Revealing the limitations of 10-year MACE observations: 20-year observed total cardiovascular burden in the EPIC-Norfolk study by Frank LJ Visseren, Harald T Jorstad, Marjolein Snaterse, S Matthijs Boekholdt, Tinka J van Trier, Jannick AN Dorresteijn, Manon van den Bogaart, Wilma JM Scholte op Reimer, Ron JG Peters

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Art of TIL immunotherapy: SITC’s perspective on demystifying a complex treatment by Robert Brown, Marco Donia, Simon Turcotte, George Coukos, John Mullinax, Brian Gastman, James C Yang, Michael T Lotze, John B A G Haanen, Inge Marie Svane, Stephanie L Goff, Vernon K Sondak, Maartje W Rohaan, Michal Besser, Benjamin Creelan

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New prognostic model in patients with advanced urothelial carcinoma treated with second-line immune checkpoint inhibitors by Ernest Choy, Yohann Loriot, Fabio Calabrò, Cora N Sternberg, Guillermo De Velasco, Daniel Castellano, Roubini Zakopoulou, Aristotelis Bamias, Nicholas James, Axel Merseburger, F Lopez-Rios, Mario Kramer, Kimon Tzannis

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Secukinumab in the treatment of psoriatic arthritis: efficacy and safety results through 3 years from the year 1 extension of the randomised phase III FUTURE 1 trial by Philip J Mease, Arthur Kavanaugh, Andreas Reimold, Hasan Tahir, Jürgen Rech, Stephen Hall, Piet Geusens, Pascale Pellet, Evie Maria Delicha, Shephard Mpofu, Luminita Pricop

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Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression by Pedro J Romero, Mauro Delorenzi, Amaia Martínez-Usatorre, Laura Ciarloni, Noushin Hadadi, Eric Durandau, Sylvain Monnier-Benoit, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Stephan Morgenthaler, Brian Hashemi, Sahar Hosseinian-Ehrensberger

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Urine proteomics defines an immune checkpoint-associated nephritis signature by Cassian Yee, Jamie S Lin, James P Long, Shailbala Singh, Yanlan Dong

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Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma by Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele

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Prognostic role of con-/discordant coronary flow reserve and microvascular resistance in coronary microvascular disease: a systematic review and network meta-analysis by Ibtihal Al Amri, Federico Oliveri, Jin Al-Gully, Jessica Parisa Forouzanfar, Jose Manuel Montero-Cabezas, Johan Wouter Jukema, Melina Cynthia den Haan, Brian Oscar Bingen

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Clinical decision fatigue: a systematic and scoping review with meta-synthesis by Nicola Grignoli, Serena Petrocchi, Peter Schulz, Luca Gabutti, Greta Manoni, Jvan Gianini

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Sacubitril/valsartan is associated with improvements in quality of life in adult congenital heart disease patients with systemic right ventricular failure by Philippine Kiès, Marieke Nederend, Ralph M.L. Neijenhuis, Anna E. van Groningen, Monique R.M. Jongbloed, Hubert W. Vliegen, J. Wouter Jukema, Anastasia D. Egorova

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Association between the subclinical level of problematic internet use and habenula volume: a look at mediation effect of neuroticism by Toshiya Murai, Hironobu Fujiwara, Qi Dai, Halwa Zakia, Yusuke Kyuragi, Naoya Oishi, Yuzuki Ishikawa, Lichang Yao, Morio Aki

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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

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Parsimonious versus extensive bleeding score: can we simplify risk stratification after percutaneous coronary intervention and reduce bleeding events by de-escalation of the antipl... by Pascal Vranckx, Stephan Windecker, Marco Valgimigli, Neil O’Leary, Yoshinobu Onuma, Peter Damman, Eva Christine Ida Woelders, Kai Ninomiya, Denise Adriana Maria Peeters, Arnoud Willem Johannes van 't Hof, Patrick Washington J C Serruys, Robert-Jan Matthijs van Geuns

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Predictors of direct oral anticoagulant concentrations in the trauma population by Laura Adams, Alan M Smith, Louis Perkins, Dmitri Lerner, Jarrett Santorelli, Leslie Kobayashi

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Emergency interventions for cardiogenic shock due to decompensated aortic stenosis: a systematic review and meta-analysis by Mauro Chiarito, Dario Bongiovanni, Evaldas Girdauskas, Bastian Wein, Eva Harmel, Tamer Owais, Stephanie Gladys Kühne, Andrea Patrignani, Sebastien Elvinger, Damyan Penev, Philip W Raake

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Modifiable factors for irritable bowel syndrome: evidence from Mendelian randomisation approach by Jinling Tang, Zhirong Yang, Shanshan Wu, Feng Sha, Tengfei Lin, Di Liu, Meiling Cao, Yiwen Jiang, Weijie Cao, Fuxiao Li

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INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses by Jason Ho, Chelsie Macedo, Garrett Cyprus, Rajay Pandit, Anya Polovina, Nadja Kern, Abrahim Hussain, Sae Jeong Ahn, William Crago, Emily Rowell, Florian J Sulzmaier, John C Timmer, Brendan P Eckelman

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Suicidal ideation and suicide attempt among pregnant adolescent girls in Ghana: a cross-sectional study by Kwaku Oppong Asante, Emmanuel Nii-Boye Quarshie, Erica Danfrekua Dickson, Sandra Naa-Shasha Quarshie, Sophia Ewuenye Adwoa Kpebu

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Consensus on rapid screening for prodromal Alzheimer’s disease in China by Yao Lu, Ying Wang, Jianping Jia, Qihao Guo, Ya Miao, Lin Huang, Xiaochun Chen, Qinjie Li, Fengfeng Pan, Liang Cui, Tianlu Chen, Yatian Li, Jingnan Wu

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Porphyromonas gingivalis associates with the presence of anti-citrullinated protein antibodies, but not with the onset of arthritis: studies in an at-risk population by Helga Westerlind, Linda Mathsson-Alm, Alexandra Circiumaru, Aase Hensvold, Karin Lundberg, Jan Potempa, Yogan Kisten, Charlotte De Vries, Marina Dehara, Barbara Potempa

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