Potential Antidepressant Effects of Omeprazole Introduced Through Network Analysis and Systems Biology Should Be Interpreted with Caution in the Clinical Environment by Seyed-Ali Mostafavi

“…They should focus on the biopsychosocial model of depression and hence need a multi-disciplinary approach. I appreciate your time and patience in considering this critical topic concerning the impact of Omeprazole and its suitability in MDD treatment. …”
Get full text

Biogas upgrading via CO2 absorption using monosodium glutamate-promoted potassium carbonate in packed absorption column: Design and performance assessment by Bambang Trisakti, Rivaldi Sidabutar, Irvan, Hani Suhastifa Rambe, Vikram Alexander, Andrew Moses Noverindo Simanjuntak, Joshua Syaloom Silalahi, Rafael Aginta Sitepu, Michael Michael, Juan Akmal Nasution, Yasmin Nabilah, Hiroyuki Daimon

“…Experimental parameters included absorbent flow rates of 1, 1.5, and 2 L/min; a biogas flow rate of 20 L/min; promoter concentrations of 1, 3, and 5 %; temperatures of 35, 45, and 55 °C; and a contact time of 5 min. Results indicated that optimal CO2 removal (47.38±1.58 %) was achieved with an absorbent flow rate of 2 L/min and MSG concentration of 5 %. …”
Get full text

Evidence construction of Silibinin capsules against alcoholic liver disease based on a meta-analysis and systematic review by Yan Wang, Yan Wang, Wenmin Yang, Wenmin Yang, Yuan Yang, Yuan Yang, Xingning Liu, Xingning Liu, Lanfen Peng, Lanfen Peng, Qi Huang, Qi Huang, Qi Huang, Kongli Fan, Kongli Fan, Rui Hu, Rui Hu, Jinyu Yi, Jinyu Yi, Xin Zhong, Xin Zhong, Jing Li, Jialing Sun, Xiaozhou Zhou, Xiaozhou Zhou

“…Primary outcomes included liver function indicators such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), total bilirubin (TBIL), lipid indicators including triglycerides (TG) and total cholesterol (TC), coagulation indicators including prothrombin time (PT), liver fibrosis indicator (PC-III), and Effective Rate. …”
Get full text

Treatment-related Hypertension as a Prognostic Factor for De Novo Metastatic Hormone-sensitive Prostate Cancer: A Retrospective Real-world Evidence Study by Giuseppe Salfi, Martino Pedrani, Selin Candan, Vasile Urechie, Sara Merler, Lorenzo Ruinelli, Amos Colombo, Luis Castelo-Branco, Irene Testi, Fabio Turco, Luigi Tortola, Ursula Vogl, Luca Gabutti, Silke Gillessen, Ricardo Pereira Mestre

“…HTN development within 7 mo from hormonal treatment initiation was graded according to the Common Toxicity Criteria for Adverse Events version 5.0, and Cox analyses were performed for time to castration resistance (TTCR) and overall survival (OS). …”
Get full text

Hesperidin enhances broiler growth performance by augmenting gastric acid secretion via the proton pump pathway by Yunfei Li, Mingyuan An, Shasha Wan, Yifan Li, Yusong Du, Yufei Zhao, Huimin Li, Qingzhen Zhong, Zewei Sun

“…Fifteen broilers from each group were euthanized and immediately dissected to obtain gizzard, proventriculus, gizzard chyme, and jugular blood samples, The proventriculus and gizzard weight were weighed and the pH of gizzard chyme was measured at the same time. The collected jugular venous blood was used to assess gastrin levels, whereas chicken gizzard chyme was utilized for the analysis of lactate, hydrochloric acid, and pepsin activity. …”
Get full text

Changes in donor lymphocyte infusion for relapsed patients post-hematopoietic stem cell transplantation: a 30-year single-center experience by Yusuke Uchibori, Shuhei Kurosawa, Yuho Najima, Kyoko Haraguchi, Daichi Sadato, Chizuko Hirama, Yasutaka Sadaga, Kaori Kondo, Chika Kato, Satoshi Sakai, Yasuhiro Kambara, Fumihiko Ouchi, Masashi Shimabukuro, Atsushi Jinguji, Naoki Shingai, Takashi Toya, Hiroaki Shimizu, Takeshi Kobayashi, Hironori Harada, Hironori Harada, Yuka Harada, Yoshiki Okuyama, Noriko Doki

“…Despite their reported efficacy, the evolution of DLI practices over time remains underexplored.MethodsThis study provided a comprehensive analysis of DLI strategies and outcomes over 30 years at a single institution. …”
Get full text

