Associations between serum cytokine levels and postmenopausal depression in postmenopausal women with and without menopause hormone therapy by Ketan Chu, Xi Lin, Saisai Li, Linjuan Ma, Yizhou Huang, Fan Wu, Mengna Shou, Nazaré Alva Galang Cabarrabang, Yibing Lan, Jianhong Zhou

“…Methods This study included a total of 136 Chinese postmenopausal women aged 40 to 65 years who visited the gynecology outpatient department between June 2020 and December 2022. …”
Get full text

Cardiovascular risk and mortality in men receiving testosterone replacement therapy for Klinefelter syndrome in Denmark: a retrospective cohort studyResearch in context by Simon Chang, Lars Pedersen, Anne Skakkebæk, Agnethe Berglund, Claus H. Gravholt

“…We similarly identified a comparison cohort of 50,150 men from the background population matched on month and year of birth. Median age at entry for KS-TRT was 31.1 years (interquartile range; 19.9–40.0) and median follow-up time was 12.9 years (interquartile range; 7.5–20.7). …”
Get full text

Potential to recover a record of Holocene climate and sea ice from Müller Ice Cap, Canada by David Armond Lilien, Niels Fabrin Nymand, Tamara Annina Gerber, Daniel Steinhage, Daniela Jansen, Laura Thomson, Madeline Myers, Steven Franke, Drew Taylor, Prasad Gogineni, Marcos Lemes, Bo Møllesøe Vinther, Dorthe Dahl-Jensen

“…The current mean annual surface temperature is −19.6 °C, which combined with modeling of the temperature profile indicates that the ice is frozen to the bed. Modeling of the depth-age scale indicates that Pleistocene ice is likely to exist with measurable resolution (300–1000 yr m−1) 20–90 m from the bed, assuming that Müller Ice Cap survived the Holocene Climatic Optimum with substantial ice thickness (~400 m or more). …”
Get full text

Work conditions and determinants of health status among industrial shift workers: a cross-sectional study by Sasha Javanmardi, Ludwig Rappelt, Ludwig Rappelt, Christian Baumgart, Daniel Niederer, Lars Heinke, Jürgen Freiwald

“…IntroductionThis study investigated potential health status differences among forging, manufacturing, and logistics workers.MethodsWe included 403 participants (age: 41 ± 12 years) from a medium-sized steel company (forge: 64, manufacturing: 299, logistics: 99). …”
Get full text

Antihypertensive drug-related problems in Vietnamese ambulatory care by Hoang Hai Nguyen, Le Anh Thu Vu, Minh-Hoang Tran, Hong Tham Pham

“…We analyzed 221 cases (patient age of 64.1 ± 9.0 years, 51.1% being female). On average, patients with SdT and SdT + add-on had 1.6 ± 1.3 and 1.6 ± 1.5 aDRP, respectively. …”
Get full text

Availability in ECMO Reduces the Failure to Rescue in Patients With Pulmonary Embolism After Major Surgery: A Nationwide Analysis of 2.4 Million Cases by Johannes Diers, MD, Nikolas Baumann, MD, Philip Baum, MD, Konstantin L. Uttinger, MD, Johanna C. Wagner, MD, Peter Kranke, MD, Patrick Meybohm, MD, Christoph-Thomas Germer, MD, Armin Wiegering, MD

“…The overall failure to rescue (FtR) rate was 24.4% and increased significantly with patient age, as well as type of surgery. The availability of and experience in ECMO therapy (defined as at least 20 ECMO applications per year; ECMO centers) are associated with a significantly reduced FtR in patients with PE after high-risk surgical procedures. …”
Get full text

Evaluation of mandibular and maxillary second molar root canal anatomy in a Turkish subpopulation using CBCT: comparison of Briseno-Marroquin and Vertucci classifications by Hüseyin Gürkan Güneç, İpek Öreroğlu, Kemal Çağlar, Kader Cesur Aydin

