Oxidative stress and dysregulated long noncoding RNAs in the pathogenesis of Parkinson’s disease by Jialu Wang, Meitong Liu, Jiuhan Zhao, Pan Hu, Lianbo Gao, Shen Tian, Jin Zhang, Huayan Liu, Xiaoxue Xu, Zhenwei He

“…Abstract Parkinson’s disease (PD) is a progressive age-related neurodegenerative disease whose annual incidence is increasing as populations continue to age. …”
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Metformin versus insulin in glycemic control in pregnancy (MevIP): a randomized clinical trial protocol by Carolina Freitas Alves Amaral-Moreira, Daiane Sofia Morais Paulino, Belmiro G. Pereira, Patricia Moretti Rehder, Fernanda G. Surita

“…Metformin is safe in pregnancy and appears to produce better results than insulin, including reduced gestational weight gain (GWG) and smaller gestational-age newborns. Few studies have been conducted on this topic in low- and middle-income countries. …”
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Comparison of Intravitreal Aflibercept and Ranibizumab for Treatment of Myopic Choroidal Neovascularization: One-Year Results—A Retrospective, Comparative Study by Burak Erden, Selim Bölükbaşı, Emine Baş, Akın Çakır

“…There were 12 eyes in IVA group, with a mean age of 60.0 ± 10.2 years. The mean BCVA significantly improved from baseline 1.54 ± 0.76 to 0.85 ± 0.61 and the mean CMT significantly decreased from baseline 384.3 ± 119.1 μm to 305.9 ± 75.4 μm at Month 12 (p:0.024 and p:0.011, respectively). …”
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Smoking Induces the Circulating Levels of Matrix Metalloproteinase-9 and Its Association with Cardiovascular Risk in Young Smokers by Dinesh NATH, Meera SHIVASEKAR, V. M. VINODHINI

“…As a result, smoking-induced elevated serum MMP-9 levels, particularly at a younger age, raise the risk of coronary heart disease (CHD). …”
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The Level of hs-CRP in Coronary Artery Ectasia and Its Response to Statin and Angiotensin-Converting Enzyme Inhibitor Treatment by Yilmaz Ozbay, Mehmet Akbulut, Mehmet Balin, Hidayet Kayancicek, Adil Baydas, Hasan Korkmaz

“…We measured serum hs-CRP level in 40 CAE (26 males, mean age: 56.32±9 years) and 41 O-CAD (34 males, mean age: 57.19±10 years) patients referred for elective coronary angiography at baseline and after 3-month statin and ACE inhibitor treatment. …”
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Iranian Pediatric COVID-19 Epidemiology and Clinical Characteristics by Shahnaz Armin, Mohammadreza Mirkarimi, Zahra Pourmoghaddas, Marjan Tariverdi, Azadeh Jafrasteh, Noushin Marhamati, Armin Shirvani, Abdollah Karimi, Sedigheh Rafiei Tabatabaei, Roxana Mansour Ghanaei, SeyedAlireza Fahimzad, Fariba Shirvani, Seyedeh Mahsan Hoseini-Alfatemi

“…Also, a small number of children received oxygen therapy, most of whom were in the age group of 1 to 5 years.…”
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Prevalence, risk factors, and adverse outcomes of bacterial vaginosis among pregnant women: a systematic review by Neha Sethi, Vallikkannu Narayanan, Rahmah Saaid, Aizura Syafinaz Ahmad Adlan, Soo Tein Ngoi, Cindy Shuan Ju Teh, Mashitah Hamidi, on behalf of WHOW research group

“…Abstract Introduction Bacterial vaginosis (BV) is one of the most common genital tract infections among women of reproductive age. The existence of BV among pregnant women has momentously attracted the attention of both clinicians and the scientific community due to its potential link with adverse clinical outcomes in pregnancy. …”
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Increased Choroidal Thickness in Keratoconus Patients: Perspectives in the Disease Pathophysiology by João Pinheiro-Costa, João Viana Pinto, Sara Perestrelo, João Nuno Beato, Luís Torrão, Elisete Brandão, Ângela Carneiro, Maria Dulce Madeira, Fernando Falcão-Reis

“…To analyze and compare choroidal thickness between keratoconus (KC) patients and age-matched non-KC subjects. Methods. A cross-sectional, case-control study. …”
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Comorbidity patterns and mortality in atrial fibrillation: a latent class analysis of the EURopean study of Older Subjects with Atrial Fibrillation (EUROSAF) by Huah Shin Ng, Richard Woodman, Nicola Veronese, Alberto Pilotto, Arduino A. Mangoni

“…We identified comorbidity patterns and their association with mortality in multimorbid older AF patients with different multidimensional frailty.Methods Hospitalised adults aged ≥65 years with non-valvular AF were followed for 12 months in the multicentre EURopean study of Older Subjects with Atrial Fibrillation (EUROSAF). …”
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Predicting Neoplastic Gallbladder Polyps: The Role of Current Surgical Indications and Preoperative Images by Ik Hyun Jo, Chang Nyol Paik, Hong Geun Ahn, Dong Do You, Jae Hyun Han, Hyun A Kim

“…Logistic regression analysis revealed larger polyps, increasing age, female sex, and lower platelet count to be associated with neoplastic polyps. …”
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Effect of frailty on the short-term functional outcome of elderly patients with traumatic brain injury by Yujing Gu, Huiqin Cui, Yang Gu, Xiaojiang Liu

