Proton therapy versus conventional radiotherapy for the treatment of cavernous sinus benign meningioma, a randomized controlled phase III study protocol (COG-PROTON-01) by Paul Lesueur, Benedicte Clarisse, Justine Lequesne, Idlir Licaj, Loic Feuvret, Dinu Stefan, Damien Ricard, Georges Noel, Jacques Balosso, Marie Lange, Aurelie Capel, Isabelle Durand-Zaleski, Marie Castera, Berenice Legrand, Nicolas Goliot, Camille Hedou, Jean Michel Grellard, Samuel Valable

“…Eligible patients with low-grade cavernous sinus meningioma will be 1:1 randomised, with stratification on age, sex, MoCA score. Overall, the inclusion of 160 patients is planned (80 in each arm). …”
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Effects of Exergaming on Morphological Variables, Biochemical Parameters, and Blood Pressure in Children and Adolescents with Overweight/Obesity: A Systematic Review with Meta-Anal... by Jordan Hernandez-Martinez, Joaquín Perez-Carcamo, Hassan Melki, Izham Cid-Calfucura, Edgar Vasquez-Carrasco, Pedro Delgado-Floody, Claudio Romero, Tomás Herrera-Valenzuela, Braulio Henrique Magnani Branco, Pablo Valdés-Badilla

“…Using a random effects model, potential sources of heterogeneity were selected, including subgroup analyses (age) and single training factor analysis (program duration, training frequency). …”
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Effect of zinc level and the thermal environment on the zootechnical performance and tibia-breaking strength of Japanese quails by Luiz Arthur dos Anjos Lima, Thiago de Assis Moraes, Larissa Kellen da Cunha Morais, Mikael Leal Cabral Menezes de Amorim, Tarsys Noan Silva Veríssimo, José Danrley Cavalcante dos Santos, Maria Isabelly Leite Maia, Severino Guilherme Caetano Gonçalves dos Santos, Fernando Guilherme Perazzo da Costa, Ricardo Romão Guerra, Lucas Rannier Ribeiro Antonino Carvalho, Edilson Paes Saraiva

“…This study evaluated the effects of different levels of Zn in the diet on zootechnical performance, organ and carcass weight, and tibial breakage resistance in quails from 1 to 42 days of age. A 5 × 2 factorial design was used, consisting of five Zn levels (30, 60, 90, 120, and 150 mg/kg) and two thermal environments (thermal comfort and heat stress), with five replicates of 10 birds per treatment. …”
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A Standardized Classification Scheme for Gastroduodenal Disorder Evaluation Using the Gastric Alimetry System: Prospective Cohort Study by Chris Varghese, Gabriel Schamberg, Emma Uren, Stefan Calder, Mikaela Law, Daphne Foong, Vincent Ho, Billy Wu, I-Hsuan Huang, Peng Du, Thomas Abell, Charlotte Daker, Christopher N. Andrews, Armen A. Gharibans, Gregory O’Grady

“…Results: Two hundred ten patients were included (80% female, median age 37), of whom 169 met the criteria for chronic nausea and vomiting syndromes and 206 met the criteria for functional dyspepsia (79% meeting both criteria). …”
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Fitness Profiling in Women Soccer: Performance Characteristics of Elite Turkish Women Soccer Players by Aras Beka Yaşar, Serdar Bayrakdaroğlu, Beyza Yıldız, İbrahim Can

“…In accordance with this purpose, 11 women football players (age: 21,5 ± 2,58 years; height: 160,8 ± 5,17 cm; weight: 55,8 ± 7,23 kg) who plays in Turkish Women’s 1st Football League participated voluntarily. …”
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Machine learning derivation of two cardiac arrest subphenotypes with distinct responses to treatment by Weidong Zhang, Chenxi Wu, Peifeng Ni, Sheng Zhang, Hongwei Zhang, Ying Zhu, Wei Hu, Mengyuan Diao

“…Results After applying exclusion criteria, 719 CA patients were included in the study, with a median age of 67.22 years (IQR: 55.50-79.34), of whom 63.28% were male. …”
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Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease by Ana Vigil, Emilia Condés, Luis Vigil, Paloma Gallar, Aniana Oliet, Olimpia Ortega, Isabel Rodriguez, Milagros Ortiz, Juan Carlos Herrero, Carmen Mon, Gabriela Cobo, Juana Jimenez

