Analysis of the efficacy of MALDI-TOF MS technology in identifying microorganisms in cancer patients and oncology hospital environment by Grażyna Czeszewska-Rosiak, Iwona Adamczyk, Agnieszka Ludwiczak, Piotr Fijałkowski, Paweł Fijałkowski, Magdalena Twarużek, Michał Złoch, Dorota Gabryś, Wioletta Miśta, Andrzej Tretyn, Paweł Piotr Pomastowski

“…Rapid diagnostics of microbes in hospitals are crucial for promptly identifying infections, enabling timely and appropriate treatment. The study was conducted to evaluate the effectiveness of the matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI TOF MS) technology in the microbial profiling of hospital environments and patient samples. …”
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Determination of a normal orogenic palaeo-geothermal gradient with clay mineral and organic matter indices: a review by Rafael Ferreiro Mählmann, Meinert Rahn, Sébastien Potel, Lan Nguyen-Thanh, Rainer Petschick

“…The observed correlation enables to determine gradual changes in metamorphic factors such as pressure, temperature and time causing sensitive shifts of the gradient slope in the range of normal gradients. …”
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CCL5 Induces a Sarcopenic-like Phenotype via the CCR5 Receptor by Francisco Aguirre, Franco Tacchi, Mayalen Valero-Breton, Josué Orozco-Aguilar, Sabrina Conejeros-Lillo, Josefa Bonicioli, Renata Iturriaga-Jofré, Daniel Cabrera, Jorge A. Soto, Mauricio Castro-Sepúlveda, Marianny Portal-Rodríguez, Álvaro A. Elorza, Andrea Matamoros, Felipe Simon, Claudio Cabello-Verrugio

“…In conclusion, we report for the first time that CCL5 is a novel myokine that exerts a sarcopenic-like effect through the CCR5 receptor.…”
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MET-PREVENT: metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty – protocol for a double-blind, randomised controlled proof-of... by Andrew Clegg, James Wason, Miles Witham, Nina Wilson, Claire J Steves, Helen C Hancock, Avan A P Sayer, Leanne Marsay, Claire McDonald, Thomas von Zglinicki, Katherine J Rennie, Penny Bradley, Stephen Connolly, Shaun Hiu, Laura Robertson, Laura Simms, Alison J Steel, Bryony Storey

“…Eligible participants with low grip strength or prolonged sit-to-stand time together with slow walk speed will be randomised to either oral metformin hydrochloride 500 mg tablets or matched placebo, taken three times a day for 4 months. …”
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Efficacy, safety and cost-effectiveness of obinutuzumab in patients with follicular lymphoma: a rapid review by Chao Wang, Yunzhuo Dong, Peng Men, Ruixia Zhang, Ying Xiao, Yishan Bu, Yinpeng Qin, Xinran Zhang, Qianqian Dou, Yiheng Yang, Huier Gao, Yi Zhang

“…The studies on obinutuzumab for FL were searched in full text with obinutuzumab, systematic review, meta-analysis, economics, cost, and health technology assessment as keywords, with a search time frame from the date of database creation to 29 November 2024. …”
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Evidence linking phthalate exposure to alterations of hematologic parameters in Chinese children: A cross-sectional study by Mei-Ting Wei, Ying Wen, Zhu-Xia Zhang, Xiu-Ju Liu, Feng-Xiang Wei, Wei-Qiang Liu, Li Zhou, Ding-Yan Chen, Yao Yao

“…Nine phthalate metabolites (mPAEs) and four hematologic parameters (white blood cell [WBC] count, red blood cell [RBC] count, hemoglobin [Hb], and platelet [PLT] count) were measured at the same time. To evaluate the connections between mPAEs and hematologic indices, both individually and in combination, several analytical approaches were used, including the generalized linear model (GLM), the Bayesian kernel machine regression (BKMR) model, and the quantile g-computation (QGC) model. …”
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Tau oligomers impair memory and synaptic plasticity through the cellular prion protein by Claudia Balducci, Franca Orsini, Milica Cerovic, Marten Beeg, Beatrice Rocutto, Letizia Dacomo, Antonio Masone, Eleonora Busani, Ilaria Raimondi, Giada Lavigna, Po-Tao Chen, Susanna Leva, Laura Colombo, Chiara Zucchelli, Giovanna Musco, Nicholas M. Kanaan, Marco Gobbi, Roberto Chiesa, Luana Fioriti, Gianluigi Forloni

