The comparative studies of Borneo plant extracts to increases vaccine efficacy in tilapia, Oreochromis niloticus by Esti Handayani Hardi, Komsanah Sukarti, Maulina Agriandini, Irawan Wijaya Kusuma, Rudi Agung Nugroho

“…The efficacy of Pseumulvacc vaccine has increased after its administration with BP (BP+V) on day 7 and day 14 after challenge (90%) and 100% at the time of challenge test d21. The conclusion is B. pandurata extract might be a promising adjuvant candidate for fish vaccination, and B. pandurata extract is the best plants as an adjuvant that mixed with the vaccine to against A. hydrophila and P. fluorescens infection.   …”
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Retrospective, Non-Interventional, Multicenter Study on the Effectiveness and Safety of Intravesical Bacillus Calmette–Guerin in Patients with Non-Muscle-Invasive Bladder Cancer: R... by Panagiotis Angelopoulos, Titos Markopoulos, Lazaros Lazarou, Andreas Skolarikos, Panagiotis Stamatakos, Georgios I. Papadopoulos, Charalampos Fragkoulis, Konstantinos Ntoumas, Napoleon Moulavasilis, Panagiotis Levis, Dimitrios Papanikolaou, Ioannis Sokolakis, Konstantinos Hatzimouratidis, Charalampos Tzanetakos, Marina Psarra, George Mavridoglou, Konstantinos Skriapas, Dimitra Akrivou, Dimitrios Karagiannis, Christos Noutsos, Andreas Georgiou, Konstantinos Hastazeris, George Gourzoulidis, Dionysios Mitropoulos

“…Tumor recurrence and progression were monitored at scheduled time intervals. Primary outcomes included recurrence-free survival (RFS) and progression-free survival (PFS), while adverse events (AEs) constituted secondary outcomes. …”
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A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma by Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner

“…This study demonstrates for the first time the therapeutic effect of the specific CYP2E1 inhibitor I-ol on the tumorigenesis of HCC. …”
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Optimization of Preparation Technology of Matcha Hickory Kernel and Study on Antioxidant and Lipid-lowering Activities by Fanping QIN, Ben NIU, Xiangjun FANG, Huizhi CHEN, Ruiling LIU, Hangjun CHEN, Weijie WU, Haiyan GAO

“…The findings indicated that the most effective processing technique for matcha hickory kernel included the following parameters: White sugar content at 15%, matcha infusion concentration at 8%, baking time of 30 min, baking temperature set at 130 ℃, and a sensory score of 88.40 points. …”
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Defining neonatal status epilepticus: A scoping review from the ILAE neonatal task force by Magda L. Nunes, Elissa G. Yozawitz, Courtney J. Wusthoff, Renée A. Shellhaas, Efraín Olivas‐Peña, Jo M. Wilmshurst, Ronit M. Pressler, Chahnez C. Triki, Hans Hartmann, Terrie Inder, Geraldine B. Boylan, Kette Valente, Solomon L. Moshe, Eli M. Mizrahi, Nicholas S. Abend

“…The majority of studies based the definition of SE on seizure duration, including summed duration of seizures comprising ≥50% of any 1‐h epoch, recurrent seizures for >50% of the total recording time, or either electrographic seizures lasting >30 min and/or repeated electrographic seizures totaling >50% in any 1‐h period. …”
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Recruiting Young People for Digital Mental Health Research: Lessons From an AI-Driven Adaptive Trial by Wu Yi Zheng, Artur Shvetcov, Aimy Slade, Zoe Jenkins, Leonard Hoon, Alexis Whitton, Rena Logothetis, Smrithi Ravindra, Stefanus Kurniawan, Sunil Gupta, Kit Huckvale, Eileen Stech, Akash Agarwal, Joost Funke Kupper, Stuart Cameron, Jodie Rosenberg, Nicholas Manoglou, Manisha Senadeera, Svetha Venkatesh, Kon Mouzakis, Rajesh Vasa, Helen Christensen, Jill M Newby

