Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing’s syndrome by Peter Wolf, Simon Travers, Oliver Domenig, Stephanie Baron, Anne Blanchard, Khaoula Bouazizi, Nadjia Kachenoura, Sylvie Salenave, Marko Poglitsch, Alban Redheuil, Severine Trabado, Jacques Young, Philippe Chanson, Peter Kamenický

“…Methods: In this ancillary study of our previous study prospectively investigating patients with ACTH-dependent Cushing’s syndrome by cardiac magnetic resonance imaging (NCT02202902), 11 patients without any interfering medication were cross-sectionally compared to 20 control subjects matched for age, sex and body mass index. Angiotensin metabolites and adrenal steroids were measured by liquid chromatography tandem mass spectrometry, and their relation to blood pressure and cardiac structure was evaluated. …”
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Factors influencing role preferences in decision-making of healthy women with BRCA1/2 pathogenic variants: subanalysis from a randomised controlled decision coaching trial by Sibylle Kautz-Freimuth, Arim Shukri, Claudia Stracke, Anna Isselhard, Birte Berger-Höger, Anke Steckelberg, Frank Vitinius, Nicola Dikow, Marion Kiechle, Cornelia Meisel, Achim Wöckel, Marion Tina von Mackelenbergh, Rita Schmutzler, Kerstin Rhiem, Stephanie Stock

“…Furthermore, in the IG, younger age (OR 1.049, 95% CI 1.001–1.098, p = 0.044) and a non-academic education (OR 0.46, 95% CI 0.213–0.775, p = 0.006) were identified as significant predictors for taking a more active role. …”
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Fatty Acids of Erythrocyte Membranes and Blood Serum in Differential Diagnosis of Inflammatory Bowel Diseases by M. V. Kruchinina, I. O. Svetlova, M. F. Osipenko, N. V. Abaltusova, A. A. Gromov, M. V. Shashkov, A. S. Sokolova, I. N. Yakovina, A. V. Borisova

“…We examined 110 patients (mean age 37,7 ± 12,1 years) with IBDs and 53 healthy patients in control group (43,3 ± 11,7 years). …”
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Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD by Yao Xu, Tianxiao Hu, Peiwu Jiang, Xiujing Wang, Jiaqi Yao, Huiling Shen, Zhenying Zhang, Bojing Zheng, Ting Wang, Yanxia Ren, Jing Wang, Qingying Tan

“…Logistic regression indicated that Sirtuin 1, age, HDL-C, P1NP, and β-CTX were independent risk factors for osteoporosis in T2DM patients.DiscussionIn conclusion, decreased serum Sirtuin 1 levels are associated with bone turnover markers in T2DM patients and may serve as an independent risk factor and potential biomarker for diagnosing bone metabolism disorders in newly diagnosed T2DM patients.…”
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SMRT sequencing and ddPCR reveal the complexity of developmental trajectories and temporal dynamics of gut bifidobacterial communities in infants by Xu Gao, Tao Zhang, Xiaoye Bai, Qiannan Wen, Dongyu Li, Lai-Yu Kwok, Heping Zhang, Zhihong Sun

“…Thus, this was a pilot study aiming to describe the developmental trajectories and temporal dynamics of bifidobacterial communities in infants before 6 months of age. A total of 28 fecal samples from 4 infants (GF, ZZ, QM, TN, respectively) were collected and analyzed after 5, 15, 30, 60, 90, 120, 150, and 180 days of birth by a bifidobacteria-target method (based on single-molecule real-time sequencing of partial bifidobacterial rpsK genes) in conjunction with droplet digital polymerase chain reaction (ddPCR). …”
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Effect of prehospital physician presence on Out-of-Hospital cardiac arrest (OHCA) patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR): A secondary analysis of t... by Futoshi Nagashima, Satoshi Inoue, Tomohiro Oda, Tomohiro Hamagami, Tomoya Matsuda, Makoto Kobayashi, Akihiko Inoue, Toru Hifumi, Tetsuya Sakamoto, Yasuhiro Kuroda

“…Propensity score matching (PSM) was performed using six covariates (age, sex, witness status, presence of bystander CPR, initial heart rhythm, and location of cardiac arrest) to adjust for baseline differences. …”
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Time Interval for Diagnosis of Tuberculosis and Related Expenditure in Selected Health Centers in Addis Ababa, Ethiopia by Ezra Shimeles, Melaku Tilahun, Tsegaye Hailu, Fikre Enquselassie, Abraham Aseffa, Alemayehu Mekonnen, Getachew Wondimagegn

