Engineered T cells secreting αB7-H3-αCD3 bispecific engagers for enhanced anti-tumor activity against B7-H3 positive multiple myeloma: a novel therapeutic approach by Punchita Rujirachaivej, Teerapong Siriboonpiputtana, Kornkan Choomee, Kamonlapat Supimon, Thanich Sangsuwannukul, Pucharee Songprakhon, Krissada Natungnuy, Piriya Luangwattananun, Pornpimon Yuti, Mutita Junking, Pa-thai Yenchitsomanus

“…Chimeric antigen receptor (CAR) T-cell therapy targeting BCMA has shown efficacy in relapsed or refractory MM, but it faces resistance due to antigen loss and the tumor microenvironment. …”
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Women's experiences and acceptability of self-administered, home delivered, intravaginal 5-Fluorouracil cream for cervical precancer treatment in Kenya by Konyin Adewumi, Aparna Ghosh Kachoria, Everlyn Adoyo, Mercy Rop, Mercy Rop, Antony Owaya, Jennifer H. Tang, Jennifer H. Tang, Lisa Rahangdale, Lisa Rahangdale, Lisa Rahangdale, Chemtai Mungo, Chemtai Mungo, Chemtai Mungo

“…To understand women's experiences with self-administered 5FU, we evaluated the acceptability of this intervention among trial participants.MethodsAll 12 participants from the Phase I trial completed a structured questionnaire and in-depth semi-structured interviews in their preferred language, focusing on their experiences with 5FU self-administration, challenges faced, and overall acceptability of the intervention, including whether they would use it again or recommend it to someone who needed it. …”
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Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

“…It disproportionately affects populations facing health disparities. Although antiretroviral therapy (ART) has improved KS control in people with HIV (PWH), treatment options for advanced KS remain limited. …”
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CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma by Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Catrin Heim, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Philipp Wendel, Philipp Wendel, Philipp Wendel, Philipp Wendel, Süleyman Bozkurt, Sabine Harenkamp, Hermann Kreyenberg, Hermann Kreyenberg, Michael Merker, Michael Merker, Christian Münch, Christian Münch, Christian Münch, Elise Gradhand, Meike Vogler, Meike Vogler, Meike Vogler, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Halvard Bönig, Halvard Bönig, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger

“…IntroductionCAR-T cell therapy, though successful in hematologic malignancies, faces challenges in solid tumors due to limitations of autologous T cells. …”
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Climate change policies reduce air pollution and increase physical activity: Benefits, costs, inequalities, and indoor exposures by Sean Beevers, Nosha Assareh, Andrew Beddows, Gregor Stewart, Mike Holland, Daniela Fecht, Yunzhe Liu, Anna Goodman, Heather Walton, Christian Brand, Dimitris Evangelopoulos, Dylan Wood, Tuan Vu, David Dajnak

“…Our findings are relevant to other countries facing the NZ transition.…”
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Innovación en sueño by Laura Vigil, Toni Zapata, Andrea Grau, Marta Bonet, Montserrat Montaña, María Piñar

“…In addition, techniques such as cluster analysis are used to identify symptomatic patterns and phenotypes, which improves understanding of OSA pathophysiology and optimizes CPAP treatment.However, implementation of AI in hospitals faces technological, ethical, and legal barriers. …”
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L’aqueduc de Fontanières : un cinquième aqueduc romain à Lyon ? by Jean-Yves Barbier

“…Within this transitional zone, the steep hillside at the foot of which flows the Saône, downstream from and at its confluence with the Rhône in Antiquity, extends from west to east between the communes of Sainte-Foy-lès-Lyon (Metropolis of Lyon) and La Mulatière (Metropolis of Lyon) around a north-south road built into a ledge that follows, mid-slope, the direction of the Narbonne road that provided access to Lugdunum from the south. Facing east, this steep slope is known as the Balme de Fontanières and, thanks to the complex history of its geological formation, it offers abundant water resources, as evidenced by the resurgences and catchments from various periods in the vicinity of the eponymous road.The Romans could neither have ignored nor neglected the availability of these nearby resources, especially as to the north and west of the town, they had been forced to develop the remarkable network of four aqueducts spanning over 200 km long –including those of the Gier, Mont d’Or, Yzeron and Brévenne rivers– which captured the attention of renowned researchers such as G. …”
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Construction of Multi-level Ecological Corridor System for National Parks: A Case Study of the Proposed Nanling National Park by Yi DENG, Zeyu HUANG, Ziyi MAO, Jinling HUANG

“…However, the current construction of ecological corridors faces challenges, such as not being able to adapt to future environmental changes, not being able to correspond to the multi-layered structure of ecosystems, and not being able to clarify the specific content of construction control. …”
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Survey on the Status and Training Demands of Capabilities for Diagnosing and Treating Common Diseases of Primary Care General Practitioners in Hunan Province by LI Lingqi, GAO Yinyan, ZHANG Yuqin, SUN Dingkui, WU Xinyin, ZHANG Weiru

