Effect of Electroacupuncture on Chondrocyte Apoptosis in Knee Osteoarthritis Rat Based on PI3K/Akt Signaling Pathway by Yuanyuan ZHANG, Xinyu JIANG, Xihai LI, Mingxia WU

“…Objective:To investigate the effect of electroacupuncture on chondrocyte apoptosis in knee osteoarthritis (KOA) rat based on PI3K/Akt signaling pathway.Methods:A total of 50 male Sprague Dawley (SD) rats, aged eight weeks, weighing (200±20) g were selected and randomly divided into sham operation group, model group, experiment group 1, experiment group 2 and experiment group 3. …”
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Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization by Tong Ni, Yu Sun, Zefeng Li, Tao Tan, Wei Han, Miao Li, Li Zhu, Jing Xiao, Huiying Wang, Wenpei Zhang, Yitian Ma, Biao Wang, Di Wen, Teng Chen, Justin Tubbs, Xiaofeng Zeng, Jiangwei Yan, Hongsheng Gui, Pak Sham, Fanglin Guan

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Trends in incidence and mortality of chronic obstructive pulmonary disease among residents of Xiamen city from 2012 to 2022: analysis of hospital records and death registration dat... by Youlan CHEN, Ahua WU, Moliang CHEN, Yilan LIN, Yanqi LAN, Qun LOU, Zhinan GUO

“…During the study period, the annual crude mortality rates (1/100 000) for COPD were 14.47, 16.19, 19.77, 24.66, 30.42, 33.05, 36.30, 38.39, 34.08, 40.37, and 45. 37 and the annual standardized mortality rates (1/100 000) of COPD were 14.74, 16.46, 19.07, 22.79, 28.23, 31.87, 35.16, 36.33, 30.75, 37.70, and 41.39, respectively; both the crude mortality rate (AAPC = 12.20%, t = 7.6, P < 0. 001) and the standardized mortality rate (AAPC = 10.60%, t = 5.7, P < 0.001) showed a significant increasing trend; further subgroup analysis showed that the increasing trend of the crude COPD mortality rate was significant for male and female residents and for residents aged 60 – 69, 70 – 79, and ≥ 80 years (all P < 0.05), and the increasing trend of standardized COPD mortality rate was significant for both male and female residents (both P < 0.05). …”
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Serum ALT activity and its isoenzymes as potential biomarkers for diagnosis of Sarcopenia in older adults: a retrospective, cross-sectional study by Jiangping Zeng, Nannan Li, Jiaying Ge, Huihui Ma, Siqi Sun, Yujie Jing, Chunhua Qian, Ran Cui, Shen Qu, Hui Sheng

“…Methods This retrospective study assessed 653 older adults (aged ≥ 55 years), 109 of whom were studied for the association of ALT1, ALT2, and ALT1/ALT2 ratio with sarcopenia measures. …”
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Influencing factors of venous thromboembolism in cancer patients and effect analysis of early nursing interventions (癌症患者静脉血栓栓塞症影响因素分析及早期护理干预效果观察)... by GUAN Lin (管玲), YU Jie (于洁)

“…There was no significant difference in the incidence of VTE between patients aged under 70 and over 70(P＞0. 05). The levels of D-dimer and thrombin-antithrombin III complex (TAT) in the patient with VTE was higher than those of patients without VTE (P＜0. 05). …”
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Adverse reactions of botulinum toxin type A for treating strabismus in children by E.E. Sidorenko, I.A. Ostanina, K.N.M. Rosel’o, D.V. Migel, E.I. Sidorenko

“…</i> </p> <p> <i><b>Patients and Methods: </b>212 children (424 eyes) aged seven months to 15 years with estab-lished strabismus were enrolled. …”
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Activated B Lymphocyte Inhibited the Osteoblastogenesis of Bone Mesenchymal Stem Cells by Notch Signaling by Mengxue Pan, Wei Hong, Ye Yao, Xiaoxue Gao, Yi Zhou, Guoxiang Fu, Yuanchuang Li, Qiang Guo, Xinxin Rao, Peiyuan Tang, Shengzhi Chen, Weifang Jin, Guoqiang Hua, Jianjun Gao, Xiaoya Xu

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The Combined Effect of Multisensory Stimulation and Therapist Support on Physical and Mental Health of Older Adults Living in Nursing Homes: Pilot Randomized Controlled Trial by Sewar Khatib, Yuval Palgi, Yoni K Ashar, Natalya Polyvyannaya, Pavel Goldstein

“…MethodsA total of 96 patients aged 65-99 years from a nursing home were randomly assigned to 3 groups: SS, TS, and combined SS+TS interventions, each delivered as four 20-minute sessions. …”
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Long-term trends and patterns in ultra-processed food consumption among Korean adults from 1998 to 2022 by Hyeseung Lee, Yesol Yim, Yerin Cho, Jiyeon Oh, Soeun Kim, Yejun Son, Hyesu Jo, Seohyun Hong, Masoud Rahmati, Hanseul Cho, Jiyoung Hwang, Dong Keon Yon

“…Dietary intake was assessed In 2020–2022, ultra-processed foods had a higher proportion using a single 24-hour recall for 96,447 individuals aged 20 years or older. Sampling weights were applied to adjust for the complex survey design and non-responses. …”
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Development of a Russian version of the Minnesota low vision reading chart by I.R. Stepanets, A.N. Kulikov, S.A. Koskin, D.I. Zhilchuk

