Obesity and Gastrointestinal Diseases by Ai Fujimoto, Shu Hoteya, Toshiro Iizuka, Osamu Ogawa, Toshifumi Mitani, Yuichiro Kuroki, Akira Matsui, Masanori Nakamura, Daisuke Kikuchi, Satoshi Yamashita, Tsukasa Furuhata, Akihiro Yamada, Noriko Nishida, Koji Arase, Mitsuyo Hashimoto, Yoshinori Igarashi, Mitsuru Kaise

“…Arterial sclerosis associated with advanced age and hyperglycemia was accompanied by an increased risk of colorectal adenoma.…”
Get full text

The association between the dietary inflammatory index and multiple myeloma: a case–control study by Hoda Zahedi, Mohammad-Reza Jowshan, Hamid Rasekhi, Maryam Amini, Omid Sadeghi, Mahshid Mehdizadeh, Sayeh Parkhideh, Moloud Payab, Erfan Zamani, Mahdi Shadnoush, Abbas Hajifathali

“…This case–controlstudy was conducted on adults aged 20 to 75 years, selecting 149 cases with newly diagnosed multiple myeloma and 359 healthy individuals. …”
Get full text

From across the globe – traumatic injuries are an international concern at the US-Mexico border wall by Allison E Berndtson, Jay Doucet, Todd W Costantini, Laura Haines, Sarah Lagan, Laura Adams, Jarrett Santorelli, Gabriella Waters

“…Patients’ nationality was then stratified by region of the world to understand geographic representation of border injury admissions.Results We identified 597 patients injured while crossing the US-Mexico border wall representing 38 different countries. The mean age of patients was 32.2±10.4 years and 446 (75%) were male. …”
Get full text

Effect of motivational interviewing to promote advance care planning among palliative care patients in ambulatory care setting: a randomized controlled trial by Helen Yue-Lai Chan, Doris Yin-Ping Leung, Po-Tin Lam, Polly Po-Shan Ko, Raymond Wai-Man Lam, Kin-Shan Chan

“…Results A total of 204 participants (mean [SD] age, 74.9 [10.8]; 64.7% male; 80.4% cancer) were recruited. …”
Get full text

Do coping strategies mediate the effects of childhood adversities and traumata on clinical high-risk of psychosis, depression, and social phobia? A cross-sectional study on patient... by Zhixiong Chang, Naweed Osman, Carolin Martha Doll, Theresa Katharina Lichtenstein, Marlene Rosen, Eva Meisenzahl, Hanna Kadel, Joseph Kambeitz, Kai Vogeley, Frauke Schultze-Lutter

“…Methods Using path analyses, we analyzed data of 736 patients (mean age 24 years, 67% male) who presented at an early detection service between 2002 and 2013, answered questionnaires on CAT, coping, depressiveness, and social phobia, and underwent clinical examination for CHR-P according to the recommendations of the Guidance project of the European Psychiatric Association. …”
Get full text

Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research by Yu Zhou, Sujie Ke, Kejun Wu, Jingze Huang, Xuelin Gao, Beibei Li, Xiaoying Lin, Xiaohong Liu, Xiaoying Liu, Li Ma, Linxi Wang, Li Wu, Lijuan Wu, Chengwen Xie, Junjun Xu, Yanping Wang, Libin Liu

“…Our results showed that the secretory capacity of the thyroid gland (SPINA-GT) and Jostel’s thyrotropin index (TSHI) were negatively correlated with BMI, WC, and WHtR, whereas the reciprocal of the thyrotroph thyroid hormone resistance index (TTSI-1) was positively correlated with BMI (all p<0.05). After adjustment for age, sex, smoking, iodine status, and glucolipid metabolism, the associations between TSHI, TTSI (reciprocal transformation), and BMI still persisted (all p<0.05). …”
Get full text

Extended Reality Interventions for Health and Procedural Anxiety: Panoramic Meta-Analysis Based on Overviews of Reviews by Tom Arthur, GJ Melendez-Torres, David Harris, Sophie Robinson, Mark Wilson, Sam Vine

