Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter by Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy

“…Both structures are in an inward (cytoplasmic side) facing conformation. The Neu5Ac-bound structure reveals the interactions of Neu5Ac with the transporter and its relationship with the Na+ binding sites. …”
Get full text

Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity by Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li

“…Abstract Lipid nanoparticles (LNPs) for mRNA delivery have advanced significantly, but LNP-mediated DNA delivery still faces clinical challenges. This study compared various LNP formulations for delivering DNA-encoded biologics, assessing their expression efficacy and the protective immunity generated by LNP-encapsulated DNA in different models. …”
Get full text

Investigating the Effect of Olfactory Stimulation in Preterm Infants: A Review Study by Hashem Lashgari Kalat, Mohammad Hasan Mohammadi, Shahabaddin Sorouri, Hossein Ali Kharazmi, Zahra Ramazanian Bafghi, Masumeh Ghazanfarpour, Najmeh Soltani Nejad

“…Background: Besides respiratory problems, the lack of or inefficient oral feeding performance is a major problem facing premature newborns. Researchers and clinicians need to be aware of procedures and positive olfactory stimuli mediating major problems and more adaptable premature infants to the neonatal intensive care unit and hospital environments. …”
Get full text

Accurate estimation of Jujube leaf chlorophyll content using optimized spectral indices and machine learning methods integrating geospatial information by Nigela Tuerxun, Sulei Naibi, Jianghua Zheng, Renjun Wang, Lei Wang, Binbin Lu, Danlin Yu

“…Hyperspectral data enable precise LCC monitoring by extracting spectral indices through optimal band combination (OBC) and predicting LCC with machine learning. However, OBC faces dimensionality issues, and machine learning models often overlook geographical influences, potentially reducing prediction accuracy. …”
Get full text

Understanding the exodus: a 15-year retrospective cohort study on the pattern and determinants of migration among Nigerian doctors and dentists by Oghenebrume Wariri, Patience Toyin-Thomas, Itua C.G. Akhirevbulu, Oladapo Oladeinde, Oluchi Omogbai, Philippa Odika, John Osakue, Avwebo Ukueku, Efetobo Orikpete, Chinelo Iwegim, Efe E. Omoyibo, Jermaine Okpere, Uwaila Otakhoigbogie, Ekhosuehi T. Agho, Sunday C. Madubueze, Nnennaya C. Ugoji, Chukwunwike W. Ozegbe, Oti N. Aria, Paul Ikhurionan

“…Background Nigeria faces a critical shortage of healthcare professionals yet experiences a significant annual exodus of doctors and dentists. …”
Get full text

C-IVAL: A Longitudinal Study of Knowledge Retention and Technology Acceptance in Collaborative Virtual Reality-Based Medical Education by Mohammed Kadri, Fatima-Ezzahra Boubakri, Gwo-Jen Hwang, Fatima Zahra Kaghat, Ahmed Azough, Khalid Alaoui Zidani

“…Anatomy education faces challenges in providing engaging, interactive, and collaborative learning experiences, particularly in understanding complex three-dimensional structures and maintaining long-term knowledge retention. …”
Get full text

The 0ν2β-decay CROSS experiment: preliminary results and prospects by The CROSS collaboration, I. C. Bandac, A. S. Barabash, L. Bergé, M. Brière, C. Bourgeois, P. Carniti, M. Chapellier, M. de Combarieu, I. Dafinei, F. A. Danevich, N. Dosme, D. Doullet, L. Dumoulin, F. Ferri, A. Giuliani, C. Gotti, P. Gras, E. Guerard, A. Ianni, H. Khalife, S. I. Konovalov, E. Legay, P. Loaiza, P. de Marcillac, S. Marnieros, C. A. Marrache-Kikuchi, C. Nones, V. Novati, E. Olivieri, C. Oriol, G. Pessina, D. V. Poda, T. Redon, V. I. Tretyak, V. I. Umatov, M. M. Zarytsky, A. S. Zolotarova

“…The basic concept of CROSS consists of rejecting this challenging background component by pulse-shape discrimination, assisted by a proper coating of the faces of the crystal containing the isotope of interest and serving as energy absorber of the bolometric detector. …”
Get full text

The multifaceted power of biochar: A review on its role in pollution control, sustainable agriculture, and circular economy by Amreen Bano, Mohd Kashif Aziz, Bablu Prasad, Rajesh Ravi, Maulin P. Shah, Pollyanna Vanessa Dos Santos Lins, Lucas Meili, Kumar Suranjit Prasad

“…It highlights the advantages, challenges, and diverse applications of biochar while critically examining current challenges and research gaps in its potential to mitigate greenhouse gas emissions, enhance soil carbon sequestration, and improve wastewater treatment processes.The potential of biochar to reduce greenhouse gas emissions and sequester carbon in soils, along with its applications in wastewater treatment, are thoroughly covered in this article. The challenges it faces and its prospects are also discussed in detail. …”
Get full text

Climate-change impacts on distribution, habitats, sustainability and cultivation planning of two economically and ecologically important forest trees (China fir and Masson pine) in... by Yanghui Zhao, Liang Xu, Ying Zhang, Yafeng Wen, Donglin Zhang

“…(ii) the suitable habitat is facing a situation of “North expansion” and “South contraction” and moving northward as a whole with climate change. …”
Get full text

Yield and Sensorial and Nutritional Quality of Strawberry (<i>Fragaria</i> × <i>ananassa</i> Duch.) Fruits from Plants Grown Under Different Amounts of Irrigation in Soilless Culti... by Davide Raffaelli, Rohullah Qaderi, Luca Mazzoni, Bruno Mezzetti, Franco Capocasa

