Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21 by Henry Chen, Henry Chen, Adam L. Numis, Adam L. Numis, Renée A. Shellhaas, John R. Mytinger, Debopam Samanta, Rani K. Singh, Rani K. Singh, Shaun A. Hussain, Danielle Takacs, Kelly G. Knupp, Li-Rong Shao, Carl E. Stafstrom

“…EEG improvement at three months was better for children treated with ACTH (74%) or oral corticosteroids (83%) than vigabatrin (20%; p = 0.048). Adjustment for time from epileptic spasms onset to treatment did not alter results.ConclusionsIn our cohort, epileptic spasms were the first presenting seizure type in all children with trisomy 21. …”
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Composición del trombo e implicaciones en la caracterización y el tratamiento en el ictus isquémico by J. Marta-Enguita, F.J.D. Machado, J. Orbe, R. Muñoz

“…Other factors as clot formation time, associated inflammatory status or activation of additional immune and coagulation pathways (Neutrophil extracellular traps [NETs] delivery, platelet aggregation, endothelial activation and Von Willebrand Factor release) have been described as determinants in thrombus characteristics. …”
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Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings... by Silvia Annunziata, Giulia Purpura, Giulia Purpura, Elena Piazza, Paolo Meriggi, Gabriele Fassina, Laura Santos, Emilia Ambrosini, Antonella Marchetti, Antonella Marchetti, Federico Manzi, Federico Manzi, Davide Massaro, Davide Massaro, Andrea Luna Tacci, Andrea Luna Tacci, Elisabetta Bolognesi, Simone Agostini, Francesca La Rosa, Alessandra Paola Giulia Pedrocchi, Paola Molina, Anna Cavallini

“…All recruited children will be evaluated at three different time points (T0 within the 8 months of life of the child, T1 after 6 months and T2 after 12 months) using behavioural, technological, and biological techniques to assess infants’ neurodevelopmental functions, parent-infant interaction, and early ASD markers.DiscussionThe ERI-SIBS study will expand knowledge regarding the impact of early intervention on families of infants at risk of neurodevelopmental disorders for the presence of a child with a diagnosis of ASD. …”
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Stratification system with dual human endogenous retroviruses for predicting immunotherapy efficacy in metastatic clear-cell renal cell carcinoma by Li Xu, Stephane Oudard, Catherine Sautes-Fridman, Xiaoping Su, Gabriel G. Malouf, Virginie Verkarre, Salma Kotti, Fangrong Yan, Yann-Alexandre Vano, Wolf Herve Fridman, Cheng-Ming Sun, Xiaofan Lu, Wenxuan Cheng

“…Our primary objective was to correlate ERV expression with progression-free survival, with overall survival and time-to-second-treatment survival as secondary endpoints. …”
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Gender differences in robotic surgery for rectal cancer: A retrospective study by Muhammad Ali, Wei Wang, Liuhua Wang, Bin Liu, Jun Ren, Daorong Wang

“…While males had longer operative times (177 ​min vs. 160 ​min for females), this was not statistically significant. …”
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Effect of Exercise Preconditioning on Autophagy and Apoptosis of Cardiomyocytes in Aged Rats with Myocardial Ischemia Reperfusion Injury by LI Hongyu, YIN Xia, WANG Yanxia, Li Yuting, ZHU Luwen, TANG Qiang

“…The Con group and the IR group did not receive special exercise intervention, the EP+IPC group, the EP+IPC+saline group and the EP+IPC+3-MA group received exercise preconditioning intervention (gradient exercise training was performed on an electric animal experimental treadmill, one time a day, five days a week, continuous training for six weeks). …”
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Les techniques de construction du second forum de Bavay (Nord) : utilisation, origine et datation des matériaux en terre cuite by Xavier Deru, Christine Louvion

“…On account of the considerable quantity of terracotta required, multiple suppliers were called upon, spread over the Meuse Valley, which led to a relative heterogeneity of materials, but reduced waiting time in line with the needs of the site. In addition, the Meuse workshops could avail of good communication routes as the Sambre, the main tributary of the Meuse, links Namur to Pont, where an agglomeration must have acted as a port for the town located less than 10 km away.Once the terracotta arrived on the construction site of Bavay, it had to be used in the colossal building project. …”
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Penerapan Metode Weighted Product (WP) Dalam Sistem Pendukung Keputusan Penerimaan Karyawan Pada Dewata Store Fakfak by Nelson Rumui, Nur Sakinah, Cahya Nur Rolan Niah, Fathurrahman Rumalutur

