Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants by Margo Tuerlings, Evelyn Houtman, Elisa J.H. Muusers, Janneke Simon, Maurice W. de Haan, Ilja Boone, Yolande F.M. Ramos, Rachid Mahdad, Ingrid Meulenbelt

“…Abstract Objective To explore IL11 co-expression profiles in our previously reported RNA-sequencing dataset of OA articular cartilage, in interaction with IL6, and to investigate the effects of hrIL11 administration as potential therapeutic strategy for OA articular cartilage using our biomimetic aged human osteochondral explant model of OA. Methods We used RNA-sequencing datasets of macroscopically preserved and lesioned OA articular cartilage (N = 35 patients). …”
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Effect of COVID-19 lockdown on child protection medical assessments: a retrospective observational study in Birmingham, UK by Julie Taylor, Nutmeg Hallett, Malcolm Price, Joanna Garstang, Geoff Debelle, Indu Anand, Jane Armstrong, Emily Botcher, Helen Chaplin, Clare Morgans, Ern Ern Henna Tan, Emily Tudor

“…Objectives To determine any change in referral patterns and outcomes in children (0–18) referred for child protection medical examination (CPME) during the COVID-19 pandemic compared with previous years.Design Retrospective observational study, analysing routinely collected clinical data from CPME reports in a rapid response to the pandemic lockdown.Setting Birmingham Community Healthcare NHS Trust, which provides all routine CPME for Birmingham, England, population 1.1 million including 288 000 children.Participants Children aged under 18 years attending CPME during an 18-week period from late February to late June during the years 2018–2020.Main outcome measures Numbers of referrals, source of disclosure and outcomes from CPME.Results There were 78 CPME referrals in 2018, 75 in 2019 and 47 in 2020, this was a 39.7% (95% CI 12.4% to 59.0%) reduction in referrals from 2018 to 2020, and a 37.3% (95% CI 8.6% to 57.4%) reduction from 2019 to 2020. …”
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Surgical interventions for simple phakic fovea-splitting rhegmatogenous retinal detachment: a comparative study of scleral buckling and pars plana vitrectomy by Haiqin Zhu, Qintuo Pan, Zhaoliang Zhang, Zhaoliang Zhang, Zongduan Zhang, Zongduan Zhang, Xiaoyin Ma, Xiaoyin Ma, Xuting Hu, Xuting Hu

“…AimsTo compare the efficiency of scleral buckling (SB) and pars plana vitrectomy (PPV) with or without SB in patients with primary simple phakic fovea-splitting rhegmatogenous retinal detachment (RRD).MethodsA retrospective case–control study included 101 patients aged <55 years diagnosed with phakic fovea-splitting RRD. …”
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<i>Myrica rubra</i> Preharvest Treatment with Melatonin Improves Antioxidant and Phenylpropanoid Pathways During Postharvest Storage by Jun-Quan Chen, Yun-Shuang Ma, Hejiang Zhou, Rui-Xue Yu, Miao Xiong, Na Yang, Ji-Qiu Wang, Yang Tian, Ling-Yan Su

“…Melatonin has been reported to delay the aging and quality decline of various fruits and vegetables after harvest. …”
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Physico-chemical characterization of natural nano calcium extracted from different fish bones in catfish (Clarias gariepinus) and snakehead fish (Channa striata) by Sri Fatmawati, Siti Mualimatul Istiqomah, Nur Hasanah, Maria Elfiana Ina Kewa Helan, Mardi Santoso, Zjahra Vianita Nugraheni, Nurul Jadid, Annis Catur Adi, Heni Rachmawati

“…Amidst a rapidly aging population, osteoporosis, a condition that causes weakened, fragile bones due to deteriorating bone structure, has become a significant public health concern in Indonesia. …”
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Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia by Dong-Qing Yuan, Wei-Wei Zhang, Liu-Wei Gu, Qing-Huai Liu

