Geographical Differences in the Safety and Efficacy of Tofacitinib Versus TNFi: A Post Hoc Analysis of ORAL Surveillance by Bogdan Batko, Slawomir Jeka, Piotr Wiland, Agnieszka Zielińska, Maria Stopińska-Polaszewska, Marcin Stajszczyk, Magdalena Kosydar-Piechna, Mary Jane Cadatal, Jose L. Rivas

“…Methods Patients with RA in ORAL Surveillance (NCT02092467), who were aged ≥ 50 years with ≥ 1 additional CV risk factor, received tofacitinib 5 or 10 mg twice daily or TNFi; 45.9% were from either Poland or North America. …”
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Impact of subgingival periodontal treatment on systemic markers of inflammation in patients with metabolic syndrome: a systematic review of randomized clinical trials by Marie Chavez, Asshly Ramirez, Akram Hernández-Vásquez, Daniel Comandé, Diego Azañedo

“…A qualitative synthesis of the evidence was performed.ResultsTwo RCTs with 228 participants (ages 35–65) were included. Montero et al. reported significant reductions in CRP levels favoring the treatment group at 3 months (2.7 mg/L ± SE: 0.4 vs. 3.9 mg/L ± SE: 0.6; p = 0.001) and 6 months (2.9 mg/L ± SE: 0.4 vs. 4.0 mg/L ± SE: 0.8; p = 0.004). …”
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Efficacy and Safety of Allisartan Isoproxil/Amlodipine in Patients With Essential Hypertension Uncontrolled by Amlodipine: A Phase III, Multicenter, Double‐Blind, Parallel‐Group, R... by Hongjie Chi, Xin Zhang, Shumei Ma, Gang Pan, Xiaojuan Lian, Yan Chen, Haotian Pei, Zichen Liu, Xiangmin Lin

“…In this phase III, multicenter, double‐blind, parallel‐group, randomized controlled trial, patients aged 18–70 years with mean sitting systolic blood pressure (msSBP) between 140 and <180 mmHg and mean sitting diastolic blood pressure (msDBP) between 90 and <110 mmHg, following a 4‐week treatment with AML 5 mg, were randomized 1:1 to receive either ALI/AML or AML once daily for 12 weeks. …”
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Recombinant α-Klotho Protein Alleviated Acute Cardiorenal Injury in a Mouse Model of Lipopolysaccharide-Induced Septic Cardiorenal Syndrome Type 5 by Xi Liu, Yangyang Niu, Xiaoqin Zhang, Yingying Zhang, Ying Yu, Jieli Huang, Jiangtao Li, Chen Yu

“…Background and Aims. Klotho is an aging-suppressor gene mainly expressed in the renal tubules. …”
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Therapeutic alliance impact on analgesic outcomes in a real-world clinical setting: An observational study by Barrachina Jordi, Margarit César, Andreu Blanca, Zandonai Thomas, Ballester Pura, Muriel Javier, Cutillas Esperanza, Peiró Ana M.

“…Patients were predominantly middle-aged (75 % women, 72 % retired), experiencing moderate pain (VAS 40–70 mm) on average, and under a high morphine equianalgesic dosage (95 ± 88 mg per day, mainly tapentadol or fentanyl). …”
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Association between air pollutants and blood cell counts in pediatric patients with asthma: a retrospective observational study by Kuo-Chen Huang, Hsiu-Yung Pan, Ting-Min Hsieh, Chih-Cheng Chen, Fu-Jen Cheng

“…Methods This retrospective observational study, performed in 2007–2018 at a medical center, enrolled non-trauma patients aged < 17 years who visited the emergency department and had asthma. …”
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Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits by Jie Wu, Jiamin Zhai, Haofan Jia, Ifeanyi Solomon Ahamba, Xianggui Dong, Zhanjun Ren

