Lost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severity by Eamonn MM Quigley, Thomas J Borody, Sabine Hazan, Neil Stollman, Huseyin S Bozkurt, Sonya Dave, Andreas J Papoutsis, Jordan Daniels, Brad D Barrows

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Spectroscopic Confirmation of a Massive Protocluster with Two Substructures at z ≃ 3.1 by Michael J. Nicandro Rosenthal, Amy J. Barger, Lennox L. Cowie, Logan H. Jones, Stephen J. McKay, Anthony J. Taylor

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STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment by Walter J Storkus, Ronald J Fecek, Manoj Chelvanambi, Jennifer L Taylor

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When is “convenient time” for residents?: a trial of Resident Study Log as asynchronous learning tool for residents by Tadayuki Hashimoto, Shoko Ariyoshi, Taira Ariyoshi, Ryosuke Horitani, Mohammad Adrian Hasdianda, Kanapa Kornsawad, Shunsuke Kosugi, Makoto Kikukawa, Tomio Suzuki

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The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats by Steve Mabry, Jessica L. Bradshaw, Jennifer J. Gardner, E. Nicole Wilson, Janak Sunuwar, Hannah Yeung, Sharad Shrestha, J. Thomas Cunningham, Rebecca L. Cunningham

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Clinical course of spinal pain in adolescents: a feasibility study in a chiropractic setting by Steven J Kamper, Christopher G Maher, Mark J Hancock, Simon D French, Lise Hestbæk, Katherine A Pohlman, Michael S Swain, Laura RC Montgomery, Anika Young, Amber Beynon

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Design and simulation of a 5 KW solar-powered hybrid electric vehicle charging station with a ANN–Kalman filter MPPT and MPC-based inverter control for reduced THD by Youness Hakam, Hajar Ahessab, Ahmed Gaga, Mohamed Tabaa, Benachir El Hadadi

“…The system achieves a Total Harmonic Distortion (THD) of just 0.56%, boosting charging speed while minimizing harmonic distortion costs. Controlled by Texas Instruments’ TMS320F28379D digital signal processor, this system offers stable, low-cost EV charging by prioritizing solar energy use, even under harsh weather conditions, over reliance on grid power.…”
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Secukinumab in the treatment of psoriatic arthritis: efficacy and safety results through 3 years from the year 1 extension of the randomised phase III FUTURE 1 trial by Philip J Mease, Arthur Kavanaugh, Andreas Reimold, Hasan Tahir, Jürgen Rech, Stephen Hall, Piet Geusens, Pascale Pellet, Evie Maria Delicha, Shephard Mpofu, Luminita Pricop

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Formation and fate of freshwater on an ice floe in the Central Arctic by M. M. Smith, N. Fuchs, E. Salganik, D. K. Perovich, I. Raphael, M. A. Granskog, K. Schulz, M. D. Shupe, M. D. Shupe, M. Webster

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Long-Term Safety and Effectiveness of Dimethyl Fumarate in Patients with Multiple Sclerosis Treated in Routine Medical Practice: Final Analysis of the ESTEEM Study by Krupa Shah Pandey, Kathryn Giles, Konstantin Balashov, Richard Macdonell, Jörg Windsheimer, Mikel Martinez, Ivan Božin, Stephanie Raynaud, Matthew Scaramozza, Oksana Mokliatchouk, Zhaonan Sun, Nicholas Belviso, Yayoi Sato, Xiaochen Lin, Annette Okai

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TAp63γ is the primary isoform of TP63 for tumor suppression but not development by Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang

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Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites by Yun Teng, Chao Luo, Xiaolan Qiu, Jingyao Mu, Mukesh K. Sriwastva, Qingbo Xu, Minmin Liu, Xin Hu, Fangyi Xu, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Maiying Kong, Zhanxu Liu, Xiang Zhang, Raobo Xu, Jun Yan, Michael L. Merchant, Craig J. McClain, Huang-Ge Zhang

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Caudate Nucleus Volume Mediates the Link between Cardiorespiratory Fitness and Cognitive Flexibility in Older Adults by Timothy D. Verstynen, Brighid Lynch, Destiny L. Miller, Michelle W. Voss, Ruchika Shaurya Prakash, Laura Chaddock, Chandramallika Basak, Amanda Szabo, Erin A. Olson, Thomas R. Wojcicki, Jason Fanning, Neha P. Gothe, Edward McAuley, Arthur F. Kramer, Kirk I. Erickson