“…[Results] Among the 127 elderly patients with traumatic brain injury, 48 cases had frailty.A total of 34 patients died during hospitalization, and 63 patients had poor neurological outcome at 3 months follow-up.Compared with the non-frailty group, the frailty group was older, had a higher mortality rate during hospitalization, and had a higher proportion of poor neurological prognosis at 3 months after onset (P<0.05).Multivariate logistics regression analysis shows that age >75 years old, higher Glasgow coma score and clinical frailty score ≥5 were independent risk factors for poor neurological prognosis in elderly patients with traumatic brain injury at 3 months onset.The results of the ROC curve indicated that the area under the curve of the Glasgow coma score predicting poor neurological prognosis in elderly patients with traumatic brain injury at 3 months after onset was 0.643 (95%CI:0.532-0.727), which was increased to 0.874 (95%CI:0.782-0.931) when indicators of patient age, Glasgow coma score and clinical frailty score were applied. …”
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Substitution of non-forage fibre sources for cereal grains and molasses in calf starter on performance and development of ruminal function by D.B. Vagnoni, C. Sousa, M.A. Messman

“…Total tract apparent NDF digestibility increased linearly with age but did not differ among diets. Blood concentrations of glucose and β-hydroxybutyrate (BHB) decreased and increased, respectively, with age. …”
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Side Effects and Patient Tolerance with the Use of Blood Flow Restriction Training after ACL Reconstruction in Adolescents: A Pilot Study by Jennifer Prue, Dylan P Roman, Nicholas G Giampetruzzi, Arthur Fredericks, Adel Lolic, Allison Crepeau, J. Lee Pace, Adam P Weaver

“… # Study Design Prospective Cohort Study # Methods Patients between 12 and 18 years of age who underwent ACLR at Connecticut Children’s were included. …”
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Nexus between risk factors and financial performance: The case of Ukrainian advertising and marketing companies by Tetiana Zavalii, Serhii Lehenchuk, Nina Poyda-Nosyk, Yana Ishchenko, Oleksandr Hrabchuk

“…Control variables (company age, company size, financial leverage, population at the place of company registration, and total solvency ratio) were added to enhance the determination level of the models. …”
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Choroidal Detachment after XEN Gel Stent Implantation by Carlo Alberto Cutolo, Letizia Negri, Sara Olivari, Francesca Cappelli, Carlo Enrico Traverso, Michele Iester

“…When carefully investigated, CD is a relatively common complication after XEN gel stent implant procedure. Older age, lower postoperative IOP, and higher number of preoperative IOP-lowering drugs were significantly associated with the development of CD.…”
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The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial by Marloes P. van der Aa, Vera Hoving, Ewoudt M. W. van de Garde, Antonius de Boer, Catherijne A. J. Knibbe, Marja M. J. van der Vorst

“…Nineteen patients (median age 14.3 (interquartile range 11.7–15.7) years, BMI 31.3 (28.8–33.8) kg/m2) treated in daily practice were compared to 23 patients receiving metformin in the RCT (age 13.6 (12.6–15.3) years, BMI 29.8 (28.1–34.5) kg/m2). …”
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P-glycoprotein and/or Histone Deacetylase 2 Regulates Steroid Responsiveness in Childhood Nephrotic Syndrome by Harshit Singh, Narayan Prasad, Durga Prasanna Misra, Akhilesh Kumar Jaiswal, Vikas Agarwal

“…Materials and Methods: Thirty-one patients were recruited at baseline (n = 31) (before initiating steroid therapy); after 6 weeks of steroid therapy, 24 patients achieved remission (steroid-sensitive NS [SSNS] n = 24 mean age, 7.96 ± 3.90), whereas seven patients were resistant to steroids (SRNS, n = 7, mean age 10.00 ± 3.55). mRNA expression of HDAC2 and P-gp and functional analysis of P-gp and enzymatic activity of HDAC2 were analyzed at baseline, and at 6 weeks of steroid treatment and at the time of relapse. …”
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Computerized Tomography-Based Volumetric Analysis Of The Maxillary, Sphenoid, And Frontal Sinuses: An Observational Study by Ashish Dhakal, Bikash Lal Shrestha, Monika Pokharel, Samip Shrestha, Subindra Karki, Krishna Sundar Shrestha

“…Results: The study included 154 patients, median age was 29 years (IQR: 22.75 - 39.25) and 84 (54.5%) were male. …”
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Global burden of colorectal cancer: epidemiology, risk factors by E. A. Medvedeva, G. G. Maryin, A. A. Leshchenko, M. V. Chernogorova, M. B. Dolgova, D. A. Nazarov, S. A. Ivanov

“…Most colon tumors develop as a result of a multistep process involving a number of histological, morphological and genetic changes, the frequency of detection of which increases with the age of the patient. Timely screening aimed at identifying and removing precancerous neoplasms in the early stages can lead to a significant reduction in the incidence of CRC. …”
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Severe Symptomatic Primary CMV Infection in Inflammatory Bowel Disease Patients with Low Population Seroprevalence by Catherine Rowan, Ciaran Judge, Mary D. Cannon, Garret Cullen, Hugh E. Mulcahy, Elizabeth Ryan, Cillian F. De Gascun, Glen A. Doherty

“…Patients presented with both gastrointestinal and extraintestinal symptoms. Mean age was 33 years, and median duration of disease was 72 months. …”
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