“…This cross-sectional study was conducted among pulmonary TB patients who are bacteriologically confirmed, whose age is above 15 years and diagnosed at health centres in Addis Ababa. …”
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Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies by Xiangjun Wang, Xiaowen Xia, Xianliang Song, Yi Zhou, Mingyu Ma, Yashuang Ren, Xitai Chen, Zenghui Xia, Yinghui Guo, Chunhong Song

“…IntroductionPremenstrual dysphoric disorder (PMDD) is a cyclical mood disorder that severely affects the daily life of women of reproductive age. Most of the medications being used clinically have limitations such as low efficacy, side effects, and high cost, so there is an urgent need to discover safer and more effective medications. …”
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Association between body size and atrial myopathy: Investigation using the prevalence of left atrial low-voltage areas by Yasuhiro Matsuda, Masaharu Masuda, Hiroyuki Uematsu, Ayako Sugino, Hirotaka Ooka, Satoshi Kudo, Subaru Fujii, Mitsutoshi Asai, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takuya Tsujimura, Yosuke Hata, Naoko Higashino, Sho Nakao, Masaya Kusuda, Toshiaki Mano

“…Methods: In total, 1,479 (age, 68 ± 10 years; female, 500 [34 %]) consecutive patients who underwent initial AF ablation were enrolled. …”
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Deltopectoral approach without subscapularis detachment for reverse shoulder arthroplasty. Technique and results of a safe and reproducible subscapularis-sparing approach by Adrien Jacquot, MD, MSc, Thomas Cuinet, MD, Lisa Peduzzi, MD, Patrice Wong, MD, Marc-Olivier Gauci, MD, PhD, Julien Uhring, MD

“…The subscapularis was intact in all the cases. The mean age at inclusion was 74.1 years. No patients were lost at the minimum 24-month follow-up. …”
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Evaluation of the Prognostic Value of Red Cell Distribution Width to Total Serum Calcium Ratio in Patients with Acute Pancreatitis by Tian-Yong Han, Tao Cheng, Bo-Fu Liu, Ya-Rong He, Pan Pan, Wen-Tao Yang, Qiang-Lai, Yu Cao

“…A total of 666 AP patients were enrolled in this study, with an average age of 47.99±14.11 years, including 633 patients who survived to discharge and 33 patients who died during hospitalization. …”
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Effects of partial replacement of soybean meal with hemp seed (Cannabis sativa L.) cake on the growth and meat quality in female three-yellow chickens by Qin He, Zongyao Zhang, Hao Tian, Haopeng Wang, Xiaoyu Lu, Hexuan Deng, Fujian Yang, Xuemei Tang, Jian Wang, Zhipeng Li, Hui Li, Shuibao Shen, Yangqing Lu, Jieping Huang

“…To assess the effects of HSC addition in diets on the growth and meat quality in broiler chicken, a total of 240 female three-yellow chickens (50 days of age) were randomly assigned to four groups and fed with varying levels of HSC (0% (HSC0), 5% (HSC5), 10% (HSC10), and 20% (HSC20)) for 9 weeks. …”
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Analysis of the relationships between the degree of migraine with right-to-left shunts and changes in white matter lesions and brain structural volume by Xin Pan, Haoran Ren, Lili Xie, Yu Zou, Furong Li, Xiaowen Sui, Li Cui, Zhengping Cheng, Jiaojiao Wu, Feng Shi, Hongling Zhao, Shubei Ma

“…The brain structural volumes of 102 migraineurs with RLS were calculated from T1-weighted images via artificial intelligence, and the brain structural volumes of healthy controls matched according to age and sex were also calculated. The correlations among WML location, RLS, headache degree, WML severity and brain structural volume changes in migraineurs were analyzed. (1) The WMLs of migraineurs with RLS were concentrated mainly in the white matter of the lateral ventricular margin and deep white matter. …”
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Evolution of burnout syndrome in Spanish healthcare professionals during and after the COVID-19 pandemic: psychosocial variables involved by Fernanda Gil-Almagro, Fernanda Gil-Almagro, Fernanda Gil-Almagro, F. Javier Carmona-Monge, Fernando J. García-Hedrera, Cecilia Peñacoba-Puente

“…Together with sociodemographic and occupational data (age, gender, professional category, years of experience, hours of work), anxiety, depression, stress, family support, friends’ support, and self-efficacy were assessed at the first time point. …”
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Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air... by Bingqian DU, Zhiqiang REN, Peian CHEN, Zhenjun LI