“… BackgroundWith increasing adoption of remote clinical trials in digital mental health, identifying cost-effective and time-efficient recruitment methodologies is crucial for the success of such trials. …”
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Differentiation of high risk prostate cancer with a facile urinary exosome detection workflow by Shuai Qiu, Yue Li, Zheng Zhang, Chunchang Li, Haoyu Wang, Ao Chen, Zhi Yan, Yang Liu, Zifei Li, Hua Huang, Yi Liu, Yiqi Seow, Ruibing Chen, Jinhong Guo, Simeng Wen, Jing Tian, Hongtuan Zhang, Ranlu Liu, Gang Han, Baolong Wang, Yong Wang, Yuanjie Niu, HaiFang Yin

“…We discovered that EEF1A1 levels, abundantly expressed on urinary exosomes, positively correlate to urinary exosome counts irrespective of source and collection time and demonstrated that EEF1A1 enables in-assay quantification of urinary exosomes. …”
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神经胶质细胞系衍生神经营养因子和雄激素受体在手术诱导隐睾小鼠睾丸管周细胞中的表达 by 吴飞, 潮敏, 张殷, 张晔, 蒋加斌

“…分别于4 d、7 d、14 d后取各组睾丸组织，然后测量睾丸体积、观察睾丸组织病理，提取各组睾丸管周细胞后利用免疫荧光、Real-Time PCR和蛋白质印记法检测AR和GDNF的mRNA和蛋白的表达。结果对照组4 d、7 d、14 d小鼠的睾丸体积分别为（125.58±19.22）mm³、（123.45±20.12）mm³、（140.09±13.62）mm³；睾丸各级生精细胞排列整齐、层次清楚，可见较多精子细胞，生精小管周围管周细胞形态规则，呈梭形围绕小管周围，细胞厚度均一；ARmRNA的表达量分别为1.00±0.05、1.06±0.07、1.19±0.13GDNFmRNA的表达量分别为1.00±0.04、1.09±0.05、1.10±0.07；AR蛋白的表达量分别为1.01±0.01、0.79±0.02、1.01±0.04；GDNF蛋白的浓度分别为（18.68±0.43）pg/mL、（14.39±0.36）pg/mL、（16.88±0.37）pg/mL。…”
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Dense Nursery Stock Detecting and Counting Based on UAV Aerial Images and Improved LSC-CNN by PENG Xiaodan, CHEN Fengjun, ZHU Xueyan, CAI Jiawei, GU Mengmeng

“…Traditional approach of conducting nursery stock inventories through on-site individual plant surveys is labor-intensive and time-consuming. Low-cost and convenient unmanned aerial vehicles (UAVs) for on-site collection of nursery stock data are beginning to be utilized, and the statistical analysis of nursery stock information through technical means such as image processing achieved. …”
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Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma by Li Zhang, Matthew Crocker, Lawrence Fong, Lisa M Coussens, Charles D Lopez, Shamilene Sivagnanam, Meenal Sinha, Brandon Chen, Jaqueline Marquez, Alexander Cheung, Whitney Tamaki, Jacob Stultz, Kendra Todd, Courtney Betts, Madeline J Griffith, Isabelle Solman, Eric Liu, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Margaret Tempero

“…Changes in abundance and functional state of immune cells in the blood was evaluated by mass cytometry by time of flight and statistical scaffold analysis, while that in the local tumor microenvironment (TME) were assessed by multiplex immunohistochemistry. …”
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Genomic deletions on 16p11.2 associated with severe obesity in Brazil by Izadora Sthephanie da Silva Assis, Izadora Sthephanie da Silva Assis, Kaio Cezar Rodrigues Salum, Kaio Cezar Rodrigues Salum, Kaio Cezar Rodrigues Salum, Rafaela de Freitas Martins Felício, Lohanna Palhinha, Gabriella de Medeiros Abreu, Gabriella de Medeiros Abreu, Tamara Silva, Fernanda Cristina Carvalho Mattos, Eliane Lopes Rosado, Verônica Marques Zembrzuski, Mario Campos Junior, Clarissa Menezes Maya-Monteiro, Pedro Hernán Cabello, João Regis Ivar Carneiro, Patrícia Torres Bozza, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca

“…We investigated the CNV using Multiplex Ligation-dependent Probe Amplification [MLPA] and real-time PCR. Chromosomal microarray analysis was used to assess the extent of genomic alterations.ResultsOne patient showed a ~206 kb deletion in the distal of the 16p11.2 region, encompassing twelve genes. …”
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“Holding on to Hope”: follow up qualitative findings of a tobacco treatment intervention for people experiencing mental health conditions by Tessa-May Zirnsak, Kristen McCarter, Melissa L. McKinlay, Ashleigh Guillaumier, Nadine Cocks, Catherine Brasier, Laura Hayes, Amanda L. Baker, Donita E. Baird, Billie Bonevski, Ron Borland, Ron Borland, David Castle, Erin Forbes, Peter J. Kelly, Catherine Segan, Catherine Segan, Rohan Sweeney, Alyna Turner, Alyna Turner, Jill M. Williams, Lisa Brophy, Lisa Brophy

“…The purpose of this paper is to report on the medium- and longer-term findings from interviews conducted at 5 and 8 months.MethodsAs a part of the broader Quitlink study, participants were invited to qualitative interviews at 2, 5 and 8 months following recruitment, in line with quantitative follow-up time points. Interviews were conducted with 28 participants in the Quitlink trial (intervention group n = 12, control group n = 16). …”
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Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging by Lukas Hingerl, Bernhard Strasser, Simon Schmidt, Korbinian Eckstein, Guglielmo Genovese, Edward J. Auerbach, Andrea Grant, Matt Waks, Andrew Wright, Philipp Lazen, Alireza Sadeghi-Tarakameh, Gilbert Hangel, Fabian Niess, Yigitcan Eryaman, Gregor Adriany, Gregory Metzger, Wolfgang Bogner, Małgorzata Marjańska

“…Concentric ring trajectories were utilized for time-efficient encoding of a spherical 3D k-space with ∼4 kHz spectral bandwidth. …”
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L’aqueduc de l’Yzeron : nouvelles données sur le double siphon de Craponne (Métropole de Lyon) by David Baldassari

“…A macroscopic study of 10 samples was undertaken to analyse the mortar used in the construction of the piers and concluded that both piers were constructed at the same time. The walls, built using the opus vittatum technique, consist of mostly rectangular gneiss rubble, subsequently refined. …”
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Protective potential of structural proteins of the SARS-CoV-2 virus in protecting against COVID-19 by Inna V. Dolzhikova, Daria M. Grousova, Ilya D. Zorkov, Anna A. Ilyukhina, Anna V. Kovyrshina, Olga V. Zubkova, Olga D. Popova, Tatiana A. Ozharovskaya, Denis I. Zrelkin, Daria M. Savina, Ekaterina G. Samokhvalova, Amir I. Tukhvatulin, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg

“…Many different vaccines for the prevention of COVID-19 have received emergency use approval in the shortest possible time. Due to the high rate of variability of the pathogen, in this study we analyzed the variability of the structural proteins of the SARS-CoV-2 virus and compared their protective potential in protecting animals from COVID-19. …”
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Révision de l’espèce Homo erectus (Dubois, 1893) by Valéry Zeitoun

“…The purpose of this new coding proposal is to be useful in paleoanthropology where most of the time the studied material is individuals and not populations.There is no reason to decide first that continuous characters are not useful to discriminate among groups of taxa. …”
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Trifluridine-tipiracil in previously treated patients with oestrogen receptor-positive, HER2-negative metastatic breast cancer (BOOG 2019-01 TIBET trial): a single-arm, multicentre... by Niels A.D. Guchelaar, Ron H.J. Mathijssen, Maaike de Boer, Marlies L. van Bekkum, Joan B. Heijns, Birgit E.P.J. Vriens, Mandy M. van Rosmalen, Lonneke W. Kessels, Lisanne Hamming, Karin J. Beelen, Peter Nieboer, Susan M. van den Berg, Esther Oomen-de Hoop, Rhodé M. Bijlsma, Monique E.M.M. Bos

