A logistic regression model to predict long-term survival for borderline resectable pancreatic cancer patients with upfront surgery by Jin-Can Huang, Shao-Cheng Lyu, Bing Pan, Han-Xuan Wang, You-Wei Ma, Tao Jiang, Qiang He, Ren Lang

“…In the long-term group (n = 32) and short-term group (n = 72), the overall median survival time and the 1-, 2-, 3- years overall survival were 38 months, 100%, 100%, 61.3% and 10 months, 38.9%, 0%, 0%, respectively. 4 variables, including age, vascular invasion length, vascular morphological malformation, and local lymphadenopathy were confirmed as independent risk factors between the two groups following univariate and multivariate analysis. …”
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Identification of common and specific fibrosis-related genes in three common chronic kidney diseases by Zhangning Fu, Xiaodong Geng, Chao Liu, Wanjun Shen, Zheyi Dong, Guannan Sun, Guangyan Cai, Xiangmei Chen, Quan Hong

“…Genes differentially expressed in all fibrotic DN, IgAN and MN tissues compared to the normal controls were regarded as the common fibrosis-related genes in CKD, whereas genes exclusively differentially expressed in fibrotic DN, IgAN or MN samples were considered to be the specific genes related to fibrosis in DN, IgAN and MN respectively. Quantitative real-time PCR (qRT-PCR) was performed to validate the expression of the selected genes.Results Protein tyrosine phosphatase receptor type C (PTPRC), intercellular cell adhesion molecule-1 (ICAM1), vascular cell adhesion molecule-1 (VCAM1), interleukin 10 receptor alpha (IL10RA) and CC chemokine receptor 2 (CCR2) were identified as the potential common genes for kidney fibrosis in different types of CKD, while peroxisome proliferator-activated receptor alpha (PPARA), lactate oxidase (LOX), secreted phosphoprotein 1 (SPP1) were identified as the specific fibrosis-associated genes for DN, IgAN and MN respectively. qRT-PCR demonstrated that the expression levels of these selected genes were consistent with the NanoString analysis.Conclusions There were both commonalities and differences in the mechanisms of fibrosis in different types of CKD, the commonalities might be used as the common therapeutic targets for kidney fibrosis in CKD, while the differences might be used as the diagnostic markers for DN, IgAN and MN respectively. …”
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High-dependency unit care after carotid endarterectomy for asymptomatic stenosis by Beatriz Guimarães, Andreia Coelho, Marina Dias-Neto, Ricardo Castro-Ferreira, João Peixoto, Luís Fernandes, Roberto Boal, Marta Machado, Francisco Basílio, Patrícia Carvalho, Armando Mansilha, Alexandra Canedo

“…A retrospective study was performed in one center: increased clamping time, preoperative systolic BP, systolic BP during pre-anesthetic procedure, maximum intraoperative mean arterial pressure (MAP), and eversion technique were significant predictors for the CO. …”
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Analisis Perilaku Entitas untuk Pendeteksian Serangan Internal Menggunakan Kombinasi Model Prediksi Memori dan Metode PCA by Rahmat - Budiarto, Yanif Dwi Kuntjoro

“…The proposed model (PCA-MPM) is also capable of performing on-the-fly learning where this capability is needed to recognize feature changes in attacks that evolve over time. In turn, this model can support a holistic cyber defense system that is being developed. …”
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Rainfall intensity profile induced changes in surface‒subsurface flow and soil loss as influenced by surface cover type: A long-term in situ field study by Jian Duan, Haijin Zheng, Lingyun Wang, Yaojun Liu, Minghao Mo, Jie Yang

“…The average SRC and SLR from the advanced pattern were 1.29–2.42 times and 2.52–39.78 times greater than those from the other patterns, respectively. …”
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Construction and Pathogenicity Analysis of a GFPuv-labeled Peanut Ralstonia solanacearum Strain by Jinling HUANG, Yushuang WU, Huiquan TANG, Minyi HUANG, Ruixue YANG, Qiang WANG, Yong YANG, Xiaodan TAN

