Pretreatment Pan-Immune-Inflammation Value Efficiently Predicts Survival Outcomes in Glioblastoma Multiforme Patients Receiving Radiotherapy and Temozolomide by Erkan Topkan, Ahmet Kucuk, Ugur Selek

“…The novel PIV was able to independently stratify newly diagnosed GBM patients into two groups with fundamentally different PFS and OS outcomes following RT and concurrent plus adjuvant TMZ.…”
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Temozolomide Therapy for Aggressive Pituitary Tumors: Results in a Small Series of Patients from Argentina by Oscar D. Bruno, Lea Juárez-Allen, Silvia B. Christiansen, Marcos Manavela, Karina Danilowicz, Carlos Vigovich, Reynaldo M. Gómez

“…We evaluated results of temozolomide (TMZ) therapy in six patients, aged 34–78 years, presenting aggressive pituitary tumors. …”
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The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells by Po-An Tai MD, PhD, Yen-Lin Liu MD, PhD, Ya-Ting Wen MD, Chien-Min Lin MD, PhD, Thanh-Tuan Huynh MD, PhD, Michael Hsiao DVM, PhD, Alexander T. H. Wu PhD, Li Wei MD, PhD

“…Furthermore, prolonged temozolomide (TMZ) treatment enriched GSCs (reflected by increased percentage of CD133+ cells). …”
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Case report: A rare case of a long-term survivor of glioblastoma who underwent two courses of hypofractionated radiotherapy as part of her care by Midhad Mrvoljak, Midhad Mrvoljak, Shubhendu Mishra, Liam Chen, Liam Chen, Elizabeth Neil, Elizabeth Neil, Eric Ehler, Stephanie Terezakis, Stephanie Terezakis, Lindsey Sloan, Lindsey Sloan

“…Although planned, concurrent TMZ was not used during the complete first course of HFRT due to the patient’s performance status. …”
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Factors involved in maintaining Karnofsky Performance Status (≥ 50%) in glioblastoma, IDH-wildtype patients treated with temozolomide and radiotherapy by Shigeo Ohba, Takao Teranishi, Kazuyasu Matsumura, Masanobu Kumon, Daijiro Kojima, Eiji Fujiwara, Kazutaka Nakao, Kiyonori Kuwahara, Kazuhiro Murayama, Eriel Sandika Pareira, Seiji Yamada, Masahiro Joko, Shunsuke Nakae, Jun Muto, Yuya Nishiyama, Kazuhide Adachi, Hikaru Sasaki, Masato Abe, Mitsuhiro Hasegawa, Yuichi Hirose

“…Ninety-eight patients with glioblastomas, IDH-wildtype, who were treated with concomitant radiotherapy (RT) and temozolomide (TMZ) followed by maintenance TMZ therapy, and whose KPS at the start of RT was ≥ 50%, were included. …”
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Partially Transparent Jaumann-Like Absorber Applied to a Curved Structure by Alireza Motevasselian, B. L. G. Jonsson

“…In addition, once the structure is applied to the wing-front end, a significant reduction in two-dimensional radar cross-section for both the TMz and TEz polarization over 2–16 GHz is observed. …”
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Targeting glycolysis: exploring a new frontier in glioblastoma therapy by Lu Yang, Sijia Li, Lei Yu, Jiao Leng, Na Li

“…Glioblastoma(GBM) is a highly malignant primary central nervous system tumor that poses a significant threat to patient survival due to its treatment resistance and rapid recurrence.Current treatment options, including maximal safe surgical resection, radiotherapy, and temozolomide (TMZ) chemotherapy, have limited efficacy.In recent years, the role of glycolytic metabolic reprogramming in GBM has garnered increasing attention. …”
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Management of asynchronous multifocal adult glioblastoma with loss of BRAFV600E -mutant clonality: a case report by Hannah Haile, Pavan S. Upadhyayula, Esma Karlovich, Michael B. Sisti, Brian J. A. Gill, Laura E. Donovan

“…Initial treatment involved surgical resection followed by radiotherapy and temozolomide (TMZ). Subsequent recurrences were managed with re-resection and dabrafenib/trametinib combination therapy. …”
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A Rapid Biochemical and Radiological Response to the Concomitant Therapy with Temozolomide and Radiotherapy in an Aggressive ACTH Pituitary Adenoma by Ana Misir Krpan, Tina Dusek, Zoran Rakusic, Mirsala Solak, Ivana Kraljevic, Vesna Bisof, David Ozretic, Darko Kastelan

“…In the last eight years temozolomide (TMZ) has been used as the last-line treatment modality for aggressive pituitary tumors to be applied after the failure of surgery, medical therapy, and radiotherapy. …”
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Nanoparticles assisted drug delivery for effective management of Glioblastoma by Mansi Damani, Nagesh Nilawar, Munira Momin, Raghumani Singh Ningthoujham, Tabassum Khan

“…Standard treatments, including surgery, radiotherapy, and chemotherapy with temozolomide (TMZ), are often limited by the ability of the tumor to circumvent therapeutic effects and by the physiological barriers that restrict drug delivery to the brain parenchyma. …”
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干扰素-α/β体外增敏替莫唑胺对MGMT阳性胶质瘤干细胞作用

“…【目的】 探讨干扰素是否能增加替莫唑胺(TMZ)对O6甲基鸟嘌呤DNA甲基转移酶(MGMT)阳性胶质瘤干细胞的抗肿瘤作用及其可能机制。【方法】采用“悬浮克隆球形成法”对常规培养条件下MGMT阴性表达的胶质瘤细胞株U251、SKMG-4进行诱导,获得MGMT阳性的胶质瘤干细胞U251G、SKMG-4G;应用CCK-8法检测干扰素-α和干扰素-β联合替莫唑胺对MGMT阳性胶质瘤干细胞的杀伤效应;分别应用逆转录PCR(RT-PCR)、Western-blot检测干扰素-α/β作用后,MGMT阳性胶质瘤干细胞MGMT?…”
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