Association of clinical signs of possible serious bacterial infections identified by community health workers with mortality of young infants in South Asia: a prospective, observat... by Gary L. Darmstadt, Saifuddin Ahmed, Mohammad Shahidul Islam, Safa Abdalla, Shams El Arifeen, Melissa L. Arvay, Abdullah H. Baqui, Zulfiqar A. Bhutta, Anuradha Bose, Nicholas E. Connor, Belal Hossain, Rita Isaac, Arif Mahmud, Dipak K. Mitra, Luke C. Mullany, Imran Nisar, Kalpana Panigrahi, Pinaki Panigrahi, Qazi Sadeq-ur Rahman, Senjuti Saha, Sajid B. Soofi, Nardos Solomon, Mathuram Santosham, Stephanie J. Schrag, Shamim A. Qazi, Samir K. Saha

“…Findings: CHWs made 522,309 visits to assess 63,017 young infants and found ≥1 sign(s) of PSBI at 14,245 visits (2.7%), including 5.8% (5568 of 96,390) and 1.8% (6635 of 365,769) of visits of infants 0–<3 and 7–<60 days of age, respectively. Each of the seven signs of PSBI when found alone was associated with significantly (p < 0.0001) increased risk for mortality, which increased further if any other additional sign of PSBI was found concurrently. …”
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Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in context by Jusen Nong, Cheng Su, Changhua Li, Congjun Wang, Wei Li, Yong Li, Peng Chen, Yanqiang Li, Zihao Li, Xinjin She, Zuxin Yuan, Sentian Liu, Chao Chen, Qian Liao, Yige Luo, Bo Shi

“…Methods: The study utilized data from the Global Burden of Disease (GBD) database to analyze neuroblastoma incidence, mortality, and DALYs in children aged 0–14 years. Rates for incidence, mortality, and DALYs were calculated per 100,000 population, with 95% uncertainty intervals (UIs). …”
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GATA2 mutated allele specific expression is associated with a hyporesponsive state of HSC in GATA2 deficiency syndrome by Laetitia Largeaud, Vincent Fregona, Laura A. Jamrog, Camille Hamelle, Stéphanie Dufrechou, Naïs Prade, Esmaa Sellam, Pauline Enfedaque, Manon Bayet, Sylvie Hébrard, Mathieu Bouttier, Christine Didier, Bastien Gerby, Eric Delabesse, Marlène Pasquet, Cyril Broccardo

“…Employing molecular and functional approaches, we investigated the mutation’s impact on hematopoiesis, revealing significant alterations in the hematopoietic stem and progenitor (HSPC) compartment in young age. These include increased LT-HSC numbers, reduced self-renewal potential, and impaired response to acute inflammatory stimuli. …”
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Analysis on the status quo and influencing factors of work engagement of neurology nurses (神经科护士工作投入的现状及影响因素分析) by FU Jing (富晶), Li Jing (苏娅丽), SU Yali (夏小童), ZHAO Rui (赵彬彬), ZHAO Binbin (许继飞), MA Shengwei (刘宇)

“…The results of univariate analysis showed that there were statistically significant differences in the scores of work engagement of neurology nurses in terms of age, employment relationship, technical title, working years and children's situation (P＜0. 05). …”
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Profil Kasus Tuberkulosis Paru di Instalasi Rawat Inap Paru RSUP Dr. M. Djamil Padang Periode 1 Januari 2010 - 31 Desember 2011 by Muhammad Gamal Eddin, Oea Khairsyaf, Elly Usman