“…Results In this study, we identified the hair follicle stages of Rex rabbits aged 3 to 5.5 months. Skin samples collected at 4, 5 and 5.5 months, representing the morphological features of the anagen, catagen and telogen stage separately, were finally selected for whole-transcriptome analysis. 25,736 mRNA, 8280 lncRNA, 24,885 circRNA and 1138 miRNA transcripts were identified. 6027 differently expressed mRNAs (DEGs), 2381 differently expressed lncRNAs (DELs), 438 differently expressed circRNAs (DECs) and 167 differently expressed miRNAs (DEMs) were detected in the anagen vs. catagen (AvC) comparison. 4092 DEGs, 1540 DELs, 356 DECs and 141 DEMs were detected in the anagen vs. telogen (AvT) comparison. 2290 DEGs, 779 DELs, 249 DECs and 92 DEMs were detected in the catagen vs. telogen (CvT) comparison. …”
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Lifestyle risk factors for overweight and obesity among rural Indian adults: a community-based prospective cohort study by Rajesh Kumar Rai, Sabri Bromage, Jan-Walter De Neve, Anamitra Barik

“…To address this evidence gap, this study used cohort data (baseline: 2018–19, follow-up: 2022–23) from the Birbhum Population Project (West Bengal, India) to analyse lifestyle risk factors and their association with incidence and remission of overweight/obesity among adults aged ≥18 years (sample: 8,974). Modified Poisson regression model was employed to attain the study objective. …”
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Undifferentiated Adipose Tissue Stem Cell Transplantation Promotes Hepatic Regeneration, Ameliorates Histopathologic Damage of the Liver, and Upregulates the Expression of Liver Re... by Konstantinos G. Apostolou, Ioannis G. Papanikolaou, Charalampos Katselis, Themistoklis Feretis, Dimitrios Kletsas, Manousos M. Konstadoulakis, Maria Lymperi, Angelica A. Saetta, Spiros Tsikalakis, George Agrogiannis, Efstratios Patsouris, George C. Zografos, Apostolos E. Papalois

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Owners’ perceptions of dog treat management in Western Romania by Sorana Daina, Anamaria Blaga-Petrean, Silvana Popescu, Ioana Delia Pop, Daniel Mierlita, Adrian Macri

“…The wide range and availability of these products often pair with the fondness of owners for their companions, leading to overfeeding them with rewards.MethodsThis study explored owner treat provision behaviors among 890 voluntarily participating dog owners in Western Romania through an online survey conducted between June and November 2023.ResultsThe majority of respondents were women (72%) and younger adults aged 18–24 (39%). Emotional attachment was the primary motivation for providing treats (52%), followed by perceived health benefits (35%) and training purposes (25%). …”
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Randomised controlled trial of topical kanuka honey for the treatment of rosacea by James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, Janwillem Kocks, Mark Holliday, Andrew Corin, Colin Helm, Davitt Sheahan, Barney Montgomery, Judith Riley, Anna Hunt, Christopher Tofield

“…Objective To investigate the efficacy of topical 90% medical-grade kanuka honey and 10% glycerine (Honevo) as a treatment for rosacea.Design Randomised controlled trial with blinded assessment of primary outcome variable.Setting Outpatient primary healthcare population from 5 New Zealand sites.Participants 138 adults aged ≥16, with a diagnosis of rosacea, and a baseline blinded Investigator Global Assessment of Rosacea Severity Score (IGA-RSS) of ≥2. 69 participants were randomised to each treatment arm. 1 participant was excluded from the Honevo group, and 7 and 15 participants withdrew from the Honevo and control groups, respectively.Interventions Participants were randomly allocated 1:1 to Honevo or control cream (Cetomacrogol), applied twice daily for 8 weeks.Main outcome measures The primary outcome measure was the proportion of participants who had a ≥2 improvement in the 7-point IGA-RSS at week 8 compared to baseline. …”
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Association of Cardiovascular Disease Risk Factors With Estimated Dietary Salt Consumption in Bangladeshi Adults: A Nationally Representative Cross‐Sectional Study by Lingkan Barua, Tahmina Akhter, Rijwan Bhuiyan, Halima Akter Sathi, Palash Chandra Banik, Mithila Faruque, Muhammad Aziz Rahman, Sheikh Mohammed Shariful Islam

