SUMO-Specific Peptidase 5 Promotes Oesophageal Squamous Cell Carcinoma Growth through the NF-κB-SLC1A3 Axis by Chaoxiang Du, Yunfan Hu, Xinyu Yang, Zhe Zhang, Jianmin Gu, Tao Zhang, Renfeng Wang, Shaoyuan Zhang, Lijie Tan, Guiping Yu

“…The correlation of SENP5 with signalling pathway components was validated via real-time quantitative PCR (qPCR), western blotting (WB), and immunoprecipitation. …”
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Desain Layanan E-Surat untuk Desa Waru Barat, Pamekasan, Madura menggunakan QR-Code by Wahyudi Agustiono, Intan Rofika Putri, Devie Rosa Anamisa

“…Another flow-map evaluation also showed that the implementation of e-certificate was able to make the administrative process more streamlined, faster, remove geographical barrier, save the resources (cost, time and utility). Despite these practical implication, the contribution of this research, especially to the IT discipline which could be adopted in the future study, is the system architecture and e-certificate application along with the algorithm for generating unique QR Code to ensure the security and validity of the document.            …”
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Predictive Factors and the Predictive Scoring System for Falls in Acute Care Inpatients: Retrospective Cohort Study by Chihiro Saito, Eiji Nakatani, Hatoko Sasaki, Naoko E Katsuki, Masaki Tago, Kiyoshi Harada

“…Demographic data, candidate predictors at admission, and fall occurrence reports were collected from medical records. The outcome was the time from admission to a fall requiring medical resources. …”
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Investigation of natural infection of BALB C mice by Bartonella henselae by Luciene Silva dos Santos, Sayros Akyro Soares Martins, Francine Ramos Scheffer, Alexandre Seiji Maekawa, Rafaela de Paula Silva, Gabriel Rabelo de Araújo, Paulo Eduardo Neves Ferreira Velho, Marina Rovani Drummond

“…DNA was extracted using a commercial kit and tested via nested PCR for the ftsZ gene, as well as conventional PCR and qualitative real-time PCR using Sybr® Green for the citrate synthase gene (gltA), all specific reactions for B. henselae. …”
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Deficiency of FABP7 Triggers Premature Neural Differentiation in Idiopathic Normocephalic Autism Organoids by Xiao Han, Yuanlin He, Yuanhao Wang, Wenzhu Hu, Chu Chu, Lei Huang, Yuan Hong, Lu Han, Xu Zhang, Yao Gao, Yuan Lin, Hongxia Ma, Hongbing Shen, Xiaoyan Ke, Yan Liu, Zhibin Hu

“…Multiple cell lines and time series scRNA‐seq combined with a histomorphological analysis revealed premature neural differentiation of neural stem cells (NSCs) and decreased expression of Fatty acid binding protein 7 (FABP7) in ASD organoids. …”
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Preliminary study on unlocking growth and yield potential of USDA foxtail millet (Setaria italica L.) lines with NPK fertilization by Hira Shahzadi, Shahbaz Khan, Abdulrahman Al-Hashimi, Shahzad M. A. Basra, Kashf Mehmood, Muhammad Ashfaq Wahid, Muhammad Nawaz, Sohail Irshad, Abdul Haseeb, Afroz Rais, Safia Gul, Danish Ibrar, Yheni Dwiningsih

“…NPK treatments were applied twice during the study periods: first dose was applied after one week of the emergence of seedlings and the second dose was applied at the age of four weeks of seedlings. The time to 50% emergence ranged from 4.33 (V111) to 5.92 (U2) days, and the emergence was highest in V111 (10.02), and V19 had the lowest emergence index of 4.95. …”
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Application of fuzzy logic in decision-making process for relocation of floating net cages in river fish farming by R. Pramana, B.Y. Suprapto, Z. Nawawi

“…The output of the decision-making program correlated with the issued warnings by the water quality warning indicators when the pH value exceeded the lower threshold limit.CONCLUSION: The fuzzy logic method implemented in the Python program for decision-making regarding the relocation of floating net cages in river fish farming revealed the fluctuating water quality conditions of the Musi River within a specific time duration. These conditions correlated with the proximity of the water bodies to pollution sources such as residential areas, factories, and tributaries. …”
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Call to Action: Lead Pharmacy into the Next Decade by Gregory Zumach, Kerry K Fierke, Gardner Lepp, Bridget McGugan, Marta Brooks, Anthony Olson, Andrew Bartlett, Nilushi Karunaratne, Betty Exintaris

