Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for <i>Trypanosoma cruzi</i> Infection by Citlali Vázquez, Rusely Encalada, Isabel Jiménez-Galicia, Rogelio Gómez-Escobedo, Gildardo Rivera, Benjamín Nogueda-Torres, Emma Saavedra

“…However, in bi-therapy, the presence of just 0.5 or 1 µM of the antidiabetics decreased the BNZ IC₅₀ by 5–10 times to 0.03–0.05 µM. Remarkably, the antidiabetic drugs in monotherapy decreased the infection in mice by 40–60% in a similar extent to BNZ (80%). …”
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Prevalence and associated factors of parental refusal rates for routine immunisation: a cross-sectional study in Peshawar, Khyber Pakhtunkhwa, Pakistan-2024 by Muhammad Hakim, Farhad Ali, Zala, Aslam Pervaiz, Saima Afaq, Zia ul Haq

“…Multivariable logistic regression revealed that employed mothers were over three times more inclined to refuse vaccination (AOR: 3.11, 95% CI: 1.25, 7.67), while factors like the total depression score was not significantly associated with refusal (p = 0.13). …”
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Alarming rise in prevalence of obesity among children with essential hypertension: Reflection of larger global epidemiological change of adolescent nutritional status by Vishwak Gundeti, Shrikiran Aroor, Koushik H, Leslie E. Lewis, Suneel C. Mundkur, Ramesh Bhat Y, Pushpa Kini

“…Conclusion: There has been a substantial increase in the proportion of essential hypertension among children and a significant rise in the incidence of overweight/obesity among children with essential hypertension. Timely screening, lifestyle alterations, and effective care are essential for reducing long-term problems related to paediatric hypertension.…”
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Survival and risk factors for metastatic colorectal cancer patients with a history of prior malignancy by Yiwen Qiu, Nida Cao, Dan Meng, Jian Yuan, Yingjie Zhu

“…The objective is to facilitate timely and proactive treatment for patients following the disclosure of results, thereby instilling confidence in the management of mCRC.…”
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From consumers to pioneers: insights from thermal energy communities in Denmark, Germany and the Netherlands by Sara Herreras Martínez, Justus Mesman, Daniel Møller Sneum, Lars Holstenkamp, Robert Harmsen, Marijke Menkveld, Sanne Akerboom, André Faaij

“…Results TECs have emerged at different times in each country, shaped by contextual circumstances and diverse forms of institutional support. …”
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The impact of teaching approach on horse and rider biomechanics during riding lessons by Anna Byström, Agneta Egenvall, Marie Eisersiö, Maria Terese Engell, Sigrid Lykken, Susanne Lundesjö Kvart

“…S2 and N2 focused relatively more on the walk, asking the riders to count each walk stride or focus on the rhythm. With S2, the timing between up-down movements of the withers and croup in walk was closest to the ideal 25 % (16–17 % vs. 8–14 % for the others, p < 0.05). …”
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Differences between frequent emergency department users in a secondary rural hospital and a tertiary suburban hospital in central Japan: a prevalence study by Makoto Kaneko, Masashi Okubo, Michael D Fetters, Machiko Inoue, Allison K Cullen Furgal, Benjamin F Crabtree

“…The study aims to (1) document the proportion of ED visits that are by frequent users and (2) describe the differences in characteristics of frequent ED users and other ED users including expenditures between a secondary and a tertiary hospital.Design A prevalence study for a period of 1 year.Setting A secondary hospital and a tertiary hospital in central Japan.Participants All patients who presented to the EDs.Primary outcome measures We defined frequent ED user as a patient who visited the ED≥5 times/year. The main outcome measures were the proportion of frequent ED users among all ED users and the proportion of healthcare expenditures by the frequent ED users among all ED expenditures.Results Of 25 231 ED visits over 1 year, 134 frequent ED users accounted for 1043 visits—0.66% of all ED users, comprised 4.1% of all ED visits, and accounted for 1.9% of total healthcare expenditures. …”
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Clinical inertia and treatment intensification among patients with type ii diabetes mellitus at Debre Tabor comprehensive specialized hospital, Ethiopia: an institutional-based cro... by Samuel Berihun Dagnew, Samuel Agegnew Wondm, Getachew Yitayew Tarekegn, Abebe Tarekegn Kassaw, Tilaye Arega Moges

“…BackgroundPeople with type 2 diabetes mellitus who have clinical inertia often struggle to control their blood sugar levels and do not receive timely treatment intensification. Strict glycemic control has advantages, but many patients with diabetes are unable to reach their target blood sugar levels. …”
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Association between maternal satisfaction and other indicators of quality of care at childbirth: a cross-sectional study based on the WHO standards by Marzia Lazzerini, Emanuelle Pessa Valente, Chiara Semenzato, Ilaria Mariani

“…Factors most strongly associated with women’s satisfaction were ‘effective communication, involvement, listening to women’s needs, respectful and timely care’ (OR 16.84, 95% CI 9.90 to 28.61, p&lt;0.001) and ‘physical structure’ (OR 6.51, 95% CI 4.08 to 10.40, p&lt;0.001). …”
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Knowledge, attitudes and preventive practices towards soil-transmitted helminthiases among teachers in schools implementing the home-grown school feeding program in Enugu Metropoli... by Daniel Chukwuemeka Obi, Blessing Hafizetu Nwazulu, Susan Chioma Udeh

