Spireoside Controls Blast Disease by Disrupting Membrane Integrity of Magnaporthe oryzae by Xu Liting, He Kaiwei, Guo Chunyu, Quan Cantao, Ma Yahuan, Zhang Wei, Ren Lifen, Wang Long, Song Li, Ouyang Qing, Yin Junjie, Zhu Xiaobo, Tang Yongyan, He Min, Chen Xuewei, Li Weitao

“…We found that 24 and 48 h post-inoculation with Magnaporthe oryzae were critical time points for metabolomic profiling, based on the infected status of M. oryzae in rice and the observed differences in shikimate accumulation between the two varieties. …”
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The Influences of Rootstock on the Performance of Pinot Noir (Vitis vinifera L.): Berry and Wine Composition by Yipeng Chen, Zijian Liang, Mark Krstic, Peter Clingeleffer, Kate Howell, Deli Chen, Pangzhen Zhang

“…The phenolic composition of the wine over the two vintages was identified and quantified by high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-QTOF-MS/MS) and HPLC with diode-array detection (HPLC-DAD). …”
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Experimental study on freeze-thaw damage characteristics and mechanical properties of fractured rock mass of surface mine slope in cold region by Sen TIAN, Ying ZHAO, Hu SI, Chun ZHU, Quangui LI

“…With the increase of freeze-thaw cycles (20–30 times), the proportion of mixed-mode microcracks increased and that of shear cracks decreased. …”
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Country-Specific Roadmaps for Scaling Up Integrated Care in Belgium, Slovenia, and Cambodia – Lessons Learned from the SCUBY Project by Martin Heine, Monika Martens, Daniel Boateng, Grace Marie Ku, Roy Remmen, Edwin Wouters, Srean Chhim, Por Ir, Antonjia Poplas Susič, Wim van Damme, Josefien van Olmen, Kerstin Klipstein-Grobusch, on behalf of the SCUBY consortium

“…The linkage of research teams with key implementation stakeholders and policy makers creates change-teams, allowing advancement from formative research to implementation of roadmap strategies and full scale-up in due time. Conclusion: The development processes and contents of the roadmaps provided essential and reciprocal learnings. …”
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Matrine Inhibits Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Through Regulating the LINC01116/miR-9-5p/ITGB1 Axis by Lili Ren, Ziru Fang, Jiaojiao Xu, Xiaoxiao Wu, Yongjun Zhang, Hu Cai, Zhicun Han

“…The BC cells (MDA-MB-231 and MCF-7) were treated with various concentrations of MAT, and the optimal dose and timing of MAT action were determined using CCK-8 and quantitative real-time polymerase chain reaction assays. …”
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Development characteristics and river blocking outburst analysis of Shadong landslide in the upper reaches of Jinsha River by Shunxiang ZHENG, Jun WANG, Yong YAN, Wen LIU, Heng ZHAO, Junxiang YANG, Xiongan FAN, Yi ZHANG, Meng WANG, Tianbin YU

“…In the event of both storm and earthquake conditions, II-1 and II-2 zone are unstable at the same time, resulting in the height of the barrier dam of approximately 153 m, with a barrier lake capacity of approximately 5.66×108 m3. …”
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Pharmacological Evaluation of Secondary Metabolites and Their Simultaneous Determination in the Arabian Medicinal Plant Plicosepalus curviflorus Using HPTLC Validated Method by Raha Orfali, Shagufta Perveen, Nasir Ali Siddiqui, Perwez Alam, Tawfeq Abdullah Alhowiriny, Areej Mohammad Al-Taweel, Sami Al-Yahya, Fuad Ameen, Najwa Majrashi, Khulud Alluhayb, Bandar Alghanem, Hayat Shaibah, Shabana Iqrar Khan

“…Results proved for the first time the dual PPAR activation effect of the PCME and catechin (P2), in addition to the promising anti-inflammatory activity of the flavonoid quercetin (P1). …”
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Emotion dysregulation in youths with obsessive-compulsive disorder and its implication for treatment - An exploratory study from the TECTO trial: A protocol and statistical analysi... by Christine Lykke Thoustrup, Camilla Uhre, Valdemar Uhre, Melanie Ritter, Signe Vangkilde, Janus Engstrøm, Jane Lindschou, Christian Gluud, Anne Katrine Pagsberg, Markus Harboe Olsen

