Targeting UGT2B15 and NR1H4 interaction: a novel therapeutic strategy for polycystic ovary syndrome using naftopidil enantiomers by Xiufen Zheng, Zikai Chen, Miao Liang, Liting Zhou, Miaoru Wang, Silin Zhang, Shuyun Zhang, Lei Ma, Wei Yi, Xiawen Liu

“…Abstract Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age. It is characterized by hyperandrogenism, ovulatory dysfunction, and the presence of polycystic ovarian morphology (PCOM) on ultrasound, often accompanied by metabolic disturbances such as insulin resistance and obesity. …”
Get full text

Efficacy of a Mobile Health–Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial by Ana Maria Ruiz-Leon, Rosa Casas, Sara Castro-Barquero, Sofia Alfaro-González, Petia Radeva, Emilio Sacanella, Francesc Casanovas-Garriga, Ainhoa Pérez-Gesalí, Ramon Estruch

“…MethodsA 12-week, parallel, single-blind randomized controlled trial was conducted with 123 participants (62/123, 50%, female; mean age 58.25 years, SD 9.46 years) recently diagnosed with T2D. …”
Get full text

Predictive value of CT-based and AI-reconstructed 3D-TAPSE in patients undergoing transcatheter tricuspid valve repair by Johannes Kirchner, Muhammed Gerçek, Hazem Omran, Kai Peter Friedrichs, Felix Rudolph, Tobias Rossnagel, Misagh Piran, Arseniy Goncharov, Maria Ivannikova, Volker Rudolph, Tanja Katharina Rudolph

“…Thus, this study aimed to analyze whether CT-captured TAPSE provides additional value in predicting outcomes after TTVI.Methods and resultsFor TTVI procedure planning, 75 patients (mean age, 77 ± 8 years; 61% female) with severe TR underwent full cardiac cycle CT. …”
Get full text

Predicting Time in Range Without Hypoglycaemia Using a Risk Calculator for Intermittently Scanned CGM in Type 1 Diabetes by Fernando Sebastian‐Valles, Jose Alfonso Arranz Martin, Julia Martínez‐Alfonso, Jessica Jiménez‐Díaz, Iñigo Hernando Alday, Victor Navas‐Moreno, Teresa Armenta Joya, Maria del Mar delFandiño García, Gisela Liz Román Gómez, Jon Garai Hierro, Luis Eduardo Lander Lobariñas, Carmen González‐Ávila, Purificación deMartinez de Icaya, Vicente Martínez‐Vizcaíno, Miguel Antonio Sampedro‐Nuñez, Mónica Marazuela

“…Results Out of 2314 models explored, the most effective predictor model included annual net income per person, sex, age, diabetes duration, pre‐isCGM HbA1c, insulin dose/kg, and the interaction between sex and HbA1c. …”
Get full text

Episiotomies and obstetric anal sphincter injuries following a restrictive episiotomy policy in France: An analysis of the 2010, 2016, and 2021 National Perinatal Surveys. by Raphaele Houlbracq, Camille Le Ray, Béatrice Blondel, Nathalie Lelong, Anne Alice Chantry, Thomas Desplanches, ENP2021 Study Group

“…Variations between 2010 (reference), 2016, and 2021 were analyzed by Cochran-Armitage tests and using Poisson regression models adjusted for maternal age, BMI, country of birth, antenatal classes, suspicion of fetal macrosomia, and neuroaxial analgesia during labor, the professional who attended the birth, the annual number of deliveries, and the maternity unit status to account for changes in women's characteristics and obstetric practices. …”
Get full text

Comparative analysis of morphologival parameters in isolated and fused L5 spondylolysis patients on the basis of CT features by Rui Ma, Xiaoxia Huang, Luyao Li, Ye Kai, Jun Liu, Gao Leilei, Xiangning Sun, Yong Teng

“…Results There were no significant differences in age, height, weight, body mass index (BMI), or Pfirrmann grade among the three groups. …”
Get full text

Sport-related concussion in Brazilian professional soccer: A four-year prospective epidemiological analysis by Guilherme Corrêa de Araújo Moury Fernandes, Ewerton Borges de Souza Lima, Paulo Henrique Schmidt Lara, Ana Camila de Castro Gandolfi, Jorge Roberto Pagura, Gustavo Gonçalves Arliani, Moisés Cohen