“…PTB with negatif acid-fast bacilii (AFB) (60%) is the most calassification of PTB. Male (72%), age 20- 29 years old (27%), senior high school graduated (47%), unemployed (33%) are the most characteristic followed by smoke on male (64%) and severe low body weigh of nutritional status (53%). …”
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Initial clinical experience with [177Lu]Lu-PNT2002 radioligand therapy in metastatic castration-resistant prostate cancer: dosimetry, safety, and efficacy from the lead-in cohort o... by Aaron R. Hansen, Stephan Probst, Jean-Mathieu Beauregard, Benjamin L. Viglianti, Jeff M. Michalski, Scott T. Tagawa, Oliver Sartor, Ronald F. Tutrone, Orhan K. Oz, Kevin D. Courtney, Ebrahim S. Delpassand, Luke T. Nordquist, Medhat M. Osman, Kim N. Chi, Richard Sparks, Noble George, Sara M. Hawley, Wenting Wu, Jessica D. Jensen, Neil E. Fleshner

“…Dosimetry (planar + SPECT/CT [n=7]; planar only [n=20]), safety, prostate-specific antigen (PSA) response, objective response rate (ORR), and radiographic progression-free survival (rPFS) per blinded independent central review were assessed.ResultsOf 34 individuals screened, 32 underwent PSMA-PET/CT; 27 met all eligibility criteria. Median (range) age was 72 (57-86) years; all participants were enrolled in North America; 40.7% initiated prior ARPI treatment without distant metastases (M0) and 25.9% while hormone sensitive. …”
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Changing Treatment and Metastatic Disease Patterns in Patients with EGFR Mutated NSCLC: An Academic Thoracic Medical Investigator’s Consortium Registry Analysis by Margaret Stalker, MD, Connor B. Grady, MPH, Alex Watts, MS, Wei-Ting Hwang, PhD, Krishna Chandrasekhara, MS, Fangdi Sun, MD, Geoffrey Liu, MD, Devalben Patel, MD, Jorge Nieva, MD, Amanda Herrmann, MD, Kristen Marrone, MD, Vincent K. Lam, MD, Vamsidhar Velcheti, MD, Stephen V. Liu, MD, Gabriela Liliana Bravo Montenegro, MD, William Tompkins, MD, Tejas Patil, MD, Jared Weiss, MD, Kelsey Leigh Miller, MD, William Schwartzman, MD, Jonathan E. Dowell, MD, Khvaramze Shaverdashvili, MD, PhD, Liza Villaruz, MD, Amanda Cass, PharmD, Wade Iams, MD, Dara Aisner, MD, PhD, Charu Aggarwal, MD, MD, D. Ross Camidge, MD, PhD, Lova Sun, MD, Melina E. Marmarelis, MD

“…Results: The full cohort included 1132 patients and the mean age of the participants was 63.4 years; among the participants, 53% were White individuals, 68% were female individuals, and 67% were nonsmokers. …”
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STRUCTURAL AND FUNCTIONAL STATE OF THE MYOCARDIUM AND SYSTEMIC INFLAMMATION ACTIVITY IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN THE PRESENCE OF ARTERIAL H... by Rostyslav Kovalchuk, Uliana Bahan

“…The study included 68 patients with STEMI aged 45 to 83 years (mean age 63,80±9,30 years) who underwent primary percutaneous coronary intervention with stenting of the infarcted coronary artery within 24 hours of the onset of clinical manifestations. …”
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Características clínicas y tratamiento farmacológico de los pacientes con insuficiencia cardíaca en una cohorte de atención primaria by Maria Giner-Sorian, Ramon Monfà, Roser Vives, Silvia Fernández-García, Antoni Vallano, Rosa Morros

“…The HfrEF group consisted mostly of men (59.5%), with a mean age of 74.8 years, and the others of women (58.8% and 54.6%, aged 78.7 and 80.6 years, respectively). …”
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Implementation of in utero laparotomy-assisted fetoscopic spina bifida repair in two centers in Latin America: rationale for this approach in this regionAJOG Global Reports at a Gl... by Jezid Miranda, PhD, Miguel A. Parra-Saavedra, PhD, William O. Contreras-Lopez, PhD, Cristóbal Abello, MD, Guido Parra, MD, Juan Hernandez, MD, Amanda Barrero, MD, Isabela Leones, MD, Adriana Nieto-Sanjuanero, MD, Gerardo Sepúlveda-Gonzalez, MD, Magdalena Sanz-Cortes, PhD

