Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD by Shaowei Wang, Boyang Li, Jie Li, Zhiheng Cai, Cristelle Hugo, Yi Sun, Lu Qian, Julia TCW, Helena C. Chui, Dante Dikeman, Isaac Asante, Stan G. Louie, David A. Bennett, Zoe Arvanitakis, Alan T. Remaley, Bilal E. Kerman, Hussein N. Yassine

“…Abstract Background Cellular senescence, a hallmark of aging, has been implicated in Alzheimer’s disease (AD) pathogenesis. …”
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Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study by Xiaoying Ding, Ying Xu, Yufan Wang, Xiaohua Li, Chunhua Lu, Jing Su, Yuhang Ma, Yuting Chen, Yanhua Yin, Lijun Zhang, Yong Wu, Yaqiong Jin, Lijun Zheng, Songmei Xu, Xiuli Zhu, Jilin Ma, Lihua Yu, Junyi Jiang, Naisi Zhao, Qingwu Yan, Andrew S. Greenberg, Qianfang Huang, Qian Ren, Haiyan Sun, Mingyu Gu, Li Zhao, Yunhong Huang, Yijie Wu, Chunxian Qian, Yongde Peng

“…A total of 9473 subjects aged over 45 years, including 1648 patients with T2DM, were enrolled in this cross-sectional study. …”
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Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment by Wenxiu Yuan, Jiaqi Liu, Zhenzhen Zhang, Chengxinyue Ye, Xueman Zhou, Yating Yi, Yange Wu, Yijun Li, Qinlanhui Zhang, Xin Xiong, Hengyi Xiao, Jin Liu, Jun Wang

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Perspectives on the use of decellularized/devitalized and lyophilized human perinatal tissues for bone repair: Advantages and remaining challenges by Lauriana Solecki, Mathilde Fenelon, Halima Kerdjoudj, Roberta Di Pietro, Gianmarco Stati, Camille Gaudet, Eugenie Bertin, Jeremie Nallet, Aurélien Louvrier, Thomas Gualdi, Jessica Schiavi-Tritz, Florelle Gindraux

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Genome-wide association study unravels mechanisms of brain glymphatic activity by Shu-Yi Huang, Yi-Jun Ge, Peng Ren, Bang-Sheng Wu, Weikang Gong, Jing Du, Shi-Dong Chen, Ju-Jiao Kang, Qing Ma, Arun L. W. Bokde, Sylvane Desrivières, Hugh Garavan, Antoine Grigis, Herve Lemaitre, Michael N. Smolka, Sarah Hohmann, IMAGEN Consortium, Jian-Feng Feng, Ya-Ru Zhang, Wei Cheng, Jin-Tai Yu

“…Genetic signals located at the 2p23.3 locus yielded significantly concordant effects in both young and aging cohorts. Genetic correlation and polygenic overlap analyses indicate a common underlying genetic mechanism between the ALPS-index, ventricular volumes, and cerebrospinal fluid tau levels, with GMNC (3q28) and C16orf95 (16q24.2) as the shared genetic basis. …”
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Assessment of a youth climate empowerment program: Climate READY by R. L. Wellman, A. Henderson, R. Coleman, C. Hill, B. T. Davey

“…</p></li><li> <p id="d2e159">An after-school mentorship (fall semester 2) component paired new Climate READY Ambassadors with fourth- and fifth-grade after-school students ages 9 to 11 years old to build community resilience awareness through four structured lessons and the creation of storybooks. …”
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Morphological evaluations in buffaloes (Bubal- us bubalis) in Venezuela by Luis Alfredo Pacheco-Díaz, José Atilio Aranguren-Méndez, Rafael Román-Bravo, Sharon Rivero-Hernández, Luis Edgardo Tovar-Briceño

“…This phenotypic characterization of buffaloes comprised quantitative and qualitative traits of 157 female buffaloes aged 24 to 48 months and 21 males aged 18 to 36 months. …”
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Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled... by Eva Skovlund, Rune Haaverstad, Henrik Zetterberg, Jorunn L Helbostad, Rolf Busund, Johan Raeder, Theis Tønnessen, Torgeir Bruun Wyller, Melanie R Simpson, Nils Kristian Skjærvold, Bjørn Erik Neerland, Svein Aslak Landsverk, Ieva Martinaityte, Hilde Margrethe Norum, Geir Selbaek, Elisabeth Skaar, Arjen JC Slooter, Øyvind Sverre Svendsen, Alexander Wahba

“…We aim to study whether repurposing of clonidine can represent a novel treatment option for delirium, and the possible effects of dexmedetomidine and clonidine on long-term cognitive trajectories, motor activity patterns and biomarkers of neuronal injury, and whether these effects are associated with frailty status.Methods and analysis This five-centre, double-blind randomised controlled trial will include 900 cardiac surgery patients aged 70+ years. Participants will be randomised 1:1:1 to dexmedetomidine or clonidine or placebo. …”
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Assessment of clinical prognosis in autoimmune encephalitis: Girona score by Gary Álvarez Bravo, Giuseppe Guglielmini, Ana Quiroga Varela, Almudena Boix Lago, Ariadna Gifreu Fraixinó, Daniele Urso, Daniele Urso, Daniele Urso, Daniele Urso, Giancarlo Logroscino, Giancarlo Logroscino, Giancarlo Logroscino, Giancarlo Logroscino, Lluís Ramió-Torrentà

