New Insights into Duckweed as an Alternative Source of Food and Feed: Key Components and Potential Technological Solutions to Increase Their Digestibility and Bioaccessibility by Krisztina Takács, Rita Végh, Zsuzsanna Mednyánszky, Joseph Haddad, Karim Allaf, Muying Du, Kewei Chen, Jianquan Kan, Tian Cai, Péter Molnár, Péter Bársony, Anita Maczó, Zsolt Zalán, István Dalmadi

“…Duckweed has special properties: It is one of the fastest-growing plants in the world (in freshwater), multiplying its mass in two days, so it can cover a water surface quickly even in filtered sunlight (doubling its biomass in 96 hours). During this time, it converts a lot of carbon dioxide into oxygen. …”
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Six months of hybrid closed-loop therapy improves diabetes-specific positive well-being, and reduces diabetes distress and fear of hypoglycemia: secondary analysis of a randomized... by Anthony C Keech, Vijaya Sundararajan, Bruce R King, Sara Vogrin, Richard J MacIsaac, Leon A Bach, Jane Speight, Alicia J Jenkins, Christel Hendrieckx, David O’Neal, Sybil A McAuley, Geoff R Ambler, Fergus J Cameron, Jan M Fairchild, Elizabeth A Davis, Timothy W Jones, Morton G Burt, Philip M Clarke, Neale D Cohen, Peter G Colman, Joey Kaye, Kavita Kumareswaran, Melissa H Lee, Roland W Mccallum, Barbora Paldus, Stephen N Stranks, Steven Trawley, Glenn M Ward, David N O’Neal, Sienna Russell-Green, Deborah Jane Holmes-Walker, Benjamin Lam, Jennifer A Halliday, Glenn Ward, Catriona M Sims, D Jane Holmes-Walker, Andrzej Januszewski, Hanafi Mohammed Husin, Martin I de Bock, Mary B Abraham

“…Introduction This analysis aimed to investigate diabetes-specific psychological outcomes among adults with type 1 diabetes (T1D) using hybrid closed-loop (HCL) versus standard therapy.Research design and methods In this multicenter, open-label, randomized, controlled, parallel-group clinical trial, adults with T1D were allocated to 26 weeks of HCL (MiniMed™ 670G) or standard therapy (insulin pump or multiple daily injections without real-time continuous glucose monitoring). Psychological outcomes (awareness and fear of hypoglycemia; and diabetes-specific positive well-being, diabetes distress, diabetes treatment satisfaction, and diabetes-specific quality of life (QoL)) were measured at enrollment, mid-trial and end-trial. …”
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Jinbei oral liquid for idiopathic pulmonary fibrosis: a randomized placebo-controlled trial by Aijun Zhang, Kangkang Han, Fangfang Chen, Xiao Chen, Jun Wang, Yikai Niu, Zhaoqiu Hu, Chunyan Zheng, Liping Han, Zhaoqing Meng, Liangzong Zhang, Qingcui Xu, Cuixiang Yu, Wei Zhang, Quanguo Li, Ningning Tao, Weixiang Kong, Fei Liu, Min Wang, Juanjuan Jiang, Honglin Li, LongBin Pang, Huaichen Li

“…Over a 26-week period, patients received the active treatment or placebo three times daily, in a 1:1 ratio. This clinical study uses a randomized method, with a cycle of every 4 patients. …”
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A Meta-Synthesis of the Integrated Model of Customer Value co-Destruction and Value co-Creation by Zohreh Dehdashti Shahrokh, Vahid Nasehifar, Mohammad Reza Karimi Alavijeh, Yazdan Rahmatabadi

“…In this regard, it is possible to redefine both creation and destruction of customer value, and appropriate measures to reduce the wastage of financial, time and credit resources can be put on the agenda.  …”
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A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer by Lijuan Chen, Lijuan Chen, Pengju Wang, Carmela Di Gioia, Ming Yuan, Zhe Zhang, Jinxin Miao, Wenli Yan, Guanghao Zhao, Yangyang Jia, Na Wang, Zhongxian Zhang, Haoran Guo, Giulia Marelli, Louisa Chard Dunmall, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang

“…VVL-m12 therapy induced increased intratumoral infiltration of CD4+ and CD8+ T cells and was able to clear tumor at early time points via increased induction and infiltration of effector T cells and central memory T cells (TCM). …”
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Acute Care Practice in the United States: The Roles of Occupational Therapy and Physical Therapy in Early Rehabilitation by Suzanne E. Holm, Kelly Nelson, Angela Patterson

