Development and validation of an LC-MS/MS method for the simultaneous estimation of tadalafil and macitentan in rat plasma: Greenness assessment and design of experiment approach by Sravanthi Gandu, Kumaraswamy Gandla, Lalitha Repudi

“…Optimization of critical parameters, including organic phase composition (50% acetonitrile), flow rate (1.0 mL/min), and pH (3.2), was achieved using a Box-Behnken Design, ensuring accurate separation and quantification. The retention times were 4.13 min for tadalafil, 5.32 min for macitentan, and 7.89 min for the internal standard, ritonavir. …”
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Safety of health workers during the COVID-19 pandemic and beyond: piloting WHO framework in Iran by Jafar Sadegh Tabrizi, Mondher Letaief, Hossein Mashhadi Abdolahi, Ramin Rezapour, Ahmed Alboksmaty, Mostafa Farahbakhsh

“…Abstract Background Health Workers Safety (HWS) is a global health priority and essential at all times, in stable situations, in emergencies, in disease epidemics or pandemics. …”
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Perceptions and Motivations of Japanese Medical Students Regarding Course Evaluations: A Cultural Perspective by Suzuki S, Imafuku R, Kawakami C, Abe Y, Jego EH, Hidai C, Saiki T

“…Logistics, including the timing of evaluations and the design of the online evaluation form, also contributed to either encouraging or discouraging their participation.Conclusion: This study has illuminated factors shaping medical students’ perceptions and motivations regarding course evaluation through Hofstede’s model. …”
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A cycle of invisibilisation: a qualitative study of Brazilian health system factors shaping access to long COVID care by Emma-Louise Aveling, Margareth Crisóstomo Portela, Letícia Soares, Bárbara Caldas, Brenda Sabaine, Flora Cornish

“…Globally, LC patients struggle to access timely, appropriate care, often experiencing disbelief, misunderstandings or being diverted from healthcare. …”
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Intestinal obstruction caused by disseminated mycobacterium avium complex disease following solid organ transplantation: a case report by Akane Mita, Sho Nakakubo, Yusuke Nishimura, Hideki Shima, Masaaki Watanabe, Tsuyoshi Shimamura, Satoshi Konno

“…Awareness and thorough differential diagnosis are essential for timely and accurate management in such complex cases. …”
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The addition of calcium oxide with different doses in the recirculation system to improve the abalone Haliotis squamata seed production by Eddy Supriyono, Debora Victoria Liubana, Tatag Budiardi, Irzal Effendi

“…The study was conducted with an experimental method with four treatments (calcium oxide with doses of 0, 15, 30, 45 mg/L) and three times replications. Abalone with 2.3 g body weight, 2.3 cm shell length, and 1.2 cm shell width was reared for 60 days in recirculation system and fed with Gracilaria verrucosa. …”
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Development of Coconut Milk-Based Spicy Ice Cream as a Nondairy Alternative with Desired Physicochemical and Sensory Attributes by K. D. S. S. Perera, O. D. A. N. Perera

“…Spices have been a major influence on Sri Lankan cuisine since times immemorial. Spices are identified as one of the most distinctive ingredients for their indigenous flavor, aroma, and medicinal properties. …”
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Impacts of coal fracture roughness and aperture on the seepage of injected water: An experimental study by Gang WANG, Xuechang CHEN, Hao CHEN, Qingming LONG, Yixin LIU

“…As the fracture aperture increased from 30 μm to 150 μm, the seepage rate of fractures increased 355.88 times at most. Through a deep exploration into the relationships of the fracture aperture and roughness with seepage rate, this study determines the key mechanisms underlying the impacts of the fracture aperture and roughness on water injection into coal seams. …”
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Implicit bias in referrals to relational psychological therapies: review and recommendations for mental health services by Chenai Mandangu, Anne Millicent Ramos, Mohona Sengupta, Rosslyn Bender, Reem El-Hayani, Ifrah Hasan, Hannah Okechukwu, Shafeena Anas, Dominik Havsteen-Franklin

“…IntroductionTimely and appropriate psychological treatment is an essential element required to address the growing burden of mental health issues, which has significant implications for individuals, society, and healthcare systems. …”
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Can the adherence to quality of care indicators for early rheumatoid arthritis in clinical practice reduce risk of hospitalisation? Retrospective cohort study based on the Record L... by Carlo Alberto Scirè, Antonella Zambon, Greta Carrara, Anna Zanetti, Lisa Argnani

“…In a 7-year period (2006–2012), early DMARDs and timely clinical monitoring treatment increased (from 52% to 62% p trend <0.001 and from 25% to 30% p trend 0.009, respectively).Intermediate and high summary adherence score categories (compared with the low category) were related significantly with a lower risk of hospitalisation (adjusted HR 0.85 (95% CI 0.77 to 0.93), p<0.001 and HR 0.76 (95% CI 0.69 to 0.84), p<0.001, respectively). …”
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Knowledge, Attitude, and Associated Factors towards Colostrum Feeding among Antenatal Care Attendant Mothers in Gununo Health Centre, Wolaita Zone, Ethiopia 2019: Cross-Sectional S... by Addisu Yeshambel Wassie, Natnael Atnafu Gebeyehu, Kelemu Abebe Gelaw