“…Statistical analyses, including the chi-squared test, were used to assess correlations between root number and demographic variables such as age and sex. Results According to Benjamı´n Brisen˜ o Marroquı´n classification system, the most common configuration for upper right three-rooted teeth mesial root was 3URM2−1 (n:66, 35.7%), for distal root was 3URM1 (n:169, 91.4%), and for palatal root was 3URM1 (n:165, 89.2%). …”
Get full text

Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast Cancer by Ramazan Oguz Yüceer, Sedanur Aydın, Iclal Gelir, Tulay Koc, Ersin Tuncer, Mahmut Ucar

“…<b>Results</b>: The median age of the cohort was 50 years old. High Trop-2 expression was observed in 55.4% of the patients and was significantly associated with advanced disease stage (<i>p</i> < 0.001). …”
Get full text

Pathway to care among adolescents and young adults with breast cancer in Nigeria: a mixed methods study by Atara Ntekim, Ayorinde Folasire, Oluwaponmile A. Odukoya, Anthonia Sowunmi, Adewunmi Alabi

“…Results A total of 46 female participants were recruited into the quantitative component of the study, and the mean age was 34.2 ± 4.4 years. Most had higher education, were married, and were in a lower earning bracket. …”
Get full text

Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects by Agnieszka Żak-Gołąb, Piotr Kocełak, Małgorzata Aptekorz, Maria Zientara, Łukasz Juszczyk, Gayane Martirosian, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz

“…Plasma zonulin level correlated positively with age (r=0.43, P<0.001), body mass (r=0.30, P<0.01), BMI (r=0.33, P<0.01), fat mass and fat percentage (r=0.31, P<0.01 and r=0.23, P<0.05, resp.). …”
Get full text

Hereditary angioedema diagnosis evaluation score (HADES): A new clinical scoring system for predicting hereditary angioedema with C1 inhibitor deficiency by Ricardo Zwiener, MD, Rafael Zamora, MD, Carlos María Galmarini, MD, PhD, Laura Brion, PhD, Laura Arias, MD, Andrea Pino, MD, Paula Rozenfeld, PhD

“…Eight clinical variables were identified as independent predictors of HAE: age at onset ≤20 years, recurrent limb edema, abdominal pain, vomiting, trauma as a trigger, absence of wheals, family history of angioedema, and recurrent edema lasting ≥24 hours. …”
Get full text

Methodological issues of retrospective surveys for measuring mortality of highly clustered diseases: case study of the 2014–16 Ebola outbreak in Bo District, Sierra Leone by Grazia Caleo, Kamalini Lokuge, Katina Kardamanidis, Jane Greig, Jaroslava Belava, Emer Kilbride, Alhaji Sayui Turay, Gbessay Saffa, Ronald Kremer, Francesco Grandesso, Kostas Danis, Armand Sprecher, Gian Luca Di Tanna, Holly Baker, Helen A. Weiss

“…Rates were calculated for all-cause, all-age, under-5 and EVD-specific mortality, respectively, by areas and overall. …”
Get full text

Prevalence of Depression and Sleep Disorders in Patients on Dialysis: A Cross-Sectional Study in Qatar by Fadwa Al-Ali, Mostafa Elshirbeny, Abdullah Hamad, Ahmad Kaddourah, Tarek Ghonimi, Rania Ibrahim, Tarek Fouda

“…Our secondary aim was to study the associations of age, sex, and comorbid conditions with the QOL measures. …”
Get full text

Evaluating atherogenic index of plasma as a predictor for metabolic syndrome: a cross-sectional analysis from Northern Taiwan by Liang-Sien Chen, Liang-Sien Chen, Liang-Sien Chen, Liang-Sien Chen, Yu-Rui Chen, Yu-Rui Chen, Yi-Hsiu Lin, Yi-Hsiu Lin, Hung-Keng Wu, Hung-Keng Wu, Yan Wen Lee, Jau-Yuan Chen, Jau-Yuan Chen

“…Our study classified AIP levels equally into three tertiles and evaluated their impact on MetS through a logistic regression model.ResultsAfter adjusting for age, gender, BMI, SBP, FPG, and LDL in our models, the ORs for MetS in the second and third tertiles of the AIP were 3.81 (95% CI: 2.33 to 6.21; OR: 37.14, 95%: 23.22 to 59.39). …”
Get full text