Pulmonary fibrosis in patients with autoimmune pulmonary alveolar proteinosis: a retrospective nationwide cohort study by Yoann Guirriec, David Luque-Paz, Gontran Bernard, Axelle Mabo, Mallorie Kerjouan, Cédric Ménard, Delphine Monnier, Hilario Nunes, Yurdagül Uzunhan, Martine Reynaud-Gaubert, Julien Bermudez, Raphaël Borie, Bruno Crestani, Julie Traclet, Lidwine Wémeau-Stervinou, Cécile Chenivesse, Emmanuel Gomez, Grégoire Prévot, Arnaud Bourdin, Benjamin Bondue, Anne Bergeron, Vincent Cottin, Mathieu Lederlin, Stéphane Jouneau

“…We identified 5 patients (8%) with fibrosis on initial computed tomography (CT) and 16 patients (26%) with fibrosis on final CT after a median time of 3.6 years. Dust exposure was associated with pulmonary fibrosis occurrence (OR 4.3; p=0.038). aPAP patients treated with whole-lung lavage, rituximab or granulocyte–monocyte colony-stimulating factor therapy did not have more fibrotic evolution than patients who did not receive these treatments (n=25 out of 45, 57% versus n=10 out of 16, 62%; p=0.69). …”
Get full text

Development and validation of a screening tool for sepsis without laboratory results in the emergency department: a machine learning studyResearch in context by Shan Jiang, Shuai Dai, Yulin Li, Xianlong Zhou, Cheng Jiang, Cong Tian, Yana Yuan, Chengwei Li, Yan Zhao

“…However, time-consuming laboratory results are often needed for screening sepsis. …”
Get full text

A diagnostic host-specific transcriptome response for Mycoplasma pneumoniae pneumonia to guide pediatric patient treatment by Sandra Viz-Lasheras, Alberto Gómez-Carballa, Xabier Bello, Irene Rivero-Calle, Ana Isabel Dacosta, Myrsini Kaforou, Dominic Habgood-Coote, Aubrey J. Cunnington, Marieke Emonts, Jethro A. Herberg, Victoria J. Wright, Enitan D. Carrol, Stephane C. Paulus, Werner Zenz, Daniela S. Kohlfürst, Nina Schweintzger, Michiel Van der Flier, Ronald de Groot, Luregn J. Schlapbach, Philipp Agyeman, Andrew J. Pollard, Colin Fink, Taco T. Kuijpers, Suzanne Anderson, Ulrich Von Both, Marko Pokorn, Dace Zavadska, María Tsolia, Henriëtte A. Moll, Clementien Vermont, Michael Levin, Federico Martinón-Torres, Antonio Salas, On behalf of EUCLIDS, PERFORM, and DIAMONDS consortia

“…Current diagnostic tests are time-consuming and have low specificity, leading clinicians to administer empirical antibiotics. …”
Get full text

The Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) project: A team‐based approach to clinically validated, research‐ready electronic health record data by Andrea L. C. Schneider, Jennifer C. Ginestra, Meeta Prasad Kerlin, Michael G. S. Shashaty, Todd A. Miano, Daniel S. Herman, Oscar J. L. Mitchell, Rachel Bennett, Alexander T. Moffett, John Chandler, Atul Kalanuria, Zahra Faraji, Nicholas S. Bishop, Benjamin Schmid, Angela T. Chen, Kathryn H. Bowles, Thomas Joseph, Rachel Kohn, Rachel R. Kelz, George L. Anesi, Monisha Kumar, Ari B. Friedman, Emily Vail, Nuala J. Meyer, Blanca E. Himes, Gary E. Weissman

“…The median age was 46.9 years (25th–75th percentiles = 31.1–64.7) at the time of the first encounter. Most patients were female (n = 418 303, 56.5%), a significant proportion were of non‐White race (n = 272 018, 36.8%), and 54 625 (7.4%) were of Hispanic/Latino ethnicity. …”
Get full text

Histopathologic Progression and Metastatic Relapse Outcomes in Small Cell Neuroendocrine Carcinomas of the Urinary Tract by Mohammad Jad Moussa, Georges C. Tabet, Arlene O. Siefker‐Radtke, Lianchun Xiao, Nathaniel R. Wilson, Jianjun Gao, Christopher J. Logothetis, Petros Grivas, Byron Lee, Amishi Y. Shah, Pavlos Msaouel, Roger Li, Leticia Campos Clemente, Jianping Zhao, Nizar M. Tannir, Ashish M. Kamat, Donna E. Hansel, Charles C. Guo, Matthew T. Campbell, Omar Alhalabi

“…Relapse event was the time‐to‐event outcome, and relapse probabilities were estimated using a competing risk method with cumulative incidence functions (CIFs). …”
Get full text

Safety of a co-designed cognitive behavioural therapy intervention for people with type 1 diabetes and eating disorders (STEADY): a feasibility randomised controlled trialResearch... by Marietta Stadler, Natalie Zaremba, Amy Harrison, Jennie Brown, Divina Pillay, Jacqueline Allan, Rachael Tan, Salma Ayis, Emmanouela Konstantara, Janet Treasure, David Hopkins, Khalida Ismail