“…Early rehabilitation must be well-timed and intensive enough to bring about positive changes. …”
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Appropriateness of urine culture requests in primary care in Spain: A cross-sectional descriptive study by Silvia Fernández-García, Ramon Monfà, Cristina Miranda Jiménez, Maria Giner-Soriano, Frederic Gómez, Ana Moragas

“…Main measures: The collected variables included sociodemographic data, urinary tract infection (UTI) symptoms at the time of the urine culture request, comorbidities, reason for the request (including diagnosis), type of urine culture, therapeutic approach before and after receiving the result, and the urine culture result. …”
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AutoLDP: An accurate and efficient artificial intelligence-based tool for automatic labeling of digital pathology by Yingnan Zhao, Huifen Ye, Jing Yang, Su Yao, Maohua Lv, Zhihong Chen, Yunrui Ye, Qingru Hu, Cheng Lu, Zaiyi Liu, Ke Zhao, Zhihua Chen

“…We used the accuracy and processing time to validate our method using two validation sets. …”
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Unveiling the toxicity of JWH-018 and JWH-019: Insights from behavioral and molecular studies in vivo and vitro by Fenghua Zhou, Yan Shi, Sujun Tan, Xiaoli Wang, Weicheng Yuan, Shuqi Tao, Ping Xiang, Bin Cong, Chunling Ma, Di Wen

“…In the present study, we aimed to investigate the toxicity and underlying mechanisms of indole SCs JWH-018 and JWH-019 in mice (C57BL/6, male, 6–8 weeks old), zebrafish (AB strain, male, 4–5 months old) and modified human embryonic kidney (HEK) 293 T cells, using behavioral, pharmacokinetic, pharmacological approaches, and molecular docking. JWH-018 induced time- and dose-dependent cannabinoid-like effects in mice (administration dosages: 0.02, 0.1, and 0.5 mg/kg, i.p.), and yielded dose-dependent anxiogenic effects and lower aggression behavior in zebrafish (administration dosages: 0.01, 0.05, and 0.25 µg/g, i.p.), unlike JWH-019. …”
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Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation by O. V. Goloshchapov, A. V. Beynarovich, A. B. Chukhlovin, R. V. Klementeva, A. A. Shcherbakov, E. A. Bakin, I. K. Golubovskaya, N. D. Ventslovayte, O. S. Yudintseva, M. V. Gorchakova, V. E. Karev, M. A. Kucher, M. A. Suvorova, E. V. Svetkina, G. G. Rodionov, V. V. Gostev, S. V. Sidorenko, I. S. Moiseev, A. D. Kulagin

“…To monitor the basic effects of FMT, we performed targeted DNA sequencing of 16S rRNA gene (V3–V4) using MiSeq platform as well as multiplex real-time PCR, MS/gas chromatography technique, immunophenotyping of blood lymphocytes, histological and immunohistochemical techniques.Clinical case. …”
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Radiosensitizing capacity of fenofibrate in glioblastoma cells depends on lipid metabolism by Bayan Alkotub, Lisa Bauer, Ali Bashiri Dezfouli, Khouloud Hachani, Vasilis Ntziachristos, Gabriele Multhoff, Morteza Hasanzadeh Kafshgari

“…Despite advances in multimodal therapy approaches such as resection, chemotherapy and radiotherapy, the overall survival of patients with grade 4 glioblastoma (GBM) remains extremely poor (average survival time <2 years). Altered lipid metabolism, which increases fatty acid synthesis and thereby contributes to radioresistance in GBM, is a hallmark of cancer. …”
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Un outil éthique, automatisé et totalement autonome pour étudier la cognition chez les primates by Jonas Fizet, Adam Rimele, Thierry Pebayle, Jean Christophe Cassel, Christian Kelche, Helene Meunier