“…Additionally, 77.2% (260/337) of participants lacked sufficient knowledge of clinical practice guidelines; 90.8% (306/337) of participants rarely consulted guidelines when facing decision-making difficulties, mainly because they felt guidelines could not address complex cases[50.0% (153/306) ], were unclear on how to search for guidelines[43.1% (132/306) ]and the resources available for retrieving guidelines[34.3% (105 /306) ]; participants mainly obtain the guidelines through the WeChat official account[72.5% (237/327) ] and databases such as the China National Knowledge Infrastructure [50.2% (164/327) ]. 97.0% (327/337) of participants expressed a demand for training to improve their capabilities, suggesting that training should be tailored to the specific needs of primary care institutions[60.8% (205/337) ]; the preferred approaches are advanced training in higher-level hospitals[71.3% (233/327) ]and primary care institutions with high diagnostic and treatment capabilities[56.3% (184/327) ]; the preferred training programs are on standardized treatment of common diseases[78.0% (263/337) ]and multiple coexisting diseases[69.4% (234/337) ]. …”
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The role of teacher-related factors in enhancing quality service provision in pre-primary schools of Gambella regional state, Ethiopia by Challa Ayale Legede, Tadesse Regassa Mamo, Desalegn Beyene Debelo, Abunu Arega Yismaw

“…This research aims to identify the challenges faced in pre-primary education and provide recommendations to improve the quality of service provision, ultimately fostering positive learning outcomes for children. …”
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Evaluation on Carbon Sequestration Capacity of 30 Common Landscaping Tree Species in Beijing by Jing QIAN, Sidong SHEN, Shuxin FAN, Li DONG

“…To maximize the carbon sink of the limited urban green spaces, it is necessary to choose landscaping tree species with high carbon sequestration capacity. Beijing is facing various environmental problems, such as severe urban island heat effect caused by vast greenhouse gas emission, and air pollution. …”
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Prevalence of Antimicrobial-Resistant Pathogens in Canadian Hospitals: Results of the Canadian Ward Surveillance Study (CANWARD 2007) by George G Zhanel, James A Karlowsky, Mel DeCorby, Kim A Nichol, Aleksandra Wierzbowski, Patricia J Baudry, Philippe Lagacé-Wiens, Andrew Walkty, Frank Schweizer, Heather Adam, Melissa McCracken, Michael R Mulvey, The Canadian Antimicrobial Resistance Alliance (CARA), Daryl J Hoban

“…BACKGROUND: Canadian hospitals as well as hospitals worldwide are increasingly faced with antibiotic-resistant pathogens, including multidrug-resistant (MDR) strains. …”
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Editorial by Jörg Tremmel, Marisa dos Reis, Joseph Burke, Raphaelle Schwarzberg (†)

“…The piece also goes into detail on the challenges faced by this young institution with respect to other actors and political processes. …”
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Harnessing root phenotyping and root growth plasticity of landraces of maize (Zea mays L.) for enhancing waterlogging tolerance in fragile and challenging agro-ecologies of Eastern... by E. Lamalakshmi Devi, Krishnappa Rangappa, Ayam Gangarani Devi, S.K. Chongtham, Ingudam Bhupenchandra, Konsam Sarika, Harendra Verma, Rumi Narzari, Samarendra Hazarika, Sankar Prasad Das, B.U. Choudhury, Anil Kumar Choudhury, T.L. Bhutia, V.K. Mishra

“…Maize is a major crop of the Eastern Himalayan Region (EHR) which faces significant environmental challenges including waterlogging (WL) under changing climate. …”
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Quais et ouvrages portuaires romains de Rouen/Rotomagus (Seine-Maritime) by Marie-Clotilde Lequoy

“…This structure presents a mixed external facing, made of medium and large limestone blocks, masoned with clay and sections of oak placed vertically about 1 m to 1.20 m apart from one another. …”
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Modified Bloom's Taxonomy: Perspective of a Doctor of Philosophy Scholar by Wafa Omer

“…It promotes a change from learning only theory to a more comprehensive strategy that emphasises real-world application and ongoing development.6 To promote a culture of creativity and lifelong learning, educational programs would concentrate not only on the creation of knowledge but also on how that information may be applied to other professional sectors.7 Current Dilemma The most prominent challenge that is being faced in the thesis being written by PhD scholars is that the new innovative discovery never finds its way into the clinical practice or the workplace. …”
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Student Engagement and Feedback on Online Learning and Facilitation: A Case Study of the National Open University of Nigeria by Adewale Adesina, Dorothy Ofoha, Olufemi A. Peters, Isaac S. Butswat

“…Thus, this study was designed to survey students’ online learning experience and gather feedback on various aspects of synchronous online facilitation including participation, satisfaction, barriers, and challenges faced during the virtual learning journey. 2,350 students took part in this study. …”
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Poverty Dynamics and the Fundamental Root Causes in Iran by Zahra Azari, Parviz Mohamadzadeh, Davoud Behboudi

“…Findings In recent decades, despite the fact that the debate on poverty and poverty alleviation strategies has been raising in the world, and in some countries, basic measures have been taken to reduce income poverty and multi-dimensional poverty have taken place, not only has the situation not improved in Iran, but the country is facing huge crises in this field. In this study, the factors affecting poverty in Iran have been presented in the form of four main themes of political, cultural, production and educational structure. …”
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Educide amid conflict: the struggle of the Palestinian education system by Dalal Iriqat, Rula Alousi, Tahani Z. Aldahdouh, Alaa AlDahdouh, Iman Dankar, Dima Alburai, Mohamed Buheji, Abdo Hassoun

“…Research limitations/implications – The research faces several limitations, including reliance on secondary sources, such as gray literature and official reports, which may limit firsthand insights and real-time data accuracy. …”
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The sport and Lithuanian national identity by Ingvaras Butautas, Rasa Čepaitienė

“…That is why the Lithuanian mentality, facing such strong challenges as EU integration and globalization, is in quest of national identity components "inventory" and reevaluation in the context of new circumstances.  …”
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