MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy by Gaofeng Ni, Yuwei Sun, Hongling Jia, Zhikai Xiahou, Yumeng Li, Fu Zhao, Hongyan Zang

“…Despite advancements in endocrine therapies, patients with advanced HR+BC often faced poor outcomes due to the development of resistance to treatment. …”
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Association Between Liver Fibrosis and Risk of Incident Stroke and Mortality: A Large Prospective Cohort Study by Zijie Wang, Zhitao Gong, Jianshang Wen, Shanyu Zhang, Xiao Hu, Wenliang Guo, Yanghua Tian, Qi Li

“…Noninvasive indices of liver fibrosis may serve as an easily accessible marker to detect individuals facing elevated risk of stroke and death in the primary prevention settings.…”
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Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3β Pathway by Zheng S, Xie Z, Zhou Z, Wang S, Xin Y, Lin J, Cheng K, Lu T, Qi R, Guo Y

“…Shuyu Zheng,1,2 Zejuan Xie,1 Ziao Zhou,1 Shanshan Wang,1 Yanlin Xin,1 Jiamin Lin,1 Keyu Cheng,1 Tianming Lu,1 Ruogu Qi,1 Yuanyuan Guo1 1Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China; 2Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang Province, 310009, People’s Republic of ChinaCorrespondence: Ruogu Qi; Yuanyuan Guo, Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China, Email rqi@njucm.edu.cn; guoyy@njucm.edu.cnPurpose: Metastatic non-small cell lung cancer (NSCLC) remains a global health threat, with patients facing inevitable disease progression despite standard-of-care therapy. …”
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Developing a comprehensive inventory to define harm reduction housing by Sofia Zaragoza, Joseph Silcox, Sabrina Rapisarda, Charlie Summers, Patricia Case, Clara To, Avik Chatterjee, Alexander Y. Walley, Miriam Komaromy, Traci C Green

“…Abstract Background The City of Boston has faced unprecedented challenges with substance use amidst changes to the illicit drug supply and increased visibility of homelessness. …”
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Management strategies for the efficient energy production of brackish water desalination to ensure reliability, cost reduction, and sustainability by A. Bdour, A. Hejab, L. Almakhadmeh, M. Hawa

“…This involved determining the expected savings by calculating the area between two curves: the new actual consumption of the brackish water reverse osmosis plant after implementing energy conservation measures and the curve generated by the model representing the usual consumption in the absence of energy conservation measures.FINDINGS: This study underscores the challenges faced by desalination, particularly regarding intensive energy consumption. …”
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Ten Machine Learning Models for Predicting Preoperative and Postoperative Coagulopathy in Patients With Trauma: Multicenter Cohort Study by Xiaojuan Xiong, Hong Fu, Bo Xu, Wang Wei, Mi Zhou, Peng Hu, Yunqin Ren, Qingxiang Mao

“…Multivariate logistic regression revealed that patients with PPTIC faced significantly higher risks of sepsis (1.75-fold), heart failure (1.5-fold), delirium (3.08-fold), abnormal coagulation (3.57-fold), tracheostomy (2.76-fold), mortality (2.19-fold), and urinary tract infection (1.95-fold), along with longer hospital and intensive care unit stays. …”
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Perbandingan Reaksi Zat Besi Terhadap Teh Hitam dan Teh Hijau Secara In Vitro dengan Menggunakan Spektrofotometer Uv-Vis by Husnil Wardiyah, Yustini Alioes, Dian Pertiwi

“…</p><p>Abstract<br />One of the nutritional problems faced by Indonesia is iron deficiency anemia. It is caused by inadequate intake and absorption. …”
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Development of an Integrated Model of Planning and Management in Free Zones with an Emphasis on Environmental Pressures by Mohammad Javad Amiri, Vahid Moghaddamzadeh, Gholamreza Nabi Bidhendi

“…Objective Nestled amidst the Arasbaran protected areas, Kiamaki wildlife sanctuary, and Dizmar protected area, the Aras Free Zone is a region teeming with environmental diversity and ecological significance. However, this region faces significant environmental challenges, primarily due to the overlooking of environmental principles in its economic development processes. …”
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Quality of life among residents of informal urban settlements during the COVID-19 pandemic in Salvador, Brazil by Albert I Ko, Federico Costa, Hammed Mogaji, Nivison Nery, Hernan D Argibay, Jaqueline S Cruz, Ianei O Carneiro, Ricardo Lustosa, Mike Begon, Hussein Khalil