“…Les tâches mises en place dans cette étude ciblent l’attention et le contrôle inhibiteur (5-Choice Serial Reaction Time), la mémoire visuelle à court terme (Delayed Matching to Sample) et la mémoire de travail (Self Order Spatial Search). …”
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ACUTE LEUKEMIA AND LATENT TUBERCULOSIS INFECTION IN ITALY: QUANTIFERON-TB TEST SCREENING IN A LOW TUBERCULOSIS INCIDENCE COUNTRY by Andrea Nunzi, Luigi Della Valle, Elisa Linnea Lindfors Rossi, Giorgia Ranucci, Flavia Mallegni, Federico Moretti, Elisa Meddi, Luca Guarnera, Ilaria Tiravanti, Kristian Taka, Elisa Buzzatti, Fabiana Esposito, Roberto Secchi, Francesca Di Giuliano, Flavia Chirico, Raffaele Palmieri, Luca Maurillo, Francesco Buccisano, Carmelo Gurnari, Giovangiacinto Paterno, Adriano Venditti, Maria Ilaria Del Principe

“…This finding suggests implementing TB screening in the pre-treatment setting, particularly in a time when more numerous active treatments are becoming available also for patients ineligible to intensive chemotherapy. …”
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A study on the correlation of care knowledge, behavior, self-efficacy and care burden of informal nursing staff in community elderly with long-term bed rest and s kin pressure inju... by JIANG Yanqin (蒋燕勤), ZHU Zhu (朱珠), WANG Jing (王静), SONG Ailin (宋爱琳), WANG Guixia (汪桂霞), ZHU Qunmei (朱群妹), LUAN Wei (栾伟)

“…The general self-efficacy and co- caregivers, development limitation, emotional burden, average time spent caring for patients every day and caregiver knowledge questionnaire score were the influencing factors of care behavior of pressure injuries. …”
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Editorial by Pieter Vanhuysse, Antony Mason, Jörg Tremmel, Markus Rutsche, Maria Lenk

“…But if intra-familial transfers of cash and, crucially, time, are taken into account, this pro-elderly bias flips over entirely. …”
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Journal of Health and Social Sciences: A reputable, DOAJ-indexed, free, open access journal by Francesco Chirico

“…Thanks to the combined efforts of some of the editorial board members and authors, our journal published 79 high-quality manuscripts from 2016 to 2018 (39 original articles, 10 commentaries, 5 reviews and 25 other types of manuscripts, including 25 works from developing countries and 54 from developed countries). In a time when it is difficult to give voice to voiceless people, JHSS provides room for discussions and views from researchers from poor and disadvantages countries on issues that have a significant health impact on all people, from climate change to other themes in global public health. …”
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Lena River biogeochemistry captured by a 4.5-year high-frequency sampling program by B. Juhls, A. Morgenstern, J. Hölemann, A. Eulenburg, B. Heim, F. Miesner, F. Miesner, H. Grotheer, H. Grotheer, G. Mollenhauer, G. Mollenhauer, H. Meyer, E. Erkens, E. Erkens, F. Y. Gehde, S. Antonova, S. Chalov, S. Chalov, M. Tereshina, O. Erina, E. Fingert, E. Abramova, T. Sanders, L. Lebedeva, N. Torgovkin, G. Maksimov, V. Povazhnyi, R. Gonçalves-Araujo, U. Wünsch, A. Chetverova, A. Chetverova, S. Opfergelt, P. P. Overduin

“…Sampling consistency and continuity and data quality were ensured through simple sampling protocols, real-time communication, and collaboration with local and international partners. …”
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Climate change policies reduce air pollution and increase physical activity: Benefits, costs, inequalities, and indoor exposures by Sean Beevers, Nosha Assareh, Andrew Beddows, Gregor Stewart, Mike Holland, Daniela Fecht, Yunzhe Liu, Anna Goodman, Heather Walton, Christian Brand, Dimitris Evangelopoulos, Dylan Wood, Tuan Vu, David Dajnak

“…By 2040 under BNZP, relative to BAU, the buildings sector was predicted to be three times more effective at reducing PM2.5 than road transport. …”
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Adverse events in the nervous system associated with blinatumomab: a real-world study by Wen Gao, Jingwei Yu, Yifei Sun, Zheng Song, Xia Liu, Xue Han, Lanfan Li, Lihua Qiu, Shiyong Zhou, Zhengzi Qian, Xianhuo Wang, Huilai Zhang

“…Concomitant use of medication for age, musculoskeletal system, genitourinary system, and sexual hormones were independent risk factors for NST, and age was an independent protective factor for fatal NST. The median time to onset (TTO) for neurological events was 3 days (range, 1 ~ 21). …”
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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics f... by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…The unique detection of sEV signals within the knee joint over time highlights its safety profile by confirming the retention of sEV in the joint. …”
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