“…Results: The gestational age (GA) at the time of surgery was significantly higher in fetoscopic centers (26±1.27 weeks) compared to the MOMs trial (23.6±1.42 weeks) and traditional hysterotomy methods (25.4±1 weeks) (P<.001). …”
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Outcomes of endometrial cancer prevention strategies in patients with Lynch syndrome: a nationwide cohort study in the NetherlandsResearch in context by Ellis L. Eikenboom, Lotte van Leeuwen, Floris Groenendijk, Jorien M. Woolderink, Anne M. Van Altena, Monique E. Van Leerdam, Manon C.W. Spaander, Helena C. van Doorn, Anja Wagner, M.C. Breijer, A.S. Tjalsma, F. Vork, H.P.M. Smedts, J. van der Velden, M.M.A. Brood-van Zanten, J.E. van de Riet, A.L.M. Oei, H. Kessel, P.M.L.H. Vencken, M.P.L.M. Snijders, R.H.M. Hermans, A. Bouman, H.W. Ünsalan, A.M.G. van de Swaluw, G.M. Plaisier, H.C. van Doorn, K. van den Berg, W. Hofhuis, Y.A.J.M. Dabekausen, P.R. Kolk, H.T.C. Nagel, A.M.L.D. van Haaften-de Jong, A.C. van Hof, M. van den Hende, J. Kaijser, H.H. de Haan, R.A. Smit, M.W.G. Moonen-Delarue, J.J. Beltman, J.E. Martens, R. Kruitwagen, J.M. van der Ploeg, J.M. Woolderink, S.F.P.J. Coppus, M.J. Duk, M.J.A. Apperloo, C.M. Koopmans, C.C.M. Buis, H. van Meurs, E.C. Dul, B.B.J. Hermsen, A.M. van Altena, A. Baalbergen, A.A. van Ginkel-Terng, M. Baas, P. van Greunen, C.M.W.H. Smeets, H. Knipscheer, J.E. Martens, C. Schmeink, M.D. van der Laan, E.J.M. van Es, J.E.W. van Dijk, F.M.F. Rosier-van Dunné, H. Nijman, C.G. Gerestein, D. Boskamp, E.C.A.H. Scheers, M. Verbruggen, L.R. Bartelink, C.B.M. Kruijdenberg, J.M. Briët, B. Visschers, M. Engelen

“…For all endometrial carcinomas together, including index carriers, cumulative incidence was 22.7% at age 70. Interpretation: In a nation-wide cohort of Lynch syndrome carriers, nearly one-third of eligible carriers did not undergo gynaecological surveillance. …”
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Progression and mortality of patients with cystic fibrosis in China by Wangji Zhou, Yaqi Wang, Yanli Yang, Yanyan Sun, Chongsheng Cheng, Jinrong Dai, Shuzhen Meng, Keqi Chen, Yang Zhao, Xueqi Liu, Dingding Zhang, Song Liu, Weiguo Zhu, Yaping Liu, Kai-Feng Xu, Xinlun Tian

“…According to the mixed-effects model, for patients ≤ 30 years of age at diagnosis, FEV1% predicted decreased 1.17% per year. …”
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An alternative to the straddle-arm technique for a conscious infant who is choking: Towards a more universal skill by Ada Chan, Adam Gesicki

“…La taille et le poids du mannequin correspondaient à ceux d’un bébé âgé de 9 à 11 mois, dans le 50e centile. La rétroaction demandée aux participantes et participants était de nature quantitative et qualitative. …”
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The prevalence and burden of musculoskeletal disorders amongst Indigenous people in Pimicikamak, northern Manitoba, Canada: A community health survey by André Bussières, Melissa Atkinson-Graham, Jennifer Ward, Muriel Scott, Jean Moss, Patricia Tavares, Deborah Kopansky-Giles, Jacqueline Ladwig, Cheryl Glazebrook, David A. Monias, Helga Hamilton, Donald Z. Mckay, Randall Smolinski, Scott Haldeman, Sheilah Hogg-Johnson, Steven Passmore

