Immunosenescence and its related comorbidities in older people living with HIV by Xiao-Yan He, Xiu-Wen Wang, Shuang Li, Na Li, Wei Li, Yan Hu, Na Guo, Yong-Tang Zheng, Hong-Yi Zheng, Bin Su, Haijuan Wang

“…Abstract. With the aging of the global population, older people living with HIV (OPLWH) have emerged as a focal point in HIV/AIDS research. …”
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Identification of patient demographic, clinical, and SARS-CoV-2 genomic factors associated with severe COVID-19 using supervised machine learning: a retrospective multicenter study by Kuganya Nirmalarajah, Patryk Aftanas, Shiva Barati, Emily Chien, Gloria Crowl, Amna Faheem, Lubna Farooqi, Alainna J. Jamal, Saman Khan, Jonathon D. Kotwa, Angel X. Li, Mohammad Mozafarihashjin, Jalees A. Nasir, Altynay Shigayeva, Winfield Yim, Lily Yip, Xi Zoe Zhong, Kevin Katz, Robert Kozak, Andrew G. McArthur, Nick Daneman, Finlay Maguire, Allison J. McGeer, Venkata R. Duvvuri, Samira Mubareka

“…Notably, inpatients were older with a mean age of 66.67 years (SD ± 17.64 years), whereas outpatients had a mean age of 44.89 years (SD ± 16.00 years). …”
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Hospitalizations, emergency medical care utilization, and contacts with the regional on-call medical services among nursing home residents in Germany: a cross-sectional study in 44... by Paula Lienesch, Heinz Rothgang, Ansgar Gerhardus, Karin Wolf-Ostermann, Falk Hoffmann, Jonas Czwikla

“…Emergency medical care utilization was positively associated with age group 85 + vs. 60–74 years (2.58 [1.14–5.84]) and long-term care grades 3 and 4/5 vs. 1/2 (2.65 [1.07–6.55], 6.31 [2.60–15.35]); negatively associated with 5 + vs. 1- < 3 years of residence (0.46 [0.24–0.86]); and not associated with sex, the number of Elixhauser diseases, and nutritional status. …”
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Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction by Aric A. Prather, PhD, Ying Gao, MS, Legna Betancourt, BS, Rose C. Kordahl, BS, Anya Sriram, BS, Chiung-Yu Huang, PhD, Steven R. Hays, MD, Jasleen Kukreja, MD, Daniel R. Calabrese, MD, Aida Venado, MD, Bhavya Kapse, PhD, John R. Greenland, MD, PhD, Jonathan P. Singer, MD, MS

“…We investigated associations between perioperative predictors on SPI and insomnia and associations between SPI and insomnia on PROs and frailty by linear regressions, adjusting for age, sex, and lung function. We evaluated the associations between SPI and insomnia on time to chronic lung allograft dysfunction (CLAD) and death using Cox models, adjusting for age, sex, and transplant indication. …”
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Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung disease by Linh T. Ngo, Michaella J. Rekowski, Devin C. Koestler, Takafumi Yorozuya, Atsushi Saito, Imaan Azeem, Alexis Harrison, M. Kristen Demoruelle, Jonathan Boomer, Bryant R. England, Paul Wolters, Philip L. Molyneaux, Mario Castro, Joyce S. Lee, Joshua J. Solomon, Koji Koronuma, Michael P. Washburn, Scott M. Matson

“…These clusters had unique survival trajectories and provided more accurate survival predictions than the Gender Age Physiology index (concordance index 0.794 versus 0.709). …”
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Clinical and Laboratorial Features That May Differentiate 46,XY DSD due to Partial Androgen Insensitivity and 5α-Reductase Type 2 Deficiency by Nélio Neves Veiga-Junior, Pedro Augusto Rodrigues Medaets, Reginaldo José Petroli, Flávia Leme Calais, Maricilda Palandi de Mello, Carla Cristina Telles de Sousa Castro, Guilherme Guaragna-Filho, Letícia Espósito Sewaybricker, Antonia Paula Marques-de-Faria, Andréa Trevas Maciel-Guerra, Gil Guerra-Junior