“…Call to Action Through our work as scholars, we can provide evidence-based, pertinent, timely solutions to address these issues, in ways that make it easily transferable to broad audiences. …”
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The Use of L-Menthol in Endoscopic Transpapillary Interventions. Prospective Randomized Dual-Center Study by M. A. Anishchenko, M. A. Nazmeev, S. G. Shapovalyants, S. A. Budzinsky, A. V. Rogov, R. R. Zaynutdinov, A. S. Melnikova, E. D. Fedorov, E. N. Platonova

“…The use of L-menthol during ERTI helps to achieve noticeable inhibition of peristalsis, promotes successful cannulation, reduces the intervention time, minimizes the risk of intraoperative complications. …”
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Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein by Marie-Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde

“…Combining MOG and TfR binding leads to distinct PK, biodistribution, and brain exposure, differentiating it from the highly investigated TfR-shuttling. It is the first time such long brain antibody exposure has been demonstrated after one single dose. …”
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Intervertebral Disc Degeneration in Long-Term Postoperative Patients with Adolescent Idiopathic Scoliosis: MRI Evaluation 34-51 Years after Surgery and its Changes during Middle an... by Tsutomu Akazawa, Toshiaki Kotani, Tsuyoshi Sakuma, Yasushi Iijima, Yoshiaki Torii, Jun Ueno, Atsuhiro Yoshida, Ken Tomochika, Sumihisa Orita, Yawara Eguchi, Kazuhide Inage, Yasuhiro Shiga, Junichi Nakamura, Yusuke Matsuura, Takane Suzuki, Hisateru Niki, Seiji Ohtori, Shohei Minami

“…Sagittal alignment parameters, such as sagittal vertical axis (SVA), pelvic incidence minus lumbar lordosis (PI-LL), and pelvic tilt (PT), worsened over time. Scores in the Scoliosis Research Society-22 Questionnaire pain, Roland-Morris Disability Questionnaire, and Oswestry Disability Index were significantly worse in the latest survey than in the previous one. …”
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Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV by Giovanni Guaraldi, Jovana Milic, Elena Bacchi, Federica Carli, Marianna Menozzi, Iacopo Franconi, Alessandro Raimondi, Giacomo Ciusa, Valentina Masi, Michela Belli, Stefano Guaraldi, Emanuele Aprile, Maria Mancini, Cristina Mussini, Jordan E. Lake, Kristine M. Erlandson

“…Of 281 PLWH (74.3% males), mean follow-up was 4.2 years, age 50.3 years, median time since HIV diagnosis 17.8 years, CD4 cell count 630 cells/µL at baseline. …”
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Mechanism of Acupuncture Therapy on RANKL/OPG Signaling Pathway to Regulate Bone Metabolism Balance in Osteoporosis Model Rats by Qin YIN, Hong PAN, Xiaojuan DING, Xiaoguang QIN, Xiaorong GUO

“…The rats in the blank group and the model group were given 0.9%NaCl solution for 50 μg/(kg·d)by gavage, the estradiol group was given estradiol valerate 50 μg/(kg·d)by gavage, the acupuncture group was given electroacupuncture at Shenshu, Sanyinjiao, Guanyuan, Zusanli acupoints with stimulation intensity of 2 mA, frequency of 2 Hz, 15 min/time, once a day. Enzyme linked immunosorbent assay(ELISA)was used to analyze bone specific alkaline phosphatase(BALP), cterminal type I collagen telopeptide(CTX-I), core-binding factor-α1(CBF-α1), procollagen type I amino-terminal peptide(PINP), osteocalcin(OC)of the four groups;The relative bone volume fraction(BV/TV), trabecular number(Tb. …”
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Unravelling the role of secretory Immnuoglobulin-A in COVID-19: a multicentre study in nursing homes during the first wave by Rafael Bielza, Patricia Pérez, Nuria García, Laura Ballesteros-Sanabria, Rosa María Martínez, Azam Ghazi, Clara Hernando, María Victoria Rodríguez, Israel J. Thuissard, Cristina Andreu-Vázquez, José Manuel Bautista

“…Resident medical records were reviewed to assess symptoms, comprehensive geriatric assessment (CGA), reinfection, and overall 30-day mortality. Results At the time of sample collection, 274 residents (89.8%) exhibited “induced” SIgA-S1 levels (≥ 57.6 U/mL), 46 (15.1%) tested positive for PCR SARS-CoV-2, and 170 (57%) had experienced COVID-19 symptoms. …”
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Clinical Study of Repetitive Transcranial Magnetic Stimulation Combined with Social Rehabilitation Training on Children with Attention Deficit Hyperactivity Disorder by JING Xinli, ZHU Min, NIU Yujia

