Unlocking the genetic potential of Ethiopian fenugreek (Trigonella foenum-graecum L.) genotypes for future breeding by Zebib Berhe, Tesfaye Awas, Asmare Dejen, Metadel Adane, Baye Akele, Musa Adal, Faris Hailu

“…The study covered a total of 168 informants (84 men and 84 women) comprising 72 general informants and 12 key informants per zone aged between 19 and 75 years. According to survey study fenugreeks is an important crop with many uses like as spice, food, fodder, and to treat different diseases. …”
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Cardiac and respiratory activities induce temporal changes in cerebral blood volume, balanced by a mirror CSF volume displacement in the spinal canal by Pan Liu, Kimi Owashi, Heimiri Monnier, Serge Metanbou, Cyrille Capel, Olivier Balédent

“…We examined 12 healthy volunteers (aged 20–34 years) using a clinical 3T MRI scanner to quantify cerebral blood flow at the intracranial level and CSF flow at the C2-C3 spinal level under free and deep breathing conditions, utilizing real-time phase-contrast sequences. …”
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Income Dynamics and Risk of Colorectal Cancer in Individuals With Type 2 Diabetes: A Nationwide Population-based Cohort Study by Yong-Moon Mark Park, Benjamin C. Amick III, Pearl A. McElfish, Clare C. Brown, Mario Schootman, Marie-Rachelle Narcisse, Seong-Su Lee, Yoon Jin Choi, Kyungdo Han

“…Methods: Using nationally representative data from the Korean Health Insurance Service database, 1,909,492 adults aged 30 to 64 years with T2DM and no history of cancer were included between 2009 and 2012 (median follow-up of 7.8 years). …”
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Utility of a novel point-of-care test for albuminuria in communities at high risk for chronic kidney disease in Thailand by Aminu K Bello, Kriang Tungsanga, Nattachai Srisawat, Kearkiat Praditpornsilpa, Somkanya Tungsanga, Rungrawee Nantanawijit, Patcharakorn Kiatamornrak, Win Kulvichit, Umphan Ngoensawat, Sasipa Tachaboon, Janejira Dinhuzen, Watchadaporn Chaisuriyong, Kittinan Komolpis, Sadudee Peerapornratana

“…The inclusion criteria were asymptomatic adult participants diagnosed with hypertension, diabetes and/or aged over 60 years. We measured serum creatinine and quantitative urine albumin–creatinine ratio (UACR) and administered POCT urine albumin strip test (Albii, K. …”
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Trends in palliative care utilization among older adult decedents with and without cancer in Taiwan: a population-based comparative studyResearch in context by Yu-Tai Lo, Tzu-Jung Chuang, Yu-Tung Huang, Yi-Lin Wu, Yi-Ching Yang, Chung-Yi Li

“…Methods: The study utilized data from the Health and Welfare Data Science Center in Taiwan, covering demographic and healthcare variables for 588,010 decedents aged 65+ years who died between 2010 and 2020. We used Poisson regression to investigate the temporal trends in palliative care utilization during the last six months of life. …”
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Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography by Guruprasad P Aithal, Indra Neil Guha, Stephen D Ryder, Emilie A Wilkes, David J Harman, Martin W James, Matthew Jelpke, Dominic S Ottey, Timothy R Card

“…Objectives To assess the feasibility of a novel diagnostic algorithm targeting patients with risk factors for chronic liver disease in a community setting.Design Prospective cross-sectional study.Setting Two primary care practices (adult patient population 10 479) in Nottingham, UK.Participants Adult patients (aged 18 years or over) fulfilling one or more selected risk factors for developing chronic liver disease: (1) hazardous alcohol use, (2) type 2 diabetes or (3) persistently elevated alanine aminotransferase (ALT) liver function enzyme with negative serology.Interventions A serial biomarker algorithm, using a simple blood-based marker (aspartate aminotransferase:ALT ratio for hazardous alcohol users, BARD score for other risk groups) and subsequently liver stiffness measurement using transient elastography (TE).Main outcome measures Diagnosis of clinically significant liver disease (defined as liver stiffness ≥8 kPa); definitive diagnosis of liver cirrhosis.Results We identified 920 patients with the defined risk factors of whom 504 patients agreed to undergo investigation. …”
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Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus by Leticia Elizondo-Montemayor, Adrian M. Gonzalez-Gil, Oscar Tamez-Rivera, Carla Toledo-Salinas, Mariana Peschard-Franco, Nora A. Rodríguez-Gutiérrez, Christian Silva-Platas, Gerardo Garcia-Rivas