“…METHODS: Twenty-one children with functional amblyopia, aged 5.7±2.1y (range: 4-10y), underwent comprehensive ophthalmic and refractive evaluations. …”
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Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease by Carolinne Thaísa de Oliveira Fernandes Miranda, Victor Hugo Rezende Duarte, Marina Sampaio de Menezes Cruz, Mychelle Kytchia Rodrigues Nunes Duarte, Jéssica Nayara Góes de Araújo, Ayda Maria Quirino Silva dos Santos, Juliana Marinho de Oliveira, Maria Sanali Moura Oliveira Paiva, Adriana Augusto Rezende, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata, Karla Danielly da Silva Ribeiro, André Ducati Luchessi, Vivian Nogueira Silbiger

“…Patients with coronary artery disease (n=177) aged 30–74 years, who underwent their first coronary angiography, were enrolled. …”
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Dietary Beliefs and Their Association with Overweight and Obesity in the Spanish Child Population by María Teresa Murillo-Llorente, Alma María Palau-Ferrè, María Ester Legidos-García, Javier Pérez-Murillo, Francisco Tomás-Aguirre, Blanca Lafuente-Sarabia, Adalberto Asins-Cubells, Miriam Martínez-Peris, Ignacio Ventura, Jorge Casaña-Mohedo, Marcelino Pérez-Bermejo

“…Methods: A cross-sectional study was conducted in 35 educational centers in 12 Spanish provinces, with a sample of 1131 children and adolescents aged 6 to 14 years. Anthropometric and sociodemographic data were collected, and dietary habits were assessed by means of questionnaires. …”
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Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population by Rocco Capuano, Federica Marchese, Raffaella Sica, Eduardo Capuano, Marzia Manilia, Anna Grazia Iannone, Alessandro D’Ambrosio, Alvino Bisecco, Gioacchino Tedeschi, Antonio Gallo, Vincenzo Capuano

“…The prevalence of 25(OH)D levels was evaluated in 1200 subjects aged 25–74 years (600 males and 600 females), enrolled in the “VIP” (from Italian for Irno Valley Prevention) Project, whereas multiple linear regression analysis was used to determine the relationship between 25(OH)D levels and CCV risk factors. …”
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Comparative study of Baduanjin and brisk walking on balance and stability in older adults by Ya-Guang Yu, Jun Zhang, Lin Wang, Dai-Feng Yu, Gong-Bing Shan, Xiao Fu

“…Sixty elderly individuals aged 65 to 79 were selected and randomly divided into the Baduanjin group, the brisk walking group, and the control group that did not engage in exercise. …”
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Passive hyperthermia alters the resting-state functional connectivity of mouse brain by Yang Ruan, Kai Liu, Bo Li, Shaowen Qian, Hongxia Lei, Yao Xing, Gang Sun

“…Purpose To investigate how passive hyperthermia affect the resting-state functional brain activity based on an acute mouse model after heat stress exposure.Materials and methods Twenty-eight rs-fMRI data of C57BL/6J male mice which weighing about 24 ∼ 29 g and aged 12 ∼ 16 weeks were collected. The mice in the hyperthermia group (HT, 40 °C ± 0.5 °C, 40 min) were subjected to passive hyperthermia before the anesthesia preparation for scanning. …”
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Preferences and access to community-based HIV testing sites among men who have sex with men (MSM) in Côte d’Ivoire by Christine Danel, Joseph Larmarange, Lazare Sika, Maxime Inghels, Arsène Kra Kouassi, Serge Niangoran, Anne Bekelynck, Séverine Carilon, Mariatou Koné, Annabel Degrées du Loû

“…Objective Measuring access and preferences to Men who have Sex with Men focused community-based HIV testing sites (MSM-CBTS) in Côte d’Ivoire.Design A respondent-driven sampling telephone survey.Setting National survey conducted in 2018 in Côte d’Ivoire.Participants 518 MSM aged over 18 years old.Primary and secondary outcome measures Knowledge, practices, satisfaction and preferences regarding MSM-CBTS. …”
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Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study by Samuel Suárez-Suárez, Fernando Cadaveira, Alfonso Barrós-Loscertales, José Manuel Pérez-García, Socorro Rodríguez Holguín, Javier Blanco-Ramos, Sonia Doallo