“…Here, outcomes were estimated for patients (level 1), studies (level 2), and anxiety indications (level 3), while meta-regressions explored possible influences of age, immersion, and different mechanisms of action. …”
Get full text

Polydatin retards the progression of osteoarthritis by maintaining bone metabolicbalance and inhibiting macrophage polarization by Qi Sun, Xin-Yu Nan, Hui Wang, Shuo Pan, Gang Ji, Ya-Feng Guo, Ya-Heng Zhao, Gao-Cen Li, Shao-Shi Guo, Lu-Feng Lin, Yu-Jie Jin, Xue Li Zhang, Chang-Cheng Liu, Guo-Bin Liu

“…However, the potential molecular mechanisms of PD in osteoarthritis have not been clearly elucidated.MethodsAnterior cruciate ligament transection (ACLT) surgery was performed to establish an osteoarthritis animal model. Female mice at the age of 12 weeks were intraperitoneally injected with different concentrations of PD (20 and 40 mg/kg). …”
Get full text

A case-matched series comparing functional outcomes for robotic-assisted unicompartmental knee arthroplasty versus functionally aligned robotic-assisted total knee arthroplasty by Jonathan R. Manara, Macdaniel Nixon, Beth Tippett, Wil Pretty, Dermot Collopy, Gavin W. Clark

“…Patients were matched for preoperative BMI, sex, age, and Forgotten Joint Score (FJS). A total of 101 matched pairs were eligible for final review. …”
Get full text

Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis by Christian Gluud, Marija Barbateskovic, Sara Russo Krauss, Janus C Jakobsen, Sesilje Bondo Petersen, Sarah Louise Klingenberg, Snezana Djurisic, Mette Kenfelt, De Zhao Kong

“…Objectives To assess the benefits and harms of aluminium adjuvants versus placebo or no intervention in randomised clinical trials in relation to human vaccine development.Design Systematic review with meta-analysis and trial sequential analysis assessing the certainty of evidence with Grading of Recommendations Assessment, Development and Evaluation (GRADE).Data sources We searched CENTRAL, MEDLINE, Embase, LILACS, BIOSIS, Science Citation Index Expanded and Conference Proceedings Citation Index-Science until 29 June 2021, and Chinese databases until September 2021.Eligibility criteria Randomised clinical trials irrespective of type, status and language of publication, with trial participants of any sex, age, ethnicity, diagnosis, comorbidity and country of residence.Data extraction and synthesis Two independent reviewers extracted data and assessed risk of bias with Cochrane’s RoB tool 1. …”
Get full text

Exploring the relationship between established HIV risk factors and depressive symptoms amongst young women without HIV in two sites in South Africa. by Zanenhlanhla Gumbi, Celia Mehou-Loko, Lindi Masson, Makhosazana Mdladla, Nokuthula Maphumulo, Jo-Ann Passmore, Sanele Mbeje, Linda Gail Bekker, Disebo Potloane, Heather Jaspan, Nina Radzey, Andrea Abrahams, Rushil Harryparsad, Pamela Mkhize, Hilton Humphries

“…Depressive symptoms were less likely to occur in adolescent girls between the ages of 14 to 17 as compared to those between the ages of 18 and 19 (OR 0.44; 95% CI 0.22-0.90). …”
Get full text

Heterogeneity of motivations among crowdinvestors: Evidence from the football industry by Szczepan Kościółek

“…The segments were also differentiated according to consumption-related behaviors (media consumption, word-of-mouth marketing, merchandise purchases, match attendance, and social media engagement) and socio-demographic profiles (age, marital status, income, and place of residence). …”
Get full text

From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases by Qing Zhao, Linxin Wei, Youxin Chen

“…To date, active trials include treatments for primary open angle glaucoma with MYOC mutations, refractory herpetic viral keratitis, CEP290-associated inherited retinal degenerations, neovascular age-related macular degeneration, and retinitis pigmentosa with RHO mutations. …”
Get full text