“…A cross-sample of 40 Mexican children and adolescents aged 7-17 were recruited, 20 diagnosed with T2DM and 20 healthy controls. …”
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Long-term volume stability of steel slag sand mortar and concrete by Zhenhao Zhou, Qiang Jin, Di Hu, Lin Zhu, Zihua Li, Wanzhong Su

“…In this study, the rapid mortar bar method and alkaline-aggregate reaction method were used to compare the volumetric and apparent morphological changes in steel slag mortar and concrete under different curing conditions, with a focus on the effects of the steel slag sand aging time, substitution rate, particle size and curing conditions on the stability of steel slag sand. …”
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Value of routine blood count surveillance in detecting relapse in acute lymphoblastic leukemia by Sarah AlHarbi, Sarah AlHarbi, Areej Taha, Areej Taha, Ahmed Ashi, Ahmed Ashi, Naglla Elimam, Naglla Elimam, Sami Althubaiti, Sami Althubaiti, Sami Althubaiti

“…We aimed to evaluate the efficacy of routine blood testing for detecting relapse using a systematic method of assessing normal and abnormal results.MethodsThis a retrospective, single center study included children aged 1–14 years diagnosed with ALL who completed therapy and were in complete remission. …”
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Effects of oral Lcarnitine supplementation on liver enzymes in pediatric acute lymphoblastic leukemia patients in the maintenance phase of treatment: a randomized clinical trial st... by Aziz Eghbali, Aygin Eghbali, Neda Ashayeri, Fatemeh Fadayi, Kazem Ghaffari, Kazem Ghaffari, Kazem Ghaffari, Ali Ghasemi, Ali Ghasemi

“…BackgroundGiven that liver diseases and subsequent increases in liver enzymes are among the most frequent complications observed in leukemia patients treated with chemotherapeutic drugs, this study aimed to assess the impact of oral Lcarnitine supplementation on liver enzyme levels the maintenance phase of treatment for pediatric acute lymphoblastic leukemia (ALL) patients.MethodsIn this clinical trial, 100 pediatric patients aged >5 years were divided into two groups after obtaining informed consent. …”
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What are the cost-savings and health benefits of improving detection and management for six high cardiovascular risk conditions in England? An economic evaluation by Katy Cooper, Alan Brennan, David Bagguley, Helen Buckley Woods, Chloe Thomas, Penny Breeze, Michael Gillett, Edward Goka, Hazel Y Squires, Gilly Brenner, Joanna Leaviss, Mark Clowes, Laura Heathcote

“…Objectives To estimate the cost savings and health benefits of improving detection of individuals at high risk of cardiovascular disease (CVD) in England, to determine to which patient subgroups these benefits arise, and to compare different strategies for subsequent management.Design An economic analysis using the School for Public Health Research CVD Prevention Model.Setting England 2018.Participants Adults aged 16 and older with one or more high cardiovascular risk conditions, including hypertension, diabetes, non-diabetic hyperglycaemia, atrial fibrillation, chronic kidney disease and high cholesterol.Interventions Detection of 100% of individuals with CVD high risk conditions compared with current levels of detection in England. …”
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Association Between Screen Time and Lifestyle Parameters with Executive Functions in Chilean Children and Adolescents: Potential Mediating Role of Health-Related Quality of Life by Felipe Caamaño-Navarrete, Carlos Arriagada-Hernández, Lorena Jara-Tomckowiack, Jordan Hernandez-Martinez, Pablo Valdés-Badilla, Guido Contreras-Díaz, Indya del-Cuerpo, Pedro Delgado-Floody

“…<b>Methods</b>: A total of 511 children and adolescents (51.3% female) aged 10–17 years participated. Lifestyle parameters and EFs were evaluated. …”
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Interpretation of indoor air surveillance for respiratory infections: a prospective longitudinal observational study in a childcare settingResearch in context by Caspar Geenen, Steven Traets, Sarah Gorissen, Michiel Happaerts, Kurt Beuselinck, Lies Laenen, Jens Swinnen, Sien Ombelet, Joren Raymenants, Els Keyaerts, Emmanuel André