“…Immunofluorescence analysis of naïve and PrPC-overexpressing HEK293 cells exposed to TauOs showed a PrPC dose-dependent association of TauOs with cells over time, and their co-localization with PrPC on the plasma membrane and in intracellular compartments, suggesting PrPC-may play a role in TauO internalization. …”
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Impact of Annually Variable Dust Activity on the Recession of the Martian South Polar Seasonal Cap by Zhibin Li, Jianjun Liu, Renhao Tian, Zhaopeng Chen, Qing Zhang, Jingjing Zhang, Wei Yan, Qiang Fu, Shaoran Liu, Nannan Ma

“…The recession process is accelerated if the dust activity peak occurs earlier. If the timing of the peak dust activity is identical, the intensity of the dust activity influences the recession. …”
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Relationship Among Macronutrients, Dietary Components, and Objective Sleep Variables Measured by Smartphone Apps: Real-World Cross-Sectional Study by Jaehoon Seol, Masao Iwagami, Megane Christiane Tawylum Kayamare, Masashi Yanagisawa

“…Multivariable regression explored the associations between quartiles of macronutrients (protein; carbohydrate; and total fat, including saturated, monounsaturated, and polyunsaturated fats), dietary components (sodium, potassium, dietary fiber, and sodium-to-potassium ratio), and sleep variables (total sleep time [TST], sleep latency [SL], and percentage of wakefulness after sleep onset [%WASO]). …”
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Levels and related factors of occupational stress among nurses: hospital-based evidence from China, 2023 by Xiaoying Zhong, Yan Zeng, Lin Peng, Xixi Li, Yuanli Jia, Changqing Pan, Bangjun Wang

“…In addition, workload and time pressure were rated highest among the sub-scales of the NJSS. …”
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Genomic adaptation of Clostridium perfringens to human intestine by Ke Wu, Juan Wang, Zelin Yan, Yanyan Zhu, Shaolin Wang, Bo Fu, Chengtao Sun, Ruichao Li, Edward M. Fox, Séamus Fanning, Li Bai, Yang Wang, Yizhi Tang, Zhe Yin, Rong Zhang, Hongning Wang

“…Notably, the food poisoning‐associated toxin gene cpe was identified in a fusion plasmid for the first time in an isolate, indicating fusion of pCP13‐like and pCW3‐like plasmids and the potential for transfer of cpe across genetic backgrounds. …”
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Severe soft tissue injuries in multiple trauma patients—a challenge we can meet? A matched-pair analysis from the TraumaRegister DGU® by Nora Kirsten, Georg Maximilian Franke, Rolf Lefering, Tim Klüter, Matthias Weuster, Michael Müller, Sebastian Lippross, Andreas Seekamp, TraumaRegister DGU®, Stefanie Fitschen-Oestern

“…Concomitant soft tissue injuries represent a particular challenge, as they can lead to complications at any time of trauma care, hold a high risk of infection and often require multiple surgical interventions and interdisciplinary collaboration.MethodsThis retrospective, multicentric study used the TraumaRegister DGU® to examine the effect of open fractures and severe soft tissue injuries on outcome of multiple trauma patients. …”
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Protein kinases MpkA and SepH transduce crosstalk between CWI and SIN pathways to activate protective hyphal septation under echinocandin cell wall stress by Alexander G. Doan, Jessica E. Schafer, Casey M. Douglas, Matthew S. Quintanilla, Meredith E. Morse, Harley Edwards, Walker D. Huso, Kelsey J. Gray, JungHun Lee, Joshua K. Dayie, Steven D. Harris, Mark R. Marten

“…We also describe, for the first time, the signaling pathway used to deploy the hyperseptation response. …”
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The effects of altitude training on hormonal response in professional cyclists by Raphael Faiss, Bastien Krumm, Basile Moreillon, Lena Mettraux, Julian Wackernell, James Spragg, Martin Faulhaber

