The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization by Annekatrin Richter, Hanna Mörl, Maria Thielemann, Markus Kleemann, Raphael Geißen, Robert Schwarz, Carolin Albertz, Philipp Koch, Andreas Petzold, Torsten Kroll, Marco Groth, Nils Hartmann, Amaury Herpin, Christoph Englert

“…Here, we demonstrate that the Y-chromosomal copy of the TGF-β family member gdf6 (gdf6Y) in Nothobranchius furzeri, an emerging model organism in aging research, gained the function of the male sex determinant through allelic diversification while retaining the skeletal developmental function shared with the X-chromosomal gdf6 allele (gdf6X). …”
Get full text

Microstructure development during thermomechanical treatment of Al-Mg-Si alloy by Martinova Z., Zlateva G.

“…The effect of natural aging and 95% cold deformation on the microstructure evolution and aging characteristics in commercial Al - 1 mass % Mg2Si alloy subjected to thermomechanical treatment (TMT) was examined. …”
Get full text

UFMylation maintains YAP stability to promote vascular endothelial cell senescence by Yanan Liu, Min Zuo, Aiwei Wu, Zhaoxiang Wang, Siting Wang, Yongping Bai, Junzhi Zhou, Hu Wang

“…Summary: Endothelial cell (EC) senescence is an accomplice for vascular aging, which leads to cardiovascular diseases (CVDs). …”
Get full text

Synergetic Effect of Nano-ZnO and Trinidad Lake Asphalt for Antiaging Properties of SBS-Modified Asphalt by Yiqun Zhan, Jun Xie, Yulin Wu, Yifan Wang

“…Several tests were conducted after adding nano-ZnO and TLA to SBS-modified asphalt, including a rotary film oven test (RTFOT), ultraviolet aging (UV), and the pressure aging vessel test (PAV). …”
Get full text

Effects of Different Types of Cognitive Training on Cognitive Function, Brain Structure, and Driving Safety in Senior Daily Drivers: A Pilot Study by Takayuki Nozawa, Yasuyuki Taki, Akitake Kanno, Yoritaka Akimoto, Mizuki Ihara, Ryoichi Yokoyama, Yuka Kotozaki, Rui Nouchi, Atsushi Sekiguchi, Hikaru Takeuchi, Carlos Makoto Miyauchi, Takeshi Ogawa, Takakuni Goto, Takashi Sunda, Toshiyuki Shimizu, Eiji Tozuka, Satoru Hirose, Tatsuyoshi Nanbu, Ryuta Kawashima

Get full text

Inflammatory biomarkers profiles and cognition among older adults by Aline Thomas, Jing Guo, Dolly Reyes-Dumeyer, Danurys Sanchez, Nikolaos Scarmeas, Jennifer J. Manly, Adam M. Brickman, Rafael A. Lantigua, Richard Mayeux, Yian Gu

“…Abstract Inflammation plays a major role in cognitive aging. Most studies on peripheral inflammation and cognitive aging focused on selected major inflammatory biomarkers. …”
Get full text

Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy by Shixue Chen, Lingling Li, Fan Zhang, Yu Wang, Yi Hu, Lei Zhao

Get full text

Advanced Glycation End Products Play Adverse Proinflammatory Activities in Osteoporosis by Roberta Sanguineti, Alessandra Puddu, François Mach, Fabrizio Montecucco, Giorgio Luciano Viviani

“…Osteoporosis is a major public health burden that is expected to further increase as the global population ages. In the last twenty years, advanced glycation end products (AGEs) have been shown to be critical mediators both in the pathogenesis and development of osteoporosis and other chronic degenerative diseases related to aging. …”
Get full text

Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…Individuals of advanced age or with severe life-limiting comorbidities separate from their end-stage organ failure are less likely to survive after receiving an allograft or a research xenograft. …”
Get full text

Change of Accent as an Atypical Onset of non Fluent Primary Progressive Aphasia by Susy Paolini, Lucia Paciaroni, Antonio Manca, Roberto Rossi, Daniela Fornarelli, Stefano F. Cappa, Angela M. Abbatecola, Osvaldo Scarpino