“…Data related to players (age and position) and injuries (diagnosis, type, body location, laterality, field location, tests performed, need for surgery, time lost in sports, and recurrence) were collected. …”
Get full text

Survival analysis of a 16-year cohort of follicular lymphoma patients receiving systemic treatment in Brazil by Pamela Santos Azevedo, Isabella Zuppo Laper, Deborah Marta do Santos Oliveira, Adriano de Paula Sabino, Marina Morgado Garcia, Isabela Cristina Menezes de Freitas, Isabela Cristina Menezes de Freitas, Wallace Mateus Prata, Wallace Mateus Prata, Mariângela Leal Cherchiglia, Juliana Álvares-Teodoro, Juliana Álvares-Teodoro, Francisco de Assis Acurcio, Francisco de Assis Acurcio, Augusto Afonso Guerra Júnior, Augusto Afonso Guerra Júnior

“…Univariate analysis indicated worse survival rates for male patients, those over 65 years of age, clinical stage III or IV and those using non-rituximab-containing regimens. …”
Get full text

Thoracolumbar fascia ultrasound shear strain differs between low back pain and asymptomatic individuals: expanding the evidence by Norio Tomita, Marie-Hélène Roy-Cardinal, Boris Chayer, Stacey Daher, Ameer Attiya, Aline Boulanger, Nathaly Gaudreault, Guy Cloutier, Nathalie J. Bureau

“…Results Thirty-two NSLBP participants (mean age, 57 ± 9 years [standard deviation]; 21 women) and 32 controls (51 ± 10 years; 22 women) (p = 0.02) were enrolled. …”
Get full text

Effects of Physical Activity Level, Strength, Balance, and Body Composition on Perceived Health in Healthy Adults by José Manuel Delfa-de-la-Morena, Pedro Pinheiro Paes, Frederico Camarotti Júnior, Débora Priscila Lima de Oliveira, Rubem Cordeiro Feitosa, Byanka Santos Cavalcante de Oliveira, Juan-José Mijarra-Murillo, Aranzazu Martínez Moya, Miriam García-González, Francisco De Asís-Fernández

“…Results: A total of 64 males with a mean age of 55 ± 5 years and a mean body mass index of 27 ± 4 kg/m² were recruited. …”
Get full text

Comment prendre en compte les mobilités saisonnières du bétail dans l’estimation de la charge animale d’un territoire sud-sahélien ? by Yanoussa Yakoubou Alzouma, Pierre Hiernaux, Mahamane Larwanou, Maguette Kaire, Issa Garba, Amadou Adamou Kalilou, Sambo Bode, Mahaman Maaouia Abdou Moussa, Harouna Abdou Bawa

“…Méthodes : Le cheptel communal a été dénombré sur une année par espèce, sexe et classe d’âge. Le cheptel des 1 556 familles d’agro-éleveurs et agropasteurs sédentaires a été systématiquement recensé dans 40 points d’abreuvements. …”
Get full text

Emerging Resistance and Virulence Patterns in <i>Salmonella enterica</i>: Insights into Silver Nanoparticles as an Antimicrobial Strategy by Irina Gheorghe-Barbu, Ilda Czobor Barbu, Rareș-Ionuț Dragomir, Ioana Cristina Marinaș, Miruna Silvia Stan, Radu Pericleanu, Andreea Ștefania Dumbravă, Liviu-Iulian Rotaru, Simona Paraschiv, Leontina Mirela Bănică, Ionuț Pecete, Dan Oțelea, Violeta Corina Cristea, Mircea Ioan Popa, Marilena Monica Țânțu, Marius Surleac

“…Results: From the total of 309 <i>Salmonella</i> isolates (65.05% from children under 4 years of age) belonging to four subtypes and four serovars, 27.86% showed resistance to at least one antibiotic, most frequently to tetracycline, ampicillin, and piperacillin. …”
Get full text

PCSK9 affects vascular senescence through the SIRT1 pathway by Yuqin Wang, Shaoqing Cao, Zhangyu Wang, Chengsi Li, Jiangping Ye, Yehong Liu, Tianhui Jin, Yuting Zhou, Wentao Su, Gangjun Zong

“…Age is an independent risk factor for atherosclerotic cardiovascular disease that increases the susceptibility of older adults to vascular intimal thickening, endothelial dysfunction, and thrombosis. …”
Get full text

Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study by Andrea R. Costantine, Sarah J. Urasa, Abid M. Sadiq, Elichilia R. Shao, Furaha S. Lyamuya, Elieishiupendo M. Niccodem, Eugénie M. Kamabu, Venance P. Maro, Elifuraha W. Mkwizu, Nyasatu G. Chamba, Francis F. Furia, Tumaini E. Mirai, Eliada B. Nziku, Doreen T. Eliah, Ibrahim Ali Ibrahim Muhina, Faryal M. Raza, Modesta P. Mitao, Kajiru G. Kilonzo

“…The patients were predominantly males (70.6%), and more than half were above 55 years old (56%), with a mean age of 58 (SD ± 14.8) years. 56.6% developed CRBSI and were predominantly gram‐positive (69.7%). …”
Get full text

Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective... by Itske Fraterman, Lucia Sacchi, Henk Mallo, Valentina Tibollo, Savannah Lucia Catherina Glaser, Stephanie Medlock, Ronald Cornet, Matteo Gabetta, Vitali Hisko, Vadzim Khadakou, Ella Barkan, Laura Del Campo, David Glasspool, Alexandra Kogan, Giordano Lanzola, Roy Leizer, Manuel Ottaviano, Mor Peleg, Konrad Śniatała, Aneta Lisowska, Szymon Wilk, Enea Parimbelli, Silvana Quaglini, Mimma Rizzo, Laura Deborah Locati, Annelies Boekhout, Lonneke V van de Poll-Franse, Sofie Wilgenhof

“…When correcting for sex, age, disease stage, and baseline scores, an adjusted difference in fatigue of −5.09 (95% CI −15.20 to 5.02, P=P ConclusionsThe intervention showed a limited effect on HRQoL, although there was a small improvement in fatigue at 3 months, as well as information satisfaction. …”
Get full text

Breeding bird communities of the pine forests in the forest-steppe zone by A. Atemasov, T. Atemasova

“…The most abundant birds in pine forests less than 25 years old were ground nesters (70.5%). In other age groups of the pine forest and the patches of birch stands, secondary cavity users and ground nesters co-dominated. …”
Get full text

Mechanical chest compression increases intrathoracic hemorrhage complications in patients receiving extracorporeal cardiopulmonary resuscitation by Yoshihisa Matsushima, Tatsuhiro Shibata, Kodai Shibao, Rei Yamakawa, Miyu Hayashida, Toshiyuki Yanai, Takashi Ishimatsu, Takehiro Homma, Shoichiro Nohara, Maki Otsuka, Yoshihiro Fukumoto

“…In the mechanical group, older age and larger thoracic transverse diameter were significantly related to intrathoracic hemorrhage requiring TAE. …”
Get full text

Identification of Inflammatory Biomarkers for Predicting Peripheral Arterial Disease Prognosis in Patients with Diabetes by Kian Draper, Ben Li, Muzammil Syed, Farah Shaikh, Abdelrahman Zamzam, Batool Jamal Abuhalimeh, Kharram Rasheed, Houssam K. Younes, Rawand Abdin, Mohammad Qadura

“…Results: The cohort of 392 patients was matched for age, sex, and comorbidities. Five proteins were identified (TNFa: tumor necrosis factor alpha, BMP-10: bone morphogenic protein 10, CCL15/MIP1 delta: chemokine (c-c motif) ligand 15/macrophage inflammatory protein 1 delta, MMP-10: matrix metalloprotease 10, and HTRA2/Omi: HTRA2, also known as Omi) as having a significantly higher level of expression in the DM PAD group. …”
Get full text

Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China by Decheng Li, Yunhe Wang, Shuai Guo, Ziyang Ren, Binbin Su, Lichuan Zhang, Zuliyaer Talifu, Xiaoying Zheng

“…Methods: We included participants aged ≥60 years from the 2015 wave of the China Health and Retirement Longitudinal Study (CHARLS). …”
Get full text

Evaluating the Impact of Pharmacotherapy in Augmenting Quit Rates Among Hispanic Adults in an App-Delivered Smoking Cessation Intervention: Secondary Analysis of a Randomized Contr... by Margarita Santiago-Torres, Kristin E Mull, Brianna M Sullivan, Ana Paula Cupertino, Ramzi G Salloum, Matthew Triplette, Michael J Zvolensky, Jonathan B Bricker

“…They were on average 34.5 (SD 9.3) years of age, 50.9% (88/173) were female, and 56.1% (97/173) reported smoking at least 10 cigarettes daily. …”
Get full text