High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone by Daejin Kim, Byul-Nim Ahn, YeongSeok Kim, Dae Young Hur, Jae Wook Yang, Ga Bin Park, Jung Eun Jang, Eun Ju Lee, Min Jeong Kwon, Tae Nyun Kim, Mi Kyung Kim, Jeong Hyun Park, Byoung Doo Rhee, Soon Hee Lee

“…Metformin or pioglitazone suppressed cell viability concentration and time dependently, which was reversed by exposure to high glucose with or without insulin. …”
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Color Stability and Surface Properties of PMMA/ZrO2 Nanocomposite Denture Base Material after Using Denture Cleanser by Mohammed M. Gad, Reem Abualsaud, Shaimaa M. Fouda, Ahmed Rahoma, Ahmad M. Al-Thobity, Soban Q. Khan, Sultan Akhtar, Khalid S. Al-Abidi, Mohamed S. Ali, Fahad A. Al-Harbi

“…The denture cleansers significantly affected the color of both PMMA denture bases (P<0.001). The immersion time in denture cleansers significantly affected all tested properties (P<0.001). …”
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Temporal dynamics of climate sensitivity of litter decomposition in a semi-arid grassland by Zhen Li, Fuwei Wang, Yue Wen, Chenglong Ye, Peng Wang, Tongshuo Bai, Xudong Gu, Liang Guo, Yunpeng Qiu, Yi Zhang, Yi Wang, Shuijin Hu

“…Overall, our findings show that the climate sensitivity of litter decomposition exhibited distinct temporal dynamics, with increasing warming sensitivity of decomposition and decreasing moisture sensitivity of decomposition over time. Given that many current decomposition models use a constant sensitivity parameter (e.g., Q10 value = 2.0) throughout the decay process, our results suggest that incorporation of such temporal dynamics into decomposition models may enhance their predictive power.…”
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Regulation of Paneth cell-specific genes in COVID-19 patients and SARS-CoV-2-infected mice by quantification of mRNA from exfoliated cells in stool samples by Gill Diamond, Erika L. Figgins, Denny Gao, Tanya O. Robinson, Kenneth Wilson, Jon D. Gabbard, Charles D. Anderson, Lalit Batra, Chithra Sreenivasan, Jian Zheng, Uyen Do, Braden Mulcahy, Lisa K. Ryan, Nathaniel McLaughlin, Anna H. Owings, Neha Dhaliwal, Haley B. Williams, T. Grant Wichman, Michelle Galeas-Pena, Sarah C. Glover

“…We observed a similar time-dependent reduction in Paneth cell-specific transcripts, which correlates with histological changes in the gut. …”
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NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma by Chao-Yan Yao, Hang-Tian Tao, Jin-Jin He, Feng-Yi Zhu, Cui-Qing Xie, Yu-Na Cheng, Ji-Qin Li, Zhuang-Zhuang Liu, Chun-Yu Hou, Xue-Li Liu, Yong-Li Fan, Dong Fang, Xin-Rui Lv

“…Western blotting, immunofluorescence, real time PCR, and immunohistochemical staining were used to investigate the underlying mechanisms by which NUAK1 regulates PD-L1 expression in hepatocellular carcinoma. …”
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Comparison of different GnRH compounds on fertility outcomes in ovulation synchronized and presynchronized beef cows by Nicola Oosthuizen, Lucas M. Goncalves, Samir Burato, Molly S. Smith, Kelsey M. Harvey, Graham Cliff Lamb, Graham Cliff Lamb, Pedro L. P. Fontes

“…Within each location, cows were randomly assigned to one of four treatments: (1 and 2) cows were estrus synchronized using the 7-day CO-Synch + CIDR protocol (7D) wherein they received an injection of one of two GnRH compounds [gonadorelin hydrochloride (GH) or gonadorelin diacetate tetrahydrate (GDT)] and a controlled internal drug release (CIDR) device on day 0, an injection of prostaglandin F2α (PG) at CIDR removal on day 7, and a second injection of their respective GnRH compound at fixed-time artificial insemination (TAI) on day 10 (7D-GH and 7D-GHT); (3 and 4) cows were treated with the 7&amp;7 Synch (7&amp;7) protocol, wherein they were treated the same as treatments 1 and 2 but received their CIDR inserts on day -7 in conjunction with an injection of PG (7&amp;7-GH and 7&amp;7-GDT). …”
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Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation by Eliot G. Peyster, MD, MSc, Cai Yuan, PhD, Sara Arabyarmohammadi, PhD, Priti Lal, MD, Michael D. Feldman, MD, PhD, Pingfu Fu, PhD, Kenneth B. Margulies, MD, MS, Anant Madabhushi, PhD, FAIMBE, FIEEE, FNAI