“…Predictors of overall mortality and for the development of renal disease progression were analyzed. Results. The median age was 75 years (interquartile range 69–82) and the median eGFRcreat 38 mL/min m2 (interquartile range 33–49). …”
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Noise-induced ribbon synapse loss in the mouse basal cochlear region does not reduce inner hair cell exocytosis by David Oestreicher, David Oestreicher, Alfonso Mauro Malpede, Alfonso Mauro Malpede, Annalena Reitmeier, Annalena Reitmeier, Carolin Paula Bräuer, Carolin Paula Bräuer, Laura Schoch, Laura Schoch, Nicola Strenzke, Nicola Strenzke, Tina Pangrsic, Tina Pangrsic, Tina Pangrsic

“…Depolarization-evoked calcium currents in IHCs 2 weeks after exposure were slightly but not significantly smaller as compared to controls from age-matched non-exposed animals. Exocytic changes monitored as changes in membrane capacitance did not follow that trend and remained similar to controls despite significant loss of ribbons, likely reflecting increased exocytosis at the remaining synapses. …”
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Urinary Incontinence in Men with Stroke: A Cross-Sectional Study by İsmail Uysal, Özgür Nadiye Doğrukök, Yalcin Golcuk, Fatih Özden, Mehmet Özkeskin, Miray Başer, Bircan Yücekaya, Zeynep Nisa Karakoyun

“…<i>Results</i>: The mean age of the participants was 68.4 ± 9.9 years. The average scores of the IIQ-7 and UDI-6 were 9.7 ± 7.2 and 36.6 ± 26.3, respectively. …”
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Prevalence of psychoactive substance use among acutely hospitalised patients in Oslo and Moscow: a cross-sectional, observational study by Stig Tore Bogstrand, Thomas Berg, Anners Lerdal, Danil Gamboa, Benedicte Jørgenrud, Evgeny A Bryun, Vigdis Vindenes, Evgenya A Koshkina, Aleksei V Nadezhdin, Saranda Kabashi, Elena J Tetenova, Anna Armika Tussilago Nyman, Alexey J Kolgashkin, Aleksei E Petukhov, Sergey N Perekhodov, Elena N Davydova, Gudmund Nordby

“…In Oslo, medicinal drug use was associated with being aged 61 to 70 years (OR 2.40, 95% CI 1.61 to 3.58) compared with 18 to 40 years, and psychological distress (OR 2.61, 95% CI 2.06 to 3.30). …”
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Effects of Metformin Added to Insulin in Adolescents with Type 1 Diabetes: An Exploratory Crossover Randomized Trial by Daizhi Yang, Jinhua Yan, Hongrong Deng, Xubin Yang, Sihui Luo, Xueying Zheng, Jing Lv, Wen Liang, Mengjie Hong, Zekai Wu, Bin Yao, Jianping Weng, Wen Xu

“…Seventeen patients with mean±SD age 14.4±2.3 years, body mass index 18.17±1.81 kg/m2, median (IQR) diabetes duration 4.50 (3.58, 6.92) years, and HbA1c 9.0% (8.5%, 9.4%) were enrolled. …”
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Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma by Michaela Plath, Martina A. Broglie, Diana Förbs, Sandro J. Stoeckli, Wolfram Jochum

“…In a multivariate analysis adjusted for age, smoking history, pT and pN category, high p16INK4a expression showed the lowest hazard ratio for death. …”
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Temporal trends of the utilization patterns of sedative-hypnotic medications in children, adolescents and young adults: a 21-year population-based study with joinpoint regression a... by Carltin Chun Ting Kwok, Heidi Ka Ying Lo, Ching Yui Chan, Joe Kwun Nam Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng, Chung Ho, Brian Man Ho Leung, Wilfred Shone Horn Wong, Zoe Hoi Shuen Yu, Edwin Ho Ming Lee, Wing Chung Chang

“…Use of all BZRA subtypes consistently increased over time for all age-groups, except decline in Z-drug prescriptions in children. …”
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Mediastinal Tracheostoma for Treatment of Tracheostenosis after Tracheostomy in a Patient with Mucopolysaccharidosis-Induced Tracheomalacia by Yasuhiro Chikaishi, Kenichi Kobayashi, Shuichi Shinohara, Akihiro Taira, Yusuke Nabe, Shinji Shinohara, Taiji Kuwata, Masaru Takenaka, Soichi Oka, Ayako Hirai, Kazue Yoneda, Koji Kuroda, Naoko Imanishi, Yoshinobu Ichiki, Fumihiro Tanaka