“…However, recruitment of Dewata Store Fakfak employees is still done manually where applicants still bring files directly and the company often has difficulties because of the large number of prospective employees so the recruitment process still takes a long time. Therefore, a decision support system is needed using a multi-criteria solution approach and the Weighted Product (WP) method, where many criteria need to be considered in employee selection. …”
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Hyperspectral estimation of chlorophyll density in winter wheat using fractional-order derivative combined with machine learning by Chenbo Yang, Chenbo Yang, Meichen Feng, Juan Bai, Hui Sun, Rutian Bi, Lifang Song, Chao Wang, Yu Zhao, Wude Yang, Lujie Xiao, Meijun Zhang, Xiaoyan Song

“…Chlorophyll density (ChD) can reflect the photosynthetic capacity of the winter wheat population, therefore achieving real-time non-destructive monitoring of ChD in winter wheat is of great significance for evaluating the growth status of winter wheat. …”
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Deeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial by Omar Nadeem, Michelle P. Aranha, Robert Redd, Michael Timonian, Sophie Magidson, Elizabeth D. Lightbody, Jean-Baptiste Alberge, Luca Bertamini, Ankit K. Dutta, Habib El-Khoury, Mark Bustoros, Jacob P. Laubach, Giada Bianchi, Elizabeth O’Donnell, Ting Wu, Junko Tsuji, Kenneth C. Anderson, Gad Getz, Lorenzo Trippa, Paul G. Richardson, Romanos Sklavenitis-Pistofidis, Irene M. Ghobrial

“…MRD-negativity (10-5 sensitivity) predicted a 5-year biochemical PFS of 100% versus 40% in MRD-positive patients (p = 0.051), demonstrating that deep responses significantly improve time to progression. Exploratory single-cell RNA sequencing linked tumor MHC class I expression to proteasome inhibitor response, and a lower proportion of GZMB+ T cells within clonally expanded CD8+ T cells associated with suboptimal outcomes.…”
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Increasing Planting Density with Reduced Topdressing Nitrogen Inputs Increased Nitrogen Use Efficiency and Improved Grain Quality While Maintaining Yields in Weak-Gluten Wheat by Wenyin Zhou, Suhui Yan, Abdul Rehman, Haojie Li, Shiya Zhang, Yudong Yong, Yang Liu, Longfei Xiao, Chengyan Zheng, Wenyang Li

“…Increasing nitrogen fertilizer will increase wheat grain yield and grain quality at the same time, but the goal of high quality and stable yield in weak-gluten wheat production is to reduce grain protein content and increase grain yield. …”
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Trial protocol of an open-label pilot study of oral naltrexone–bupropion combination pharmacotherapy for the treatment of methamphetamine use disorder (the NABU trial) by Jonathan Brett, Paul S Haber, Nicholas Lintzeris, Didier Jutras-Aswad, Nadine Ezard, Brendan Clifford, Krista J Siefried, Adrian John Dunlop, Liam Acheson, Carl Moller, Michael Christmass, Kirsten Morley, Steven Shoptaw, Madhukar H Trivedi

“…Primary outcomes are safety (measured by treatment-emergent adverse events (AEs)/adverse reactions) and feasibility (measured by the time taken to recruit, the proportion of ineligible participants, retention in the study and study medication adherence). …”
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Characterization of feeding damage by tea mosquito bug, Helopeltis theivora Waterhouse (Hemiptera: Miridae) on Hainan Dayezhong tea cultivar by Qi Yao, Qi Yao, Qi Yao, You-Ze Lin, You-Ze Lin, You-Ze Lin, Shuang Qin, Shuang Qin, Shuang Qin, Zhu-Feng Lin, Zhu-Feng Lin, Zhu-Feng Lin, Xun-Cong Ji, Xun-Cong Ji, Xun-Cong Ji

“…Furthermore, the adjacent scattered spots would connect after 48 hours, resulting in a necrotic patch on the leaves by 72 hours. The peak feeding time for H. theivora occurred at night, specifically from 7:00 PM to 1:00 AM. …”
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Acceptance and attitudes towards COVID-19 vaccination during pregnancy in Canada by Suraya Bondy, Elisabeth McClymont, Gal Av-Gay, Arianne Albert, Janice Andrade, Sandra Blitz, Ianna Folkes, Lucia Forward, Erin Fraser, Sela Grays, Jon Barrett, Julie Bettinger, Tali Bogler, Isabelle Boucoiran, Eliana Castillo, Rohan D’Souza, Darine El-Chaâr, Shaza Fadel, Verena Kuret, Gina S. Ogilvie, Vanessa Poliquin, Manish Sadarangani, Heather Scott, John W. Snelgrove, Modupe Tunde-Byass, Deborah Money