“…Results: The survey was completed by 130 adults (65 % females, mean age, 48.4 years). Nearly all participants (89.6 %) reported having spine symptoms in the past four weeks, with a majority experiencing activity limitations lasting one day or more due to neck (77.9 %) or low back pain (55.6 %). …”
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Efficacy of Alginate-Antacid Medication in the Treatment of Patients with Gastroesophageal Reflux Disease by O. A. Storonova, A. S. Trukhmanov, V. T. Ivashkin

“…To this end, we set out to confirm the formation of the layer of unbuffered acidic gastric juice over the gastric chyme after eating, as well as to determine the acidneutralizing effect of alginate-antacid medication upon its interaction with the acidic contents of the stomach.Materials and methods. 36 case records of GERD patients were analyzed (20 women and 16 men, mean age 47.03 years old). All patients were asked to report the heartburn intensity (according to a Likert scale) prior and during the treatment. …”
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The Protocol for the Multi-Ethnic, multi-centre raNdomised controlled trial of a low-energy Diet for improving functional status in heart failure with Preserved ejection fraction (... by Noelle Robertson, Melanie J Davies, Thomas Yates, Gerry P McCann, Gaurav Singh Gulsin, Emer M Brady, Joanne V Wormleighton, Eylem Levelt, Oliver Rider, Jiliu Pan, Christopher Miller, Iain Squire, Mehak Asad, Fardad Soltani, Michelle Hadjiconstantinou, Rachel L Brown, Joanna M Bilak

“…This pragmatic randomised trial aims to evaluate the efficacy of MRP-directed weight loss on exercise intolerance, symptoms, quality of life and cardiovascular remodelling in a multiethnic cohort with obesity and HFpEF.Methods and analysis Prospective multicentre, open-label, blinded endpoint randomised controlled trial comparing low-energy MRP with guideline-driven care plus health coaching. Participants (n=110, age ≥18 years) with HFpEF and clinical stability for at least 3 months will be randomised to receive either MRP (810 kcal/day) or guideline-driven care for 12 weeks. …”
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Intersemiotic Translation: From Medieval Poetry to Modern Movie by Leila Nik Nasab

“…The tale revolves around a pious man, on the verge of old age, who suddenly, while dealing with worldly matters, distances himself from spirituality and becomes entrapped by the love of a young woman. …”
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Hydroxychloroquine plus personal protective equipment versus personal protective equipment alone for the prevention of laboratory-confirmed COVID-19 infections among healthcare wor... by Rohina Joshi, Sudha Vidyasagar, Niveditha Devasenapathy, Rinaldo Bellomo, Vivekanand Jha, Chirag Patel, Vijay Kumar, Lachlan Donaldson, Oommen John, Balasubramanian Venkatesh, Michael John, Naomi Hammond, Jeyaraj Pandian, Ashwani Kumar, Arpita Ghosh, S Radhakrishnan, Rajib Paul, Bharath Kumar Tirupakuzhi Vijayaraghavan, Dorrilyn Rajbhandari, Sheila Nainan Myatra, Amritendu Bhattacharya, Sumaiya Arfin, Abhinav Bassi, Lachlan Hugh Donaldson, Naomi E Hammond, Mallikarjuna Kunigari, Cynthia Amrutha, Syed Haider Mehdi Husaini, Subir Ghosh, Santosh Kumar Nag, Hari Krishnan Selvaraj, Viny Kantroo, Kamal D Shah, Sheila Myatra, Amritendu Battacharya, Pavan Kumar Vecham, Evangeline Elvira, Gomathi Parthasarathy, Archana Ragunathan, Gnanavel Rajendra Kunjurao, Pavithra Sampath Kumar, Hilda Nirmala Kumari, Jayanthi Swaminathan, Murshid Cheriyeri Peediyekkal, Arun Chander Yadav, Aarthi Venkatramanan, Cynthia Amrutha Sukumar, Dharini Prasad, Krishnanda Nayak, Ravindra Prabhu, Rohini Bilagi, Akash Bhange, Bhumika Patel, Ekta Ramchandani, Jinesh Patel, Krupa Gandhi, N Prathyusha, Rayshma Rao Bonshlay Lakshmanan, S Hari Krishnan, Abhishek George Mehta, Mousumi Pradhan, Syed Haider Mehdi Husaini, Shahid Ali Siddique, Naved-ur Rahman, Mohammad Jamalludeen, Mounika Amarneni, Suresh Sankar, Vidya Rajesh Joshi, Alka Yadav, Nikhil Modi, Rinku Dahiya, Serena Knowles, Nikita Bathla, Fatima Butt