“…Both overt and indolent inflammatory insults propel this remodeling, but there is a paucity of tools for monitoring the speed and severity of remodeling over time. Methods: This retrospective cohort consisted of n = 2,167 digitized heart transplant biopsy slides along with records of prior inflammatory events and future allograft outcomes (cardiac death or allograft vasculopathy). …”
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Neighborhood environment associations with cognitive function and structural brain measures in older African Americans by Dima L. Chaar, Le Tu, Kari Moore, Jiacong Du, Lauren A Opsasnick, Scott M Ratliff, Thomas H Mosley, Sharon L. R. Kardia, Wei Zhao, Xiang Zhou, Ana V Diez Roux, Fazlay S Faruque, Kenneth R Butler, Jennifer A Smith

“…Abstract Background Since older adults spend significant time in their neighborhood environment, environmental factors such as neighborhood socioeconomic disadvantage, high racial segregation, low healthy food availability, low access to recreation, and minimal social engagement may have adverse effects on cognitive function and increase susceptibility to dementia. …”
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Transfer of Cytoplasmic Male Sterility to the Female Parents of Heat- and Drought-Resilient Maize (<i>Zea mays</i> L.) Hybrids by Ayyanagouda Patil, Kushal Gowda, Shivananda T. Lakshman, Prakash H. Kuchanur, Gajanan Saykhedkar, Sudha Krishnan Nair, Kisan B. Jadhav, Sharanabasappa Yeri, Gururaj Sunkad, Jayaprakash M. Nidagundi, Vinayan Madhumal Thayil, Pervez H. Zaidi

“…For maize hybrid seed production, a prominent step is detasseling in the female parent, which is laborious, time consuming, and increases the hybrid seed cost by 15 to 20 percent. …”
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A systematic review and meta-analysis of the effectiveness of perineural dextrose injection in peripheral compression neuropathies of the upper limbs by Fatemeh Azizi, Faezeh Saber Gharesoo, Fereshteh Eidy, Sama Heidari, Nastaran Maghbouli, Shirin Djalalinia, Amir Kasaeian

“…Initial findings indicate significant pain relief with dextrose injection within a short time (≤4 weeks) compared to normal saline (MD: −1.30, 95%CI: −2.12; −0.47). …”
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Neurocognitive Function, Psychosocial Outcome, and Health-Related Quality of Life of the First-Generation Metastatic Melanoma Survivors Treated with Ipilimumab by Anne Rogiers, Christophe Leys, Justine Lauwyck, Adrian Schembri, Gil Awada, Julia Katharina Schwarze, Jennifer De Cremer, Peter Theuns, Paul Maruff, Mark De Ridder, Jan L. Bernheim, Bart Neyns

“…Out of 18 eligible survivors, 17 were recruited (5F/12M); median age is 57 years (range 33-86); and median time since initiating IPI was 5.6 years (range 2.1-9.3). …”
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The Impact of Health Promotion Using Leaflet Media on Mothers&rsquo; Knowledge of the Early Stimulation of Toddlers&rsquo; Development and Growth by Shalahuddin I, Salsabila S, Rukmasari EA, Rosidin U, Eriyani T, Pebrianti S, Maulana I

“…The findings using the non-parametric in Wilcoxon Test, the significant values for respondents, particularly mothers with children ages 1– 1.5 a long time, 1.5– 2 years, and 2– 3 years, are 0.002, 0.000, and 0.000, respectively.Conclusion: In summary, before and after health education using leaflet media can increase mothers’ knowledge about stimulation of toddler growth and development in Gunung Tua the village, Subang Regency.Keywords: growth and development, leaflet, knowledge, stimulation, toddler…”
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Psychological peculiarities of professional development in late adulthood by E. F. Zeer, E. E. Symanyuk, A. A. Ryabukhina, G. I. Borisov

“…Scientific novelty. For the first time in developmental psychology, the relationship between motivation and quality of life at a later age is discussed; the most significant factors of professional development are analysed. …”
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A long-term drought reconstruction based on oxygen isotope tree ring data for central and eastern parts of Europe (Romania) by V. Nagavciuc, V. Nagavciuc, G. Helle, M. Rădoane, C.-C. Roibu, M.-G. Cotos, M. Ionita, M. Ionita

