctor Quesada-Cubo, Ana María Pérez-Alonso, Alicia Gutiérrez-Misis

“…The greatest economic impact was on exacerbation of COPD in 2015, with an annual cost of €2,726,893 (which equals to US $2,864,628). ConclusionsCOPD exacerbations had the higher prevalence in the Madrid region among the respiratory diseases studied. …”
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Establishment of the fingerprint of ganoderma lucidum spore powder and study on the anti-inflammatory activity of ganoderma lucidum spore oil by Yu Zhang, Lihui Hou, Le Wang, Yunshan Si, Hongjuan Wen, Ying Gao, Xiuhua Yu

“…Ganoderma lucidum spore oil concentration less than or equal to 180 μg/mL had no significant effect on the activity of RAW264.7 cells; the protective effect on LPS-induced RAW264.7 cells was dose-dependent; compared with the model group, the medium-dose group (90 μg/mL) significantly decreased the expression of IL-1β (P<0.05), and the high-dose group (180 μg/mL) significantly decreased the expression of IL-6 and TNF-α release (P<0.05), slightly reduced IL-1β release, but not significant (P>0.05). …”
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Immediate Results of Colonic Flat Epithelial Neoplasms Removal Using Diathermic Snare Endoscopic Mucosal Resection and Mucosectomy Combined with Dissection in the Submucosal Layer:... by A. A. Fedorenko, P. V. Pavlov, A. P. Kiryukhin, A. S. Tertychnyy

“…The patients were separated into two equally sized groups and treated with EMR and ESD methods.Results. …”
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