“…Baseline mental health data (Structured Clinical Interview for DSM-5, SCID-5RV), and secondary biomedical outcomes (HbA1c; glucose time in range; TIR) and person-reported outcome measures (PROM: Diabetes Eating Problems Survey-Revised, DEPS-R; Eating Disorder Examination Questionnaire Short, EDE-QS; Type 1 Diabetes Distress Scale, T1DDS; Generalised Anxiety Disorder Assessment, GAD-7; Patient Health Questionnaire, PHQ-9; Impact of Diabetes Profile, DIDP) were collected. …”
Get full text

Autonomous robotic ultrasound scanning system: a key to enhancing image analysis reproducibility and observer consistency in ultrasound imaging by Xin-Xin Lin, Ming-De Li, Si-Min Ruan, Wei-Ping Ke, Hao-Ruo Zhang, Hui Huang, Shao-Hong Wu, Mei-Qing Cheng, Wen-Juan Tong, Hang-Tong Hu, Dan-Ni He, Rui-Fang Lu, Ya-Dan Lin, Ming Kuang, Ming Kuang, Ming-De Lu, Ming-De Lu, Li-Da Chen, Qing-Hua Huang, Qing-Hua Huang, Wei Wang

“…PurposeThis study aims to develop an autonomous robotic ultrasound scanning system (auto-RUSS) pipeline, comparing its reproducibility and observer consistency in image analysis with physicians of varying levels of expertise.Design/methodology/approachAn auto-RUSS was engineered using a 7-degree-of-freedom robotic arm, with real-time regulation based on force control and ultrasound visual servoing. …”
Get full text

Assessing microbial biodiversity in oil palm seedlings using oil palm waste compost mixed media by Siti Suliza Salamat, Mohd Zulkhairi Mohd Yusoff, Mohd Ali Hassan Hassan, Mohd Huzairi Mohd Zainuddin, Yoshihito Shirai, Ahmad Husni Mohd Hanif, Mohd Shahkhirat Norizan, Fatini Mat Arisah, Mohammed Abdillah Ahmad Farid, Toshinari Maeda, Mohd Noor Mat Isa, Mohd Faizal Abu Bakar

“…However, conventional practices that rely exclusively on inorganic fertilizers can degrade soil over time, highlighting the need to reassess planting materials. …”
Get full text

The high-resolution global shipping emission inventory by the Shipping Emission Inventory Model (SEIM) by W. Yi, X. Wang, T. He, H. Liu, Z. Luo, Z. Lv, K. He

“…Subsequently, integrating real-time vessel positions and speeds from AIS data with static technical parameters, emission factors, and other computational parameters, SEIM simulated ship emissions on a ship-by-ship, signal-by-signal basis. …”
Get full text

Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Histological staining, immunohistochemistry, quantitative real-time polymerase chain reaction (PCR), and Western blotting were applied to study the regulation of miR-26a on Ang-II-induced cardiac and renal injury. …”
Get full text

Editorial by Jörg Tremmel, Markus Rutsche

“…Pathogens are among the existential risks to humanity that could potentially kill a large part of it in a very short time. For all the tragedy and horror it has brought upon the world, the Corona virus has not been lethal on such a large, all-encompassing scale. …”
Get full text

GravIS: mass anomaly products from satellite gravimetry by C. Dahle, E. Boergens, I. Sasgen, I. Sasgen, T. Döhne, S. Reißland, H. Dobslaw, V. Klemann, M. Murböck, M. Murböck, R. König, R. König, R. Dill, M. Sips, U. Sylla, A. Groh, M. Horwath, F. Flechtner, F. Flechtner

“…These mass change data, available in both a gridded representation and as time series for predefined regions, are routinely updated when new monthly GRACE/-FO gravity field models become available. …”
Get full text

25 años de cirugía de Ross: seguimiento y resultados en pacientes reoperados en nuestro centro by Consuelo M. Sisinni-Ganly, Julio C. Lugo-Adán, Francisco Estévez-Cid, Rocío Casais-Pampín, Juan J. Legarra-Calderón

“…During this period, 29 patients (26.9%) required at least one reintervention: 13 patients (44.8%) due to autograft dysfunction, 7 patients (24.1%) due to homograft dysfunction, and 9 patients (31%) due to dysfunction of both autograft and homograft. The mean time to reintervention due to autograft dysfunction was 11.8 ± 5.2 years (median 12 years, range 2-19 years) and due to homograft dysfunction was 12.6 ± 5 years (median 13 years, range 2-19 years). …”
Get full text

A Study on the Yield and Related Traits of some Forage Low-Tannin Faba bean (Vicia faba L.) Genotypes by Hamidreza Ghorbani, Mohamad Taghi Feyzbakhsh

“…The seeds were sown by hand at a depth of 5 cm in the soil in November. From the time of planting to harvesting during agricultural operations, necessary notes were taken at different stages of growth and development. …”
Get full text