“…A <span class="inline-formula"><i>δ</i>¹⁸</span>O site chronology spanning 1803–2020 was compiled from seven individual time series. <span class="inline-formula"><i>δ</i>¹⁸</span>O values exhibited a significant negative correlation with moisture-related variables (cloud cover, relative humidity, and precipitation) and a positive correlation with temperature and sunshine duration. …”
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Immunosuppression and Outcomes in Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck by Doriana Iancu, Ana Fulga, Doina Vesa, Iuliu Fulga, Dana Tutunaru, Andrei Zenovia, Alin Ionut Piraianu, Elena Stamate, Corina Sterian, Florentin Dimofte, Mihail Alexandru Badea, Alin Laurentiu Tatu

“…</b> In this cohort of 68 subjects with cSCC, patients with immunosuppression had significantly lower overall survival, as well as lower three- and five-year survival rates compared with those without immunosuppression, even after adjustment for age, sex, stage, and previous surgical treatment. The median survival time for immunosuppressed individuals ranged from 11 to 21 months, varying based on their particular characteristics, and most critically, on the presence of other malignancies, while that of immunocompetent patients ranged from 18 to 51 months. …”
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Comparative Analysis of Multiple Hydrological Models in Assessing Climate Change Impacts on the Mille Watershed, Awash Basin, Ethiopia by Asmare Belay Nigussie, Mihiretie Ayana, Dessalegn Worku Ayalew, Gerawork Feleke, Asnake Enawgaw Amognehegn, Anteneh Yayeh Adamu, Andualem Endalew, Tewodrose Desale Meselaw, Shankar Karuppannan

“…Precipitation and temperature scenarios data were obtained using the CMhyd Tool and then bias-corrected using various methods based on the base time period (1985–2014). The projected annual rainfall is expected to increase by 8.91-18.68% and 8.09-18.65%, while the average temperature is projected to increase by 1.08–3.04°C and 1.59–4.05°C in the 2050s (2041–2070) and 2080s (2071–2100), respectively. …”
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Reducing catheter-associated urinary tract infections in a large health system: a quality improvement approach using a fractal management system by Elie A. Saade, Esther J. Thatcher, Tina Lewis, Susan Carr, Marcia Cornell, Rachel Arnold, Lisa Bushong, Zainab Albar, Peter Pronovost

“…Performance tracking and visual management boards provided real-time insights, while collaborative efforts, including staff huddles and multidisciplinary teamwork, ensured consistent adherence to best practices. …”
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Long non-coding RNA OSTM1-AS1 promotes renal cell carcinoma progression by sponging miR-491-5p and upregulating MMP-9 by Jun-Feng Chen, Sha-Zhou Ye, Ke-Jie Wang, Xiang-yu Meng, Bin-bin Yang, Ke Rong Wu, Qi Ma

“…In summary, our findings indicate, for the first time, at least to the best of our knowledge, that OSTM1-AS1 serves as an oncogene among RCC by promoting proliferation, invasion, and metastasis through its targeting of the miR-491-5p/MMP9 axis. …”
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Association of the Monocyte to High-Density Lipoprotein Cholesterol Ratio and Neutrophil to High-Density Lipoprotein Cholesterol Ratio With the Severity of New-Onset Coronary Arter... by Shu H, Han S, Qiu W, Li J, Zhang X, Su H, Wu H, Zhao G, Li Q

“…However, the correlation between MHR, NHR, and the severity of newly diagnosed coronary artery disease (CAD) has not been thoroughly explored.Methods: In this retrospective study, we enrolled 1489 patients who underwent coronary angiography for the first time between January 2022 and December 2023, of which 1143 were diagnosed with CAD. …”
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Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis by Piotr Wojdasiewicz, Łukasz A. Poniatowski, Andrzej Kotela, Marta Skoda, Michał Pyzlak, Aleksandra Stangret, Ireneusz Kotela, Dariusz Szukiewicz

“…In our study, we have documented increased average concentration of CX3CL1 in the blood serum of the study group (7.16±0.53 ng/ml) compared to the control group (5.85±0.70 ng/ml) without statistically significant difference in synovial fluid concentration at the same time. We have observed an increased macrophage presence with more marked proliferation and fibrosis of the synovial membrane in the study group. …”
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