Total neoadjuvant therapy based on short-course radiotherapy versus standard long-course chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis... by Wenji Pu, Wenji Pu, Wenji Pu, Wenqi Chen, Haiman Jing, Jishi Li, Yong Jiang, Shasha Li, Weijie Wen, Zhiyuan Xu, Jing Jin

“…Moreover, survival outcomes, distant recurrence rate, and surgical indicators were comparable between the two groups.ConclusionFor LARC patients, the SCRT/CCT regimen not only has a higher pCR rate, equivalent OS, and comparable additional indicators versus standard LCCRT but also shortens the treatment time, costs less, and improves patients’ adherence to the innovative anti-tumor therapy; hence, with the concept of acute toxicity control, it could be further widely and safely utilized, especially in resource-limited settings.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024600180.…”
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Multi-thermal recovery layout for a sustainable power and cooling production by biomass-based multi-generation system: Techno-economic-environmental analysis and ANN-GA optimizatio... by Ma Zihao, Naeim Farouk, Pradeep Kumar Singh, Azher M. Abed, Sarminah Samad, Samah G. Babiker, Iskandar Shernazarov, Ahmed Hendy, Ahmad Almadhor, Belgacem Bouallegue, Abdul Rahman Afzal

“…A novel approach combining artificial neural networks (ANN) with a non-dominated sorting genetic algorithm II (NSGA-II) has been developed to optimize the system, substantially reducing computational time and costs associated with system performance analysis. …”
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Establishment of political and diplomatic relations between Lithuania and France in 1918-1920: Exchange of mistrust by Vilma Bukaitė

“…The unfavourable attitude of the Lithuanian government and the public towards the French policy was anchored by the demarcation line which was defined at the time when Poland laid its claims to the southern and eastern territories of Lithuania. …”
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Nurses' self-efficacy and outcome expectancy in evidence-based practice: Translation, construct validity and internal consistency of the Dutch scales by Peter Hoegen, Michael Echteld, Cindy de Bot, Annemarie de Vos, Derya Demirçay, Mary-Anne Ramis, Lidwine Mokkink, Hester Vermeulen

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Establishment and validation a relapse prediction model for bipolar disorder by Xiaoqian Zhang, Xiaoqian Zhang, Xiaoqian Zhang, Xiaoqian Zhang, Minghao Wu, Daojin Wang, Long Wang, Long Wang, Long Wang, Wen Xie, Wen Xie, Wen Xie

“…We collected a multidimensional assessment of the characteristics of patients eligible for enrollment, including general demographic characteristics, medical history, treatment, and assessment of selected scales. At the same time, they were followed up for 1 year after reaching the recovery standard after treatment. …”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…The expression levels of SERPINE1, GATA2, p53, and p21 were determined by real-time quantitative PCR and Western blot. Additionally, a dual-luciferase reporter gene assay was conducted to validate the binding effect of SERPINE1 and GATA2.ResultsTranscriptome Analysis revealed that genes including GATA2 and SERPINE1 were downregulated in HK-2 cells following tocilizumab treatment. …”
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Formation of forest mensuration indicators of Pseudotsuga menziesii (Mirb.) Franco in artificial plantations of the western region of Ukraine by Iurii Debryniuk, Stepan Myklush, Yuriy Myklush

“…Moreover, as Pseudotsuga matures, its growth rate intensifies, leading to an increasing share of the species within the total stand volume over time, which also needs to be taken into account when designing afforestation strategies and forest management practices to support sustainable stand development and productivity in mixed-species plantations. …”
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Research Note: Reduction of Salmonella load in Brazilian commercial chicken farms using INSPEKTOR®: a bacteriophage-based product by Michael Pino, Karen Mujica, Paola Mora-Uribe, Héctor Garcias-Papayani, Braulio Paillavil, Camilo Avendaño, Diego Flores-Crisosto, Rodrigo Norambuena, Victoria Rojas-Martínez, Matías Aguilera, Nicolás Cifuentes Muñoz, Pablo Cifuentes, Hans Pieringer, Soledad Ulloa