“…【Objective】The study aimed to construct a GFPuv-labeled peanut Ralstonia solanacearum, which was used to observe the infection pathway in host plants in real-time. Meanwhile, genomic integration sites suitable for exogenous gene were identified.…”
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Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-direct... by Marshall Pitz, Eng-Siew Koh, Elizabeth H Barnes, Lucille Sebastian, Mandy L Ballinger, David M Thomas, Christopher O'Callaghan, John Simes, Hui K Gan, Sonia Yip, Hao-Wen Sim, Desma Spyridopoulos, Richard De Abreu Lourenco, Cynthia Hawkins, Kristen McParland, Benjamin Kong, Subotheni Thavaneswaran, Patrick J Wheeler

“…Introduction All grade 2/3 gliomas are incurable and at the time of inevitable relapse, patients have significant unmet needs with few effective treatments. …”
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Liquid-based cytological diagnosis of pancreatic neuroendocrine tumors using hyperspectral imaging and deep learning by Taojing Ran, Wei Huang, Xianzheng Qin, Xingran Xie, Yingjiao Deng, Yundi Pan, Yao Zhang, Ling Zhang, Lili Gao, Minmin Zhang, Dong Wang, Yan Wang, Qingli Li, Chunhua Zhou, Duowu Zou

“…For cell classification, the CNN system identified hyperspectral images containing PanNETs and benign cells with areas under the curve (AUCs) of 0.9981 and 0.9815 in datasets from two different time points, respectively, showing superior performance compared to the conventional RGB group, with corresponding AUCs of 0.9716 and 0.9550. …”
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Periodontitis promotes tumor growth and immune evasion via PD-1/PD-L1 by Suli Wang, Fujiao Nie, Qiuyue Yin, Haoyang Tian, Pizhang Gong, Jinhong Ju, Jiayi Liu, Pishan Yang, Chengzhe Yang

“…THP-1 cells were stimulated using conditioned media of LPS-stimulated Cal-27 cells and PD-L1 expression was measured by quantitative real-time PCR, western blotting and immunofluorescence. …”
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High levels of histone acetylation modifications promote the formation of PGCs by Ziduo Zhao, Yuhui Wu, Fufu Cheng, Zhe Wang, Qingqing Geng, Yingjie Niu, Qisheng Zuo, Yani Zhang

“…Functional enrichment analysis indicated these genes are involved in pathways critical for germ cell differentiation, underscoring their importance in avian reproductive biology. Quantitative real-time PCR (qRT-PCR) confirmed significant differential expression of HAT8 and HDAC10 between ESCs and PGCs (P < 0.01). …”
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Probiotic Supplementation Alleviates Corticosterone-Induced Fatty Liver Disease by Regulating Hepatic Lipogenesis and Increasing Gut Microbiota Diversity in Broilers by Yuyan Feng, Wenqing Mei, Qu Chen, Xiaojing Chen, Yingdong Ni, Mingming Lei, Jie Liu

“…We demonstrate for the first time that the supplementation of probiotics to chicks had a beneficial effect on preventing fatty liver disease through regulating lipogenic gene expression and improving the gut microbial balance. …”
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Effect of integrated traditional Chinese and Western medicine nursing management model in relieving constipation of deficiency syndrome in cancer patients (中西医结合护理管理模式改善肿瘤患者虚证便秘效果观... by LIU Yin (柳吟), HUANG Jun (黄君)

“…Methods A total of 60 cancer patients with constipation of deficiency syndrome were selected as the research objects, and they were divided into control group and observation group according to hospital admission time, with 30 cases in each group. The control group was given routine nursing, and the observation group was treated with traditional Chinese and Western medicine on the basis of conventional treatment and nursing. …”
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La datation dendrochronologique du coffrage de fondation d’une pile du pont-siphon de l’Yzeron à Beaunant (Sainte-Foy-lès-Lyon, Métropole de Lyon) by François Blondel, David Baldassari

“…The posts most often have their first growth ring preserved (pith) and sometimes their last ring at the time of collection (cambium). However, they correspond to the shortest growth series, from 16 to 40 rings. …”
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Screening semen samples for Zika virus infection: role for serologic and RT-PCR testing by Humberto Ferraz, Humberto Ferraz, Humberto Ferraz, Kevan Akrami, Kevan Akrami, Kevan Akrami, Laise de Moraes, Laise de Moraes, Lais Cambuí Gusmão, Genevieve Coelho, Daniele Freitas, Daniele Freitas, Manoel Barral-Netto, Aldina Barral, Viviane Boaventura, Viviane Boaventura, Luciane Amorim Santos, Luciane Amorim Santos, Luciane Amorim Santos, Ricardo Khouri, Ricardo Khouri