“…Fifty-eight patients (51 families) were included. Age at first evaluation, weight and height at birth, consanguinity, familial recurrence, severity of AG, penile length, LH, FSH, T, dihydrotestosterone (DHT), Δ4-androstenedione (Δ4), and T/DHT and T/Δ4 ratios were evaluated. …”
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Prevalence of Diabetes, Prediabetes, and Associated Factors in an Adult Chinese Population: Baseline of a Prediabetes Cohort Study by Xinjie Yu, Fang Duan, Da Lin, Hai Li, Jian Zhang, Qiuyu Wang, Xianglong Wang, Qian Zhao, Jiayu Deng, Guangwei Song, Qingqing Ji, Haihua Zheng, Xiang Chen, Guoyi Zhou

“…Data from 406 participants were used in the baseline analysis, with a mean age of 51.2 ± 11.0 years and 160 (33.0%) males. …”
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Altered Topological Properties of Grey Matter Structural Covariance Networks in Complete Thoracic Spinal Cord Injury Patients: A Graph Theoretical Network Analysis by Wen-Li Wang, Yu-Lin Li, Mou-Xiong Zheng, Xu-Yun Hua, Jia-Jia Wu, Fei-Fei Yang, Nan Yang, Xia He, Li-Juan Ao, Jian-Guang Xu

“…Structural MRI of brain was acquired in 24 complete thoracic SCI patients (38.50±11.19 years, 22 males) within the first postinjury year, while 26 age- and gender-matched healthy participants (38.38±10.63 years, 24 males) were enrolled as control. …”
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Premorbid predictors of death at initial presentation of coronary heart disease in the Women's Health Initiative study by Ming-Li Chen, Jin Li, Kruthika R. Iyer, Catherine Tcheandjieu, Shirin Jimenez, Elias Levy Itshak Salfati, Liana C. Del Gobbo, Marcia L Stefanick, Manisha Desai, Xiaonan Xue, Themistocles L Assimes

“…A five-year increase in age, smoking 5 to 34 cigarettes per day, and a standard deviation (SD) increase in the Cornel voltage product, an electrocardiographic measure highly correlated with left ventricular mass index on echocardiography, each independently increased the relative risk (RR) of dying from one's initial presentation of CHD by 46 % (95 % confidence interval [CI], 35 to 58 %), 30 % (8 to 51 %,), and 17 % (7 to 28 %), respectively. …”
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Syphilis reactivity among blood donors in Brazil: associated factors and implications for public health monitoring by Natalia A. Braga, Sheila de Oliveira Garcia Mateos, Renata Buccheri, Vivian I. Avelino-Silva, Donald E. Warden, Cesar de Almeida-Neto, Maisa Ribeiro, Luiz Amorim, Paula Loureiro, Nelson Fraiji, Marcio K. Oikawa, Eduard Grebe, Mars Stone, Ester C. Sabino, Brian Custer, for the NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P)

“…The incidence of syphilis in RD was 90/105 person-years (95% CI 86–95), with younger age, male gender, Black and Mixed race (relative to White) and lower education associated with incident syphilis in RD. …”
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The mC2HEST Score for Incident Atrial Fibrillation by Yanguang Li, MD, Qiaoyuan Li, MD, Lili Wang, MD, Tao Zhang, MD, Hai Gao, MD, Daniele Pastori, MD, PhD, Zhuo Liang, MD, Gregory Y.H. Lip, MD, Yunlong Wang, MD

“…Results: A total of 4,524 subjects (mean age 60.2 ± 9.5 years; 53.0% female) were included; 565 (mean age 67.0 ± 7.9 years; 46.5% female) developed AF during 13.6 ± 2.5 years of follow-up, with an incidence of 0.93%/year. …”
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Diagnostic accuracy of calculated serum osmolarity to predict dehydration in older people: adding value to pathology laboratory reports by Lee Shepstone, John F Potter, Lee Hooper, Asmaa Abdelhamid, Amy Jennings, Paul R Hunter, W Garry John, Neil P Walsh, Adam Ali, Diane K Bunn, Susan Kerry, Gregor Lindner, Carmen A Pfortmueller, Fredrik Sjöstrand, Susan J Fairweather-Tait

“…It appeared useful in people aged ≥65 years with and without diabetes, poor renal function, dehydration, in men and women, with a range of ages, health, cognitive and functional status.Conclusions Some commonly used osmolarity equations work poorly, and should not be used. …”
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Associations of health literacy with metabolic status and quality of life among comunity patients with type 2 diabetes in Shanghai by YANG Liping, SONG Haihong, SHEN Jue, GAO Jinli, ZHANG Zhiping, QIAN Liuyu, GONG Huan