ICU Admission, Invasive Mechanical Ventilation, and Mortality among Children and Adolescents Hospitalized for COVID-19 in a Private Healthcare System by Maria da Gloria Cruvinel Horta, Geraldo Jose Coelho Ribeiro, Nelson Otavio Beltrao Campos, Douglas Ribeiro de Oliveira, Lelia Maria de Almeida Carvalho, Karina de Castro Zocrato, Daniel Pitchon dos Reis, Mariana Ribeiro Fernandes, Ricardo Mesquita Camelo, Fernando Martin Biscione, Silvana Marcia Bruschi Kelles

“…The median monthly rate of index hospitalization was 2.7 (interquartile range [IQR], 1.6-3.9) per 100,000 clients aged 21 years or less. The median age of the patients was 4.5 years (IQR, 1.4-14.1). …”
Get full text

Nasal microbial diversity is associated with survival in piglets infected by a highly virulent PRRSV-1 strain by Pau Obregon-Gutierrez, Martí Cortey, Gerard E. Martín-Valls, Hepzibar Clilverd, Florencia Correa-Fiz, Virginia Aragón, Enric Mateu

“…Results Piglets that survived the PRRSV-1 outbreak reported a more diverse and different nasal microbiota at three weeks of age compared to piglets dying, which was highly related with the litter of origin and the sow of the piglets. …”
Get full text

Specific shoot formation in Miscanthus sacchariflorus (Poaceae) under different environmental factors and DNA passportization using ISSR markers by O. V. Dorogina, N. S. Nuzhdina, G. A. Zueva, Yu. A. Gismatulina, O. Yu. Vasilyeva

“…As a result of analysis of variance, it was found that the number of shoots does not depend on environmental conditions, but on the age of the plant, while environmental conditions have a significant effect on plant height. …”
Get full text

Circular RNA encoded by PPARG in the peripheral blood and a lipopolysaccharide-induced cardiomyocyte inflammation model is identified as a marker of fulminant myocarditis by Shasha Huang, Shumin He, Fei Xiao, Yang Zhou, Su Lyu

“…Methods Peripheral blood was collected from 5 children with FM and 5 sex- and age-matched healthy controls; total RNA was extracted from each sample, and the extracted RNA from each group was pooled. …”
Get full text

Revealing the limitations of 10-year MACE observations: 20-year observed total cardiovascular burden in the EPIC-Norfolk study by Frank LJ Visseren, Harald T Jorstad, Marjolein Snaterse, S Matthijs Boekholdt, Tinka J van Trier, Jannick AN Dorresteijn, Manon van den Bogaart, Wilma JM Scholte op Reimer, Ron JG Peters

“…Therefore, we aimed to quantify how well 10-year observed incidence reflects 20-year observed incidence and how MACE reflects total CVD events across demographic groups, using observations in long-term prospective data.Methods In individuals aged 40–79 without CVD or diabetes from the population-based EPIC-Norfolk cohort, we compared the first occurrence of 10 and 20 years (1) 3-point MACE events (non-fatal myocardial infarction+non-fatal stroke+fatal CVD) and (2) total CVD events (all non-fatal and fatal CVD events leading to hospitalisation), stratified by sex and age.Results Among 22 569 participants (57% women), incident 10-year and 20-year 3-point MACE was 5.3% and 15.5%, respectively, yielding 20/10 year ratios from 2.2 (in older men) to 4.5 (in younger women). …”
Get full text

Laser Based ¹³C-urea Breath Test in Quantitative Assessment of Bacterial Colonization, Severity of Inflammation and Atrophy in Gastric Mucosa by E. V. Stepanov, V. T. Ivashkin

“…To analyze the dependence of the results of diode laser spectroscopy (DLS) based 13C-UBT on age, nosology, activity and severity of the inflammatory process, the degree of atrophy and metaplasia.Materials and methods. …”
Get full text