“…Respondents who had more than four children (AOR = 1.21, 95% CI [1.31, 2.47], ANC visit (four times and above) (AOR=2.8, 95% CI [2.23, 4.49]), and counseled about colostrum feeding (AOR = 2.29, 95% CI [2.34, 3.74]), were some variables that significantly associated with knowledge of colostrum feeding. …”
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Serum Exosomes miR-122-5P Induces Hepatic and Renal Injury in Septic Rats by Regulating TAK1/SIRT1 Pathway by Wang J, Jiang Y, Yuan Y, Ma X, Li T, Lv Y, Zhang J, Chen L, Zhou J, Meng Y, Zhang B, Dong X, Ma L

“…Jiaqi Wang, Yujing Jiang, Yamin Yuan, Xin Ma, Tongqin Li, YaTing Lv, Jing Zhang, Liao Chen, Jinquan Zhou, Yanfei Meng, Bei Zhang, Xiaorong Dong, Li Ma Department of Critical Care Medicine, Lanzhou University Second Hospital, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of ChinaCorrespondence: Li Ma, Email ery_mali@lzu.edu.cnAim: Sepsis is a potentially fatal condition characterized by organ failure resulting from an abnormal host response to infection, often leading to liver and kidney damage. Timely recognition and intervention of these dysfunctions have the potential to significantly reduce sepsis mortality rates. …”
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Serum KL-6 levels reflect the severity of interstitial lung disease caused by immune checkpoint inhibitors by Xiaoping Li, Dan Xue, Qiongying Wei, Xuexue Tan

“…The lack of clear correlations with dosage, duration, or drug efficacy, coupled with nonspecific clinical manifestations, poses challenges in timely diagnosis and effective management. This study examined the association between ICIs-related ILD and serum levels of KL-6 and inflammatory markers in NSCLC patients. …”
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Perspectives towards training approaches to skill achievement in swimming athletes: mixed methods by Ari Tri Fitrianto, Hegen Dadang Prayoga, Oddie Barnanda Rizky, Nina Sutresna, Albadi Sinulingga, Syahruddin Syahruddin, Trisnar Adi Prabowo

“…The number of athletes in junior and student categories has also increased, and their average performance times have shown significant improvement. Therefore, further studies are needed to explore how coaches train swimming skills from the initial training stages to the development of athletes. …”
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Stress assessment instruments for hospitalized preterm newborns: scoping review by Mónica Costa, Maria Filomena Gaspar, Maria Alice Curado, Ana Brantes

“…The preterm newborn must be observed in a systematic and structured way, before, during and after any intervention, aiming at the correct assessment and interpretation of his behaviour and signs of stress, and at the timely planning of interventions that minimize and prevent stress. …”
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Empire Seen from Within. Cinema Objects, Spaces and Edifices in the Limelight in Colonial India and Ceylon (1899-1950) by Vilasnee Tampoe-Hautin

“…While research on material culture has focused abundantly on objects of everyday life as a way of observing societies and understanding our past, only in recent times has it concerned itself with the study of those related to cinema, one of the ‘more readily consumable forms of entertainment’ (MacKenzie 2), which came out of the late 19th century workshops of the geniuses of the day, Edison, Urban or Lumière. …”
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Intestinal flora composition and fecal metabolic phenotype in elderly patients with sleep disorders combined with type 2 diabetes by Zhuohao Yin, Huaze Xie, Fuyuan Liu, Xue Kong, Wei Chen, Yangfan Gong, Wei Ge

“…Notably, older individuals with T2D were 3.3 times more likely to experience sleep disorders than normal individuals. …”
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To be or not to be: a cross-sectional study on suicidal ideation, intensity of suicidal ideation and suicide attempts among medical students in Kerala, India by Sangeetha Merrin Varghese, Nikhil V Paulson, Pranathi Ajayan, Jithin Mathew Abraham, Pramod Thomas, Anoop Ivan Benjamin, George Chandy Matteethra

“…Those who had active suicidal ideation with specific plans were 5.4% (4.18 to 6.95), which puts them at 16 times higher risk of suicide when compared with their counterparts without suicidal ideation. …”
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Effect of Dry, Vacuum, and Modified Atmosphere Ageing on Physicochemical Properties of Roe Deer Meat by Natalia Kasałka-Czarna, Róża Biegańska-Marecik, Jędrzej Proch, Aleksandra Orłowska, Magdalena Montowska

“…The selection of suitable storage conditions and times plays an important role in a deterioration of the meat's functional and nutritional values. …”
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Downregulation of serum miR-30c-5p serves as a biomarker to predict disease onset and short-term prognosis in acute coronary syndrome patients by Bo Chang, Xiangfeng Zhang, Riliang Fang, Huibin Li, Youdan Zhou, Yakun Wang

“…Abstract Background & objective Timely intervention for Acute coronary syndrome (ACS) could effectively reduce the mortality rate of ACS patients. …”
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