“…A 16-year-old male patient underwent long-term follow-up after postnatal diagnosis of type II mucopolysaccharidosis. At 11 years of age, tracheostomy was performed for mucopolysaccharidosis-induced laryngeal stenosis. …”
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Identification of genetic mechanisms of non-isolated auditory neuropathy with various phenotypes in Chinese families by Yang Cao, Xiaolong Zhang, Lan Lan, Danyang Li, Jin Li, Linyi Xie, Fen Xiong, Lan Yu, Xiaonan Wu, Hongyang Wang, Qiuju Wang

“…Results A total of 11 variants linked to non-isolated AN were identified in this study, eight of which were novel. Patients’ age of hearing loss onset ranged from 2 to 25 years, averaging 11 years. …”
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A mixed-methods observational study of strategies for success in implementation science: overcoming emergency departments hurdles by Deonni P. Stolldorf, Alan B. Storrow, Dandan Liu, Cathy A. Jenkins, Rachel A. Hilton, Karen F. Miller, Joy Kim, Deepika Boopathy, Satheesh Gunaga, Bory Kea, Joseph Miller, Sean P. Collins

“…Results Participants were predominately white (76%) with median (IQR) age 37.0 (32.0, 41.0). ED leaders/administrators, providers, and nurses comprised 15%, 55%, and 29% of participants, respectively. …”
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Comparison of Therapeutic Effects of Different Rehabilitation Methods on Patients Undergoing Total Knee Arthroplasty: A Network Meta‐Analysis of Randomized Controlled Trials by Zhaokai Jin, Yi Tang, Hua Huang, Lei Chen, Zhongyi Zhang, Tianyou Ma, Zhengming Wang, Hai Su, Haojing Zhou, Shuaijie Lv, Peijian Tong

“…Finally, 32 trials involving 2292 patients were included, the mean age of the enrolled patients was ~69.10 years, the sex ratio of males was (31.6%), and the longest follow‐up time was 2 years. …”
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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Random... by Jarrod L. Thomas, Kirsty C. McGee, Anower Hossain, Gavin D. Perkins, Anthony C. Gordon, Duncan Young, Danny McAuley, Mervyn Singer, Ranjit Lall, Tina Kramaric, Janet M. Lord, Tony Whitehouse, Luis A. J. Mur, for the STRESS-L. collaborators

“…The individual-level models were adjusted for confounders, such as age, sex, noradrenaline dosage and patient (random effect). …”
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Assessing the Comparative Efficacy and Safety of Warfarin and Rivaroxaban for Cancer Associated Thrombosis: Experience From a Resource Limited Setting by Abel Tenaw Tasamma, Tsegab Alemayehu Bukate, Abdulrahim Mehadi, Bereket Tagesse Handiso, Beniam Yohannes Kassa, Eman Omer Hassen, Zekarias Seifu Ayalew, Dawit Habtie Tegegne, Gebeyehu Tessema Azibte, Tigest Abebaw Zewdie, Tinsaye Zergaw Shihur, Yonas Degelo Geremamo, Yeabsira Dessalegne Mesfin, Rediet M. Alemayehu, Amanuel Kassu Asefa, Fozia Abdela, Addisu Melkie

“…The baseline mean (standard deviation) age of the patients was 48.4 (15.0) and 140 (69.7%) of them were female. 41.3% of the participants had one or more comorbidities, and the most common types of cancer were gynecologic (28.9%), hematologic (21.4%), and intra‐abdominal (16.9%). …”
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Evaluation of Common and Atypical Clinical Presentations of Tinea Faciei: A Cross-sectional Study from Barabanki, Uttar Pradesh, India by Suganita, Deepika Agarwal, Sonal Sachan, Vandana Yadav, Harshit Jaiswal, Divya Prajapati

“…Results: The present study comprised 45 (60%) males and 30 (40%) females, with a mean age of 30.7 years. A total of 27 (36%) patients had pets at their homes, and 35 (46.6%) patients were involved in handling domestic animals. …”
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