The potential of stem cell therapy in Multiple Sclerosis treatment: a review by Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

“…Currently, there is no standardised treatment or cure for Multiple Sclerosis with many strategies focusing on symptoms. …”
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Remission: does it already exist in chronic rhinosinusitis with nasal polyposis? by Yvonne Chan, Andrew V. Thamboo, Joseph K. Han, Martin Desrosiers

“…Future efforts will attempt to improve on these outcomes by achieving symptomatic and endoscopic control of disease following cessation of therapy, potentially paving the way towards clinical remission or a ‘cure’ in CRS.…”
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An optimized data analytics pipeline for improving healthcare diagnosis using ensemble learning by Lomat Haider Chowdhury, Shaira Tabassum, Swakkhar Shatabda, Ashir Ahmed

“…Imposing a treatment without proper diagnosis cannot guarantee a cure and sometimes may lead the patient to a more detrimental scenario. …”
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Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease by Kaili Ou, Qingqing Jia, Dandan Li, Shihua Li, Xiao-Jiang Li, Peng Yin

“…Currently, available treatments for various neurodegenerative diseases can alleviate symptoms but do not provide a definitive cure. Gene therapy, which aims to modify or express specific proteins for neuroprotection or correction, is considered a powerful tool in managing neurodegenerative conditions. …”
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Evaluating Dose- and Time-Dependent Effects of Vitamin C Treatment on a Parkinson’s Disease Fly Model by Huynh Man Anh, Dao My Linh, Vuu My Dung, Dang Thi Phuong Thao

“…Currently, there is no potent therapy to cure PD, and the medications merely support to control the symptoms. …”
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Total Phenolic, Flavonoid Contents, and Antioxidant Activities of Fruit, Seed, and Bark Extracts of Zanthoxylum armatum DC by Nirmala Phuyal, Pramod Kumar Jha, Pankaj Prasad Raturi, Sangeeta Rajbhandary

“…These plants contain polyphenols and flavonoids that act as free radical scavengers and reduce oxidative stress and may be an alternative remedy to cure various harmful human diseases. This study aims to quantify the total phenolic and flavonoid contents (TPC and TFC) and antioxidant properties of methanol extracts of fruits, seeds, and bark of an important medicinal and aromatic plant, Zanthoxylum armatum collected from wild and cultivated populations in Nepal. …”
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End-Of-Life Care for Persons with Advanced Chronic Obstructive Pulmonary Disease: Report of a National Interdisciplinary Consensus Meeting by DM Goodridge, DD Marciniuk, D Brooks, A van Dam, S Hutchinson, P Bailey, S Baxter, P Dorasamy, S Dumont, S Hassan, P Hernandez, A Kerigan, G Rocker, D Wilson, J Young

“…For instance, the American Thoracic Society has issued an official statement on palliative care for patients with respiratory diseases, affirming that the prevention, relief, reduction and soothing of symptoms “without affecting a cure” must become an integral component of standard care. …”
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Herald Patch as the Only Evidence of Pityriasis Rosea: Clinical, Laboratory and Pathogenetic Features by Francesco Drago, Astrid Herzum, Serena Varesano, Gaetano Serviddio, Francesco Broccolo, Giulia Ciccarese

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iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study by Peter D. Westenskow, Felicitas Bucher, Stephen Bravo, Toshihide Kurihara, Daniel Feitelberg, Liliana P. Paris, Edith Aguilar, Jonathan H. Lin, Martin Friedlander

“…Photoreceptors rely heavily on the RPE, and death or dysfunction of RPE is characteristic of age-related macular degeneration (AMD), a very common neurodegenerative disease for which no cure exists. RPE replacement is a promising therapeutic intervention for AMD, and large numbers of RPE cells can be generated from pluripotent stem cells. …”
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The Challenges of Living with Inflammatory Bowel Disease: Summary of a Summit on Patient and Healthcare Provider Perspectives by Judith Bray, Aida Fernandes, Geoffrey C. Nguyen, Anthony R. Otley, Joan Heatherington, Jennifer Stretton, Natasha Bollegala, Eric I. Benchimol

“…There is currently no cure for IBD, although earlier diagnosis and new therapies have improved the overall health outcomes and quality of life for patients. …”
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Liver diseases: epidemiology, causes, trends and predictions by Can Gan, Yuan Yuan, Haiyuan Shen, Jinhang Gao, Xiangxin Kong, Zhaodi Che, Yangkun Guo, Hua Wang, Erdan Dong, Jia Xiao