“…It included a non‐institutionalized adults’ population of 6189 men and women aged 18–69 years. Their daily salt consumption was estimated using the spot urine sodium concentration following the Tanaka equation and reported according to the standard nomenclature proposed by the World Hypertension League and partner organizations involved in dietary salt reduction. …”
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Yngre förskolebarns litteratursamtal by Hanna Thuresson

“…This article aims to contribute knowledge about how children aged 1–2 years interact in literary encounters when educators are not involved. …”
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The Application of Machine Learning Algorithms to Predict HIV Testing in Repeated Adult Population–Based Surveys in South Africa: Protocol for a Multiwave Cross-Sectional Analysis... by Musa Jaiteh, Edith Phalane, Yegnanew A Shiferaw, Refilwe Nancy Phaswana-Mafuya

“…MethodsA retrospective analysis of multiwave cross-sectional survey data will be conducted to determine the predictors of HIV testing among South African adults aged 18 years and older. A supervised ML technique will be applied across the five cycles of the South African National HIV Prevalence, Incidence, Behavior, and Communication Survey (SABSSM) surveys. …”
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Jovens e os Stories do Instagram: estudo netnográfico durante a pandemia da Covid-19 by Alan César Belo Angeluci, Brasilina Passarelli, Carolina Gois Falandes, Milena Possar Garcia

“…A netnography (a variation of online ethnography) was conducted in three stages: participant observation, web scraping, and video interviews with young people aged 15 to 18 in the metropolitan region of São Paulo, following Bardin's Content Analysis. …”
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Personality traits and their relationship with oral health related quality of life among adolescents in Saudi Arabia by Danah Sahmi Alhajri, Danah Abdullatif Alhammad, Lulwah Fouad Alabdulqader, Reem Rashed Alasbly, Muhanad Alhareky, Mazin Algahtani, Asim Al-Ansari, Muhammad Ashraf Nazir

“…Methods This cross-sectional study included male and female students aged 12–18 years from different schools in the Eastern Province of Saudi Arabia. …”
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Nissen-Sleeve procedure versus laparoscopic Roux-en-Y gastric bypass in patients with morbid obesity and gastro-oesophageal reflux disease: protocol for a non-inferiority randomise... by Jan A Apers, Martin Dunkelgrun, Ivonne Leeuwenburgh, Judith W H 't Hart, Bo J Noordman, Laser U Biter

“…Patients with morbid obesity aged 18 years and older with GORD according to the Montreal definition will be included after obtaining informed consent. …”
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The Metabolome Characteristics of Aerobic Endurance Development in Adolescent Male Rowers Using Polarized and Threshold Model: An Original Research by Fanming Kong, Miaomiao Zhu, Xinliang Pan, Li Zhao, Sanjun Yang, Jinyuan Zhuo, Cheng Peng, Dongkai Li, Jing Mi

“…Methods: Twenty-four male rowers aged 14–16 were randomly divided into a THR group and a POL group (12 participants each). …”
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Comparative Evaluation of the Effectiveness of Manual and Electric Toothbrushes in Blind Children: A Randomised Controlled Trial by PS Thanalakshme, R Ramesh

“…Materials and Methods: A randomised controlled clinical trial conducted at a high school for the blind in Palayamkottai, Tirunelveli district, Tamil Nadu, India on 120 blind chidren aged 6-12 years. The study participants was divided into Group 1, the manual toothbrush group, received a standard soft-bristle manual toothbrush (Colgate Sanxiao Co., Ltd., No. 8 Gaolujie Road, Guang Ling District, Yangzhou, 225111). …”
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Global prevalence, treatment and outcome of tuberculosis and COVID-19 coinfection: a systematic review and meta-analysis (from November 2019 to March 2021) by Qiang Sun, Hui Li, Jie Zhao, Xiaolin Wei, Quan Wang, Shasha Guo, Quanfang Dong, Ning Xu

“…The only study revealing prevalence rate came from West Cape Province, South Africa (people aged above 20 years, 0.04% until 1 June 2020 and 0.06% until 9 June 2020). …”
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