Prevalence of Corneal Astigmatism in Patients before Cataract Surgery in Western China by Wei Ma, Chengguo Zuo, Weirong Chen, Shaoyang Zheng, Jiangang Xu, Ruowen Gong, Maierhaba Mijiti, Kaidiliya Alifu, Lin Ding, Mingkai Lin

“…This study comprised 12,236 eyes of 7065 patients with a mean age of 64.75 ± 9.66 years, and 52.77% of the patients were female. …”
Get full text

Behavior of SD-OCT Detectable Hyperreflective Foci in Diabetic Macular Edema Patients after Therapy with Anti-VEGF Agents and Dexamethasone Implants by Anne Rübsam, Laura Wernecke, Saskia Rau, Dominika Pohlmann, Bert Müller, Oliver Zeitz, Antonia M. Joussen

“…Diabetic macular edema (DME) is the most common cause of blindness in the working-age population. Spectral-domain optical coherence tomography (SD-OCT) allows detection and monitoring of the edema and a detailed analysis of the retinal structure. …”
Get full text

A Morphological and Immunohistochemical Study of the Tumoral and Inflammatory Cells in Pancreatic Ductal Adenocarcinoma by Vlad Herlea, Elena Stoica Mustafa, Andreea Cristina Iorgescu, Nicolae Catalin Pechianu, Dragos Cretoiu, Maria Sajin, Simona Olimpia Dima, Catalin Vasilescu, Cezar Stroescu, Constantin Ungureanu, Traian Dumitrascu, Vladislav Brasoveanu, Minerva Ghinescu, Irinel Popescu

“…There were 133 male (57.8%) and 97 female (42.2%) patients included in this study, with ages between 20 and 81 years old (mean age: 58.2 years) and with tumors located in the pancreatic head (n=196; 85.2%), pancreatic body (n=12; 5.2%), and pancreatic tail (n=20, 8.7%), as well as panpancreatic tumors (n=2; 0.9%). …”
Get full text

Transconjunctival correction of involutional entropion: A video demonstration by Neelam Pushker, B. Mounica, Sahil Agrawal

“…Background: Involution or aging is the most common cause of lower eyelid entropion (in-turning of eyelid margin) in the elderly population. …”
Get full text

The evolving landscape of COVID-19: factors associated with in-hospital COVID-19 related mortality during the 2023–2024 phase of JN.1 subvariant dominance by Drieda Zaçe, Albiana Çekrezi, Christopher Jones, Ludovica Ferrari, Giuseppe De Simone, Elisabetta Teti, Vincenzo Malagnino, Marco Iannetta, Loredana Sarmati, Anna Maria Geretti

“…Results Among 122 individuals (median age 76 years, 58.2% males, median comorbidity index 5), 114/122 (93.4%) had received ≥ 1 SARS-CoV-2 vaccination, with a median of 23 months elapsed since the last dose. …”
Get full text

The association between dietary omega-3 intake and osteoporosis: a NHANES cross-sectional study by Zhiwen Liu, Shaoming Cai, Yuzhen Chen, Zijing Peng, Huanling Jian, Zhihai Zhang, Hongxing Huang

“…Subgroup analyses indicated stronger associations in individuals under 60 years of age, female and non-smokers. In individuals aged under 60, higher omega-3 intake was associated with significantly reduced osteoporosis risk (OR = 0.51, 95%CI: 0.26–0.95), females showed a protective effect of high omega-3 intake against osteoporosis (OR = 0.65, 95% CI: 0.49–0.87). …”
Get full text

Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China by Xiaolong Cao, Zexuan Song, Ping He, Xinyue Li, Nan Lei, Qian Sun, Xue Wang, Ruida Xing, Bing Zhao, Xinyu Yang, Zhiguo Zhang, Yanlin Zhao

“…A statistically significant difference in cavity formation across different age groups was observed (r = -0.198, P < 0.05). …”
Get full text