“…The increase in both testosterone and IGF-1 during the time course of the altitude sojourn suggests an anabolic stimulus linked to training adaptations. …”
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Functional interaction between receptor tyrosine kinase MET and ETS transcription factors promotes prostate cancer progression by Elisa Carouge, Clémence Burnichon, Martin Figeac, Shéhérazade Sebda, Nathalie Vanpouille, Audrey Vinchent, Marie‐José Truong, Martine Duterque‐Coquillaud, David Tulasne, Anne Chotteau‐Lelièvre

“…Thus, our results demonstrate for the first time in prostate cancer models a functional interaction between ETS transcription factors (ETV1 and ERG) and MET signalling that confers more aggressive properties and highlight a molecular signature characteristic of this combined action.…”
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Kidney failure-related excess mortality during the first three years of the COVID-19 pandemic in the United States: a nation-wide, population-based analysis by Zhenhu Chen, Pingping Jia, Di Xie, Jingyu Xie, Juan Liu, Wangnan Cao, Lefei Han, Jinjun Ran, Shengzhi Sun, Shi Zhao, Yang Ge, Leonardo Martinez, Xin Chen, Peihua Cao

“…Methods We aim to estimate time-varying excess kidney failure-related mortality, which is defined as the difference between observed mortality and expected mortality predicted by a Poisson log-linear regression model, in the United States (March 2020—March 2023). …”
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What is the optimal outcome after endoscopic sinus surgery in the treatment of chronic rhinosinusitis? A consultation of Canadian experts by Nadim Saydy, Sami P. Moubayed, Marie Bussières, Arif Janjua, Shaun Kilty, François Lavigne, Eric Monteiro, Smriti Nayan, Marilou Piché, Kristine Smith, Doron Sommer, Leigh Sowerby, Marc A. Tewfik, Ian J. Witterick, Erin Wright, Martin Desrosiers

“…Abstract Objectives Many experts feel that in the absence of well-defined goals for success, they have an easier time identifying failure. As success ought to not be defined only by absence of failure, we aimed to define optimal outcomes for endoscopic sinus surgery (ESS) in chronic rhinosinusitis (CRS) by obtaining expert surgeon perspectives. …”
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An Ultra-Low-Power 2.4 GHz All-Digital Phase-Locked Loop With Injection-Locked Frequency Multiplier and Continuous Frequency Tracking by Muhammad Riaz Ur Rehman, Arash Hejazi, Imran Ali, Muhammad Asif, Seongjin Oh, Pervesh Kumar, Younggun Pu, Sang-Sun Yoo, Keum Cheol Hwang, Youngoo Yang, Yeonjae Jung, Hyungki Huh, Seokkee Kim, Joon-Mo Yoo, Kang-Yoon Lee

“…In the proposed ADPLL architecture to save power, the need for Time-to-Digital Converter (TDC) is eliminated through providing the CFTL circuitry. …”
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Exogenous cystine increases susceptibility of drug-resistant Salmonella to gentamicin by promoting oxidation of glutathione metabolism and imbalance of intracellular redox levels by Junyuan Du, Junyuan Du, Zhiyi Wu, Zhiyi Wu, Chunyang Zhu, Chunyang Zhu, Heng Yang, Heng Yang, Feike Zhao, Feike Zhao, Binghu Fang, Binghu Fang

“…The expression of glutathione and stress genes was determined using real-time quantitative PCR.ResultWe confirmed that exogenous cystine increased the lethal effect of gentamicin against strain S. enterica Typhimurium (ATCC 14028) and other clinically resistant Salmonella serotypes. …”
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Achieving reliable patient reported outcomes collection to measure health care improvement in a learning health network: lessons from pediatric rheumatology care and outcomes impro... by Nancy Pan, Nancy Pan, Esi M. Morgan, Meghan Ryan, Beth Gottlieb, Beth Gottlieb, Julia G. Harris, Julia G. Harris, Tzielan Lee, Tzielan Lee, Y. Ingrid Goh, Y. Ingrid Goh

“…Barriers to PRO collection cited were limited time, lack of infrastructure, and lack of staff. …”
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