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Donors With Previous Malignancy: When Is It Safe to Proceed With Organ Transplantation? by Vitor Turra, Joao Manzi, Sarah Rombach, Simone Zaragoza, Raphaella Ferreira, Giselle Guerra, Kendra Conzen, Trevor Nydam, Alan Livingstone, Rodrigo Vianna, Phillipe Abreu

“…In 2022, 7% of all donors were aged 65 and above, despite the complexities their medical histories may introduce, particularly the risk of donor-transmitted cancer (DTC). …”
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Application of Traditional Chinese Medicine nursing technology in rehabilitation nursing of stroke hemiplegia patients (中医护理技术在脑卒中偏瘫患者康复护理中的应用研究论述)... by BU Mengdi (卜梦笛), YANG Le (杨乐)

“…With the continuous progress of China’s aging population, the number of stroke patients is increasing. …”
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Spoofing detection on adaptive authentication System‐A survey by Hind Baaqeel, Sunday Olusanya Olatunji

“…Although biometric systems usually provide efficient solutions, the recognition performance tends to be affected over time due to changing conditions and the ageing of biometric data, which results in intra‐class variability. …”
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Synthesis of Orange Colored Silica Gel Based on Rice Husk Ash by Using Iron Salt Indicator by Pooneh Abachi, Reza Khoshbin, Ramin Karimzadeh

“…The BET surface area of orange silica gels synthesized from commercial sodium silicate and RHA (Aging time = 24 hours) was found to be 248.6 and 179.86 m2/gr, respectively but the high Smeso/Smicro in silica gel from rice husk ash contributes to its suitable moisture adsorption capacity compared to silica gel from industrial sodium silicate.…”
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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids by Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu

“…Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). …”
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Quantifying the Impact of Obesity Category on Major Chronic Diseases in Canada by Ying Jiang, Yue Chen, Douglas Manuel, Howard Morrison, Yang Mao, Obesity Working Group

“…We grouped overweight/obese participants aged 18 years and over into four levels based on body mass index (BMI, kg/m2): overweight (25.0– 29.9), class I obesity (30.0–34.9), class II obesity (35–39.9), and class III obesity (extreme/clinical obesity, BMI ≥ 40.0). …”
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Professional Strategies of University Teachers: Neo-Weberian Ideas in the Realities of Russian Higher Education by A. V. Garmonova, E. A. Opfer, D. V. Shcheglova, S. V. Gavrilov

“…This increases the risk of a decrease in the quality of higher education due to the ageing of teaching staff.The authors conclude that “social closure” of the teaching profession is legalized, while maintaining the status quo and agreeing with the rigid regulatory framework in the neo-Weberian tradition.…”
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An Action Research on Improving Parents’ Digital Advertising Literacy Skills by Ahmet Ayhan, Hediye Aydoğan

“…For this purpose, the action research model, which is one of the qualitative research methods, was adopted in the study and a 12-hour digital-based training was conducted with the participation of seven parents with children between the ages of 7 and 13 living in Antalya. Semi-structured interview was used to collect research data. …”
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The mediating role of physical activity and quality of life in the association between knee osteoarthritis-related symptoms and physical function of post-COVID patients in Metro Ma... by Donald Manlapaz, Jon Timothy Rivero, Eliana Caris Cabildo, Jeremy Christian Advincula, Marc Angelo Aquino, Miguel Gabriel De la Paz, Maria Paulina Duldulao, Andrea Amor Maravilla, Cyd Ahnilark Montera, Kent Stefon Tee

“…However, there is a scarcity of studies relating to knee OA during the COVID-19 pandemic, particularly its impact on symptoms and quality of life.Methods This analytic cross-sectional study design will recruit participants aged 40 and above from Metro Manila with knee pain and COVID-19 history. …”
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Evaluating modified atmosphere with variable CO₂-O₂ concentrations for Tribolium castaneum management and quality preservation in Rice storage by Xue Dong, Ming Yang, Peian Tang

“…Quality assessments revealed that TD effectively mitigated lipid oxidation by reducing aldehydes and alcohols, major contributors to rice aging and off-flavors while maintaining acceptable enzymatic activities and VOC profiles. …”
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The Multicomponent Anthropometric Model for Assessing Body Composition in a Male Pediatric Population: A Simultaneous Prediction of Fat Mass, Bone Mineral Content, and Lean Soft Ti... by Dalmo Machado, Sérgio Oikawa, Valdir Barbanti

“…The newly proposed model represents an alternative to accurately assess the body composition in male pediatric ages.…”
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