Get full text

Nonfluent/Agrammatic PPA with In-Vivo Cortical Amyloidosis and Pick’s Disease Pathology by Francesca Caso, Benno Gesierich, Maya Henry, Manu Sidhu, Amanda LaMarre, Miranda Babiak, Bruce L. Miller, Gil D. Rabinovici, Eric J. Huang, Giuseppe Magnani, Massimo Filippi, Giancarlo Comi, William W. Seeley, Maria Luisa Gorno-Tempini

Get full text

Vascular Effects of Dietary Advanced Glycation End Products by Alin Stirban, Diethelm Tschöpe

“…AGEs originating from diet have a significant contribution to the AGEs body pool and therefore dietary interventions aiming at reducing AGEs load are believed to exert health promoting effects. …”
Get full text

Microstructural Evolution during Thermal Exposure of G115 Steel and Its Influence on Mechanical Properties by Shaohai Ma, Kai Yan, Chang Che, Xisheng Yang, Gong Qian

“…In this paper, the microstructural stability and strength as well as impact toughness were investigated after aging at 650°C and 700°C up to 5000 h. It was found that when aged at 650°C in the G115 steel, the size of M23C6 carbides and the width of martensitic laths had little change even increasing aging time up to 5000 h. …”
Get full text

Effects of Fast Simple Numerical Calculation Training on Neural Systems by Hikaru Takeuchi, Tomomi Nagase, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Rui Nouchi, Ryuta Kawashima

Get full text

Dickens et Gaskell ou les difficultés mid-victoriennes à dire le vieillir by Marianne Camus

“…The analysis of the representation of ageing will be limited to the midVictorian period and centred on the works of Charles Dickens and Elizabeth Gaskell. …”
Get full text

CHAMP1 premature termination codon mutations found in individuals with intellectual disability cause a homologous recombination defect through haploinsufficiency by Yujiro Yoshizaki, Yunosuke Ouchi, Dicky Kurniawan, Eisuke Yumoto, Yuki Yoneyama, Faiza Ramadhani Rizqullah, Hiyori Sato, Mirjam Hanako Sarholz, Toyoaki Natsume, Masato T. Kanemaki, Masanori Ikeda, Ayako Ui, Kenji Iemura, Kozo Tanaka

Get full text

Heterologous vaccination with subunit protein vaccine induces a superior neutralizing capacity against BA.4/5‐included SARS‐CoV‐2 variants than homologous vaccination of mRNA vacci... by Dandan Peng, Tingmei Zhao, Weiqi Hong, Minyang Fu, Cai He, Li Chen, Wenyan Ren, Hong Lei, Jingyun Yang, Aqu Alu, Yanghong Ni, Jian Liu, Jiong Li, Wei Wang, Guobo Shen, Zhiwei Zhao, Li Yang, Jinliang Yang, Zhenling Wang, Yoshimasa Tanaka, Guangwen Lu, Xiangrong Song, Xiawei Wei

Get full text

Different Planting Media in Barangan Banana (Musa Acuminata Colla) Breeding in Southeast Aceh by Nico Syahputra Sebayang, Diah Eka Puspita, Surya Basri

“…Parameters observed were plant height aged 2, 4, 6 and 8 weeks after planting (WAP), stem diameter aged 2, 4, 6 and 8 WAP and number of leaves aged 2, 4, 6 and 8 WAP. …”
Get full text

Enhanced Hepatocarcinogenicity Due to Agonists of Peroxisome Proliferator-Activated Receptors in Senescent Rats: Role of Peroxisome Proliferation, Cell Proliferation, and Apoptosis by Jihan Youssef, Mostafa Badr

“…In addition, aged livers showed remarkably higher levels of the antiapoptotic protein Bcl-2 than livers of young, adult, and middle-aged animals. …”
Get full text

Care partner experience with telepresence robots in long-term care during COVID-19 pandemic by Grace Hu, Joey Wong, Lily Haopu Ren, Sarah Kleiss, Annette Berndt, Lily Wong, Ali Hussein, Nazia Ahmed, Jim Mann, Lillian Hung

Get full text