“…Currently, liver diseases contribute to approximately 2 million deaths globally each year, imposing significant economic and social burdens worldwide. However, there is no cure for many kinds of liver diseases, partly due to a lack of thorough understanding of the development of these liver diseases. …”
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Similarities and Differences between Clavicular Bacterial Osteomyelitis and Nonbacterial Osteitis: Comparisons of 327 Reported Cases by Nan Jiang, Ping Zhang, Wei-ran Hu, Zi-long Yao, Bin Yu

“…Overall, the BO patients achieved a statistically higher cure rate than that of the NBO patients (P=0.018). …”
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Awareness and perception of prevention and management options of sexually transmitted infections among students at secondary school in Rivers State, Nigeria by Florence Mandah, Oluebubechukwu Udi, Pamela Thompsom-Abiye, Basil Ogbu

“…Results 99.3% of participants agreed that STIs can be treated with pharmaceutical drugs, 33% believed in the effectiveness of local concoctions, while 68.3% indicated that divine intervention of prayers offers a cure. 290 (96.6%) participants strongly agreed that young people should be educated on STIs in schools. …”
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Modulation of adiposity and adipocyte inflammation by methanol extracts of Alpinia calcarata leaf in high-fat-diet induced-obese mice: Involvement of COX-2 and PPAR-γ by Imtiaz Ahmad, Maruful Hasan, Dipty Rani Bhowmik, Rahima Begum, Sourav Roy, Md Monirul Islam, Md Abdur Rahman Ripon, Mohammad Salim Hossain

“…Obesity is a worldwide problem linked to several lifestyle disorders like diabetes, hypertension, heart failure, dyslipidaemias, asthma, etc. Finding a cure for obesity and its consequences is essential. …”
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Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE) by Jennifer Clough, Peter Irving, A Toby Prevost, Graham M Lord, Joana Vasconcelos, James B Canavan, Beverley Rodger, D Macallan

“…Introduction Crohn’s disease (CD) is a chronic, immune-mediated inflammatory bowel disease (IBD), presenting with symptoms of abdominal pain and bleeding from the gastrointestinal tract. There is no known cure. In vitro-expanded ‘thymus-derived’ regulatory T cells (tTreg) have shown promise in preclinical models of IBD, leading to interest in their use as a potential therapy in CD. …”
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Hematohidrosis in Pediatric Practice  – a Case Report and Review of the Literature by Oksana Matsyura, Lesya Besh, Svitlana Jefimova, Khrystyna Slivinska-Kurchak, Sergiy Gerasymov

“…A properly formed treatment complex and the great trust of the parents enabled to stabilize the child’s condition, and later to cure her. Currently, hematohidrosis is recognized as an independent disease that requires in-depth study of the triggering mechanisms of development, pathogenetic and clinical features. …”
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Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances by Chong Ning, Yuhan Jiao, Jiaqi Wang, Weiwei Li, Jingqiu Zhou, Yi-Chieh Lee, Dik-Lung Ma, Chung-Hang Leung, Rugang Zhu, Hui-Min David Wang

“…The etiology and pathogenesis of diabetes have not been fully elucidated, and no radical therapeutic cure has been found. Patients with T2DM suffer from complications such as the development of a chronic hyperglycemic condition and even serious metabolic disorders and organ damage in the body and depression and dementia, in addition to other chronic complications. …”
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Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease by Wang H, Zhou F, Shen M, Ma R, Yu Q

“…These complex causes make it difficult to achieve a complete cure. Patients with IBD frequently experience recurrent abdominal pain and bloody diarrhea, while severe cases may result in intestinal obstruction, perforation, and cancer. …”
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Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine by Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Aya Hasan Alshammari, Hideyuki Hatakeyama, Eric di Luccio, Andrea Vecchione, Takaaki Hirotsu, Hideshi Ishii

“…Cancer is one of the major causes of death, and as it becomes more malignant, it becomes an intractable disease that is difficult to cure completely. Therefore, early detection is important to increase the survival rate. …”
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Thermal properties and non-bonded interactions in human PMP2 variants: A molecular dynamics study by Prabin Aryal, Jhulan Powrel

“…Many studies on this disease have been conducted, including clinical as well as computational, but no effective medical cure has yet been found. This disease is caused due to mutation in the human peripheral myelin protein 2 (PMP2) responsible for myelin formation and maintenance. …”
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