Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation by Hermine Counil, Rummenigge Oliveira Silva, Jean‐Michel Rabanel, Charlotte Zaouter, Mohamed Haddad, Mohamed Raâfet Ben Khedher, Davide Brambilla, Tamas Fülöp, Shunmoogum A. Patten, Charles Ramassamy

“…Abstract Alzheimer's disease (AD) is an age‐related neurodegenerative pathology. Brain‐derived extracellular vesicles (EVs) have been demonstrated to be implicated in AD pathogenesis by facilitating the propagation of Tau, amyloid‐β and inflammatory cytokines. …”
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Frequency and structure of emergency calls to the eye centers at the third stage of ophthalmic care depending on its availability in the regions of Azerbaijan by B.Kh. Gadzhieva

“…</p> <p> <b>Conclusion</b>: the frequency of emergency calls to the NCO depends on the availability of ophthalmic care at the local level. Men of working age predominate among the patients. </p> <p> <b>Keywords</b>: emergency call, ophthalmic care, third level, availability, Azerbaijan, nosological structure. …”
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Serum prolactin levels and its clinical correlates in women presenting with infertility at the gynaecologic clinic of a tertiary hospital in North-central Nigeria by Julius Kolajo Dare, Tola Yinka Bakare, Grace Ezeoke, Muideen Gbenga Adesola, Hafeez Ayotunde Salawu, Kikelomo Temilola Adesina, Abiodun Akanbi Gafar Jimoh, Sikiru Abayomi Biliaminu

“…Methods: A comparative descriptive cross-sectional study involving reproductive-aged women with infertility Consenting female hospital staff in the same age group, without prior infertility were the control group. …”
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Understanding the vaginal microbiome among women with different genotypes of human papillomavirus infection in remote Andaman islands by Rehnuma Parvez, Santhiya Vijayakumar, Alwin Vins, Sudha Ramaiah, Anand Anbarasu, Lipika Biswas, Nisha Beniwal, Harpreet Kaur, Nagarajan Muruganandam

“…In terms of bacterial diversity, the study found statistically significant association when comprising individuals aged 21 to 30 years to those aged 31 to 40 years.ConclusionMost research concluded that exposure to HPV can boost bacterial diversity in vagina compared to healthy women, increasing the risk of cervical cancer development. …”
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Application value of central venous-arterial carbon dioxide partial pressure difference in postoperative cognitive dysfunction in patients with acute aortic dissection by Lei Wang, Zhen Hong Wang, Duan Qi Zhu, Xin Yi Xie, Xin Chen, Xiao Liang Wang

“…In addition, logistic regression analysis revealed that advanced age, serum S100β levels, female gender, CPB time, unilateral brain perfusion time, hyperlipidemia, diabetes, and smoking history were all independent risk factors for postoperative POCD (all P < 0.05). …”
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Clinical and molecular analyses of isolated central congenital hypothyroidism based on a survey conducted in Japan by Nao Shibata, Chikahiko Numakura, Takashi Hamajima, Kenichi Miyako, Ikuma Fujiwara, Jun Mori, Akihiko Saitoh, Keisuke Nagasaki

“…Five patients with isolated central CH diagnosed after 3 months of age were variant-negative, except for one female patient with a heterozygous IGSF1 variant. …”
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Dispersion and Intersection of Hydrothermal Plumes in the Manus Back-Arc Basin, Western Pacific by Zhigang Zeng, Xiaoyuan Wang, Bramley J. Murton, Haiyan Qi, Berit Lehrmann, Xiaohui Li, Zuxing Chen, Yunchao Shu

“…This implied that the plumes proximal to their vent fluid sources, which were interpreted to have relatively young ages, dispersed chemically over time, and their concentrations became more similar to those of the plumes that were more distal from their vent fluid sources.…”
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Double Transseptal Puncture for Catheter Ablation of Atrial Fibrillation: Safety of the Technique and Its Use in the Outpatient Setting by Laurent M. Haegeli, Thomas Wolber, Ercüment Ercin, Lukas Altwegg, Nazmi Krasniqi, Paul G. Novak, Laurence D. Sterns, Corinna B. Brunckhorst, Thomas F. Lüscher, Richard A. Leather, Firat Duru

“…Method. 269 ablation procedures were performed in 243 patients (mean age 56.6±9.3 years, 75% men) using the double transseptal puncture for catheter access in all cases. …”
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Relationship between effective blood flow rate and clinical outcomes in maintenance hemodialysis patients: a single-center study by Zhoucang Zhang, Jiarui Li, Jiaxiang Ding, Shenglei Zhang, Mei Wang, Jinsheng Xu

“…After adjusting for relevant factors including age, sex, vintage, diabetes, CVD, receiving hemodiafiltration (HDF) treatment and spKt/V, Cox models indicated a low time-averaged eBFR (≤ 275 ml/min) was associated with increased risks of all-cause mortality (hazard ratio [HR] 14.18; 95% confidence interval [CI], 3.14–64.1) and new MACE (HR 3.76; 95% CI, 1.91–7.40) in MHD patients. …”
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Gardé·es à vue. Domination(s) et reconfigurations des rapports entre manifestant·es et policier·es pendant le hirak (2019-2021) by Lina Benchekor

“…The practices of the forces of law and order towards demonstrators can take different forms depending on their sociological characteristics: gender, social class, age, marital status, level of education, etc. This article seeks to understand the lived experiences, shared representations of the security apparatus and biographical consequences of confrontation with repressive violence by citizens first involved in the hirak movement. …”
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Non-Invasive Cancer Detection Using Blood Test and Predictive Modeling Approach by Tarawneh AS, Al Omari AK, Al-khlifeh EM, Tarawneh FS, Alghamdi M, Alrowaily MA, Alkhazi IS, Hassanat AB