“…After adjusting for confounders such as gender and age, multiple linear regression analysis showed that for every 1 μg/m3 increase in PM2.5 concentration, MCHC decreased by 2.947 g/L; for every 1 μg/m3 increase in PM10 concentration, NEUT#, MO#, and SIRI increased by 0.236 × 109/L, 0.025 × 109/L, and 0.112, respectively; for each 1 μg/m3 increase in NO2 concentration, MO#, RDW-SD, and SIRI increased by 0.011×109/L, 0.136 fL, and 0.023, respectively, and MCHC decreased by 2.743 g/L; for every 1 μg/m3 increase in SO2 concentration, MCHC decreased by 1.871 g/L; for every 1 μg/m3 increase in CO concentration, MCHC and RDW-SD decreased by 1.383 g/L and 0.460 fL, respectively; for each 1 μg/m3 increase in O3 concentration, MO#, RDW-SD, and SIRI increased by 0.005×109/L, 0.113 fL, and 0.005, respectively, and MCHC decreased by 1.245 g/L. …”
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Safety and efficacy of catheter ablation in atrial fibrillation patients with heart failure with preserved ejection fraction by Songbing Long, Yuanjun Sun, ShiYu Dai, Xianjie Xiao, Zhongzhen Wang, Wei Sun, Lianjun Gao, Yunlong Xia, Xiaomeng Yin

“…Results After a mean (± SD) follow-up of 36 ± 3 months, 50.8% of patients in the AFPHF-CA group and 52.0% in the AF-CA group remained in sinus rhythm (P = 0.94), compared to only 12.5% in the AFPHF-Med group (P < 0.001). Age (OR: 1.09, 95% CI: 1.02–1.08, P = 0.016), duration of AF history (OR: 1.01, 95% CI: 1.00-1.02, P = 0.017), left atrial diameter (OR: 1.52, 95% CI: 1.06–2.19, P = 0.024), and the type of atrial fibrillation (OR: 4.02, 95% CI: 1.28–12.62, P = 0.017) were consistent multivariable predictors for sinus rhythm maintenance in AFPHF. …”
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Meibomian gland alterations in allergic conjunctivitis: insights from a novel quantitative analysis algorithm by Jingting Wei, Jingting Wei, Kunhong Xiao, Qingyuan Cai, Qingyuan Cai, Shenghua Lin, Xiangjie Lin, Yujie Wang, Yujie Wang, Jiawen Lin, Kunfeng Lai, Yunxi Ye, Yuhan Liu, Li Li

“…Correlation analysis revealed that the gland dropout ratio was positively associated with male gender and negatively associated with age and OSDI scores. Additionally, despite an increased number of MG, tear film stability was not improved.ConclusionThrough the intelligent quantitative algorithm, we found that AC leads to significant changes in MG structure, particularly affecting gland length and central area.…”
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Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production by Beatriz Castro-Robles, Francisco J. Cimas, Francisco J. Cimas, Lourdes Arias-Salazar, Jesús Ontañón, Julia Lozano, Susana López-López, Fernando Andrés-Pretel, María Ángeles Requena-Calleja, Antonio Mas, Antonio Mas, Antonio Mas, Gemma Serrano-Heras, Tomás Segura, Tomás Segura, Javier Solera

“…Incremental and decremental response groups did not differ in terms of age, sex, cardiovascular risk factors, previous SARS-CoV-2 infection and influenza vaccine co-administration. …”
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Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer by Tilo Wuensch, Jonas Wizenty, Janina Quint, Wolfgang Spitz, Madeleen Bosma, Olaf Becker, Andreas Adler, Wilfried Veltzke-Schlieker, Martin Stockmann, Sascha Weiss, Matthias Biebl, Johann Pratschke, Felix Aigner

“…The expression of FNDCs and GPR116 was independent of age and sex. Conclusions. FNDC1 and FNDC4 may play a relevant role in the pathobiology of IBD, but none of the investigated FNDCs is regulated in CRC. …”
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Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022 by Rosa María Gómez-García, Javier De-Miguel-Díez, Ana López-de-Andrés, Valentín Hernández-Barrera, Ana Jimenez-Sierra, Natividad Cuadrado-Corrales, José J. Zamorano-León, David Carabantes-Alarcón, Andrés Bodas-Pinedo, Rodrigo Jiménez-García

“…To obtain comparable populations, for each subject with COPD and RSV infection, a subject without an RSV code was selected, with the COPD code in the same diagnostic position (1 to 20), as well as the same year of admission, sex, and age. Results: Among subjects aged ≥40 years, 1,429,288 were identified as having COPD, of whom 5673 also had RSV infection. …”
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