“…Salmonella load was quantified (DNA copies/mL) by real-time PCR using the invA marker for Salmonella spp., together with serovars Minnesota and Heidelberg, which are relevant to the industry in Brazil. …”
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福莫特罗对哮喘小鼠气道杯状细胞增生及 粘蛋白MUC5ac mRNA表达的影响

“…【目的】 探讨长效β2受体激动剂福莫特罗对哮喘(支气管哮喘)小鼠气道杯状细胞增生及粘蛋白MUC5ac mRNA表达的影响65377;【方法】 40只雌性SPF级BABL/c小鼠,随机分为4组,每组10只65377;A组为生理盐水对照组;B组为卵蛋白(ovalbumin,OVA)哮喘组;C组为哮喘福莫特罗干预组;D组为哮喘地塞米松干预组65377;在末次激发24 h后所有小鼠取左肺组织行过碘酸雪夫(PAS)染色,采用医学图像分析软件测定支气管上皮杯状细胞面积占上皮细胞总面积的百分比并计算杯状细胞数量65377;取右肺组织行real-time qRT-PCR,检测粘蛋白MUC5ac mRNA的表达65377;【结果】 B组小鼠支气管上皮杯状细胞的数量65380;杯状细胞占上皮细胞总面积的百分比和MUC5ac mRNA水平显著高于A组[(163.63 ± 16.68)个vs (0.46 ± 0.16)个,(77.36 ± 5.05)% vs (0.03 ± 0.01)%,(10.31 ± 0.73) vs ( 1.00 ± 0.13),P均 < 0.05];C组小鼠支气管上皮杯状细胞的数量65380;杯状细胞占上皮细胞总面积的百分比和MUC5ac mRNA水平均低于B组[(52.04 ± 4.60)个 vs (163.63 ± 16.68)个,(30.05 ± 3.72)% vs (77.36 ± 5.05)%,(1.64 ± 0.14) vs (10.31 ± 0.73),P均 < 0.05] ;D组小鼠支气管上皮杯状细胞的数量65380;杯状细胞占上皮细胞总面积的百分比和MUC5ac mRNA水平均低于B组[(63.41 ± 6.39)个 vs (163.63 ± 16.68)个,(38.52 ± 3.83)% vs(77.36 ± 5.05)%,(1.72 ± 0.10) vs (10.31 ± 0.73),P均 < 0.05];C组和D组的杯状细胞数量65380;面积百分比和MUC5ac mRNA水平间差异均无统计学意义[(52.04 ± 4.60)个 vs (63.41 ± 6.39)个,(30.05 ± 3.72)% vs (38.52 ± 3.83)%,(1.64 ± 0.14 ) vs (1.72 ± 0.10),P均 > 0.05]65377;【结论】 长效β2受体激动剂福莫特罗可抑制哮喘小鼠气道杯状细胞增生及粘蛋白MUC5ac mRNA的表达65377;…”
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Derivation and validation of a prediction model for inadequate bowel preparation in Chinese outpatients by Huifang Yin, Yan Wang, Hangfang Wang, Tian Li, Xiangxiang Xu, Fengyu Li, Lihua Huang

“…Multivariate analysis identified that male sex (OR = 1.690, 95% CI: 1.242–2.300), diabetes (OR = 1.769, 95% CI: 1.059–2.954), constipation (OR = 2.375, 95% CI: 1.560–3.617), history of colorectal surgery (OR = 2.915, 95% CI: 1.455–5.840), a high fiber diet used at 24 h before examination (OR = 2.662, 95% CI: 1.636–4.334) and the time interval from the end of the bowel preparation to the start of the colonoscopy (PC) >5 h (OR = 2.471, 95% CI: 1.814–3.366) were independent risk factors. …”
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Induced-volatolomics, a new research field in chemical biology by Blochouse, Estelle, Eid, Rony, Cannoni, Elsa, Châtre, Rémi, Geffroy, Claude, Opalinski, Isabelle, Papot, Sébastien, Poinot, Pauline