“…In the control arm, participants continued to use personal protective equipment alone.Main outcome Proportion of laboratory-confirmed COVID-19 in the 6 months after randomisation.Results Participants were young (mean age 32.1 years, SD 9.1 years) with low-comorbid burden. 47.4% were female. …”
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Investigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective coho... by Stefanie Aeschbacher, David Conen, Diederick E Grobbee, Raphael Twerenbold, Thomas Lung, Theo Rispens, Jakob Kjellberg, Lorenz Risch, Martin Risch, Marianna Mitratza, Harald Renz, Spiros Denaxas, Billy Franks, Diederick Grobbee, Martina Rothenbühler, Janneke Wijgert, Santiago Montes, Richard Dobson, Hans Reitsma, Christian Simon, Titia Leurink, Charisma Hehakaya, Patricia Bruijning, Kirsten Grossmann, Ornella C Weideli, Marc Kovac, Fiona Pereira, Nadia Wohlwend, Corina Risch, Dorothea Hillmann, Daniel Leibovitz, Vladimir Kovacevic, Andjela Markovic, Paul Klaver, Timo B Brakenhoff, George S Downward, Ariel Dowling, Maureen Cronin, Brianna M Goodale, Brianna Goodale, Ornella Weideli, Regien Stokman, Hans Van Dijk, Eric Houtman, Jon Bouwman, Kay Hage, Lotte Smets, Marcel van Willigen, Maui Chodura, Niki de Vink, Tessa Heikamp, Timo Brakenhoff, Wendy van Scherpenzeel, Wout Aarts, Alison Kuchta, Antonella Chiucchiuini, Steve Emby, Annemarijn Douwes, George Downward, Nathalie Vigot, Pieter Stolk, Duco Veen, Daniel Oberski, Amos Folarin, Pablo Fernandez Medina, Eskild Fredslund

“…SARS-CoV-2 infection was diagnosed by molecular and/or serological assays.Results A total of 1.5 million hours of physiological data were recorded from 1163 participants (mean age 44±5.5 years). COVID-19 was confirmed in 127 participants of which, 66 (52%) had worn their device from baseline to symptom onset (SO) and were included in this analysis. …”
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Interplay between physical activity volume and intensity with modeled life expectancy in women and men: A prospective cohort analysis by Francesco Zaccardi, Alex V. Rowlands, Paddy C. Dempsey, Cameron Razieh, Joe Henson, Jonathan Goldney, Benjamin D. Maylor, Atanu Bhattacharjee, Yogini Chudasama, Charlotte Edwardson, Jari A. Laukkanen, Ulf Ekelund, Melanie J. Davies, Kamlesh Khunti, Thomas Yates

“…Results: 40,953 (57.1%) women (median age = 61.9 years) and 30,820 (42.9%) men (63.1 years) were included. …”
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