“…We will; 1) assess if emotion dysregulation, measured by the Difficulties in Emotion Regulation Scale (DERS), decreases from baseline to end-of-treatment; 2) compare the proportion of participants with normative emotion regulation to a 90% reference interval from healthy controls (n = 90); 3) use linear regression to examine if baseline emotion dysregulation moderates treatment effects measured by the Children's Yale-Brown Obsessive-Compulsive Scale; 4) investigate if changes in emotion dysregulation mediate treatment effects; and 5) investigate the stability of emotion regulation over time in the healthy controls. Analyses 1–4 will be conducted for all OCD participants and separately for the two treatment groups. …”
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In-vivo high-resolution χ-separation at 7T by Jiye Kim, Minjun Kim, Sooyeon Ji, Kyeongseon Min, Hwihun Jeong, Hyeong-Geol Shin, Chungseok Oh, Robert J. Fox, Ken E. Sakaie, Mark J. Lowe, Se-Hong Oh, Sina Straub, Seong-Gi Kim, Jongho Lee

“…However, applying χ-separation at 7T presents difficulties due to the requirement of an R2 map, coupled with issues such as high specific absorption rate (SAR), large B1 transmit field inhomogeneities, and prolonged scan time. To address these challenges, we developed a novel deep neural network, R2PRIMEnet7T, designed to convert a 7T R2* map into a 3T R2′ map. …”
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Dyssynchronous heart failure models in canines: New insights into electrocardiographic, echocardiographic and histological features by Han Jin, Shengwen Yang, Hao Huang, Sijing Cheng, Pengkang He, Sixian Weng, Min Gu, Hongxia Niu, Wei Hua, Yiran Hu, Hui Li

“…The RAP+LBBB group exhibited a prolonged overall ventricular activation time, delayed left ventricular activation, and lesser impact on the right ventricle. …”
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A Randomized Study to Compare the Effects of Once-Weekly Dulaglutide Injection and Once-Daily Glimepiride on Glucose Fluctuation of Type 2 Diabetes Mellitus Patients: A 26-Week Fol... by Huiqin Li, Xiaohua Xu, Jie Wang, Xiaocen Kong, Maoyuan Chen, Ting Jing, Zhiying Zhang, Guoping Yin, Xiaomei Liu, Yun Hu, Lei Ye, Xiaofei Su, Jianhua Ma

“…Furthermore, no statistically significant difference was found between the two groups in MBG, SDBG, MAGE, and MODD (P>0.05). The percentage time (PT) (>10 mmol/L and 3.9-10 mmol/L) of the two groups was significantly changed after the treatment (P<0.05). …”
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Screening potential antileukemia ingredients from sweet potato: integration of metabolomics analysis, network pharmacology, and experimental validation by Lianling Xu, Lianling Xu, Kaixuan Zeng, Kaixuan Zeng, Zuoyue Duan, Zuoyue Duan, Jing Liu, Yan Zeng, Miao Zhang, You Yang, Qulian Guo, Yanling Jin, Wenjun Liu, Ling Guo

“…Subsequently, based on the results of metabolomics analysis and network pharmacology, cynaroside, nepitrin, and yuanhuanin were identified as potential antileukemia agents present in sweet potato for the first time; while CASP3, KDR, EGFR, and SRC were recognized as pivotal targets of these three monomers against AML. …”
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Associations of dose to the urethra and long-term patient-reported outcomes after radiotherapy with EBRT and HDR brachytherapy boost for prostate cancer by Lars Haack, David Krug, Justus Domschikowski, Olaf Wittenstein, Severin Rodler, Philipp Nuhn, Christof van der Horst, Claudia Schmalz, Christian Schulz, Oliver Blanck, Frank-André Siebert, Alexander Fabian

“…Results: Among 277 screened patients, 113 patients were alive, eligible, consented, and provided PRO. The median time passed since radiotherapy was 4 years. Per univariable analysis, a higher near maximum point dose of the urethra (DU0.1cc) was associated with worse urinary incontinence (r = -0.32; CI = −0.48 − -0.13; p < 0.001) and worse overall urinary function (r = -0.21; CI = −0.38 − -0.03; p = 0.02) of the respective EPIC-26 domains. …”
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Isolation of a tumor neoantigen specific CD8+ TCR from a skin biopsy of a vaccination site by Maria Paula Roberti, Pornpimol Charoentong, Yanhong Lyu, Marten Meyer, Stefan B. Eichmüller, Patrick Schmidt, Frank Momburg, Miray Cetin, Felix Hartmann, Nektarios A. Valous, Albrecht Stenzinger, Laura Michel, Peter Lichter, Andreas Schneeweiss, Verena Thewes, Carlo Fremd, Inka Zörnig, Dirk Jäger

