Longitudinal Metabolomics Data Analysis Informed by Mechanistic Models by Lu Li, Huub Hoefsloot, Barbara M. Bakker, David Horner, Morten A. Rasmussen, Age K. Smilde, Evrim Acar

“…<b>Methods</b>: We arranged time-resolved metabolomics measurements of plasma samples collected during a meal challenge test from the COPSAC₂₀₀₀ cohort as a third-order tensor: <i>subjects</i> by <i>metabolites</i> by <i>time samples</i>. …”
Get full text

Defining the sensitivity of cosmic ray muons to groundwater storage changes by Tramontini, Matías, Rosas-Carbajal, Marina, Zyserman, Fabio Iván,  Longuevergne, Laurent, Nussbaum, Christophe, Marteau, Jacques

“…We use a muon detector to compute a muon image of average density, and to study muon rate variations over time. After correcting these variations for atmospheric effects, we interpret the muon time series in terms of groundwater storage changes. …”
Get full text

Analysis of Adverse Pregnancy Outcomes of Pregnant Women with Syphilis and Maternal-Infant Serological Association in Changzhou, China, 2015–2019 by Chaorong Bian, Zhiqiang Qin, Jieying Zhang, Mengtao Sun, Manman Gu, Kejin Chen

“…There were statistically significant differences (P<0.01) in serologic titer changes, time to antibody regression, and time to exclusion of syphilis infection in children of pregnant women with syphilis infection after receiving different interventions during pregnancy, but different time distributions of interventions had no effect on these three indicators. …”
Get full text

Impact of postoperative morbidity on the prognosis of patients with hepatocellular carcinoma after laparoscopic liver resection: a multicenter observational study by Shiye Yang, Haishun Ni, Aixian Zhang, Jixiang Zhang, Hong Zang, Zhibing Ming

“…Independent prognostic factors of overall survival and time to recurrence of these patients were investigated using Cox regression analysis. …”
Get full text

Comparison of the Accuracy of Fixture-Level Implant Impression Making with Different Splinting Techniques by Mehrdad Nateghi, Ramin Negahdari, Sahar Molaei, Ali Barzegar, Sepideh Bohlouli

“…Also, choosing the right time of taking impressions after splinting implants is one of the important criteria that affects the impression-taking technique. …”
Get full text

Outcomes of intravitreal dexamethasone implant (Ozurdex®) in patients with post-surgical macular edema – a real-world scenario by Elder Ohara de Oliveira Júnior, Isabel Ahn, Rodrigo Antonio Brant Fernandes, Arthur Gustavo Fernandes

“…We observed a significant effect of the moment of Ozurdex implantation on VA improvement, so that cases with implantation at the time of oil removal showed lower improvement than cases with implantation at a distinct timing (Coef. 0.19, 95%CI: 0.02 to 0.36, p = 0.027). …”
Get full text

Public support for smoke-free private indoor and public outdoor areas in the Netherlands: A trend analysis from 2018– 2022 by Nienke W. Boderie, Sabri Ennissay, Wilhelmina IJzelenberg, Frank J. van Lenthe, Jessica Baars, Jasper V. Been

“…Interaction terms were added for time with smoking status and with socioeconomic status. …”
Get full text

Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir. by Brandon F Keele, Afam A Okoye, Christine M Fennessey, Benjamin Varco-Merth, Taina T Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P Davenport, Jeffrey D Lifson, Louis J Picker

“…The rebound competent viral reservoir (RCVR)-virus that persists during antiretroviral treatment (ART) and can reignite systemic infection when treatment is stopped-is the primary barrier to eradicating HIV. We used time to initiation of ART during primary infection of rhesus macaques (RMs) after intravenous challenge with barcoded SIVmac239 as a means to elucidate the dynamics of RCVR establishment in groups of RMs by creating a multi-log range of pre-ART viral loads and then assessed viral time-to-rebound and reactivation rates resulting from the discontinuation of ART after one year. …”
Get full text

Long-Term Homogeneity and Trends of Hydroclimatic Variables in Upper Awash River Basin, Ethiopia by Mekonnen H. Daba, Gebiaw T. Ayele, Songcai You

“…Mann-Kendall (Z) and Sen’s slope tests (Q) were applied for the selected homogeneous time series to detect the trend and magnitude of changes in hydroclimatic variables. …”
Get full text

Cost-Effectiveness of a New Outpatient Pulmonology Care Model Based on Physician-to-Physician Electronic Consultation by José Manuel Álvarez-Dobaño, Malena Toubes, José Ángel Novo-Platas, Francisco Reyes-Santías, Gerardo Atienza, Manuel Portela, Carlos Rábade, Tamara Lourido, Ana Casal, Carlota Rodríguez-García, Vanessa Riveiro, Romina Abelleira, Jorge Ricoy, Nuria Rodríguez-Núñez, Carlos Zamarrón, Felipe Calle, Francisco Gude, Luis Valdés

“…Physician-to-physiciane-consultations reduce waiting times, improve access of complex patients to specialty care, and ensure that cases are managed at the appropriate level. …”
Get full text

«Talgenism» in the Digital Age: A Domestic History of cMOOC by M. A. Babaeva, E. B. Golubev

“…One hundred years ago, the famous teacher Alexander Rivin for the first time realized the idea of collective mutual learning. …”
Get full text