“…In addition, we experimented with the dataset’s missing values using the histogram gradient boosting (HGB) model.Results: The feature ranking method demonstrated the ability to distinguish cancer patients from healthy individuals based on hematological features such as WBCs, red blood cell (RBC) counts, and platelet (PLT) counts, in addition to age and creatinine level. The random forest (RF) classifier, followed by linear discriminant analysis (LDA) and support vector machine (SVM), achieved the highest prediction accuracy (ranging from 0.69 to 0.72 depending on the scenario and method investigated), reliably distinguishing between malignant and benign conditions. …”
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The effects of the Wnt/β-catenin signaling pathway on the in vitro differentiation of rat BMSCs into leydig cells by Pengyu Yan, Yaxiong Guo, Shoaib Muhammad, Jinxiong Zhu, Yuxiang Liu, Chun Liu

“…Abstract Late-onset hypogonadism (LOH) refers to sexual and non-sexual symptoms in men caused by age-related decreases in circulating testosterone. …”
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Genetically edited human placental organoids cast new light on the role of ACE2 by Anya L. Arthurs, Bianca Dietrich, Martin Knöfler, Caleb J. Lushington, Paul Q. Thomas, Fatwa Adikusuma, Jessica M. Williamson, Susan Babikha, Tyla Damhuis, Tanja Jankovic-Karasoulos, Melanie D. Smith, Kirsty G. Pringle, Claire T. Roberts

“…Abstract ACE2 expression is altered in pregnancy disorders and ACE2 gene variants are associated with several major pregnancy complications including small-for-gestational-age, fetal growth restriction and preeclampsia. …”
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Females have Lower Knee Strength and Vertical Ground Reaction Forces During Landing than Males Following Anterior Cruciate Ligament Reconstruction at the Time of Return to Sport by Zachary B. Sullivan, Barrie S. Sugarman, Mallory S. Faherty, Carrie Killelea, Dean C. Taylor, Daniel Le, Alison P. Toth, Jonathan C. Riboh, Lee H. Diehl, Jocelyn R. Wittstein, Annunziato Amendola, Timothy C. Sell

“… # Methods Ten male and eight female athletes (age: 20.8 years &plusmn;6.3, height: 173.2 cm &plusmn;10.1, mass: 76.6 kg &plusmn;18.3) participated in the study following ACLR at time of RTS (mean 10.2 months). …”
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Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients by Kota Hori, Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Ayaka Matsumoto, Sayuri Shimazu, Ai Shiraishi, Yoshifumi Kido, Takahiro Bise, Aomi Kuzuhara, Takenori Hamada, Kouki Yoneda, Kenichiro Maekawa

“…Results Of the 1,490 patients recruited, 158 (median age of 79 years; 88 men) had systemic inflammation on admission and were included in the study. …”
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Gambaran Tingkat Depresi pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis di RSUP DR. M. Djamil Padang by Fitri Amalia, Nadjmir ., Syaiful Azmi Azmi

“…Most characteristics of the respondents who were depressed were as follows : age 40-49 years, female, married, educated, past high school, housewives work and do not work, 13-18 months undergoing hemodialysis.…”
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Evaluation of throwing ability after coracoid transfer in non-overhead athletes by Ryota Yokoi, DP, Takayuki Kawasaki, MD, PhD, Yuuki Hirai, DP, Hiroki Tanabe, MD, Tomohiko Tateishi, MD, PhD, Nobukazu Maki, DP, Daichi Morikawa, MD, PhD, Muneaki Ishijima, MD, PhD

“…Methods: The study included non-overhead athletes (n = 11; Bristow-Latarjet [BL] group) who suffered shoulder dislocation and underwent coracoid transfer on the dominant side of the shoulder and healthy volunteers (n = 20; C group) from the same population (overall age distribution: 18–22 years). All participants were evaluated for shoulder function including ball-throwing abilities (e.g., ball velocity and long-throw distance). …”
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Evaluating a targeted selective speech, language, and communication intervention at scale – Protocol for the Happy Talk cluster randomised controlled trial. [version 3; peer review... by Pauline Frizelle, Darren Dahly, Aoife O'Shea, Aileen Murphy, Cristina McKean

“…Background In areas of social disadvantage up to 40–50% of children enter preschool with speech and language skills significantly poorer than would be expected for their age. The Happy Talk trial tests if a community embedded, targeted selective speech and language programme that simultaneously engages with parents and early childhood educators, (1) improves language outcomes in children aged between 2 years 10 months and 6 years and (2) is cost effective for the health care system. …”
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A mobile-based multidomain lifestyle intervention using Cognitive Evergreenland for older adults with subjective cognitive decline: a feasibility study by Rong Lin, Yuanjiao Yan, Zhili Chen, Chenshan Huang, Junyu Zhao, Mingfeng Chen, Hong Li

“…Results The retention rate for MLIP-CE was 90.2% (37/41). Mean participant age was 70.93 ± 6.91 years, 73.2% of participants were female, and mean Montreal Cognitive Assessment score was 24.51 ± 2.87. …”
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Retrospective analysis of 1539 nasopharyngeal carcinoma cases: chemotherapy should not be excluded for non-Asian patients with T1-2N1M0 stage by Xin-Yu Li, Chang-Ying Zhong, Hui-Xian Xu

“…The variables included age, sex, race, marital status, survival time, survival status, TNM stage, radiation and chemotherapy. …”
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