“…In comparison to their “always-on” counterparts, such stimuli-responsive probes stand out as promising candidates for exploring biological processes because of their high sensitivity, ingenious spatiotemporal resolution, ease of operation, and real-time and in situ imaging capacity. However, these imaging tools meet several bottlenecks related to either stability, background noise, limited penetration depth or systemic toxicity, pharmacokinetics, tissue distribution, and renal clearance.In parallel, novel volatile organic compound (VOC)-based probes have been proposed under the emerging paradigm of induced-volatolomics. …”
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Concomitant exposure to benzodiazepines during pembrolizumab-based therapy for advanced non-small-cell lung cancer: a propensity-score matched analysis of monitoring agency data by Fabrizio Nelli, Enzo Maria Ruggeri, Antonella Virtuoso, Diana Giannarelli, Armando Raso, Federica Natoni, Gloria Pessina, Daniele Remotti, Mario Giovanni Chilelli, Carlo Signorelli, Agnese Fabbri

“…The classification of BZD relied on the molecular composition, distinguishing between N-substituted and N-unsubstituted compounds. Results: During the time frame from April 2018 to May 2023, we enrolled 258 patients, 156 (60.5%) and 102 (39.5%) of whom received pembrolizumab alone or the combination regimen, respectively. …”
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The Use of Biopsy and “No-Biopsy” Approach for Diagnosing Paediatric Coeliac Disease in the Central European Region by Petra Riznik, Márta Balogh, Piroska Bódi, Luigina De Leo, Jasmina Dolinsek, Ildikó Guthy, Judit Gyimesi, Ágnes Horváth, Ildikó Kis, Martina Klemenak, Berthold Koletzko, Sibylle Koletzko, Ilma Rita Korponay-Szabó, Tomaz Krencnik, Tarcisio Not, Goran Palcevski, Éva Pollák, Daniele Sblattero, István Tokodi, Matej Vogrincic, Katharina Julia Werkstetter, Jernej Dolinsek

“…Out of the remaining 412 children who underwent duodenal biopsies, 214 (51.9%) had TGA≥10 times upper level of normal (ULN) and would have been eligible for the “no-biopsy” approach. …”
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Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo by Claudia Palazzo, Roberta Mastrantonio, Noemi Gioelli, Erika Testa, Francesco Recco, Donatella Lucchetti, Giulia Villari, Alessio D’Alessio, Alessandro Sgambato, Flavio Mignone, Guido Serini, Maria Teresa Viscomi, Luca Tamagnone

“…Wound healing, transwell, and digital real-time migration assays were carried out to assess the activity of cancer cell-derived exosomes in the regulation of endothelial cells. …”
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Winter wheat yield responses to growing degree days: Long-term trends and adaptability in major producing areas of China by Ziyang Liu, Davide Cammarano, Xiaojun Liu, Yongchao Tian, Yan Zhu, Weixing Cao, Qiang Cao

“…The study found that the accumulated GDD in wheat sowing-to-jointing stage and the accumulated GDD in jointing-to-flowering and flowering-to-maturity stages showed an opposite trend in latitudinal distribution. Over time, the total GDD accumulation increased by an average of 345.23 ℃·d, and the GDD accumulation in the three key growth stages increased by an average of 273.26 ℃·d, 27.21 ℃·d, and 44.77 ℃·d. …”
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Effect of Chloroform Extraction Site of Jiangu Granule on Obteoblast Differentiation <italic>in Vitro</italic> via BMP2/Smad1/Runx2/Osterix Signaling Pathway by ZHOU Fen, SUN Yuqing, SUN Pan, ZHANG Chutian, YANG Juan, LIN Yanping