“…Agriculture has been confirmed as the sector accounting for the highest water consumption globally, and it faces significant challenges relating to drought, impacting crop yields and food security. …”
Get full text

An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing by Jacob W. Fleming, Molly C. McCloskey, Kevin Gray, David R. Nash, Vincent Leung, Christos Michas, Shawn M. Luttrell, Christopher Cavanaugh, Julie Mathieu, Shawn Mcquire, Mark Bothwell, David L. Mack, Nicholas A. Geisse, Alec S.T. Smith

“…However, these models have faced challenges associated with their poorly scalable creation, sourcing suitable cells, and the extraction of reliable, quantifiable metrics. …”
Get full text

Provider Preference, Logistical Challenges, or Vaccine Hesitancy? Analyzing Parental Decision-Making in School Vaccination Programs: A Qualitative Study in Sydney, Australia by Leigh McIndoe, Alexandra Young, Cristyn Davies, Cassandra Vujovich-Dunn, Stephanie Kean, Michelle Dives, Vicky Sheppeard

“…<b>Results:</b> Analysis revealed three distinct groups of parents whose children were not vaccinated through the school program: (1) those favoring general practitioners for vaccination, driven by trust in medical providers and a preference for personalized care; (2) those intending to consent but facing logistical barriers, including communication breakdowns and online consent challenges; and (3) vaccine-hesitant parents, particularly regarding HPV vaccination, influenced by safety concerns and misinformation. …”
Get full text

Risks of Autologous Abdominal Free Flap Breast Reconstruction in Patients With Elevated Body Mass Index by Nathaniel A. Teitler, MD, Courtney J. Doherty, BS, Madalyn R. Adams, MD, Anna A. Podber, MD, Peter M. Granger, MD, Kaeli K. Samson, MPH, MA, Sean C. Figy, MD, Shannon L. Wong, MD, Heidi H. Hon, MD

“…To provide a clearer understanding of the challenges faced by patients with obesity, we present a single-center outcome analysis of individuals who underwent DIEP flap reconstruction. …”
Get full text

First note of QTL mapping of low vigor traits using the updated F2 ‘Koroneiki’ linkage map of olive by Irene Granata, Aparna S. Balan, Aparna S. Balan, Claudio Di Vaio, Antonino Ioppolo, Tiziano Caruso, Silvia Fretto, Jubina Benny, Antonio Giovino, Daniel James Sargent, Francesco Paolo Marra, Annalisa Marchese

“….), which characterizes the agriculture of the Mediterranean basin, faces challenges adapting to high-density orchards and mechanized cultivation. …”
Get full text

Current and future burden of breast cancer in Asia: A GLOBOCAN data analysis for 2022 and 2050 by Mengxia Fu, Zhiming Peng, Min Wu, Dapeng Lv, Yanping Li, Shuzhen Lyu

“…Global collaboration is essential to reduce its growing burden, especially in low-HDI countries facing rising incidence and high mortality rates.…”
Get full text

Quantitative evaluation of essential amino acids and omega-3 long-chain polyunsaturated fatty acids from global marine bivalve aquaculture by Karsoon Tan, Peng Xu, Leiheng Huang, Cong Luo, KhaiHang Choong, Zexin Li, Yu Guo, Kit-Leong Cheong

“…However, expanding protein production from land-based farming, fisheries, and fish aquaculture faces challenges such as limited land and water resources, high carbon emissions, overfished stocks, and reliance on unsustainable fish meal and fish oil. …”
Get full text

Morphological, Physiological, and Molecular Responses to Heat Stress in Brassicaceae by Iram Batool, Ahsan Ayyaz, Tongjun Qin, Xiaofen Wu, Weiqi Chen, Fakhir Hannan, Zafar Ullah Zafar, Muhammad Shahbaz Naeem, Muhammad Ahsan Farooq, Weijun Zhou

“…<i>Brassica napus</i>, the second-largest source of vegetable oil worldwide, faces drastic reductions in seed yield and quality under heat stress. …”
Get full text

Vaping – A Beneficial Alternative to Traditional Cigarettes or an Unexplored Danger? by Paulina Błasiak, Aleksandra Ślusarska, Patryk Mikołajec, Barbara Bilecka, Jolanta Mędyk, Małgorzata Wirkijowska, Jakub Wirkijowski, Yauheniya Patarocha, Michał Rogulski, Ruslan Huk

“…In addition, the article addresses the social aspect of vaping as a significant challenge faced by national public health institutions, with a special focus on the prevalence of addiction among youth. …”
Get full text

HALAL INDUSTRY IN KYRGYZSTAN: CURRENT STATE AND DEVELOPMENT PROSPECTS by Niyazali Turdalievich Aripov, Murat Zhuratovich Abdiev, Ahmad Syukran Baharuddin, Mirlanbek Baidusenovich Ubaidullaev

“… The halal industry in the Kyrgyz Republic faces a low level of development despite its great potential for economic growth and international market integration. …”
Get full text

Integrative analysis of metabolite and transcriptome reveals the biosynthetic pathway and candidate genes for iridoid glycoside biosynthesis in Neopicrorhiza scrophulariiflora (Pen... by Ke Rao, Ke Rao, Siyu Liu, Siyu Liu, Xiaohui Tang, Guofu Jia, Shaohua Yang, Chaoxiang Ren, Chaoxiang Ren, Jin Pei, Jin Pei

“…Due to overharvesting, N. scrophulariiflora resources are facing the risk of depletion, urgently requiring resource protection and rational utilization. …”
Get full text