Empowering access: unveiling an overall composite spatial accessibility index to healthcare services in Southeastern Iran by Ahmad Raeesi, Soheil Hashtarkhani, Mahmood Tara, Narjes Sargolzaei, Behzad Kiani

“…Almost 75% of the population had low/no access to overall primary care services within a 30-minute drive time. For secondary care, nearly 45% had low/no access to hospital inpatient beds within a 30-minute drive time, and around 40% had low/no access to specialists within a 60-minute drive time. …”
Get full text

Estimating population attributable risk fraction of determinants of pediatric obesity by Maryam Yazdi, Ibrahim Abdollahpour, Mostafa Qorbani, Saba Karimi, Mohammad Esmail Motlagh, Majid Khademian, Roya Kelishadi

“…In addition to physical examination, a self-administered questionnaire was completed to obtain the study variables including dietary behavior, physical activity, screen time, sleep duration, socioe-conomic status (SES), and passive smoking. …”
Get full text

Efficient Path Planning and Formation Control in Multi-Robot Systems: A Neural Fields and Auto-Switching Mechanism Approach by Raouf Fareh, Mohammed Baziyad, Tamer Farouk Rabie, Sofiane Khadraoui, Mohammad Habibur Rahman

“…Thus, this work proposes leveraging neural fields to achieve high-quality path planning in significantly reduced time. By utilizing the expressiveness and memory efficiency of neural fields, the suggested approach aims to generate optimized paths quickly, making it well-suited for real-time applications where both accuracy and speed are critical. …”
Get full text

Plant Growth and Nutritional Quality Attributes of Basella alba Applied with Variable Rates of Nitrogen Fertilizer at Different Planting Dates under Canadian Maritime Climatic Cond... by Nishchitha Hemmige Natesh, Mercy O. Ijenyo, Samuel Kwaku Asiedu, H. P. Vasantha Rupasinghe, Lord Abbey

“…Nitrogen (N) fertilization at critical planting time is important to optimize productivity and reduce nitrate accumulation in edible portions of green leafy vegetable plants. …”
Get full text

Limited Vitrectomy versus Complete Vitrectomy for Epiretinal Membranes: A Comparative Multicenter Trial by Matteo Forlini, Purva Date, Domenico D’Eliseo, Paolo Rossini, Adriana Bratu, Andrea Volinia, Giovanni Neri, Tommaso Verdina, Maria Rosaria Carbotti, Gian Maria Cavallini, Luigi Sborgia, Alessandra Galeone, Aurelio Imburgia, Alessandro Mularoni, Alessandro Meduri

“…Incidence of iatrogenic retinal breaks, retinal detachment, surgical time, and visual outcomes were compared between groups. …”
Get full text

Edible Film Whey-Gelatin: Lama Gelasi, Solubilitas dan Mikrostruktur dengan Penggabungan Bubuk Teh Hijau by Fahrullah Fahrullah, Basriani Basriani, Cis Anita, Farah Febryanti, Fitriyani Fitriyani

“…This study evaluates the effect of green tea powder on the characteristics of whey-gelatin-based edible films using a completely randomized design with three treatments: P1(5%), P2 (10%), and P3 (15%), each replicated three times. Results indicate that green tea powder significantly affects gelation time and solubility (P<0.01). …”
Get full text

Combined Aerobic and Resistance Exercises Evokes Longer Reductions on Ambulatory Blood Pressure in Resistant Hypertension: A Randomized Crossover Trial by Nayara Fraccari Pires, Helio José Coelho-Júnior, Bruno Bavaresco Gambassi, Ana Paula Cabral de Faria, Alessandra Mileni Versuti Ritter, Catarina de Andrade Barboza, Silvia Elaine Ferreira-Melo, Bruno Rodrigues, Heitor Moreno Júnior

“…Notably, ambulatory BP was reduced during awake-time and night-time periods after COM. On the other hand, the effects of AER were more prominent during awake periods, while RES caused greater reductions during the night-time period. …”
Get full text

Exploration of treatment burden through examination of workload and patient capacity during transition onto kidney replacement therapy: a systematic review of qualitative research by Catrin Jones, Ross Cairns, Heather Walker, Silje Welsh, Benjamin Edgar, Karen Stevenson, Bhautesh D. Jani, Patrick B. Mark, David Kingsmore, Katie I. Gallacher

“…The aim of this review is to examine the experience of healthcare workload and the factors that affect capacity to meet that workload for people transitioning onto KRT for the first time, using a framework synthesis of published literature informed by normalisation process theory (NPT) and theory of patient capacity (TPC). …”
Get full text

A Mechanistic, Stochastic Model Helps Understand Multiple Sclerosis Course and Pathogenesis by Isabella Bordi, Renato Umeton, Vito A. G. Ricigliano, Viviana Annibali, Rosella Mechelli, Giovanni Ristori, Francesca Grassi, Marco Salvetti, Alfonso Sutera

“…We show that relapses and remissions follow exponential decaying distributions, excluding periodic recurrences and confirming that relapses manifest randomly in time. It is found that a mechanistic model with a random forcing describes in a satisfactory manner the occurrence of relapses and remissions, and the differences in the length of time spent in each one of the two states. …”
Get full text