“…RT-PCR and Western blot detection showed that, compared with the blank group, the expression levels of each index gene in the inhibitor group significantly decreased, and the relative protein expression significantly decreased (<italic>P</italic>&lt;0.01 or <italic>P</italic>&lt;0.05); compared with the blank group, the expression levels of 6 index genes in the drug group significantly increased, and the relative protein expression also significantly increased (<italic>P</italic>&lt;0.01 or <italic>P</italic>&lt;0.05); compared with the inhibitor group, the expression levels of index genes and proteins in inhibitor plus drug group significantly increased (<italic>P</italic>&lt;0.01 or <italic>P</italic>&lt;0.05).Conclusion1) The gene and protein expressions of Smad1, Runx2, and Osterix significantly decreased when Noggin was used to inhibit the expression of intracellular BMP2. At the same time, osteoblast differentiation-related indicators ALP and Collagen Ⅰ also significantly decreased, suggesting that the BMP2 pathway could be closely related to osteoblast differentiation. 2) After the chloroform extraction site of Jiangu Granule intervention in osteoblasts, the expression of BMP2, Smad1, Runx2, Osterix and osteoblast differentiation-related indexes ALP and Collagen Ⅰ genes and proteins increased in the cells, which promoted the differentiation of osteoblast-like cells. …”
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Efficacy of a reduced-dosage PRRS MLV vaccine against a NADC34-like strain of porcine reproductive and respiratory syndrome virus by Xinyu Yan, Jiayu Liu, Fengxiong Yue, Yan Lin, Yan Li, Wensi Wu, Shan Zhao, Xiaobo Huang, Qin Zhao, Yiping Wen, Sanjie Cao, Senyan Du, Nanfang Zeng, Qigui Yan

“…IntroductionAfter being discovered for the first time in China in 2017, porcine reproductive and respiratory syndrome virus (PRRSV) NADC34-like strains have become the prevalent strain of PRRSV in certain regions of China. …”
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A Simple Spatial Working Memory and Attention Test on Paired Symbols Shows Developmental Deficits in Schizophrenia Patients by Wei Song, Kai Zhang, Jinhua Sun, Lina Ma, Forrest Fabian Jesse, Xiaochun Teng, Ying Zhou, Hechen Bao, Shiqing Chen, Shuai Wang, Beimeng Yang, Xixia Chu, Wenhua Ding, Yasong Du, Zaohuo Cheng, Bin Wu, Shanguang Chen, Guang He, Lin He, Xiaoping Chen, Weidong Li

“…In a healthy control group with ages ranging from 12 to 60, the efficiency score (accuracy divided by reaction time) reached a peak in the 20–27 age range and then declined with increasing age. …”
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Factors influencing the quality of life and mental health of Brazilian Federal Education Network Employees: An epidemiological cross-sectional study by Isabela Fernanda Rodrigues de Oliveira, Nicolli Godoi Pereira, Luís Fernando Monteiro, Leonardo Mateus Teixeira de Rezende, Claudio Andre Barbosa de Lira, Manuel Monfort-Pañego, Woska Pires da Costa, Priscilla Rayanne E. Silva Noll, Matias Noll

“…The current findings emphasize the need for intervention measures for Brazilian education employees to promote physical activity, healthy food consumption, reduced screen time, and awareness of the harm of risky behaviors, such as tobacco and alcohol, to enhance their QoL and mental health.…”
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Meta-analysis of the clinicopathologic features of endometrial cancer molecular staging by Xiaoxia Yin, Xiaoxia Yin, Bing Luo, Bing Luo, Yong Li, Yong Li

“…Therefore, a meta-analysis of articles related to the clinicopathological features of molecular typing was performed to observe how the prevalence of the four subgroups varied across different pathological features and whether they were associated with certain specific pathological features and to understand how molecular typing may influence current pathological assessments.MethodsPubMed, Embase, Web of Science, CNKI, Wanfang, and VIP were searched from the time of library construction until May 2024, and the following data were extracted: histological type, FIGO grade, FIGO stage, LVSI, depth of muscularis propria infiltration, and lymph node status of each TCGA group. …”
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