“…Significant differences in HbA1c achievement rates were observed across age groups, education levels, disease durations, and BMI levels (P<0.05). …”
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Uncovering women's healthcare access challenges in low- and middle-income countries using mixed effects modelling approach: Insights for achieving the Sustainable Development Goals... by Bewuketu Terefe, Belayneh Shetie Workneh, Gebreeyesus Abera Zeleke, Enyew Getaneh Mekonen, Alebachew Ferede Zegeye, Agazhe Aemro, Berhan Tekeba, Tadesse Tarik Tamir, Mulugeta Wassie, Mohammed Seid Ali

“…Sociodemographic factors such as age, education, marital status, wealth, media exposure, and health insurance are associated with lower odds of experiencing healthcare access issues. …”
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Corticostriatal maldevelopment in the R6/2 mouse model of juvenile Huntington's disease by Carlos Cepeda, Sandra M. Holley, Joshua Barry, Katerina D. Oikonomou, Vannah-Wila Yazon, Allison Peng, Deneen Argueta, Michael S. Levine

“…In contrast, excitatory inputs began to decrease at this age. We conclude that the developing HD brain is capable of compensating for early developmental abnormalities and that cortical alterations precede and are a main contributor of striatal changes. …”
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Vegetation disturbance and regrowth dynamics in shifting cultivation landscapes by Yamini Bhat, Subrata Nandy, Krishna Das, Muna Tamang, Hitendra Padalia, Arun Jyoti Nath, Koushik Majumdar, Rocky Pebam, Pynkhlainbor Thongni, Bandana Kurmi, Ashesh Kumar Das, S. P.S. Kushwaha, R. P. Singh

“…Abstract Shifting cultivation, an age-old agricultural practice, is a major factor in forest cover change across Southeast Asia, where repeated cycles of vegetation disturbance and regrowth lead to far-reaching environmental and socio-economic impacts. …”
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Determinants of Dropout From a Virtual Agent–Based App for Insomnia Management in a Self-Selected Sample of Users With Insomnia Symptoms: Longitudinal Study by María Montserrat Sanchez Ortuño, Florian Pecune, Julien Coelho, Jean Arthur Micoulaud-Franchi, Nathalie Salles, Marc Auriacombe, Fuschia Serre, Yannick Levavasseur, Etienne De Sevin, Patricia Sagaspe, Pierre Philip

“…ResultsThe users’ mean age was 47.95 (SD 15.21) years. Of those who dropped out early and those who completed the treatment, 65.1% (3153/4846) were women and 34.9% (1693/4846) were men. …”
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Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort by Sarah Damanti, Sarah Damanti, Rebecca De Lorenzo, Rebecca De Lorenzo, Lorena Citterio, Laura Zagato, Elena Brioni, Cristiano Magnaghi, Marco Simonini, Maria Pia Ruggiero, Simona Santoro, Eleonora Senini, Marco Messina, Francesca Farina, Costanza Festorazzi, Giordano Vitali, Paolo Manunta, Paolo Manunta, Angelo Andrea Manfredi, Chiara Lanzani, Chiara Lanzani, Patrizia Rovere-Querini, Patrizia Rovere-Querini

“…Concordance was assessed using Cohen’s Kappa coefficients. Age-and sex-adjusted Cox regression analyses were conducted to evaluate the association with mortality.ResultsOut of 1,114 participants (median age 72 years, IQR 69–77), 186 were classified as frail by the FI, 13 by the FP and 48 by both definitions. …”
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Malnutrisi Energi Protein Berat: Laporan Kasus by Peter Prayogo Hsieh, Putri Dariyanti Wijaya, Putri Aziana, Prahara Wahyu Purnomo, Sitti Radhiah

“…She was alert with weight – for – age, height – for – age, and weight – for – height <3 Z – score WHO growth chart. …”
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Gambaran Faktor Risiko dan Tipe Stroke pada Pasien Rawat Inap di Bagian Penyakit Dalam RSUD Kabupaten Solok Selatan Periode 1 Januari 2010 - 31 Juni 2012 by Cintya Agreayu Dinata, Yuliarni Safrita Safrita, Susila Sastri

“…<br />Kata kunci: stroke ischemic, stroke hemorrhagic, faktor risiko stroke<br />Abstract<br />Stroke is a disease caused by disorder of brain blood circulation with many risk factors that contribute in this disease, consist of non modifiable risk factor including age and sex and modifiable risk factors example hypertension, high glucose level, dyslipidemia, and jobs. …”
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