“…Then, two versions of the test in Russian language (MNREAD-R) with different series of sentences were printed out and tested randomly in 30 subjects aged 18–22 years during one session. The reading parameters were assessed at a 40-cm distance; subjects were asked to read the charts for testing their monocular (right and left eyes) and binocular reading. …”
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Polypharmacy and self-medication among older adults in Indian urban communities—a cross-sectional study by Saibal Das, Pavithra Gnanavel, Shalini Smanla, Anku Moni Saikia, Shilpi Mishra, Shweta Khare, S. Arun Murugan, Vadanere Nidhi Prakash, Parimita Roychoudhury, Ishteyaque Ahmad, Vishal Diwan, J. Rajesh, K. Sathish Kumar, Jugal Kishore, Namita Srivastava, Sabrina Yasmin, Mahmuda Nasrin, Rinku Borah, Mandeep Sarma Basistha, Chetanjit Baruah, Manoj Kalita, Shambo Samrat Samajdar, Jerin Jose Cherian, Ashish Pathak, Samiran Panda, Santanu Kumar Tripathi, Cecilia Stålsby Lundborg

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How far back do we need to look to capture diagnoses in electronic health records? A retrospective observational study of hospital electronic health record data by Tom Marshall, Elizabeth Sapey, Miles D Witham, Steve Harris, Rachel Cooper, Chris Plummer, Felicity Evison, James Wason, Heather J Cordell, Suzy Gallier, Fiona E Matthews, Ewan Pearson, Avan A Sayer, Mervyn Singer, Joanne Field, Mohammed Osman, Sian Robinson, Victoria Bartle, Thomas Scharf, Jadene Lewis, Rominique Doal, Peta le Roux, Ray Holding, Paolo Missier

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Comparison of Long-Term Antibody Titers in Calves Treated with Different Conjunctival and Subcutaneous <i>Brucella abortus</i> S19 Vaccines by Ali Uslu, Zafer Sayın, Aslı Balevi, Yasin Gulcu, Fırat Ergen, Islam Akıner, Oguzhan Denizli, Osman Erganis

“…In this study, a total of 115 calves aged 3 to 4.5 months were created in five groups, with 23 animals in each group: group 1 (vaccine brand A), group 2 (vaccine brand B), and group 3 (vaccine brand C) received the two-dose conjunctival vaccine, group 4 received the single-dose subcutaneous vaccine (vaccine brand C), and group 5 received the subcutaneous vaccine (vaccine brand C) plus the booster dose conjunctival vaccine (vaccine brand B). …”
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Ultrasound investigation at examination of gastro-intestinal tract at combined trauma by A. S. Yermolov, O. A. Alekseyechkina, Ye. S. Vladimirova, G. P. Titova, V. M. Abuchina

“…Data of ultrasound investigations (US) in 48 patients with combined trauma (36 men, 12 women, aged 20–50 years) with disorders of gastro-intestinal function were analyzed. …”
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Dynamics of cortisol levels and the state of vitamin D supply during the full-scale war in Ukraine in patients with type 2 diabetes mellitus by M.I. Bobryk, V.I. Pankiv, V.M. Yerokhovych, V.S. Yuzvenko, D.Yu. Malyi, Yu.I. Komisarenko, L.V. Mikulets

“…In 2021–2024, a prospective study was conducted, which inclu­ded patients with T2DM and a glycated hemoglobin (HbA1c) level ≥ 7 %, individuals with insulin resistance without DM and people without DM aged 19–75 years. Exclusion criteria were as follows: T2DM with severe chronic complications, HbA1c level < 7 %, acute inflammatory processes, oncological diseases, body mass index ≥ 40 kg/m2, intake of antidepressants, vitamin D drugs less than 2 months before the study. …”
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STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer by Changli Qian, Gordon J Freeman, Tao Jiang, Ursula Matulonis, Ziying Lin, Hye-Jung Kim, Anniina Färkkilä, Hua Yu, Xin Cheng, Panagiotis A Konstantinopoulos, Antons Martincuks, Joyce F Liu, Qiwei Wang, Liya Ding, Michael J Kearns, Shaozhen Xie, Inga-Maria Launonen, Thomas M Roberts, Jean J Zhao

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Apolipoprotein C-II Mimetic Peptide Promotes the Plasma Clearance of Triglyceride-Rich Lipid Emulsion and the Incorporation of Fatty Acids into Peripheral Tissues of Mice by Tomohiro Komatsu, Toshihiro Sakurai, Anna Wolska, Marcelo J. Amar, Akiko Sakurai, Boris L. Vaisman, Denis Sviridov, Stephen Demosky, Milton Pryor, Katsunori Ikewaki, Alan T. Remaley

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Analyzing the serum biochemical factors that influence early neurological deterioration in ischemic Stroke patients and developing a nomogram prediction model by Xiaoni Zhan, Yunyun Xu, Rongrong Ma

“…The study's inclusion and exclusion criteria select patients aged 18+ with a first-time diagnosis of IS who undergo lab tests within 24 hours of admission while excluding those with multiple organ dysfunction, sensory impairments, coagulation disorders, or other serious medical conditions. …”
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Preservative-free therapy for glaucoma after corneal refractive surgery by A.A. Antonov, I.V. Kozlova, T.S. Mitichkina, I.I. Vedmedenko

“…As a result of an increased percentage of these patients and their aging, glaucoma is diagnosed more often in this group. …”
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Hubungan Konsumsi Makanan Fungsional Sumber Antioksidan dengan Fungsi Kognitif dan Kadar 4-Hydroxynonenal (4-HNE) Plasma Lansia by Widia Rahmawati, Nur Indrawati Lipoeto, Yuliarni Syafrit Syafrita

“…The sample</em><em>s</em><em> were choosen systematically and randomly in</em><em> </em><em>the population of elderly aged over 60 years with a sample of 134 people</em><em>s. …”
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