“…In this two-year follow-up study, the impact of sustained BD on RS-FC was investigated in 44 college students (16 binge-drinkers) via two fMRI sessions at ages 18–19 and 20–21. Using a seed-to-voxel approach, RS-FC differences were examined in nodes of the main brain functional networks vulnerable to alcohol misuse, according to previous studies. …”
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Provider Preference, Logistical Challenges, or Vaccine Hesitancy? Analyzing Parental Decision-Making in School Vaccination Programs: A Qualitative Study in Sydney, Australia by Leigh McIndoe, Alexandra Young, Cristyn Davies, Cassandra Vujovich-Dunn, Stephanie Kean, Michelle Dives, Vicky Sheppeard

“…This study investigates patterns of vaccine decision-making within Australia’s school-based immunization program, specifically focusing on human papillomavirus (HPV) and diphtheria-tetanus-pertussis (dTpa) vaccines offered free to adolescents aged 12–13. <b>Methods:</b> This qualitative study was conducted in the South Eastern Sydney Local Health District (2022–2023). …”
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Randomised cross-over trial of vildagliptin and pioglitazone as add-on therapy in patients with type 2 diabetes: predicting Which One is Right Here (WORTH) study protocol by Yannan Jiang, Tony R Merriman, Rui Qian Yeu, Rebecca Brandon, Dale Griffiths, Kate Smallman, Allan Moffitt, Glenn Doherty, Ryan Paul, Jennie Harré Hindmarsh, Kerry Macaskill-Smith, Brandon Orr-Walker, Rinki Murphy

“…It is conducted in New Zealand with a target of 300 patients (40% with Māori or Pacific ancestry) eligible if aged ≥18 and ≤80 years, with T2D for more than 1 year, on stable doses of metformin and/or sulfonylurea for at least 3 months, with HbA1c between 59 and 110 mmol/mol inclusive. …”
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Regulation of MAP2, GFAP, and calcium in the CA3 Region Following Kainic Acid Exposure to  organotypic hippocampal slice culture [version 3; peer review: 2 approved] by Aulanni'am Aulanni'am, Kusworini Handono, Ettie Rukmigarsari, Hidayat Sujuti, Machlusil Husna

“…Methods OHSC was obtained from three healthy wild type Wistar rats aged P10. Healthy culture slices were obtained and lasted up to 10 days in vitro (DIV 10). …”
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Effects of concave thoracoplasty on chest circumference and ventilatory function in adolescence with idiopathic scoliosis by Khaled Takey Ahmed, Abla Mohamed Hamed, Youssry El Hawary, Nesreen G. El-Nahas, Akram M. Helmy, Mohammed Hesham Aboelenien

“…Methods This study included thirty AIS patients of both genders, aged 12 to 18 years, who had a concave thoracoplasty with posterior correction. …”
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Association of geriatric nutritional risk index with renal prognosis and all-cause mortality among older patients with chronic kidney disease: a secondary analysis of CKD-ROUTE stu... by Lei Chen, Mengyao Yan, Jie Li, Xue Zhao, Lu Zeng, Zhumei Gao, Hongli Jiang, Limin Wei

“…Objectives The aim of the study was to assess the association between the geriatric nutritional risk index (GNRI) and incidence of CKD progression, all-cause mortality, and cardiovascular events in the elderly patients with chronic kidney disease (CKD) before dialysis initiation.Methods We performed a post hoc analysis of the CKD-ROUTE database, which included 538 pre-dialysis CKD patients aged ≥65 years in this prospective cohort study. …”
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Clinical course of spinal pain in adolescents: a feasibility study in a chiropractic setting by Steven J Kamper, Christopher G Maher, Mark J Hancock, Simon D French, Lise Hestbæk, Katherine A Pohlman, Michael S Swain, Laura RC Montgomery, Anika Young, Amber Beynon

