Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…Background Successful development of chimeric antigen receptor (CAR) T cell immunotherapy for children and adults with relapsed/refractory acute myeloid leukemia (AML) is highly desired given their poor clinical prognosis and frequent inability to achieve cure with conventional chemotherapy. Initial experiences with CD19 CAR T cell immunotherapy for patients with B-cell malignancies highlighted the critical impact of intracellular costimulatory domain selection (CD28 vs 4-1BB (CD137)) on CAR T cell expansion and in vivo persistence that may impact clinical outcomes. …”
Get full text

Hubungan Keteraturan Penggunaan Kortikosteroid Inhalasi dengan Tingkat Kontrol Asma Pasien Berdasarkan ACT di Poliklinik Paru RSUP Dr. M. Djamil Padang by Wulan Prisilla Prisilla, Irvan Medison, Selfi Renita Rusjdi

“…It is known that there is no cure for asthma, so the goal of asthma management is to obtain controlled asthma. …”
Get full text

Mechanical properties and damage mechanism of steel fiber reinforced cemented tailings backfill by Yanbi XIONG, Xiaohui LIU, Haiyong CHENG, Shunchuan WU, Jing ZHANG, Weihua LIU, Rujun TUO, Zemin LIU

“…The results indicate that with increasing SF content and curing age, the uniaxial compressive strength, splitting tensile strength, and shear strength of FR–CTB increase to varying extents. …”
Get full text

Assessing the visibility and public engagement of bone marrow and stem cell transplantation research: An altmetric analysis by Mohammad Ahmadian, Shaban Alizadeh, Azadeh Omidkhoda, Fatemeh Sheikhshoaei, Brenda Van Wyk

“…Background: Bone marrow and stem cell transplantation have led to significant advancements in modern medicine, offering potential cures for various hematological disorders and specific cancers. …”
Get full text

Clinical Study on Lumbar Disc Herniation Treated by Sling and Tuina Exercise Technique by Yi DING, Chenchen GUO, LI Li

“…The recurrence rates of the three groups were counted at six months'follow-up.Results:The cure rate of the sling and tuina exercise technique group was higher than that of the other two groups(<italic>P</italic>&lt;0.05). …”
Get full text

Peer-assisted telemedicine hepatitis-C treatment for people who use drugs in rural communities: a mixed methods study by Kim Hoffman, Gillian Leichtling, Sarah Shin, Andrew Seaman, Tonhi Gailey, Hunter C. Spencer, P. Todd Korthuis

“…Implementing support from peer specialists, telemedicine technology, and streamlined testing and treatment strategies may connect more rural PWUD living with HCV with the cure.…”
Get full text

Sex-differences in the risk of carpal tunnel syndrome: results from a large Ontario, Canada worker cohort by Fanni R. Eros, Paul A. Demers, Jeavana Sritharan

“…We observed elevated risks of CTS in many occupations requiring repetitive and forceful manual work: slaughtering and meat cutting, canning, curing and packing (HRf = 2.28, 95%CI = 1.42–3.68; HRm = 1.95, 95%CI = 1.33–2.85); welding and flame cutting (HRf = 1.83, 95%CI = 1.01–3.32; HRm = 1.65, 95%CI = 1.35–2.01); motor vehicle fabricating and assembling (HRf = 2.14, 95%CI = 1.74–2.62; HRm = 2.43, 95%CI = 2.04–2.89); and packaging (HRf = 2.06, 95%CI = 1.43–2.97; HRm = 1.82, 95%CI = 1.12–2.98). …”
Get full text

Profil Sindrom Stevens Johnson pada Pasien Rawat Inap di RSUP Dr. M. Djamil Padang Periode Januari 2010 sampai Desember 2011 by Amelia Rahayu, Rina Gustia, Rahmatini .

“…Variables that were evaluated covered gender, age, causes of SJS, clinical manifestation of SJS, treatment time, the severity, cure rate, and mortality rate. The data were processed, counted the percentage, and presented in tabular form.The result showed there were 22 SJS cases (0,05%) with incidence ratio between male and female was 3:1. …”
Get full text

Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers by Mei Zhang, Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons

“…Background Efforts to modulate the function of tumor-associated myeloid cell are underway to overcome the challenges in immunotherapy and find a cure. One potential therapeutic target is integrin CD11b, which can be used to modulate the myeloid-derived cells and induce tumor-reactive T-cell responses. …”
Get full text

Sacredness of the Landscape of Vokė River in the Geography of Tatar Life Stories by Lina Leparskienė

“…As follows from this literature, at that time the Muslim could pray at the image of Our Lady of Trakai, and a Christian seek to cure the disease with help of Tatar ‘sorcery’. Therefore, the second perspective explores Vokė as a space that has attracted people of various denominations in search for help to recover health and spiritual state of mind thanks to knowledge and mysterious power of Tatar healers, known as ‘faldjey’ (Pol. fałdżej). …”
Get full text

Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11 by Ling Li, Manzhi Zhao, Marjan van Meurs, Inge Brouwers-Haspels, Renske J. H. den Dekker, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Shringar Rao, Casper Rokx, Yvonne M. Mueller, Peter D. Katsikis

“…As effective CD8+ T cell responses are essential for eliminating reactivated virus and achieving a cure, it is important to investigate how bryostatin-1 affects HIV-specific CD8+ T cells. …”
Get full text

CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma by Victoria Jennings, Kevin Harrington, Hardev Pandha, Alan Melcher, Adel Samson, Fiona Errington-Mais, Victoria Roulstone, Eva Crespo-Rodriguez, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Martin McLaughlin, Malin Pedersen, Richard Vile, Joan Kyula, Jehanne Hassan, Lizzie Appleton, Charleen ML Chan Wah Hak, Gabby Baker, Edward Armstrong, Matthew Chiu, Masahiro Ono

“…Targeting CD25 high, antigen-engaged Treg with a depleting anti-CD25 ICI, achieved complete cures in 100% of mice with triple therapy. Transcriptomic analysis confirmed reduction in Foxp3 on addition of anti-CD25 to HSV/BRAFi, as well as increases in expression of genes reflecting interferon signaling and cytotoxic activity.Conclusions Combination HSV/BRAFi is an immunogenic therapy for BRAF mutant melanoma, but cannot fully control tumors. …”
Get full text

A Meta-analysis of the effect of functional dressing in nursing of pressure injury (功能性敷料在压力性损伤护理中应用效果的Meta分析) by WU Qian (吴倩), NING Yuyin (宁余音), BAI Zhiyu (柏志玉), HUANG Jie (黄洁), LU Junchen (陆俊辰), LIU Rui (刘芮), LIAO Zipeng (廖子鹏)

“…Conclusion Compared with traditional dressings, functional dressings can reduce the number of dressing changes, shorten the healing time, increase the cure rate, and thus improve the patient's nursing satisfaction. …”
Get full text

Dysbiosis of gut microbiota in COVID-19 is associated with intestinal DNA phage dynamics of lysogenic and lytic infection by Aya Ishizaka, Azumi Tamura, Michiko Koga, Taketoshi Mizutani, Seiya Yamayoshi, Kiyoko Iwatsuki-Horimoto, Atsuhiro Yasuhara, Shinya Yamamoto, Hiroyuki Nagai, Eisuke Adachi, Yutaka Suzuki, Yoshihiro Kawaoka, Hiroshi Yotsuyanagi

“…SARS-CoV-2 infection, which follows a transient pathological course from disease onset to cure, may provide a reliable model to investigate these interactions in the gut environment. …”
Get full text

Shining light on knee osteoarthritis: an overview of vitamin D supplementation studies by Di Zhang, Miaoyu Ye, Yao Xu, Luyu Jiang, Yanmei Hu, Qi Zhang, Xiao Han, Qian Dai, Junhui Qian, Jian Luo, Qiang Yuan

“…In recent years, Vitamin D supplements cure osteoarthritis has garnered attention from medical professionals and patients due to its simplicity and portability. …”
Get full text

RETRACTED ARTICLE: Extracorporeal membrane oxygenation support for SARS-CoV-2: a multi-centered, prospective, observational study in critically ill 92 patients in Saudi Arabia by Saad Alhumaid, Abbas Al Mutair, Header A. Alghazal, Ali J. Alhaddad, Hassan Al-Helal, Sadiq A. Al Salman, Jalal Alali, Sana Almahmoud, Zulfa M. Alhejy, Ahmad A. Albagshi, Javed Muhammad, Amjad Khan, Tarek Sulaiman, Maha Al-Mozaini, Kuldeep Dhama, Jaffar A. Al-Tawfiq, Ali A. Rabaan

“…Results ECMO use was associated with higher in-hospital mortality (40.2% vs. 48.9%; p = 0.000); lower COVID-19 virological cure (41.3% vs 14.1%, p = 0.000); and longer hospitalization (20.2 days vs 29.1 days; p = 0.000), ICU stay (12.6 vs 26 days; p = 0.000) and mechanical ventilation use (14.2 days vs 22.4 days; p = 0.000) compared to non-ECMO group. …”
Get full text

Feasibility of trancutaneous auricular vagus nerve stimulation in Black and Hispanic/Latino people with peripheral neuropathy by Marlon L. Wong, Eva Widerström-Noga, Jessica L. Bolanos, Gabriel Gonzalez, Frank J. Penedo, Peter J. Hosein, Melissa M. Tovin, Juan P. Gonzalez, Lisa M. McTeague

Get full text

Fourier Descriptor Pada Klasifikasi Daun Herbal Menggunakan Support Vector Machine Dan Naive Bayes by Mutmainnah Samir, Purnawansyah, Herdianti Darwis, Fitriyani Umar

“…Abstract Herbal leaves are beneficial as alternative medicine because their natural content can cure various diseases and maintain a healthy body. …”
Get full text

Can exercise as a complementary technique manage inflammatory markers in women with breast cancer who are overweight and obese? A systematic review and meta-analysis by Liang Tan, Jinyu Mei, Ruihong Tang, Duo Huang, Kai Qi, Zbigniew Ossowski, Xiaoning Wang

“…Background: Inflammation can result in the development of breast cancer in women with overweight and obese, and also affects the outcome and prognosis of breast cancer patients, thereby decreasing the cure and survival rates of breast cancer patients. …”
Get full text

Artemia sp. as a DNA vaccine vector for common carp Cyprinus carpio larvae by Sri Nuryati, Sekar Sulistyaning Hadiwibowo, . Alimuddin

“…Generally, viral disease is difficult to cure because virus is intra-cellular parasite, that virus survives, multiplies, and lives only if it on the host cell. …”
Get full text