“…The observation group received rTMS combined with the program for the education and enrichment of relational skills (PEERS) social rehabilitation training in addition to the routine medication, including 15 minutes rTMS treatment a time, twice a week for 12 weeks. The PEERS social rehabilitation training course consisted of 6 parts: communication, information interaction, game initiation, self-initiative, disagreement resolution and social pragmatics, which had 12 classes, 50 minutes per session, once a week, for 12 weeks. …”
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X-ray phase contrast imaging and diffraction in the laser-heated diamond anvil cell: A case study on the high-pressure melting of Pt by Emma Ehrenreich-Petersen, Bernhard Massani, Thea Engler, Olivia S. Pardo, Konstantin Glazyrin, Nico Giordano, Johannes Hagemann, Daniel Sneed, Timofey Fedotenko, Daniel J. Campbell, Mario Wendt, Sergej Wenz, Christian G. Schroer, Mathias Trabs, R.Stewart McWilliams, Hanns-Peter Liermann, Zsolt Jenei, Earl F. O’Bannon

“…In this paper, we present a novel approach for melting determination at high pressure where time-resolved synchrotron X-ray phase contrast imaging is used to observe the solid to liquid phase transition in laser heated samples in the diamond anvil cell along with simultaneous X-ray diffraction. …”
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Micronutrient status, food security, anaemia, Plasmodium infection, and physical activity as predictors of primary schoolchildren's body composition in Côte d'Ivoire by Kurt Z. Long, Kurt Z. Long, Sylvain G. Traoré, Sylvain G. Traoré, Kouadio B. Kouassi, Kouadio B. Kouassi, Jean T. Coulibaly, Jean T. Coulibaly, Bomey C. Gba, Bomey C. Gba, Daouda Dao, Daouda Dao, Johanna Beckmann, Christin Lang, Harald Seelig, Nicole Probst-Hensch, Nicole Probst-Hensch, Uwe Pühse, Markus Gerber, Jürg Utzinger, Jürg Utzinger, Bassirou Bonfoh, Bassirou Bonfoh, Bassirou Bonfoh

“…Associations of children's nutritional status, Plasmodium infection, physical activity and household characteristics with body composition were analyzed to identify what factors might be contributing to this dual burden of disease.MethodsLongitudinal growth curve models (LGCM) evaluated associations of micronutrient status, household food security, Plasmodium falciparum prevalence and physical activity assessed at three time points with fat free mass and fat mass.ResultsMore severe anaemia was inversely associated with FFM and TrFFM trajectories overall and among girls. …”
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Dexmedetomidine versus Dexamethasone as Perineural Adjuvants in Supraclavicular Brachial Plexus Block: An Interventional Study by Charmi Hitenbhai Shah, Jinesh Pareshbhai Kothari, Nilesh Vrajmohan Shah, Rajsi Rajan Shah, Sara Mary Thomas

“…Group 2 also showed significantly longer durations for motor blockade (918.75±65.80 minutes vs. 632.60±23.09 minutes, p=3.10×10-44), postoperative analgesia (1051.00±90.18 minutes vs. 811.12±17.23 minutes, p=1.00×10-28), and time for rescue analgesia (1116.75±93.96 minutes vs. 826.50±13.92 minutes, p=2.40×10-32). …”
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No major impact of new grape varieties on Bordeaux wine typicity: expert assessments in blind and non-blind tastings by Marc Plantevin, Sophie Tempère, Cécile Thibon, Lucile Dijkstra, Julien Lecourt, Agnès Destrac-Irvine, Cornelis van Leeuwen

“…Varietal mix is strictly regulated by protected denomination of origin (PDO) rules, although these can change over time. If new varieties were to be accepted in the Bordeaux varietal mix, it would most likely be as secondary varieties accounting for a small proportion in the final Bordeaux blend. …”
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Seasonal Variation in Chemical Composition and Antioxidant and Antibacterial Activity of Essential Oil from <i>Cinnamomum cassia</i> Leaves by Yanrong Cheng, Ying Fu, Dingze Gu, Yan Huang, Yongqi Lu, Yujie Liu, Xiulan Li, Xinyue Yao, Xinxuan Zhang, Wanying Jian, Peiwei Liu, Hong Wu, Yanqun Li

“…This study provides essential data and valuable references for optimizing resource utilization and determining the ideal harvest time for <i>C. cassia</i> leaves.…”
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