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Tolerability and Effectiveness of Regorafenib Treatment in Patients with Unresectable Hepatocellular Carcinoma: Real-World Data from the United States by Finn RS, Iyer R, Kalman RS, Parikh ND, Cabrera R, Babajanyan S, Kaseb AO

“…Richard S Finn,1 Renuka Iyer,2 Richard S Kalman,3 Neehar D Parikh,4 Roniel Cabrera,5 Svetlana Babajanyan,6 Ahmed O Kaseb7 1Department of Medicine, University of California, Los Angeles, CA, USA; 2Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA; 3Department of Medicine, Einstein Medical Center, Philadelphia, PA, USA; 4Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA; 5Department of Medicine, University of Florida Health, Gainesville, FL, USA; 6US Medical Affairs, Oncology, Bayer Healthcare, Whippany, NJ, USA; 7Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Richard S Finn, Department of Medicine, University of California, Los Angeles, CA, USA, Tel +1-310-586-2091, Email rfinn@mednet.ucla.eduIntroduction: While several systemic therapies are available for unresectable hepatocellular carcinoma (uHCC), there is a lack of granular real-world evidence to support the efficacy and safety of these therapies. …”
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A maturity model for Clinical Trials Management Ecosystem by Shruti Sehgal, E. Chris Pua, Svetlana Rojevsky, Michael J. Becich, Joshua Fehrmann, Boyd M. Knosp, Adam Wilcox, Jeffery C. Talbert, Catherine K. Craven, Justin Starren

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Assessing survey design changes of long-term fishery-independent groundfish trawl surveys in the Gulf of Mexico by Adam G. Pollack, Eric R. Hoffmayer, Theodore S. Switzer, David S. Hanisko, Jill M. Hendon, John Mareska, Fernando Martinez-Andrade, Jeff Rester, Zachary C. Zuckerman, Gilmore Pellegrin

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First Results from the JWST Early Release Science Program Q3D: The Fast Outflow in a Red Quasar at z = 0.44 by Weizhe Liu, Sylvain Veilleux, Swetha Sankar, David S. N. Rupke, Nadia L. Zakamska, Dominika Wylezalek, Andrey Vayner, Caroline Bertemes, Yuzo Ishikawa, Yu-Ching Chen, Jenny E. Greene, Timothy Heckman, Guilin Liu, Hsiao-Wen Chen, Dieter Lutz, Sean D. Johnson, Nicole P. H. Nesvadba, Patrick Ogle, Nadiia Diachenko, Andy D. Goulding, Kevin N. Hainline, Fred Hamann, Hui Xian Grace Lim, Nora Lützgendorf, Vincenzo Mainieri, Ryan McCrory, Grey Murphree, Lu Shen, Eckhard Sturm, Lillian Whitesell

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Discovering Large-scale Structure at 2 < z < 5 in the C3VO Survey by Denise Hung, Brian C. Lemaux, Olga Cucciati, Ben Forrest, Ekta A. Shah, Roy R. Gal, Finn Giddings, Derek Sikorski, Emmet Golden-Marx, Lori M. Lubin, Nimish Hathi, Giovanni Zamorani, Lu Shen, Sandro Bardelli, Letizia P. Cassarà, Gabriella De Lucia, Fabio Fontanot, Bianca Garilli, Lucia Guaita, Michaela Monika Hirschmann, Kyoung-Soo Lee, Andrew B. Newman, Vandana Ramakrishnan, Daniela Vergani, Lizhi Xie, Elena Zucca

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The association of origin and environmental conditions with performance in professional IRONMAN triathletes by Beat Knechtle, Mabliny Thuany, David Valero, Elias Villiger, Pantelis T. Nikolaidis, Marilia S. Andrade, Ivan Cuk, Thomas Rosemann, Katja Weiss

“…Most of the athletes competed in IRONMAN Hawaii (925), IRONMAN Florida (563), IRONMAN Austria (452), IRONMAN France (354), IRONMAN Wisconsin (330), IRONMAN Lanzarote (322) and IRONMAN Texas (313). The Decision Tree and the XG Boost models were the best performing models (r2 = 0.48) and rated the relative feature importances in the order gender, country of origin, water temperature, air temperature and event location. …”
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Prolonged Cardiopulmonary Bypass Time-Induced Endothelial Dysfunction via Glypican-1 Shedding, Inflammation, and Matrix Metalloproteinase 9 in Patients Undergoing Cardiac Surgery by Shiyi Li, Katherine V. Nordick, Iván Murrieta-Álvarez, Randall P. Kirby, Rishav Bhattacharya, Ismael Garcia, Camila Hochman-Mendez, Todd K. Rosengart, Kenneth K. Liao, Nandan K. Mondal

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