Potential role of particulate matter in the spreading of COVID-19 in Northern Italy: first observational study based on initial epidemic diffusion by Alessandro Miani, Annamaria Colao, Prisco Piscitelli, Leonardo Setti, Fabrizio Passarini, Gianluigi De Gennaro, Pierluigi Barbieri, Sabina Licen, Maria Grazia Perrone, Andrea Piazzalunga, Massimo Borelli, Jolanda Palmisani, Alessia Di Gilio, Emanuele Rizzo

“…In Milan, the average growth rate before the lockdown was significantly higher than in Rome (0.34 vs 0.27 per day, with a doubling time of 2.0 days vs 2.6, respectively), thus suggesting a basic reproductive number R0>6.0, comparable with the highest values estimated for China.Conclusion A significant association has been found between the geographical distribution of daily PM10 exceedances and the initial spreading of COVID-19 in the 110 Italian provinces.…”
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Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis by William J Murphy, Robert J Canter, Nikhil Joshi, Sean J Judge, Morgan A Darrow, Steve W Thorpe, Alicia A Gingrich, Lauren M Perry, Sylvia M Cruz, Kara T Kleber, Louis B Jones, Ugur N Basmaci, Matthew L Settles, Blythe P Durbin-Johnson, Arta Monir Monjazeb, Janai Carr-Ascher, Jonathan A Eisen

“…In the tumor microenvironment, we observed a strong positive correlation between viral relative abundance and natural killer (NK) infiltration, and higher NK infiltration was associated with superior metastasis-free and overall survival by immunohistochemical, flow cytometry, and multiplex immunofluorescence analyses.Conclusions We prospectively demonstrate the presence of a distinct and measurable intratumoral microbiome in patients with STS at multiple time points. Our data suggest that the STS tumor microbiome has prognostic significance with viral relative abundance associated with NK infiltration and oncologic outcome. …”
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Effect of intermittent infusion hemodiafiltration on cerebral and hepatic oxygenation by Susumu Ookawara, Kiyonori Ito, Kazuma Fukuda, Tomoko Iida, Kazumi Yahagi, Haruhisa Miyazawa, Keiji Hirai, Mamoru Yoshizawa, Yoshiyuki Morishita

“…During I-HDF, cerebral and hepatic rSO2 levels significantly increased in response to dialysate infusion, compared with corresponding time points during HD. The percentage (%) change in hepatic rSO2 after the seventh dialysate infusion was significantly greater than those after the first, third, and fifth infusions. …”
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A meta-core outcome set for stillbirth prevention and bereavement care following stillbirth in LMIC by Jamie J Kirkham, Declan Devane, Carol Bedwell, Tina Lavender, Tracey A Mills, Sabina Wakasiaka, Rose Laisser, Bellington Vwalika, Nasim Chaudhry, Angela Chimwaza, Elizabeth Ombeva Ayebare, Sudhindrashayana Fattepur, Tayyeba Kiran, Kushupika Dube, Farai Marenga, Idesi Chilinda, Unice Goshomi, Allen Nabisere, Zaib Un Nisa

“…To address this gap, the objective of this study was to establish consensus on the most important outcomes for stillbirth prevention and bereavement care following stillbirth in sub-Saharan Africa and South Asia.Methods Previous stillbirth outcomes were reviewed for inclusion into the COS by senior research leaders and community engagement and involvement members from six sub-Saharan African and two South Asian countries. An online real-time Delphi survey was then conducted with healthcare professionals, parents who have experienced a stillbirth and researchers in the field to score the agreed list. …”
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The association of HIV status and depressive symptoms in the Ndlovu Cohort study by Li Xiang Y. den Boer, Karine Scheuermaier, Hugo A. Tempelman, Roos E. Barth, Walter L. J. M. Devillé, Roel A. Coutinho, Diederick E. Grobbee, Francois Venter, Alinda G. Vos-Seda, Kerstin Klipstein-Grobusch

“…Future research to investigate the relation between ART regimen and depressive symptoms, to establish causality and to identify changes over time, is warranted.…”
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<i>Ex Vivo</i> Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study by Arijita Sarkar, Matthew C. Gallo, Jennifer A. Bell, Cory K. Mayfield, Jacob R. Ball, Mina Ayad, Elizabeth Lechtholz-Zey, Stephanie W. Chang, Osamu Sugiyama, Denis Evseenko, Jay R. Lieberman