“…Human reproductive clinics typically perform serologic tests to screen for Zika infection.MethodsIn this study, we evaluated semen samples stored in a human reproduction clinic in Salvador, Brazil, during the Zika virus outbreak, using real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) technique.Results36 sperm samples from 23 donors were analyzed, including 5 with positive IgG serology for ZIKV and all negative for IgM. …”
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Prevalence and determinants of overweight/obesity, elevated blood pressure, and their comorbidities among primary and secondary school students in Guizhou province: a cross-section... by Zhuan WANG, Xiangdong DU, Xin LI, Xiaoqin ZHANG, Xiujuan LU, Xiying PENG

“…Overweight/obesity, elevated blood pressure, and inadequate sleep were assessed according to national references including Screening for Overweight and Obesity in School-Aged Children and Adolescents: WS/T 586 – 2018, Screening Threshold for High Blood Pressure in Children and Adolescents Aged 7 – 18: WS/T 610 – 2018, and Hygiene Requirements for Daily Study Time of Primary and Secondary School Students: GB/T 17223 – 2012. …”
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Disease burden of biliary tract cancer in 204 countries and territories, 1990–2021: A comprehensive demographic analysis of the Global Burden of Disease Study 2021 by Xuheng Sun, Jiangmei Liu, Wei Zhang, Yijun Wang, Yan Jiang, Lijun Wang, Yixin Zou, Yuxuan Xiao, Yongbing Xiang, Maolan Li, Maigeng Zhou, Yingbin Liu, Sihan Zhou, Xiuyuan Hao

“…This study provided a comprehensive comparison of differences in the burden of disease across populations and over time, and further presented evidence concerning the formulation of prevention and control policies and etiologic studies for BTCs and proposed logical hypotheses to investigate.…”
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NaHS alleviates neuropathic pain in mice by inhibiting IL-17-mediated dopamine (DA) neuron necroptosis in the VTA by Jun Wang, Nan Zhang, Hong-Zheng Liu, Jin-Liang Wang, Yong-Bo Zhang, Dong-Dong Su, Li-Min Zhang, Bao-Dong Li, Hui-Tao Miao, Jun Miao

“…Additional experiments, including electrophysiological studies and immunofluorescence assays, western blotting, real-time quantitative Polymerase Chain Reaction (PCR) were conducted to elucidate the precise mechanism underlying the analgesic effects of H2S therapy on neuropathic pain. …”
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Platinum drugs upregulate CXCR4 and PD‐L1 expression via ROS‐dependent pathways, with implications for novel combined treatment in gastric cancer by Xiaoyu Kang, Lin Zhang, Shushang Liu, Fei Wang, Haiming Liu, Fenli Zhou, Fei Wu, Haohao Zhang, Daiming Fan, Yongzhan Nie, Zhangqian Chen

“…Increased levels of CXCR4 and PD‐L1 expression, in a dose‐ and time‐dependent manner upon cisplatin treatment, were observed in GC cells (p < 0.05). …”
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Have the COVID-19 pandemic and lockdown affected children’s mental health in the long term? A repeated cross-sectional study by Alan Johnson, Sayan Mukherjee, Sushant Mane, Manas Pustake, Ajit Bhagwat, Mohammad Arfat Ganiyani, Misba Sayed, Varada Mithbavkar, Zaid Memon, Abdus Samad Momin, Krishna Deshmukh, Ayush Chordia, Sabyasachi Parida, Sanket Warghade, Deepankar Varma

“…Regression models were constructed to predict the factors affecting increased anxiety levels and depressive symptoms in the COVID-19 period.Results 832 and 1255 children/adolescents were included in the study during the pre-COVID-19 and COVID-19 times, respectively. The median age of the participants was 10 years (IQR=4 years). …”
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Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis by Lu Cheng, Lu Cheng, Yanhong Li, Yu Zhou, Yingying Ling, Tong Wu, Zongan Liang, Yinlan Wu, Chunyu Tan, Yi Liu, Yong Zhang

“…The role of abnormal glycosylation in the onset of autoimmune diseases has been recognized for some time. Nonetheless, the intricate details of intact glycopeptides in SSc remain elusive owing to challenges in their detection. …”
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