“…Of 1093 respondents who were pregnant at the time of the survey, 87.7% received or intended to receive a COVID-19 vaccine during pregnancy. …”
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DepRescribing inapprOpriate Proton Pump InhibiTors (DROPIT): study protocol of a cluster-randomised controlled trial in Swiss primary care by Stefan Neuner-Jehle, Katharina Tabea Jungo, Sven Streit, Sven Trelle, Nicolas Rodondi, Carole Elodie Aubert, Kristie Rebecca Weir, Enriqueta Vallejo-Yagüe, Samantha Chan, Marie Roumet, Pascal Juillerat, Sofia Carolina Zambrano Ramos, Jennifer Inauen, Angela Edith Schulthess-Lisibach, Renata Vidonscky Lüthold, Clémentine Tombez, Martina Zangger, Flurina Jenal, Yvonne Mattmann, Christof Bieri, Michaela Barbier

“…Data will be collected at baseline, 3-, 6-, 9- and 12-month follow-up time through online surveys or a phone call for both GPs and participants.Primary and secondary outcome measures The first co-primary endpoint is the effectiveness of the deprescribing intervention measured by the change of prescribed PPI dose. …”
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F. NIETZSCHE: VALIOS SIEKTI GALIOS PRINCIPAS by Arūnas Mickevičius

“…With respect to the genesis of power or its generation, the will to power determines the relation between forces, but in its own turn is determined by the activity of these forces. It is at the same time both determined and determiner. Nietzschean „slave“ and „master“ moralities are based upon active and reactive forces. …”
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Characterization of the Collagen Extraction Manufacturing Process Using Markov Chains and Artificial Neural Networks by Rosa Trasvina-Osorio, Sergio Alonso-Romero, Juan de Anda-Suarez, Valentin Calzada-Ledesma, Javier Yanez-Mendiola, Luis Fernando Villanueva-Jimenez, Erick Rojas-Mancera

“…The product of this research is a four-dimensional predictive model that estimates the yield with decreasing material, energy resources, and the time required for the collagen extraction process from the skin waste of tilapia. …”
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LoCS-Net: Localizing convolutional spiking neural network for fast visual place recognition by Ugur Akcal, Ugur Akcal, Ugur Akcal, Ivan Georgiev Raikov, Ekaterina Dmitrievna Gribkova, Ekaterina Dmitrievna Gribkova, Anwesa Choudhuri, Anwesa Choudhuri, Seung Hyun Kim, Mattia Gazzola, Rhanor Gillette, Rhanor Gillette, Ivan Soltesz, Girish Chowdhary, Girish Chowdhary, Girish Chowdhary

“…Still, training SOTA SNNs for VPR is often intractable on large and diverse datasets, and they typically demonstrate poor real-time operation performance. To address these shortcomings, we developed an end-to-end convolutional SNN model for VPR that leverages backpropagation for tractable training. …”
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One Year Duration of Immune Response Following a 3rd Booster Dose of mRNA Vaccine Against COVID‐19 in 292 Patients With Hematological Malignancies in University Hospital Ostrava, C... by Ondrej Šušol, Barbora Šušolová, Ondřej Klempíř, Milan Navrátil, Jaromír Gumulec, Zdeněk Kořístek, Juraj Ďuraš, Michal Kaščák, Jana Mihályová, Lukáš Stejskal, Tomáš Jelínek, Petra Richterová, Lenka Szeligová, Hana Plonková, Jana Zuchnická, Barbora Dluhošová, Ivo Demel, David Buffa, Katarína Hradská, Tereza Popková, Ludmila Muroňová, Martin Lachnit, Klára Lančová, Roman Hájek

“…We have seen better results if the time interval between anti‐CD20 therapy and additional vaccine dose was longer than 6 months (5/8 patients achieved seroconversion on 4th booster dose after previous failure). …”
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Coronavirus Disease 2019-Related Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis by Ji-Gan Wang, Zhi-Juan Zhong, Meng Li, Jun Fu, Yu-Heng Su, You-Min Ping, Zi-Ji Xu, Hao Li, Yan-Hao Chen, Yu-Li Huang

“…PICU hospitalization and shock rates of multisystem inflammatory syndrome in children associated with COVID-19 were high, and its cumulative multiorgans and inflammatory indicators are increased, but if treated in time, the mortality rate was low.…”
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