“…However, the cellular and transcriptional mechanisms regulating the response to these two strategies for BMP-2 mediated bone regeneration are largely unknown. Here, for the first time, we performed single-cell RNA sequencing (10x Genomics) of hematoma tissue in six rats with critical-sized femoral defects that were treated with either regional gene therapy or rhBMP-2. …”
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Efficacy of Unsupervised YouTube Dance Exercise for Patients With Hypertension: Randomized Controlled Trial by Mizuki Sakairi, Taiju Miyagami, Hiroki Tabata, Naotake Yanagisawa, Mizue Saita, Mai Suzuki, Kazutoshi Fujibayashi, Hiroshi Fukuda, Toshio Naito

“…Many previous studies have evaluated the effects of exercise on BP improvement; however, exercise requires securing a location, time, and staff, which can be challenging in clinical settings. …”
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Lithium and Valproate Levels Do Not Correlate with Ketamine’s Antidepressant Efficacy in Treatment-Resistant Bipolar Depression by Annie J. Xu, Mark J. Niciu, Nancy B. Lundin, David A. Luckenbaugh, Dawn F. Ionescu, Erica M. Richards, Jennifer L. Vande Voort, Elizabeth D. Ballard, Nancy E. Brutsche, Rodrigo Machado-Vieira, Carlos A. Zarate

“…The primary depression outcome measure—the Montgomery-Åsberg Depression Rating Scale (MADRS)—was assessed before infusion and at numerous postinfusion time points. Both lithium (F1,118 = 152.08, p<0.001, and d=2.27) and valproate (F1,128 = 20.12, p<0.001, and d=0.79) significantly improved depressive symptoms, but no statistically significant difference was observed between mood stabilizer groups (F1,28 = 2.51, p=0.12, and d=0.60). …”
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RETRACTED ARTICLE: Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Sna... by Yaodong Zhu, Yanqing Liu, Yayun Qian, Xiaojun Dai, Ling Yang, Jue Chen, Shiyu Guo, Tadashi Hisamitsu

“…Viability, invasion and migration, protein and mRNA expression of tumor cells were analyzed by MTT assay, transwell assay, western blot and real-time PCR, respectively. The molecular targets of COE in SGC-7901 cells were investigated by two-dimensional gel electrophoresis (2-DE) and MALDI-TOF-TOF mass spectrometer. …”
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Sex, Knowledge, and Attitude of Stroke Survivors Attending Bebe Herbal Center on Risk Factors before and after Stroke by Polycarp U. Nwoha, Florence O. Okoro, Emmanuel C. Nwoha, Fidelia N. Chukwu, Chidinma O. Nwoha, Nkeiru C. Ogoko, Peace N. Nwoha, Chika A. Idaguko, Augustine U. Obi, Ezenna M. Agwu, Iyanu O. Ayoola, Sunday O. Osonwa, Ifeoma H. Okpara

“…This was a cross-sectional study conducted from January to June 2018 at Bebe Herbal Center, and it involved two well-trained assistants who interviewed 149 first-time stroke survivors after consent and ethical approval were obtained. …”
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Ecological problem identification based on spatial and temporal dynamics of ecosystem quality: A case study by Rui Zhang, Huamin Liu, Zhichao Xu, Xinchuan Zhao, Lu Wen, Yi Zhuo, Lixin Wang

“…The study found that: (1) Resource utilization efficiency varies among ecosystems in Bayannur, with human activities significantly impacting local ecosystems; (2) Ecological quality shows substantial variation over time and across regions. While ecological conditions have improved in some areas over recent decades, severe degradation persists in the northwest. …”
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Effect of Robot-Assisted Gait Training on Lower Limb Motor Function of Children with Cerebral Palsy： A Meta-Analysis by JIANG Xiaoyu, BI Hongyan, SUN Wenyu, LIU Huifen, SU Hang, JIANG Jiahui

“…The randomized controlled trials (RCTs) of RAGT on children with CP were included, and the retrieval time was from inception to December 2021. The main outcome measures were GMFM-D and GMFM-E scores of the gross motor function measure (GMFM), Berg balance scale (BBS), functional ambulation category (FAC) scale, walking speed, 6-minute walk test (6MWT), modified Ashworth scale (MAS). …”
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The Effect of the Concurrent Use of Angiotensin-Converting Enzyme Inhibitors or Receptor Blockers on Toxicity and Outcomes in Patients Treated with Radiotherapy: A Systematic Revie... by Wan-Chuen Liao, Hala Shokr, Corinne Faivre-Finn, Clare Dempsey, Kaye Janine Williams, Li-Chia Chen