“…At data cutoff (January 8, 2024), the median follow-up time was 18.2 months (IQR, 13.1–25.1 months). The median PFS was 5.4 months (95% CI: 2.0–7.2 months) and the median OS 14.0 months (95% CI: 8.8–17.8 months). …”
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Acute exacerbations in patients with progressive pulmonary fibrosis by Michael Kreuter, Elizabeth A. Belloli, Elisabeth Bendstrup, Stefania Cerri, Kevin R. Flaherty, Shane Shapera, Jin Woo Song, Heiko Mueller, Klaus B. Rohr, Yasuhiro Kondoh, on behalf of the INBUILD trial investigators, S. Quadrelli, M. Otaola, M.A. Bergna, P. Elias, G. Arce, A. Cazaux, J. Guiot, B. Bondue, C. Dahlqvist, L. Homik, S. Shapera, A. Cantin, M. Kolb, M. Salinas Fénero, R. Maturana Rozas, A. Silva Orellana, Z. Xu, Q. Luo, J. Kang, H. Cai, S. Marchand-Adam, E. Bergot, A. Gamez-Dubuis, F. Riviere, R. Kessler, H. Nunes, C. Marquette, L. Wemeau, S. Jouneau, F. Lebargy, B. Crestani, V. Cottin, M. Reynaud-Gaubert, S. Blaas, F. Bonella, W. Randerath, J. Hetzel, D. Koschel, M. Kreuter, A. Prasse, D. Skowasch, S. Stieglitz, R. Refini, S. Cerri, A. Pesci, S. Tomassetti, C. Vancheri, F. Varone, N. Sakamoto, S. Abe, H. Hayashi, T. Saito, T. Suda, H. Kitamura, M. Okamoto, Y. Kondoh, S. Makino, T. Takeuchi, Y. Yamada, C. Kono, Y. Inoue, H. Sugiura, K. Kishi, H. Takaya, H. Yamauchi, K. Ichikado, K. Tomii, H. Takahashi, S. Izumi, T. Kawamura, Y. Nishioka, Y. Miyazaki, J.W. Song, J.S. Park, Y. Kim, E. Jassem, J. Kus, W. Piotrowski, A. Barczyk, D. Ziora, E. Bazdyrev, S. Moiseev, S. Avdeev, M. Ilkovich, V. Yakusevich, C. Valenzuela, O. Acosta, M. Martínez, L. Gómez, M. Molina-Molina, D.M. Castillo Villegas, M. Aburto, J.A. Rodríguez Portal, A. Villar, A. León Jiménez, J. Sauleda, M. Arias, P. Beirne, H. Stone, B. Hope-Gill, N. Hirani, N. Chaudhuri, A. Gifford, L. Jones, L. Morrison, D. Antin-Ozerkis, N. Bhatt, T. Kulkarni, T. Moua, N. Ettinger, L. Pitts, S. Veeraraghavan, M. Padilla, E.R. Fernández Pérez, G. Giessel, M. Strek, S. Danoff, J. Burk, M. Rossman, N. Patel, E. Belloli, D. Hotchkin, S. Weigt, M.B. Scholand, R. Kaner, B. Sigal, Z. Safdar, L. Tolle, R. Martinez, M. Glassberg, R. Hallowell, J. Golden, M. Schwartz, E. Britt, L. Morrow, Y. Mageto, K. Buch, S. Chaaban, H. Poonyagariyagorn, D. Dilling, O. Shlobin, K. Thavarajah, A. Nambiar, I. Rosas, R. Bascom, J. Oldham, S. Schmidt, J. Dematte D'Amico, J. Falk, C. Glazer, G. Criner

“…Associations between baseline characteristics and time to first acute exacerbation were assessed using pooled data from both treatment groups using Cox proportional hazard models, firstly univariable models and then a multivariable model using forward stepwise selection. …”
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Comparative evaluation of multimarker algorithms for early-stage HCC detection in multicenter prospective studies by Jinlin Hou, Thomas Berg, Arndt Vogel, Teerha Piratvisuth, Jörg Trojan, Enrico N. De Toni, Masatoshi Kudo, Katarina Malinowsky, Peter Findeisen, Johannes Kolja Hegel, Wenzel Schöning, Kairat Madin, Konstantin Kroeniger, Henry Lik-Yuen Chan, Ashish Sharma

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Child mortality in England after national lockdowns for COVID-19: An analysis of childhood deaths, 2019-2023. by David Odd, Sylvia Stoianova, Tom Williams, Peter Fleming, Karen Luyt

“…Poisson regression was used to test for an overall trend across the time period and tested if trends differed between April 2019 to March 2021 (Period 1)) and April 2021 to March 2023 (Period 2: after lockdown restrictions). …”
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