“…Age was a significant predictor of good practice with teachers aged 35–44 years being 7.72 times more likely to report good practices than those ≥ 45 years (AOR: 7.72, 95% CI: 5.66–35.9). …”
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Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications by Vincenzo Salpietro, Agata Polizzi, Gabriella Di Rosa, Anna Claudia Romeo, Valeria Dipasquale, Paolo Morabito, Valeria Chirico, Teresa Arrigo, Martino Ruggieri

“…Physicians should be aware of potential neurological manifestations in children with adrenal dysfunction to achieve better prevention and timely diagnosis and treatment of these disorders. …”
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Snake Venom Pharmacokinetics and Acute Toxic Outcomes Following <i>Daboia siamensis</i> Envenoming: Experimental and Clinical Correlations by Sethapong Lertsakulbunlue, Wipapan Khimmaktong, Orawan Khow, Wittawat Chantkran, Jureeporn Noiphrom, Kanyanat Promruangreang, Lawan Chanhome, Janeyuth Chaisakul

“…An understanding of snake venom pharmacokinetics is essential for determining clinical outcomes of envenoming and developing therapeutic approaches to the treatment of envenoming, especially regarding the timing and optimal dosage of antivenom administration. …”
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Histological Ex Vivo Evaluation of the Suitability of a 976 nm Diode Laser in Oral Soft Tissue Biopsies by Gaspare Palaia, Federico Renzi, Daniele Pergolini, Alessandro Del Vecchio, Paolo Visca, Gianluca Tenore, Umberto Romeo

“…In oral pathology, many times, there is fear in using the laser to remove some lesions due to its thermal effect on the tissues close to the lesion. …”
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Medication Administration Through Feeding Tubes in a Tertiary Hospital: A Retrospective Observational Study by Zhu Y, Zhu B, Jin P

“…In total, there were 10,164 instances of inappropriate medication administration, averaging 1.40 times per patient in the tube feeding group. Inappropriate medications included enteric-coated drugs, modified-released, soft capsules, and other non-crushable drugs.Conclusion: Our results Our findings highlight a significant issue of inappropriate medication administration via FTs. …”
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Integrated technique of buffalo fertility management in Nepal by Bhuminand Devkota, Shatrughan Shah, Gokarna Gautam

“…Putting together all those information, we developed an integrated technique of buffalo fertility management that includes anthelmintic treatment at least one month prior to the initiation of specific timed artificial insemination (TAI) protocol and nutritional management by means of providing vitamin–mineral supplementation in addition to improving the roughage supply and energy-protein content in the ration soon after anthelmintic treatment until two weeks after AI. …”
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Laser Synthesis of Platinum Single-Atom Catalysts for Hydrogen Evolution Reaction by Hengyi Guo, Lingtao Wang, Xuzhao Liu, Paul Mativenga, Zhu Liu, Andrew G. Thomas

“…The atomically dispersed Pt on the carbon substrate exhibited a small overpotential of 68.8 mV at 10 mA cm⁻² for the hydrogen evolution reaction with a mass activity 20.52 times that of a commercial Pt/C catalyst at an overpotential of 50 mV vs. …”
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Helicobacter pylori Infection and Its Risk Factors: A Prospective Cross-Sectional Study in Resource-Limited Settings of Northwest Ethiopia by Markos Negash, Habtamu Wondifraw Baynes, Demeke Geremew

“…In those patients with H. pylori (a positive result with either the Ab or Ag test), drinking water from well sources had 2.23 times risk of getting H. pylori infection (P=0.017), and drinking coffee (1.51 (0.79–2.96, P=0.025)) and chat chewing (1.78 (1.02–3.46, P=0.008) are the common risk factors. …”
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Availability and Key Characteristics of National Early Warning Systems for Emerging Profiles of Antimicrobial Resistance in High-Income Countries: Systematic Review by Jessica Iera, Claudia Isonne, Chiara Seghieri, Lara Tavoschi, Mariateresa Ceparano, Antonio Sciurti, Alessia D'Alisera, Monica Sane Schepisi, Giuseppe Migliara, Carolina Marzuillo, Paolo Villari, Fortunato D'Ancona, Valentina Baccolini

“… Abstract BackgroundThe World Health Organization (WHO) recently advocated an urgent need for implementing national surveillance systems for the timely detection and reporting of emerging antimicrobial resistance (AMR). …”
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Patient experience with eosinophilic esophagitis symptoms and impacts on daily life based on in-trial qualitative interviews by Calvin N. Ho, Harald Fjällbrant, Evan S. Dellon, Cecilio Santander, Marc E. Rothenberg, Julie Bailey, Shehan McFadden, Jason Ritchie

“…Interviews were held at two different times to assess the impact of EoE on patients’ lives before and during trial participation. …”
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Research on Formation Mechanism and Evolution Pattern of Bed Separation Zone during Repeated Mining in Multiple Coal Seams by Jianshuai Ji, Zhihua Li, Ke Yang, Guanghua Zhou, Guojun Ma, Cheng Liu, Peng Zhou

“…When mining the lower coal, when the coal seam spacing is less than 4 times of the mining height of the lower coal, the crack will penetrate the upper coal floor. …”
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