“…Differences in the median survival time, recurrence, and death rates were also calculated. …”
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Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan by Tsukasa Okamoto, Mariko Hanafusa, Taketomo Abe, Takashi Shimamura, Masaru Ito, Yoko Wakai, Torahiko Jinta, Katsuyuki Higa, Yasuhiro Kondoh, Yasumi Okouchi, Ryo Okuda, Masashi Bando, Takafumi Suda, Hiromi Tomioka, Takeo Fujiwara, Masato Takase, Shigemi Yoshihara, Hiroshi Odajima, Yasunari Miyazaki

“…Conclusions: This study determined the prevalence and incidence of fibrotic and non-fibrotic HP in Japan for the first time.…”
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Insights Into Antimicrobial Resistance From Dental Students in the Asia–Pacific Region by Saba Ghafoor, Gabriela Salvadori, Shiho Kino, Vy Thi Nhat Nguyen, Tam Thi-Thanh Nguyen, Miho Ishimaru, Antônio Pedro Ricomini-Filho, Cassiano Kuchenbecker Rösing, Dileep De Silva, Jun Aida, Belinda Farias Nicolau, Ratilal Lalloo, Roger Junges

“…Final-year students presented a mean (SEM) level of confidence to prescribe antibiotics of 6.01 (0.14) on a scale from 1 to 10, whilst 59.7% and 56.8% indicated feeling pressured to prescribe by patients or when lacking time, respectively. Final-year students participating in research activities assigned a higher priority to AMR compared to their peers not involved in research (mean [SEM] 8.6 [0.19] vs 7.81 [0.16]; P = .01). …”
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Inactivation of antibiotic resistant bacteria by nitrogen-doped carbon quantum dots through spontaneous generation of intracellular and extracellular reactive oxygen species by Weibo Xia, Zixia Wu, Bingying Hou, Zhang Cheng, Dechuang Bi, Luya Chen, Wei Chen, Heyang Yuan, Leo H. Koole, Lei Qi

“…The N-CQDs demonstrated antimicrobial activity against Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus, which was both dose- and time-dependent, reducing the survival rate to below 1 %. …”
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Complementary Embryonic and Adult Cell Populations Enhance Myocardial Repair in Rat Myocardial Injury Model by Sergio Li Calzi, Todd Cook, Domenico G. Della Rocca, Juan Zhang, Vinayak Shenoy, Yuanqing Yan, Andrew Espejo, Anandharajan Rathinasabapathy, Max H. Jacobsen, Tatiana Salazar, George E. Sandusky, Lynn C. Shaw, Keith March, Mohan K. Raizada, Carl J. Pepine, Michael J. Katovich, Maria B. Grant

“…Six-week-old female Sprague-Dawley rats underwent permanent left anterior descending (LAD) coronary artery ligation and received intramyocardial injection of either saline, Isl-1+ cells, CD90+ cells, or a combination of Isl-1+ and CD90+ cells, at the time of infarction. Cells were delivered transepicardially to the peri-infarct zone. …”
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Does the habitual dietary intake of adults in Bavaria, Germany, match dietary intake recommendations? Results of the 3rd Bavarian Food Consumption Survey by Florian Rohm, Nina Wawro, Nina Wawro, Sebastian Gimpfl, Nadine Ohlhaut, Melanie Senger, Christine Röger, Martin Kussmann, Kurt Gedrich, Jakob Linseisen, Jakob Linseisen

“…The conclusions based on the intake of selected essential nutrients hardly changed over time. From a public health perspective, the still low intake of vegetables, fruit, nuts, cereal products, and particularly of whole grain products, and associated higher risks of insufficient supply of several vitamins and minerals call for action for improvement.…”
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Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled tri... by Karen J. Bosma, Myriam Lafreniere-Roula, Arlene Jiang, Anna Heath, Yongdong Ouyang, Kaitlyn Wade, Pingzhao Hu, Karen E. A. Burns, Claudio M. Martin, Yoanna Skrobik, Sorcha Mulligan, Kevin E. Thorpe, Laurent Brochard, members of the Canadian Critical Care Trials Group and the REVA Network

“…Methods/design The Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING) study is a multi-center, open-label, randomized controlled trial designed to determine if ventilation with proportional assist ventilation with load-adjustable gain factors will result in a shorter duration of time spent on mechanical ventilation compared to ventilation with pressure support ventilation for patients with acute respiratory failure. …”
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Legal Disputes of Emigrant Periodical Publishers from the End of the 19th Century to 1904 by Remigijus Misiūnas

“…Evaluating the causes of the cases, it is possible to discuss the complicated perception of the satirical genre within the emigrant community of that time. On one hand, the hyperbolization of problems and ills in the emigrant life attracted readers with engaging texts, but on the other, it was interpreted as propaganda for a dissolute lifestyle and rejection of religious norms, dismissing the satirical aspect. …”
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