“…Females and older adults faced more COVID-impacted challenges (p&lt;0.001) related to health, education, family, social relationships, work, finances and employment.Conclusion We found lower HRQOL among adults, females, the unemployed and those with lower school attainment. …”
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Water, Sanitation and Hygiene in a Conflict Area: A Cross-Sectional Study in South Kordofan, Sudan by Rofida Asmally, Abdelmalik A. Imam, Abdullatif Eissa, Abubakr Saeed, Ahmed Mohamed, Eahaa Abdalla, Mariam Alazraa M. Esmaeel, Mariam Elbashir, Mohamed H. Elbadawi, Mohammed Omer, Raghad Eltayeb, Ranya Mohammed, Tibyan Abdalhamed, Tina Merghani

“…South Kordofan, a state in southern Sudan, faces WASH challenges due to conflict, geographical factors, and inadequate services, impacting over 600,000 residents. …”
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Biofloc technology significantly reshapes water microbiome and improves survival rates in Japanese eel (Anguilla japonica) by Jiho Yang, Hyunjun Choi, Jun Seong Park, Yehyeon Cha, Ju-Ae Hwang, Seung-Yoon Oh

“…ABSTRACT Global aquaculture production faces the challenge of biologically cycling nitrogenous waste. …”
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Healthcare performance of leprosy management in peripheral health facilities of Dhanusa and Mahottari, Nepal by Ram Kumar Mahato, Uttam Ghimire, Bijay Bajracharya, Binod K. C., Deepak Bam, Deepak Ghimire, Uttam Raj Pyakurel, David T. S. Hayman, Basu Dev Pandey, Chuman Lal Das, Krishna Prasad Paudel

“…The results highlight many of the challenges facing leprosy elimination programs.…”
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Ethnobotanical survey of medicinal plants used in management of breast cancers in Qatar by Rasha.S.Abo El Alaa, Hend Al-Jaber, Fatima Al Zahraa Chokor, Abdullah A. Shaito, Layla Al-Mansoori

“…In Qatar, herbal medicine is widely used by the population, including breast cancer patients, yet preserving this knowledge faces significant challenges. This study aimed to document herbalists' ethnobotanical practices concerning breast cancer treatment in Qatar and corroborate any identified plant remedies' anticancer use with the literature. …”
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Glycogen and proximate content of white shrimp fed on different carbohydrate level and feeding frequency by , Zainuddin, , Haryati, Siti Aslamyah

“…One problem that commonly faced by pond farmer is the high price of feed with high protein content. …”
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Peripheral blood cell counts as predictors of immune-related adverse events in cancer patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis by Xinyu Zhang, Bei Zhang, Danfei Li, Yunchao Yang, Sen Lin, Ruiqi Zhao, Yijia Li, Lisheng Peng

“…Due to the variability in the frequency and severity of irAEs, clinical management faces a significant challenge in balancing antitumor efficacy with the risk of irAEs. …”
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Balancing Requirement Statements, Features and Technology Development Using QFD in Indigenous Macro Products in the Aviation Industry by Mahdi Googerdchian, Mohsen Asadi, Seyed ziaodin Ghazizadeh Fard, Soheil Imamian

“…In this research, the researchers faced with challenges due to the lack of familiarity with the elites or complete and sufficient research and training of the elites and managers of the country's research and defence industries. …”
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Identifying factors affecting the distribution strategy in the food industry with the attitude of marketing and online sales by solmaz seyedghafouri, Vahid nasehifar, Farid askari

“…Therefore, deciding on the way to transfer goods to the place of purchase or consumption is one of the important decisions that the marketing manager faces. These decisions are important in at least two aspects. …”
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The Role of Different Emotional States of Customers on Food Preferences by Mahmood Ghanbari, Kambiz Heidarzadeh Hanzaee, Behnaz Khodayari, Maryam Khalili Araghi

“…Depending on changes in lifestyle, food choices are becoming more complex, and consumers are faced with making informed decisions based on more diverse factors. …”
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Prevalence and temporal trends in myopia and high myopia children in China: a systematic review and meta-analysis with projections from 2020 to 2050Research in context by Wei Pan, Seang-Mei Saw, Tien Yin Wong, Ian Morgan, Zhikuan Yang, Weizhong Lan

“…Interpretation: China is facing a substantial and potentially worsening epidemic of childhood myopia. …”
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Assessment of Antibiotic Resistance Among Isolates of <i>Klebsiella</i> spp. and <i>Raoultella</i> spp. in Wildlife and Their Environment from Portugal: A Positive Epidemiologic Ou... by Carolina Sabença, Rani de la Rivière, Paulo Barros, João Alexandre Cabral, Roberto Sargo, Luís Sousa, Maria de Lurdes Enes Dapkevicius, Filipe Silva, Filipa Lopes, Ana Carolina Abrantes, Madalena Vieira-Pinto, Manuela Caniça, Gilberto Igrejas, Carmen Torres, Patrícia Poeta

“…One of the significant challenges facing modern medicine is the rising rate of antibiotic resistance, which impacts public health, animal health, and environmental preservation. …”
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