“…Design Prospective feasibility study.Objectives To inform the design and conduct of a large-scale clinical cohort study investigating adolescents with moderate-to-severe spinal pain.Setting Chiropractic care in Sydney, Australia.Participants Adolescents aged 12–17 years with spinal pain (≥4/10 pain intensity score).Methods Adolescents and chiropractors completed baseline and week-12 follow-up questionnaires, with adolescents reporting pain intensity and recovery weekly via text messages during weeks 1–11. …”
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Socioeconomic status has direct impact on asthma control: Turkish adult asthma registry by Bahar Arslan, Murat Türk, Serhat Hayme, Ömür Aydin, Derya Gokmen, Gozde Koycu Buhari, Zeynep Celebi Sozener, Bilun Gemicioglu, Ismet Bulut, Sengul Beyaz, Cihan Orcen, Secil Kepil Ozdemir, Metin Keren, Ebru Damadoglu, Tugce Yakut, Ayse Fusun Kalpaklioglu, Ayse Baccioglu, Sumeyra Alan Yalim, Insu Yilmaz, Ilkay Koca Kalkan, Elif Yelda Ozgun Niksarlioglu, Ali Fuat Kalyoncu, Gul Karakaya, Muge Erbay, Sibel Nayci, Fatma Merve Tepetam, Asli Akkor Gelincik, Hulya Dirol, Ozlem Goksel, Selen Karaoglanoglu, Ferda Oner Erkekol, Sacide Rana Isik, Fusun Yildiz, Yasemin Yavuz, Dilek Karadogan, Nurgul Bozkurt, Ummuhan Seker, Ipek Kivilcim Oguzulgen, Ilknur Basyigit, Serap Argun Baris, Elif Yilmazel Ucar, Tuba Erdogan, Mehmet Polatli, Dane Ediger, Fatma Esra Gunaydin, Leyla Pur, Zeynep Yegin Katran, Yonca Sekibag, Enes Furkan Aykac, Dilsad Mungan, Ozcan Gul, Ali Cengiz, Bulent Akkurt, Seyma Ozden, Semra Demir, Derya Unal, Ayse Feyza Aslan, Ali Can, Reyhan Gumusburun, Gulhan Bogatekin, Hatice Serpil Akten, Sinem Inan, Munevver Erdinc, Aliye Candan Ogus, Murat Kavas, Demet Polat Yulug, Mehmet Erdem Cakmak, Saltuk Bugra Kaya, Gulistan Alpagat, Eylem Sercan Ozgur, Oguz Uzun, Sule Tas Gulen, Gulseren Pekbak, Deniz Kizilirmak, Yavuz Havlucu, Halil Donmez, Gulden Pacaci Cetin, Sadan Soyyigit, Bilge Yilmaz Kara, Gulden Pasaoglu Karakis, Adile Berna Dursun, Resat Kendirlinan, Ayse Bilge Ozturk, Can Sevinc, Gokcen Omeroglu Simsek, Oznur Abadoglu, Pamir Cerci, Taskin Yucel, Irfan Yorulmaz, Zahide Ciler Tezcaner, Emel Cadalli Tatar, Ahmet Emre Suslu, Serdar Ozer, Engin Dursun, Arzu Yorgancioglu, Gulfem Elif Celik, Mehmet Atilla Uysal

“…Results Illiteracy (OR:2.687 [95% CI: 1.235–5.848]; p = 0.013) and lower household income (OR:1,76 [95% CI: 1.002–3.09]; p = 0.049) were found as independent risk factors for hospitalization in the multivariate logistic regression analysis. Therewithal, being aged between 40 and 60 (OR: 1.435 [95% CI: 1.074–1.917]; p = 0.015), illiteracy (OR: 2.188 [95% CI: 1.262–3.795]; p = 0.005) and being employed (OR: 1.466 [95% CI: 1.085–1.847]; p = 0.011) were considered as independent risk factors for systemic corticosteroid use at least 3 days within last 1 year. …”
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