“…Concurrently, we collected the paper tissues used to wipe the noses of 23 regular attendees: children aged zero to three and childcare workers. All samples were tested for 29 respiratory pathogens using PCR. …”
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Flow cytometric characterisation of acute leukaemia in adolescent and adult Ethiopians by Jemal Alemu, Balako Gumi, Aster Tsegaye, Abdulaziz Sherif, Fisihatsion Tadesse, Amha Gebremedhin, Rawleigh Howe

“…Results: Of 140 cases aged 13 years to 76 years, 74 (53%) were men and 66 (47%) were women, 68 (49%) had acute lymphocytic leukaemia (ALL), 65 (46 %) had acute myelogenous leukaemia (AML), and 7 (5.0%) had acute leukaemia non-otherwise specified. …”
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Outpatient treatment of worsening heart failure with intravenous and subcutaneous diuretics: a systematic review of the literature by Eric Wierda, Cathelijne Dickhoff, Martin Louis Handoko, Liane Oosterom, Wouter Emmanuel Kok, Y. deRover, B.A.J.M. deMol, Loek vanHeerebeek, Jutta Maria Schroeder‐Tanka

“…Abstract Aims In the coming decade, heart failure (HF) represents a major global healthcare challenge due to an ageing population and rising prevalence combined with scarcity of medical resources and increasing healthcare costs. …”
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Trend in CT utilisation and its impact on length of stay, readmission and hospital mortality in Western Australia tertiary hospitals: an analysis of linked administrative data 2003... by Rachael Moorin, Max K Bulsara, Jenny Doust, David Youens, Donald Mcrobbie, John Slavotinek, Thi Ninh Ha, Cameron Wright, Sviatlana Kamarova

“…This study examined trends of CT during admission to tertiary hospitals and its associations with length of stay (LOS), readmission and mortality.Design Retrospective observational study from 2003 to 2015.Setting West Australian linked administrative records at individual level.Participants 2 375 787 episodes of tertiary hospital admission in adults aged 18+ years.Main outcome measures LOS, 30-day readmissions and mortality stratified by CT use status (any, multiple (CTs to multiple areas during episode), and repeat (repeated CT to the same area)).Methods Multivariable regression models were used to calculate adjusted rate of CT use status. …”
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Apallic syndrome of toxic origin: the diagnostic criteria by N.V. Kurdil, A.O. Volosovets, O.V. Ivashchenko, V.S. Lisovska, H.M. Balan, O.M. Rozhkova, V.V. Andriushchenko

“…A retrospective analysis of the medical data of six people aged 21–38 years with drug poisoning involving illegal methadone, psychostimulants, barbiturates and alcohol was carried out. …”
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Comparative evaluation of intravenous versus intranasal dexmedetomidine on emergence delirium and hemodynamics in pediatric patients undergoing adenotonsillectomy: a randomized con... by Chenxu Dai, Chenxu Dai, Xuemei Zhao, Xuemei Zhao, Aoxue Li, Xuedong Zhang, Penglei Wang, Ye Zhang, Yun Wu

“…This study aimed to evaluate the effects of intranasal versus intravenous dexmedetomidine on emergence recovery and hemodynamics in children undergoing adenotonsillectomy.MethodsA total of 139 children, aged 3–10 years, who were scheduled for elective adenotonsillectomy were randomly assigned to receive intravenous dexmedetomidine (IV DEX group) or intranasal dexmedetomidine (IN DEX group), or saline (control group) after anesthesia induction. …”
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Childhood contact with social services, self-harm and suicidal or self-harm ideation in young adulthood: a population-wide record-linkage study by S. McKenna, D. O’Reilly, E. Ross, A. Maguire

“…Results There were 253,495 individuals born 1985–1993 with full data, alive and resident in Northern Ireland during 2012–2015 (ages 18–30 years). Of all young adults that presented to EDs with self-harm or ideation, 40.9% had contact with social services in childhood. …”
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Interrelationships between social exclusion, mental health and wellbeing in adolescents: insights from a national Youth Survey by K. Filia, S. M. Teo, N. Brennan, T. Freeburn, D. Baker, V. Browne, A. Watson, J. Menssink, A. Prasad, E. Killackey, P. D. McGorry, S. M. Cotton, C. X. Gao

“…Methods Data were obtained from the Mission Australia 2022 Youth Survey, Australia’s largest annual population-wide survey of young people aged 15–19 years (n = 18,800). Participants’ experiences of social exclusion in different domains were explored (e.g., prevalence, co-occurrence and controlling for differences in demographic characteristics). …”
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