“…Our study shows, for the first time, that tumor mutation – specific T cells are generated at high frequencies in the vaccination site and can be isolated with standard methods for TCR screening. …”
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Behavior of tellurium during vacuum thermal decomposition of Ag–Cu–Te alloy by Jia Deng, Hongjun Ding, Huan Luo, Xianjun Lei, Baoqiang Xu, Bin Yang

“…The experimental results show the volatilization of tellurium reached 99.93% at 1523 K, 10 Pa, and 480 min holding time, and the content of tellurium in the residue was only 0.0045 wt%. …”
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Simplified Physical Stability Assessment of Chilean Mine Waste Storage Facilities Using GIS and AI: Application in the Antofagasta Region by Gabriel Hermosilla, Gabriel Villavicencio, Giovanni Cocca-Guardia, Vicente Aprigliano, Manuel Silva, Juan Carlos Quezada, Pierre Breul, Vinicius Minatogawa, Jaime Morales

“…This approach reduces analysis time and minimizes human error. Validated in the Antofagasta Region, Chile&#x2019;s primary mining area, we identified and evaluated 70 WRD and 54 LWD. …”
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Integrating BRCA testing into routine prostate cancer care: a multidisciplinary approach by SIUrO and other Italian Scientific Societies by Giulia Mammone, Simona Borghesi, Nicolò Borsellino, Anna Caliò, Roberta Ceccarelli, Alessia Cimadamore, Giario Natale Conti, Laura Cortesi, Rolando Maria D’Angelillo, Gaetano Facchini, Lorena Incorvaia, Alberto Lapini, Luigi Mearini, Giovanni Pappagallo, Paolo Prontera, Daniela Turchetti, Grazia Sirgiovanni, Sergio Bracarda, on behalf of the Italian Society of Uro-Oncology (SIUrO)

“…A preliminary meeting convened teams from different Italian regions to establish minimal requirements for a mini-counseling program (defined as a pre-test consultation carried out by clinicians responsible of patients’ management) and propose care pathway models. At the same time, a comprehensive survey was launched to highlight regional variations in BRCA testing and identify eventual obstacles to testing activities. …”
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Deltopectoral approach without subscapularis detachment for reverse shoulder arthroplasty. Technique and results of a safe and reproducible subscapularis-sparing approach by Adrien Jacquot, MD, MSc, Thomas Cuinet, MD, Lisa Peduzzi, MD, Patrice Wong, MD, Marc-Olivier Gauci, MD, PhD, Julien Uhring, MD

“…Results: There was no intraoperative complication, and the mean operative time was 62 minutes. We observed a significant improvement in Constant score (from 36 to 70, P <.001), simple shoulder value (from 33 to 81, P <.001), pain (from 6.3 to 0.7, P <.001), strength (from 0.5 to 3.5, P <.001), and most of the active mobilities. …”
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EIF1AX mutation in thyroid tumors: a retrospective analysis of cytology, histopathology and co-mutation profiles by Noha Elsherbini, Dong Hyun Kim, Richard J. Payne, Thomas Hudson, Véronique-Isabelle Forest, Michael P. Hier, Alexandra E. Payne, Marc P. Pusztaszeri

“…While 55% of thyroid nodules were benign at the time of surgery, the possible malignant transformation of these nodules, had they not been resected, is unknown. …”
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Parboiled rice supplementation alleviates high-fat diet-induced hyperlipidemia by regulating genes and gut microbiota in mice by Xiuxiu Wu, Tianyi Guo, Biao Li, Shuai Han, Zuomin Hu, Yi Luo, Dandan Qin, Yaping Zhou, Feijun Luo, Qinlu Lin

“…And 15 differentially expressed genes (DEGs) were validated by quantitative real-time PCR (RT-qPCR), while protein interaction network showed that protein tyrosine phosphatase receptor type C (PTPRC) has a central role. …”
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